{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:54:53Z","timestamp":1793048093690,"version":"4.5.0"},"reference-count":43,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>A 20-year-old man was admitted to the intensive care unit for septic shock due to Lemierre\u2019s syndrome. It is a rare syndrome that manifests as an upper respiratory infection, although systemic involvement, severe coagulopathy, and multi-organ failure can dangerously complicate the clinical picture. In this syndrome, sepsis-related neuroendocrine dysregulation and microcirculation impairment can have a rapid deleterious progression. Consequently, proper diagnosis, early source control, and appropriate antibiotics administration are mandatory to improve the prognosis. The intensive treatment is aimed at limiting organ damage through hemodynamic optimization. Remarkably, in septic shock due to Lemierre\u2019s syndrome, hemodynamic optimization can be achieved through the synergic effect of norepinephrine, argipressin, and hydrocortisone.<\/jats:p>","DOI":"10.3390\/antibiotics10121526","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T09:34:25Z","timestamp":1639474465000},"page":"1526","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Early Diagnosis and Antibiotic Treatment Combined with Multicomponent Hemodynamic Support for Addressing a Severe Case of Lemierre\u2019s Syndrome"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0376-7464","authenticated-orcid":false,"given":"Andreaserena","family":"Recchia","sequence":"first","affiliation":[{"name":"Anesthesia and Intensive Care 2, IRCCS \u201cCasa Sollievo della Sofferenza\u201d, 71013 San Giovanni Rotondo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5236-3132","authenticated-orcid":false,"given":"Marco","family":"Cascella","sequence":"additional","affiliation":[{"name":"Anesthesia and Pain Medicine Istituto Nazionale Tumori-IRCCS, Fondazione G. Pascale, 80100 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Altamura","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care 2, IRCCS \u201cCasa Sollievo della Sofferenza\u201d, 71013 San Giovanni Rotondo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felice","family":"Borrelli","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care 2, IRCCS \u201cCasa Sollievo della Sofferenza\u201d, 71013 San Giovanni Rotondo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazario","family":"De Nittis","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care 2, IRCCS \u201cCasa Sollievo della Sofferenza\u201d, 71013 San Giovanni Rotondo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Dibenedetto","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care 2, IRCCS \u201cCasa Sollievo della Sofferenza\u201d, 71013 San Giovanni Rotondo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Labonia","sequence":"additional","affiliation":[{"name":"Microbiology and Virology, IRCCS \u201cCasa Sollievo della Sofferenza\u201d, 71013 San Giovanni Rotondo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Pavone","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care 2, IRCCS \u201cCasa Sollievo della Sofferenza\u201d, 71013 San Giovanni Rotondo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Del Gaudio","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care 2, IRCCS \u201cCasa Sollievo della Sofferenza\u201d, 71013 San Giovanni Rotondo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1056\/NEJMicm1808378","article-title":"Lemierre\u2019s Syndrome","volume":"380","author":"Walkty","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4103\/0972-5229.128708","article-title":"Lemierr\u2019s syndrome: An often missed life-threatening infection","volume":"18","author":"Srivali","year":"2014","journal-title":"Indian J. Crit. Care Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.jmii.2020.03.027","article-title":"Lemierre\u2019s syndrome: A forgotten and re-emerging infection","volume":"53","author":"Lee","year":"2020","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s10096-008-0496-4","article-title":"Lemierre\u2019s syndrome and other disseminated Fusobacterium necrophorum infections in Denmark: A prospective epidemiological and clinical survey","volume":"27","author":"Prag","year":"2008","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1136\/pgmj.2003.014274","article-title":"Lemierre\u2019s syndrome: More than a historical curiosa","volume":"80","author":"Riordan","year":"2004","journal-title":"Postgrad. Med. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/S0163-4453(17)30191-3","article-title":"The long shadow of lemierre\u2019s syndrome","volume":"74","author":"Osowicki","year":"2017","journal-title":"J. Infect."