{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T22:11:09Z","timestamp":1774822269322,"version":"3.50.1"},"reference-count":56,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T00:00:00Z","timestamp":1640304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>This study aims to systematically assess the efficacy of parenteral and oral antibiotic prophylaxis compared to parenteral-only prophylaxis for the prevention of surgical site infection (SSI) in patients undergoing laparoscopic surgery for colorectal cancer resection. Published and unpublished randomized clinical trials comparing the use of oral and parenteral prophylactic antibiotics vs. parenteral-only antibiotics in patients undergoing laparoscopic colorectal surgery were collected searching electronic databases (MEDLINE, CENTRAL, EMBASE, SCIENCE CITATION INDEX EXPANDED) without limits of date, language, or any other search filter. The outcomes included SSIs and other infectious and noninfectious postoperative complications. Risk of bias was assessed using the Cochrane revised tool for assessing risk of bias in randomized trials (RoB 2). A total of six studies involving 2252 patients were finally included, with 1126 cases in the oral and parenteral group and 1126 cases in the parenteral-only group. Meta-analysis results showed a statistically significant reduction of SSIs (OR 0.54, 95% CI 0.40 to 0.72; p &lt; 0.0001) and anastomotic leakage (OR 0.55, 95% CI 0.33 to 0.91; p = 0.02) in the group of patients receiving oral antibiotics in addition to intravenous (IV) antibiotics compared to IV alone. Our meta-analysis shows that a combination of oral antibiotics and intravenous antibiotics significantly lowers the incidence of SSI compared with intravenous antibiotics alone.<\/jats:p>","DOI":"10.3390\/antibiotics11010021","type":"journal-article","created":{"date-parts":[[2021,12,27]],"date-time":"2021-12-27T01:00:54Z","timestamp":1640566854000},"page":"21","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Oral and Parenteral vs. Parenteral Antibiotic Prophylaxis for Patients Undergoing Laparoscopic Colorectal Resection: An Intervention Review with Meta-Analysis"],"prefix":"10.3390","volume":"11","author":[{"given":"Giuseppe","family":"Sangiorgio","sequence":"first","affiliation":[{"name":"Department of General Surgery and Medical-Surgical Specialties, University of Catania, Via S. Sofia 78, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6815-5012","authenticated-orcid":false,"given":"Marco","family":"Vacante","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Medical-Surgical Specialties, University of Catania, Via S. Sofia 78, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6831-5840","authenticated-orcid":false,"given":"Francesco","family":"Basile","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Medical-Surgical Specialties, University of Catania, Via S. Sofia 78, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9374-779X","authenticated-orcid":false,"given":"Antonio","family":"Biondi","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Medical-Surgical Specialties, University of Catania, Via S. Sofia 78, 95123 Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/2047-2994-1-28","article-title":"Concordance between European and US Case Definitions of Healthcare-Associated Infections","volume":"1","author":"Hansen","year":"2012","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.amjsurg.2008.11.030","article-title":"Deep and Organ\/Space Infections in Patients Undergoing Elective Colorectal Surgery: Incidence and Impact on Hospital Length of Stay and Costs","volume":"198","author":"Eagye","year":"2009","journal-title":"Am. J. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1067\/msy.2003.212","article-title":"Surgical Complications Exert a Lasting Effect on Disease-Specific Health-Related Quality of Life for Patients with Colorectal Cancer","volume":"134","author":"Anthony","year":"2003","journal-title":"Surgery"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s00595-012-0126-8","article-title":"Impact of Surgical Site Infection after Colorectal Surgery on Hospital Stay and Medical Expenditure in Japan","volume":"42","author":"Kashimura","year":"2012","journal-title":"Surg. Today"},{"key":"ref_5","unstructured":"(2021, November 28). Peri-Operative Antimicrobial Prophylaxis. Available online: https:\/\/www.ecdc.europa.eu\/en\/publications-data\/directory-guidance-prevention-and-control\/prudent-use-antibiotics\/peri-operative."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1089\/sur.2013.9999","article-title":"Clinical Practice Guidelines for Antimicrobial Prophylaxis in Surgery","volume":"14","author":"Bratzler","year":"2013","journal-title":"Surg. Infect."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1086\/501620","article-title":"Guideline for Prevention of Surgical Site Infection, 1999. Hospital Infection Control Practices Advisory Committee","volume":"20","author":"Mangram","year":"1999","journal-title":"Infect. Control. Hosp. Epidemiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s00384-004-0736-8","article-title":"Prospective, Randomised Study on Antibiotic Prophylaxis in Colorectal Surgery. Is It Really Necessary to Use Oral Antibiotics?","volume":"20","year":"2005","journal-title":"Int. J. Colorectal Dis."