{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T10:41:48Z","timestamp":1793356908998,"version":"4.5.0"},"reference-count":51,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,19]],"date-time":"2021-12-19T00:00:00Z","timestamp":1639872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Antimicrobial resistance represents one of the main threats to healthy ecosystems. In recent years, among the multidrug-resistant microorganisms responsible for nosocomial infections, the Enterococcus species have received much attention. Indeed, Enterococcus have peculiar skills in their ability to acquire resistance genes and to cause severe diseases, such as endocarditis. This study showed the prevalence and antimicrobial resistance rate of Enterococcus spp. isolated from clinical samples, from January 2015 to December 2019 at the University Hospital \u201cSan Giovanni di Dio e Ruggi d\u2019Aragona\u201d in Salerno, Italy. A total of 3236 isolates of Enterococcus\u00a0faecalis (82.2%) and Enterococcus\u00a0faecium (17.8%) were collected from urine cultures, blood cultures, catheters, respiratory tract, and other samples. Bacterial identification and antibiotic susceptibility were performed with VITEK 2. E. faecium showed a high resistance rate against ampicillin (84.5%), ampicillin\/sulbactam (82.7%), and imipenem (86.7%), while E. faecalis showed the highest resistance rate against gentamicin and streptomycin high level, but both were highly sensitive to such antibiotics as tigecycline and vancomycin. Studies of surveillance are an important tool to detect changes in the resistance profiles of the main pathogens. These antimicrobial susceptibility patterns are necessary to improve the empirical treatment guideline of infections.<\/jats:p>","DOI":"10.3390\/antibiotics10121552","type":"journal-article","created":{"date-parts":[[2021,12,19]],"date-time":"2021-12-19T20:41:55Z","timestamp":1639946515000},"page":"1552","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Prevalence and Antimicrobial Resistance of Enterococcus Species: A Retrospective Cohort Study in Italy"],"prefix":"10.3390","volume":"10","author":[{"given":"Mariarosaria","family":"Boccella","sequence":"first","affiliation":[{"name":"Department of Laboratory and Infectious Disease Sciences, Agostino Gemelli University Hospital IRCCS, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5010-1390","authenticated-orcid":false,"given":"Biagio","family":"Santella","sequence":"additional","affiliation":[{"name":"Section of Microbiology and Virology, University Hospital \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Pagliano","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry \u201cScuola Medica Salernitana\u201d, University of Salerno, 84081 Baronissi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0395-7962","authenticated-orcid":false,"given":"Anna","family":"De Filippis","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9810-0488","authenticated-orcid":false,"given":"Vincenzo","family":"Casolaro","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry \u201cScuola Medica Salernitana\u201d, University of Salerno, 84081 Baronissi, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1576-6290","authenticated-orcid":false,"given":"Massimiliano","family":"Galdiero","sequence":"additional","affiliation":[{"name":"Section of Microbiology and Virology, University Hospital \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"},{"name":"Department of Experimental Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Borrelli","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero Universitaria San Giovanni di Dio e Ruggi D\u2019Aragona, 84131 Salerno, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Capunzo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry \u201cScuola Medica Salernitana\u201d, University of Salerno, 84081 Baronissi, Italy"},{"name":"Dai Dipartimento Di Igiene Sanitaria e Medicina Valutativa U.O.C. Patologia Clinica E Microbiologica, A.O.U. San Giovanni di Dio e Ruggi D\u2019Aragona Scuola Medica Salernitana, Largo Citt\u00e0 di Ippocrate, 84131 Salerno, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7757-6855","authenticated-orcid":false,"given":"Giovanni","family":"Boccia","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry \u201cScuola Medica Salernitana\u201d, University of Salerno, 84081 Baronissi, Italy"},{"name":"Dai Dipartimento Di Igiene Sanitaria e Medicina Valutativa U.O.C. Patologia Clinica E Microbiologica, A.O.U. San Giovanni di Dio e Ruggi D\u2019Aragona Scuola Medica Salernitana, Largo Citt\u00e0 di Ippocrate, 84131 Salerno, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3321-4331","authenticated-orcid":false,"given":"Gianluigi","family":"Franci","sequence":"additional","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry \u201cScuola Medica Salernitana\u201d, University of Salerno, 84081 Baronissi, Italy"},{"name":"Dai Dipartimento Di Igiene Sanitaria e Medicina Valutativa U.O.C. Patologia Clinica E Microbiologica, A.O.U. 