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1865-1380-6-40","article-title":"Lemierre\u2019s syndrome","volume":"6","author":"Eilbert","year":"2013","journal-title":"Int. J. Emerg. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1002\/lary.20542","article-title":"Lemierre\u2019s syndrome: A systematic review","volume":"6","author":"Karkos","year":"2009","journal-title":"Laryngoscope"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1001\/jama.2016.20328","article-title":"Australian and New Zealand Intensive Care Society (ANZICS) Centre for Outcomes and Resource Evaluation (CORE). Prognostic Accuracy of the SOFA Score, SIRS Criteria, and qSOFA Score for In-Hospital Mortality Among Adults With Suspected Infection Admitted to the Intensive Care Unit","volume":"317","author":"Raith","year":"2017","journal-title":"JAMA"},{"key":"ref_10","first-page":"86","article-title":"A case of Lemierre\u2019s syndrome with septic shock and complicated parapneumonic effusions requiring intrapleural fibrinolysis","volume":"16","author":"Croft","year":"2015","journal-title":"Respir. Med. Case Rep."},{"key":"ref_11","first-page":"5469053","article-title":"Atypical Presentation of Lemierre\u2019s Syndrome Causing Septic Shock and Acute Respiratory Distress Syndrome","volume":"2018","author":"Nemakayala","year":"2018","journal-title":"Case Rep. Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/SMJ.0b013e31825581ef","article-title":"Lemierre syndrome","volume":"6","author":"Wright","year":"2012","journal-title":"South Med. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/S1473-3099(12)70089-0","article-title":"Lemierre\u2019s syndrome due to Fusobacterium necrophorum","volume":"12","author":"Kuppalli","year":"2012","journal-title":"Lancet Infect. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00423-010-0650-1","article-title":"Early source control in sepsis","volume":"395","year":"2010","journal-title":"Langenbecks Arch. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1002\/lary.25835","article-title":"The impact of delayed surgical drainage of deep neck abscesses in adult and pediatric populations","volume":"126","author":"Cramer","year":"2016","journal-title":"Laryngoscope"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/hed.20014","article-title":"Deep neck infection: Analysis of 185 cases","volume":"26","author":"Huang","year":"2004","journal-title":"Head Neck."},{"key":"ref_17","first-page":"CD006287","article-title":"Needle aspiration versus incision and drainage for the treatment of peritonsillar abscess","volume":"12","author":"Chang","year":"2016","journal-title":"Cochrane Database Syst Rev."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Gehrke, T., Scherzad, A., Hagen, R., and Hackenberg, S. (2021). Deep neck infections with and without mediastinal involvement: Treatment and outcome in 218 patients. European Archives of Oto-Rhino-Laryngology, Springer.","DOI":"10.1007\/s00405-021-06945-9"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1053\/joms.2002.31218","article-title":"Tracheotomy versus endotracheal intubation for airway management in deep neck space infections","volume":"60","author":"Potter","year":"2002","journal-title":"J. Oral. Maxillofac. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1136\/bmj.38467.485671.E0","article-title":"Systematic review and meta-analysis of studies of the timing of tracheostomy in adult patients undergoing artificial ventilation","volume":"330","author":"Griffiths","year":"2005","journal-title":"BMJ"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1097\/CCM.0000000000000330","article-title":"Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: Results from a guideline-based performance improvement program","volume":"42","author":"Ferrer","year":"2014","journal-title":"Crit. Care Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1099\/0022-1317-51-3-269","article-title":"Fusobacterium necrophorum infections in England and Wales 1990\u20132000","volume":"51","author":"Brazier","year":"2002","journal-title":"J. Med. Microbiol."},{"key":"ref_23","first-page":"Doc03","article-title":"Clinical characteristics of a large cohort of patients with positive culture of Fusobacterium necrophorum","volume":"6","author":"Klasinc","year":"2018","journal-title":"GMS Infect. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s10096-008-0468-8","article-title":"Minimum requirements for a rapid and reliable routine identification and antibiogram of Fusobacterium necrophorum","volume":"27","author":"Jensen","year":"2008","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1086\/313970","article-title":"Human Necrobacillosis, with Emphasis on Lemierre\u2019s Syndrome","volume":"31","author":"Prag","year":"2000","journal-title":"Clin. Infect. Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"i3410","DOI":"10.1136\/bmj.i3410","article-title":"Safety of reduced antibiotic prescribing for self limiting respiratory tract infections in primary care: Cohort study using electronic health records","volume":"354","author":"Gulliford","year":"2016","journal-title":"BMJ"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Akata, K., Muratani, T., Yatera, K., Naito, K., Noguchi, S., Yamasaki, K., Kawanami, T., Kido, T., and Mukae, H. (2019). Induction of plasmid-mediated AmpC \u03b2-lactamase DHA-1 by piperacillin\/tazobactam and other \u03b2-lactams in Enterobacteriaceae. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0218589"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s10096-019-03533-y","article-title":"New antimicrobial options for the management of complicated intra-abdominal infections","volume":"38","author":"Leone","year":"2019","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s00134-017-4683-6","article-title":"Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016","volume":"43","author":"Rhodes","year":"2017","journal-title":"Intensive Care Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1056\/NEJMra002709","article-title":"The pathogenesis of vasodilatatory shock","volume":"345","author":"Landry","year":"2001","journal-title":"N. Eng. J. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.cardiores.2006.07.011","article-title":"Role of KATP channels in sepsis","volume":"72","author":"Buckley","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.ccc.2018.11.004","article-title":"Vasopressin in Vasodilatory Shock","volume":"35","author":"Ukor","year":"2019","journal-title":"Crit. Care Clin."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1007\/s00134-017-4914-x","article-title":"Critical illness-related corticosteroid insufficiency (CIRCI): A narrative review from a Multispecialty Task Force of the Society of Critical Care Medicine (SCCM) and the European Society of Intensive Care Medicine (ESICM)","volume":"43","author":"Annane","year":"2017","journal-title":"Intensive Care Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev-physiol-020518-114556","article-title":"Regulation of Thirst and Vasopressin Release","volume":"81","author":"Bichet","year":"2019","journal-title":"Annu. Rev. Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"S609","DOI":"10.1097\/01.CCM.0000279158.51481.41","article-title":"Vasopressin in septic shock","volume":"35","author":"Russell","year":"2007","journal-title":"Crit. Care Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1378\/chest.120.3.989","article-title":"Physiology of vasopressin relevant to management of septic shock","volume":"120","author":"Holmes","year":"2001","journal-title":"Chest"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1056\/NEJMoa067373","article-title":"Vasopressin versus norepinephrine infusion in patients with septic shock","volume":"358","author":"Russell","year":"2008","journal-title":"N. Eng. J. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1097\/CCM.0b013e3181961ace","article-title":"Interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock","volume":"37","author":"Russell","year":"2009","journal-title":"Crit. Care Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1001\/jama.288.7.862","article-title":"Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock","volume":"288","author":"Annane","year":"2002","journal-title":"JAMA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1007\/s00134-011-2334-x","article-title":"Time course of organ failure in patients with septic shock treated with hydrocortisone: Results of the Corticus study","volume":"37","author":"Moreno","year":"2011","journal-title":"Intensive Care Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1001\/jama.2016.10485","article-title":"Effect of Early Vasopressin vs. Norepinephrine on Kidney Failure in Patients With Septic Shock: The VANISH Randomized Clinical Trial","volume":"316","author":"Gordon","year":"2016","journal-title":"JAMA"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/SHK.0000000000000864","article-title":"Neuroendocrine Derangements in Early Septic Shock: Pharmacotherapy for Relative Adrenal and Vasopressin Insufficiency","volume":"48","author":"Schurr","year":"2017","journal-title":"Shock"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1097\/CCM.0000000000000212","article-title":"The interaction of vasopressin and corticosteroids in septic shock: A pilot randomized controlled trial","volume":"42","author":"Gordon","year":"2014","journal-title":"Crit. 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