{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:56:59Z","timestamp":1790204219010,"version":"4.1.0"},"reference-count":63,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>The limitations in the therapeutic options for foodborne pathogens lead to treatments failure, especially for multidrug-resistant (MDR) Salmonella sp., worldwide. Therefore, we aimed to find alternative and complementary therapies against these resistant foodborne pathogens. Out of 100 meat products samples, the prevalence rate of salmonella was 6%, serotyped only as S. Typhimurium and S. Enteritidis. According to the antibiotic susceptibility assays, the majority of our isolates were MDR and susceptible to cefotaxime. Out of the 13 tested plant extracts, five only showed an inhibition zone in the range of 8\u201350 mm against both serotypes. Based on their promising activity, the oily extract of cinnamon and aqueous extract of paprika represented the highest potency. Surprisingly, a significant synergistic effect was detected between cinnamon oil and cefotaxime. Depending on Gas Chromatography\/Mass Spectrometry (GC-MS), the antimicrobial activity of cinnamon oil was attributed to four components including linalool, camphor, (Z)-3-Phenylacrylaldehyde and its stereoisomer 2-Propenal-3-phenyl. The anti-virulence activities of these compounds were confirmed on the basis of computational molecular docking studies. Accordingly, we recommended the use of cinnamon oil as a food additive to fight the resistant foodborne pathogens. Additionally, we confirmed its therapeutic uses, especially when co-administrated with other antimicrobial agents.<\/jats:p>","DOI":"10.3390\/antibiotics10121453","type":"journal-article","created":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T22:19:16Z","timestamp":1638137956000},"page":"1453","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Alternative and Complementary Therapies against Foodborne Salmonella Infections"],"prefix":"10.3390","volume":"10","author":[{"given":"Mohamed F.","family":"Ghaly","sequence":"first","affiliation":[{"name":"Microbiology Department, Faculty of Science, Zagazig University, Zagazig 44511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahraa M.","family":"Nasr","sequence":"additional","affiliation":[{"name":"Microbiology Department, Faculty of Science, Zagazig University, Zagazig 44511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira I.","family":"Abousaty","sequence":"additional","affiliation":[{"name":"Microbiology Department, Faculty of Science, Zagazig University, Zagazig 44511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanan G.","family":"Seadawy","sequence":"additional","affiliation":[{"name":"Agriculture Research Center (ARC), Animal Health Research Institute (AHRI), Zagazig 44511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A. A.","family":"Shaheen","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Faculty of Medicine, Al Azhar University, Chairo 11311, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0774-5550","authenticated-orcid":false,"given":"Sarah","family":"Albogami","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, College of Science, Taif University, Taif 21974, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9820-4022","authenticated-orcid":false,"given":"Mohammad M.","family":"Al-Sanea","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Department, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1788-0038","authenticated-orcid":false,"given":"Mahmoud M.","family":"Bendary","sequence":"additional","affiliation":[{"name":"Microbiology and Immunology Department, Faculty of Pharmacy, Port Said University, Port Side 42511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.3201\/eid1805.111153","article-title":"Antimicrobial drug resistance in Escherichia coli from humans and food animals, United States, 1950\u20132002","volume":"18","author":"Tadesse","year":"2012","journal-title":"Emerg. Infect. Dis."},{"key":"ref_2","first-page":"1","article-title":"Food preservatives and their harmful effects","volume":"5","author":"Sharma","year":"2015","journal-title":"Int. J. Sci. Res. Publ."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S1473-3099(05)70189-4","article-title":"Antimicrobial resistance in developing countries. Part I: Recent trends and current status","volume":"5","author":"Okeke","year":"2005","journal-title":"Lancet Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3389\/fmicb.2012.00012","article-title":"Essential oils in food preservation: Mode of action, synergies, and interactions with food matrix components","volume":"3","author":"Hyldgaard","year":"2012","journal-title":"Front. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4081\/jbr.2017.6534","article-title":"Biological Activity and Chemical Identification of Ornithine Lipid Produced by Burkholderia Gladioli Pv. Agaricicola ICMP 11096 Using LC-MS and NMR Analyses","volume":"90","author":"Elshafie","year":"2018","journal-title":"J. Biol. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4081\/jbr.2019.8296","article-title":"Bacillus Mojavensis: Biofilm Formation and Biochemical Investigation of Its Bioactive Metabolites","volume":"92","author":"Camele","year":"2019","journal-title":"J. Biol. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.3389\/fmicb.2019.02619","article-title":"Anti-quorum Sensing and Antimicrobial Effect of Mediterranean Plant Essential Oils Against phytopathogenic bacteria","volume":"10","author":"Camele","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.bse.2007.03.012","article-title":"Chemical compositions, antimicrobial and herbicidal effects of essential oils isolated from Turkish Tanacetum aucheranum and Tanacetum chiliophyllum var. chiliophyllum","volume":"35","author":"Salamci","year":"2007","journal-title":"Biochem. Syst. Ecol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.fm.2005.01.016","article-title":"Synergistic bactericidal effect of carvacrol, cinnamaldehyde or thymol and refrigeration to inhibit Bacillus cereus in carrot broth","volume":"23","author":"Valero","year":"2006","journal-title":"Food Microbiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"813","DOI":"10.2174\/0929867033457719","article-title":"Antibacterial and antifungal properties of essential oils","volume":"10","author":"Kalemba","year":"2003","journal-title":"Curr. Med. Chem."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1006\/fmic.2001.0415","article-title":"The potential application of plant essential oils as natural food preservatives in soft cheese","volume":"18","author":"Stewart","year":"2001","journal-title":"Food Microbiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1046\/j.1365-2672.2003.01825.x","article-title":"Activity and mechanisms of action of selected biocidal agents on Gram-positive and-negative bacteria","volume":"94","author":"Walsh","year":"2003","journal-title":"J. Appl. Microbiol."},{"key":"ref_13","first-page":"195","article-title":"The antibacterial principles of (Allium sativum L.): Isolation, physical properties and antibacterial action","volume":"66","author":"Cavalitto","year":"1994","journal-title":"J. Am. Chem. Soc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ijfoodmicro.2007.03.003","article-title":"The in vitro antibacterial activity of dietary spice and medicinal herb extracts","volume":"117","author":"Shan","year":"2007","journal-title":"Int. J. Food Microbiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.4315\/0362-028X-63.8.1113","article-title":"Recalls of food and cosmetics due to microbial contamination reported to the U.S. Food and Drug Administration","volume":"63","author":"Wong","year":"2000","journal-title":"J. Food Protect."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.jchromb.2006.11.011","article-title":"A TLC bioautographic assay for the detection of nitrofurantoin resistance reversal compound","volume":"850","author":"Shahverdi","year":"2007","journal-title":"J. Chromatogr. B"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.3390\/molecules17043989","article-title":"Essential oils in combination and their antimicrobial properties","volume":"17","author":"Juliani","year":"2012","journal-title":"Molecules"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1590\/1519-6984.08716","article-title":"Microencapsulation of essential thyme oil by spray drying and its antimicrobial evaluation against Vibrio alginolyticus and Vibrio parahaemolyticus","volume":"78","author":"Tomazelli","year":"2018","journal-title":"Braz. J. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"107879","DOI":"10.1016\/j.meatsci.2019.107879","article-title":"Coriander essential oil as natural food additive improves quality and safety of cooked pork sausages with different nitrite levels","volume":"157","author":"Sojic","year":"2019","journal-title":"Meat Sci."},{"key":"ref_20","first-page":"196","article-title":"A Review on the Extraction Methods Use in Medicinal Plants, Principle, Strength and Limitation","volume":"4","author":"Azwanida","year":"2015","journal-title":"Med. Aromat. Plants"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s10096-019-03761-2","article-title":"Genetic diversity of carbapenem-resistant Klebsiella pneumoniae causing neonatal sepsis in intensive care unit, Cairo, Egypt","volume":"39","author":"Ghaith","year":"2019","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_22","first-page":"221","article-title":"Existence of vancomycin resistance amongmethicillin resistant S. aureues recovered from animal and human sources in Egypt","volume":"55","author":"Bendary","year":"2018","journal-title":"Slov. Vet. Res."},{"key":"ref_23","first-page":"1506","article-title":"What is behind phylogenetic analysis of hospital, community and livestock associated methicillin-resistant Staphylococcus aureus?","volume":"66","author":"Bendary","year":"2019","journal-title":"Transbound. Emerg. Dis."},{"key":"ref_24","first-page":"10","article-title":"Alternative therapy to manage otitis media caused by multidrug-resistant fungi","volume":"1","author":"Ghaly","year":"2020","journal-title":"Arch. Microbiol."},{"key":"ref_25","first-page":"55","article-title":"Genetic diversity of multidrug resistant Staphylococcus aureus isolated from clinical and non clinical samples in Egypt","volume":"62","author":"Bendary","year":"2016","journal-title":"Cell. Mol. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"7742","DOI":"10.1038\/s41598-021-86990-w","article-title":"Thymol nanoemulsion promoted broiler chicken\u2019s growth, gastrointestinal barrier and bacterial community and conferred protection against Salmonella typhimurium","volume":"11","author":"Ibrahim","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_27","first-page":"94","article-title":"Characterization of Methicillin Resistant Staphylococcus aureus isolated from human and animal samples in Egypt","volume":"62","author":"Bendary","year":"2016","journal-title":"Cell. Mol. Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.3389\/fmicb.2019.02353","article-title":"Genetic Diversity of Campylobacter jejuni Isolated from Avian and Human Sources in Egypt","volume":"10","author":"Samir","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Kra\u00b4sniewska, K., Kosakowska, O., Pobiega, K., and Gniewosz, M. (2020). The Influence of Two-Component Mixtures from Spanish OriganumOil with Spanish Marjoram Oil or Coriander Oil on Antilisterial Activity and Sensory Quality of a Fresh Cut Vegetable Mixture. Foods, 9.","DOI":"10.3390\/foods9121740"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1136\/jech.2007.065227","article-title":"Incidence of adverse events related to health care in Spain: Results of the Spanish National Study of Adverse Events","volume":"62","year":"2008","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1557\/s43578-021-00226-1","article-title":"Potency of a novel synthesized Ag- eugenol nanoemulsion for treating some bacterial and fungal pathogens","volume":"36","author":"Mosallam","year":"2021","journal-title":"J. Mater. Res."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Bendary, M.M., Ibrahim, D., Mosbah, R.A., Mosallam, F., Hegazy, W.H., Awad, N.S., Alshareef, W.A., Alomar, S.Y., Zaitone, S.A., and Abd El-Hamid, M.I. (2021). Thymol Nanoemulsion: A New Therapeutic Option for Extensively Drug Resistant Foodborne Pathogens. Antibiotics, 10.","DOI":"10.3390\/antibiotics10010025"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Hegazy, W.A., Khayat, M.T., Ibrahim, T.S., Nassar, M.S., Bakhrebah, M.A., Abdulaal, W.H., Alhakamy, N.A., and Bendary, M.M. (2020). Repurposing Anti-diabetic Drugs to Cripple Quorum Sensing in Pseudomonas aeruginosa. Microorganism, 8.","DOI":"10.3390\/microorganisms8091285"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"317","DOI":"10.5604\/12321966.1235180","article-title":"Prevalence and antimicrobial resistance of Salmonella in meat and meat products in Latvia","volume":"24","author":"Terentjeva","year":"2017","journal-title":"Ann. Agric. Environ. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.foodcont.2014.01.032","article-title":"The prevalence and serovar diversity of Salmonella in various food products in Estonia","volume":"42","author":"Kramarenko","year":"2014","journal-title":"Food Control"},{"key":"ref_36","first-page":"20","article-title":"Aerobic bacteria isolated from eggs and day-old chicks and their antibacterial resistance in Shiraz, Iran","volume":"7","author":"Nazer","year":"2006","journal-title":"Iran. J. Vet. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1128\/AAC.47.5.1672-1680.2003","article-title":"Trends in antimicrobial susceptibilities among Enterobacteriaceae isolated from hospitalized patients in the United States from 1998 to 2001","volume":"47","author":"Karlowsky","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2217\/fmb-2020-0119","article-title":"Impact of European pet antibiotic use on enterococci and staphylococci antimicrobial resistance and human health","volume":"16","author":"Miranda","year":"2021","journal-title":"Future Microbiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1111\/jam.14723","article-title":"Biological investigations of essential oils extracted from three Juniperus species and evaluation of their antimicrobial, antioxidant and cytotoxic activities","volume":"129","author":"Elshafie","year":"2020","journal-title":"J. Appl. Microbiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/s00203-020-01858-3","article-title":"Synergistic antibacterial, antifungal and antioxidant efficacy of cinnamon and clove essential oils in combination","volume":"202","author":"Purkait","year":"2020","journal-title":"Arch. Microbiol."},{"key":"ref_41","first-page":"5","article-title":"Evaluating the effect of selected midicinal plant extracts and their synergistic effect with metronidazole against Entamoeba histolytica","volume":"6","author":"Dardona","year":"2014","journal-title":"Eur. J. Biomed. Pharm. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.4014\/jmb.1407.07054","article-title":"Antibacterial mode of action of Cinnamomum verum bark essential oil, alone and in combination with piperacillin, against a multi-drug-resistant Escherichia coli strain","volume":"25","author":"Yap","year":"2015","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_43","first-page":"692625","article-title":"Morpho structural damage in food-spoiling bacteria due to the lemon grass oil and its vapour: SEM, TEM, and AFM investigations","volume":"2012","author":"TyaTyagi","year":"2012","journal-title":"Evid. Based Compl. Altern. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1111\/j.1365-2672.2008.04124.x","article-title":"Investigation of functional and morphological changes in Pseudomonas aeruginosa and Staphylococcus aureus cells induced by Origanum compactum essential oil","volume":"106","author":"Bouhdid","year":"2009","journal-title":"J. Appl. Microbiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.imu.2017.08.002","article-title":"Investigations of binding mode insight in Salmonella typhi type-III secretion system tip protein (SipD): A molecular docking and MD simulation study","volume":"9","author":"Gopinath","year":"2017","journal-title":"Inform. Med. Unlocked"},{"key":"ref_46","first-page":"30","article-title":"Assessment of the prevalence of Salmonellae in food","volume":"3","author":"Jakee","year":"2014","journal-title":"Int. J. Curr. Microbiol. Appl. Sci."