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Available online: https:\/\/www.who.int\/news\/item\/29-04-2019-new-report-calls-for-urgent-action-to-avert-antimicrobial-resistance-crisis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13756-018-0336-y","article-title":"Estimating the burden of antimicrobial resistance: A systematic literature review","volume":"7","author":"Naylor","year":"2018","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1179\/2047773215Y.0000000030","article-title":"Antimicrobial resistance: A global multifaceted phenomenon","volume":"109","author":"Prestinaci","year":"2015","journal-title":"Pathog. Glob. Health"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"156","DOI":"10.4065\/mcp.2010.0639","article-title":"General principles of antimicrobial therapy","volume":"86","author":"Leekha","year":"2011","journal-title":"Mayo Clin. Proc."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Esposito, S., Gioia, R., De Simone, G., Noviello, S., Lombardi, D., Di Crescenzo, V.G., Filippelli, A., Rega, M.R., Massari, A., and Elberti, M.G. (2015). Bacterial Epidemiology and Antimicrobial Resistance in the Surgery Wards of a Large Teaching Hospital in Southern Italy. Mediterr. J. Hematol. Infect. Dis., 7.","DOI":"10.4084\/mjhid.2015.040"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Manyi-Loh, C., Mamphweli, S., Meyer, E., and Okoh, A. (2018). Antibiotic Use in Agriculture and Its Consequential Resistance in Environmental Sources: Potential Public Health Implications. Molecules, 23.","DOI":"10.3390\/molecules23040795"},{"key":"ref_8","unstructured":"Bhardwaj, S.B. (2019). Enterococci: An Important Nosocomial Pathogen. Pathogenic Bacteria, IntechOpen."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Fiore, E., Van Tyne, D., and Gilmore, M.S. (2019). Pathogenicity of Enterococci. Microbiol. Spectr., 7.","DOI":"10.1128\/microbiolspec.GPP3-0053-2018"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Sanz-Garc\u00eda, F., Gil-Gil, T., Laborda, P., Ochoa-S\u00e1nchez, L.E., Mart\u00ednez, J.L., and Hernando-Amado, S. (2021). Coming from the Wild: Multidrug Resistant Opportunistic Pathogens Presenting a Primary, Not Human-Linked, Environmental Habitat. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22158080"},{"key":"ref_11","first-page":"1039","article-title":"Update on bacterial nosocomial infections","volume":"16","author":"Bereket","year":"2012","journal-title":"Eur. Rev. Med. Pharm. Sci."},{"key":"ref_12","first-page":"177","article-title":"Prevalence of vancomycin resistance among isolates of enterococci in Iran: A systematic review and meta-analysis","volume":"9","author":"Moghimbeigi","year":"2018","journal-title":"Adolesc. Health Med. Ther."},{"key":"ref_13","unstructured":"Higuita, N.I.A., and Huycke, M.M. (2014). Enterococcal disease, epidemiology, and implications for treatment. Enterococci: From Commensals to Leading Causes of Drug Resistant Infection [Internet], Massachusetts Eye and Ear Infirmary."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s15010-017-1039-7","article-title":"Bacterial meningitis complicating the course of liver cirrhosis","volume":"45","author":"Pagliano","year":"2017","journal-title":"Infection"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1177\/030089161309900103","article-title":"GHPSS multicenter Italian survey: Smoking prevalence, knowledge and attitudes, and tobacco cessation training among third-year medical students","volume":"99","author":"Saulle","year":"2013","journal-title":"Tumori"},{"key":"ref_16","first-page":"1197","article-title":"Distribution of antibiotic resistance among Enterococcus spp. isolated from 2017 to 2018 at the University Hospital","volume":"9","author":"Santella","year":"2019","journal-title":"Int. J. Mol. Clin. Microbiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"340","DOI":"10.4103\/0366-6999.198923","article-title":"Emergence of Vancomycin-resistant Enterococci at a Teaching Hospital, Saudi Arabia","volume":"130","author":"Alotaibi","year":"2017","journal-title":"Chin. Med. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13756-019-0466-x","article-title":"Emergence of vancomycin-resistant enterococci in Switzerland: A nation-wide survey","volume":"8","author":"Buetti","year":"2019","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"6274","DOI":"10.1038\/s41598-018-24614-6","article-title":"Emergence of Vancomycin-Resistant Enterococcus faecium at an Australian Hospital: A Whole Genome Sequencing Analysis","volume":"8","author":"Leong","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"ofz503","DOI":"10.1093\/ofid\/ofz503","article-title":"ESKAPE Pathogens in Bloodstream Infections Are Associated With Higher Cost and Mortality but Can Be Predicted Using Diagnoses Upon Admission","volume":"6","author":"Marturano","year":"2019","journal-title":"Open Forum Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Solache, M., and Rice, L.B. (2019). The Enterococcus: A Model of Adaptability to Its Environment. Clin. Microbiol. Rev., 32.","DOI":"10.1128\/CMR.00058-18"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Rogers, L.A., Strong, K., Cork, S.C., McAllister, T.A., Liljebjelke, K., Zaheer, R., and Checkley, S.L. (2021). The Role of Whole Genome Sequencing in the Surveillance of Antimicrobial Resistant Enterococcus spp.: A Scoping Review. Front. Public Health, 9.","DOI":"10.3389\/fpubh.2021.599285"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1586\/14787210.2014.956092","article-title":"Mechanisms of antibiotic resistance in enterococci","volume":"12","author":"Miller","year":"2014","journal-title":"Expert Rev. Anti-Infect. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.1038\/s41598-020-61002-5","article-title":"Surveillance of Enterococcus spp. reveals distinct species and antimicrobial resistance diversity across a One-Health continuum","volume":"10","author":"Zaheer","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"7936156","DOI":"10.1155\/2019\/7936156","article-title":"Characterization of clinical isolates of enterococci with special reference to glycopeptide susceptibility at a tertiary care center of Eastern Nepal","volume":"2019","author":"Karna","year":"2019","journal-title":"Int. J. Microbiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"7854968","DOI":"10.1155\/2019\/7854968","article-title":"Antibiotic Susceptibility Pattern and Biofilm Formation in Clinical Isolates of Enterococcus spp.","volume":"2019","author":"Shridhar","year":"2019","journal-title":"Interdiscip. Perspect. Infect. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"44","DOI":"10.4103\/0255-0857.93032","article-title":"Prevalence and antimicrobial resistance pattern of multidrug-resistant enterococci isolated from clinical specimens","volume":"30","author":"Moussa","year":"2012","journal-title":"Indian J. Med. Microbiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.284.5418.1318","article-title":"Bacterial biofilms: A common cause of persistent infections","volume":"284","author":"Costerton","year":"1999","journal-title":"Science"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1080\/08927014.2016.1231300","article-title":"Role of interspecies interactions in dual-species biofilms developed in vitro by uropathogens isolated from polymicrobial urinary catheter-associated bacteriuria","volume":"32","author":"Galvan","year":"2016","journal-title":"Biofouling"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3329\/bmrcb.v40i1.20320","article-title":"Antimicrobial resistance and in vitro biofilm-forming ability of Enterococci spp. isolated from urinary tract infection in a tertiary care hospital in Dhaka","volume":"40","author":"Akhter","year":"2014","journal-title":"Bangladesh Med. Res. Counc. Bull."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"483","DOI":"10.4103\/0971-5916.159309","article-title":"Antimicrobial susceptibility pattern of vancomycin resistant enterococci to newer antimicrobial agents","volume":"141","author":"Gupta","year":"2015","journal-title":"Indian J. Med. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"787","DOI":"10.12980\/jclm.3.2015j5-95","article-title":"Isolation and species identification of enterococci from clinical specimen with their antimicrobial susceptibility pattern in a tertiary care hospital","volume":"3","author":"Islam","year":"2015","journal-title":"Bangladesh J. Coast. Life Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.mjafi.2014.08.007","article-title":"Emergence of multidrug resistant enterococci at a tertiary care centre","volume":"71","author":"Bhatt","year":"2015","journal-title":"Med. J. Armed Forces India"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"European Food Safety Authority, and European Centre for Disease Prevention and Control (2018). The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2016. EFSA J., 16.","DOI":"10.2903\/j.efsa.2018.5182"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1590\/S0037-86822011005000009","article-title":"Trends in antimicrobial resistance among clinical isolates of enterococci in a Brazilian tertiary hospital: A 4-year study","volume":"44","year":"2011","journal-title":"Rev. Da Soc. Bras. De Med. Trop."