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1099\/00207713-48-2-605","article-title":"Phylogenetic relationships of Salmonella based on rRNA sequences","volume":"48","author":"Christense","year":"1998","journal-title":"Int. J. Syst. Bacteriol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Jorgensen, J.H., and Turnidge, J.D. (2015). Susceptibility test methods: Dilution and disk diffusion methods. Man. Clin. Microbiol., 1253\u20131273.","DOI":"10.1128\/9781555817381.ch71"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/jpbs.JPBS_175_19","article-title":"Preparation of medicinal plants: Basic extraction and fractionation procedures for experimental purposes","volume":"12","author":"Abubakar","year":"2020","journal-title":"J. Pharm. Bioallied. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1590\/S0074-02762006000400007","article-title":"Synergism between plant extract and antimicrobial drugs used on Staphylococcus aureus diseases","volume":"101","author":"Betoni","year":"2006","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5812\/jjm.14814","article-title":"Fresh garlic extract enhances the antimicrobial activities of antibiotics on resistant strains in vitro","volume":"8","author":"Li","year":"2015","journal-title":"Jundishapur. J. Microbiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/ajcp\/45.4_ts.493","article-title":"Antibiotic susceptibility testing by a standard single disk method","volume":"45","author":"Bauer","year":"1966","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e01934-17","DOI":"10.1128\/JCM.01934-17","article-title":"CLSI methods development and standardization working group best practices for evaluation of antimicrobial susceptibility tests","volume":"56","author":"Humphries","year":"2018","journal-title":"J. Clin. Microbiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.cvsm.2013.04.005","article-title":"Antimicrobials, susceptibility testing, and minimum inhibitory concentrations (MIC) in veterinary infection treatment. The Veterinary Clinics of North America","volume":"43","author":"Papich","year":"2013","journal-title":"Small Anim. Pract."},{"key":"ref_55","unstructured":"Clinical and Laboratory Standards Institute M07 (2018). Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically, Approved Standard CLSI. [11th ed.]."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.apjtb.2015.09.024","article-title":"Evaluation of antibacterial activity and synergistic effect between antibiotic and the essential oils of some medicinal plants","volume":"6","author":"Moussaoui","year":"2016","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1039\/a907050h","article-title":"Synthesis of novel hypotensive aromatic thiocarbamate glycosides","volume":"1","author":"Saleem","year":"2000","journal-title":"J. Chem. Soc. Perkin. Trans."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.5897\/AJB09.941","article-title":"Analysis of the essential oil from the leaves of Sesamum radiatum, a potential medication for male infertility factor, by gas chromatography-mass spectrometry","volume":"9","author":"Ogunlesi","year":"2010","journal-title":"Afr. J. Biotechnol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/mas.20342","article-title":"Multi-dimensional mass spectrometry-based shotgun lipidomics and novel strategies for lipidomic analyses","volume":"31","author":"Han","year":"2012","journal-title":"Mass. Spectrom. Rev."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"112492","DOI":"10.1016\/j.indcrop.2020.112492","article-title":"Qualitative changes of spearmint essential oil as affected by drying methods","volume":"153","author":"Mokhtarikhah","year":"2020","journal-title":"Ind. Crops Prod."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/jcc.540150503","article-title":"ICM? A new method for protein modeling and design: Applications to docking and structure prediction from the distorted native conformation","volume":"15","author":"Abagyan","year":"1994","journal-title":"J. Comput. Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s10822-012-9547-0","article-title":"Docking and scoring with ICM: The benchmarking results and strategies for improvement","volume":"26","author":"Neves","year":"2012","journal-title":"J. Comput. Aided Mol. Des."},{"key":"ref_63","unstructured":"Kolde, R. (2021, October 29). Pheatmap: Pretty Heatmaps, R Package Version 1.0.12. Available online: https:\/\/CRAN.R-project.org\/package=pheatmap."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/10\/12\/1453\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:36:03Z","timestamp":1760168163000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/10\/12\/1453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,26]]},"references-count":63,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["antibiotics10121453"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics10121453","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,26]]}}}