},{"key":"ref_36","first-page":"323","article-title":"Vancomycin-resistant enteroccus faecium and enterococcus faecalis isolated from education hospital of iran","volume":"9","author":"Kafil","year":"2014","journal-title":"Maedica"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s12519-010-0212-1","article-title":"Nosocomial infections and fever of unknown origin in pediatric hematology\/oncology unit: A retrospective annual study","volume":"7","author":"Soliman","year":"2011","journal-title":"World J. Pediatrics"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13756-017-0231-y","article-title":"Incidence, clinical characteristics, and outcomes of nosocomial Enterococcus spp. bloodstream infections in a tertiary-care hospital in Beijing, China: A four-year retrospective study","volume":"6","author":"Zhang","year":"2017","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Buetti, N., Atkinson, A., Marschall, J., and Kronenberg, A. (2017). Incidence of bloodstream infections: A nationwide surveillance of acute care hospitals in Switzerland 2008-2014. BMJ Open, 7.","DOI":"10.1136\/bmjopen-2016-013665"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ijid.2014.02.012","article-title":"Incidence, risk factors, and outcomes for Enterococcus spp. blood stream infections: A population-based study","volume":"26","author":"Billington","year":"2014","journal-title":"Int. J. Infect. Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/1469-0691.12236","article-title":"Incidence, clinical characteristics and 30-day mortality of enterococcal bacteraemia in Denmark 2006-2009: A population-based cohort study","volume":"20","author":"Pinholt","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Santella, B., Folliero, V., Pirofalo, G.M., Serretiello, E., Zannella, C., Moccia, G., Santoro, E., Sanna, G., Motta, O., and De Caro, F. (2020). Sepsis-A Retrospective Cohort Study of Bloodstream Infections. Antibiotics, 9.","DOI":"10.3390\/antibiotics9120851"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2147\/IDR.S54125","article-title":"Vancomycin-resistant enterococcal infections: Epidemiology, clinical manifestations, and optimal management","volume":"8","author":"Crank","year":"2015","journal-title":"Infect. Drug Resist."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"401","DOI":"10.21307\/pjm-2018-043","article-title":"Emergence of High-level Gentamicin Resistance among Enterococci Clinical Isolates from Burn Patients in South-west of Iran: Vancomycin Still Working","volume":"67","author":"Labibzadeh","year":"2018","journal-title":"Pol. J. Microbiol."},{"key":"ref_45","unstructured":"Istituto Superiore di Sanit\u00e0 (2021, September 10). Rapporto AR-ISS. Available online: https:\/\/www.epicentro.iss.it\/antibiotico-resistenza\/ar-iss-rapporto-enterococcus-faecium."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"111062","DOI":"10.1016\/j.msec.2020.111062","article-title":"Functional behavior of chitosan\/gelatin\/silica-gentamicin coatings by electrophoretic deposition on surgical grade stainless steel","volume":"115","author":"Aydemir","year":"2020","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_47","first-page":"59","article-title":"Clinical and prognostic features of prosthetic joint infections caused by Enterococcus spp.","volume":"23","author":"Ascione","year":"2019","journal-title":"Eur. Rev. Med. Pharm. Sci."},{"key":"ref_48","first-page":"63","article-title":"Release of gentamicin from cement spacers in two-stage procedures for hip and knee prosthetic infection: An in vivo pharmacokinetic study with clinical follow-up","volume":"29","author":"Balato","year":"2015","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"5541706","DOI":"10.1155\/2021\/5541706","article-title":"Trend of Bacterial Uropathogens and Their Susceptibility Pattern: Study of Single Academic High-Volume Center in Italy (2015-2019)","volume":"2021","author":"Serretiello","year":"2021","journal-title":"Int. J. Microbiol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Santella, B., Serretiello, E., De Filippis, A., Veronica, F., Iervolino, D., Dell\u2019Annunziata, F., Manente, R., Valitutti, F., Santoro, E., and Pagliano, P. (2021). Lower Respiratory Tract Pathogens and Their Antimicrobial Susceptibility Pattern: A 5-Year Study. Antibiotics, 10.","DOI":"10.3390\/antibiotics10070851"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/j.1469-0691.2006.01454.x","article-title":"European Committee on Antimicrobial Susceptibility Testing (EUCAST) technical notes on antimicrobial susceptibility testing","volume":"12","author":"Kahlmeter","year":"2006","journal-title":"Clin. Microbiol. Infect."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/10\/12\/1552\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:51:51Z","timestamp":1760169111000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/10\/12\/1552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,19]]},"references-count":51,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["antibiotics10121552"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics10121552","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,19]]}}}