},{"key":"ref_9","first-page":"152","article-title":"Mechanical preparation in elective colorectal surgery, a usual practice or a necessity?","volume":"22","year":"2002","journal-title":"Rev. Gastroenterol. Peru"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Nelson, R.L., Gladman, E., and Barbateskovic, M. (2014). Antimicrobial Prophylaxis for Colorectal Surgery. Cochrane Database Syst. Rev., CD001181.","DOI":"10.1002\/14651858.CD001181.pub4"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1007\/s00268-015-3050-4","article-title":"Laparoscopic Colorectal Cancer Resection in High-Volume Surgical Centers: Long-Term Outcomes from the LAPCOLON Group Trial","volume":"39","author":"Huscher","year":"2015","journal-title":"World J. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1002\/bjs.7160","article-title":"Five-Year Follow-up of the Medical Research Council CLASICC Trial of Laparoscopically Assisted vs. Open Surgery for Colorectal Cancer","volume":"97","author":"Jayne","year":"2010","journal-title":"Br. J. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1007\/s00595-007-3684-4","article-title":"Wound Infection after a Laparoscopic Resection for Colorectal Cancer","volume":"38","author":"Yamamoto","year":"2008","journal-title":"Surg. Today"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S1470-2045(05)70221-7","article-title":"Laparoscopic Surgery vs. Open Surgery for Colon Cancer: Short-Term Outcomes of a Randomised Trial","volume":"6","author":"Veldkamp","year":"2005","journal-title":"Lancet Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Clinical Outcomes of Surgical Therapy Study Group, Nelson, H., Sargent, D.J., Wieand, H.S., Fleshman, J., Anvari, M., Stryker, S.J., Beart, R.W., Hellinger, M., and Flanagan, R. (2004). A Comparison of Laparoscopically Assisted and Open Colectomy for Colon Cancer. N. Engl. J. Med., 350, 2050\u20132059.","DOI":"10.1056\/NEJMoa032651"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1056\/NEJMoa1414882","article-title":"A Randomized Trial of Laparoscopic vs. Open Surgery for Rectal Cancer","volume":"372","author":"Bonjer","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1007\/s00464-015-4704-x","article-title":"Laparoscopic right hemicolectomy: Short- and long-term outcomes of intracorporeal vs. extracorporeal anastomosis","volume":"30","author":"Hanna","year":"2016","journal-title":"Surg. Endosc."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"5017","DOI":"10.3748\/wjg.v25.i34.5017","article-title":"Reducing anastomotic leak in colorectal surgery: The old dogmas and the new challenges","volume":"25","author":"Meyer","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.surg.2016.12.033","article-title":"Anastomotic leak after colorectal resection: A population-based study of risk factors and hospital variation","volume":"161","author":"Nikolian","year":"2017","journal-title":"Surgery"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12957-020-01968-8","article-title":"Risk factors for anastomotic leakage and its impact on long-term survival in left-sided colorectal cancer surgery","volume":"18","author":"Kryzauskas","year":"2020","journal-title":"World J. Surg. Oncol."},{"key":"ref_21","unstructured":"European Centre for Disease Prevention and Control (2013). Systematic Review and Evidence-Based Guidance on Perioperative Antibiotic Prophylaxis."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Walming, S., Angenete, E., Block, M., Bock, D., Gessler, B., and Haglind, E. (2017). Retrospective review of risk factors for surgical wound dehiscence and incisional hernia. BMC Surg., 17.","DOI":"10.1186\/s12893-017-0207-0"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1055\/s-0036-1584501","article-title":"Postoperative Complications: Looking Forward to a Safer Future","volume":"29","author":"Tevis","year":"2016","journal-title":"Clin. Colon. Rectal. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.amsu.2020.04.024","article-title":"Surgical complications in colorectal cancer patients","volume":"55","author":"Pak","year":"2020","journal-title":"Ann. Med. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"776","DOI":"10.3389\/fphar.2018.00776","article-title":"Prevention of Surgical Site Infections: A Systematic Review of Cost Analyses in the Use of Prophylactic Antibiotics","volume":"9","author":"Purba","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s10151-011-0714-4","article-title":"Combination of oral non-absorbable and intravenous antibiotics vs. intravenous antibiotics alone in the prevention of surgical site infections after colorectal surgery: A meta-analysis of randomized controlled trials","volume":"15","author":"Bellows","year":"2011","journal-title":"Tech. Coloproctol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jclinepi.2016.01.021","article-title":"PRESS Peer Review of Electronic Search Strategies: 2015 Guideline Statement","volume":"75","author":"McGowan","year":"2016","journal-title":"J. Clin. Epidemiol."},{"key":"ref_29","unstructured":"Higgins, J.P.T., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M.J., and Welch, V.A. (2021). Cochrane Handbook for Systematic Reviews of Interventions Version 6.2 (Updated February 2021), Cochrane. Available online: www.Training.Cochrane.Org\/Handbook."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: A Revised Tool for Assessing Risk of Bias in Randomised Trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"ref_31","unstructured":"The Cochrane Collaboration (2020). 2020 Review Manager (RevMan) [Computer Program], Version 5.4, The Cochrane Collaboration. Available online: https:\/\/training.cochrane.org\/online-learning\/core-software-cochrane-reviews\/revman."},{"key":"ref_32","unstructured":"(2021, May 01). GRADEpro GDT: GRADEpro Guideline Development Tool [Software]; McMaster University: 2020 (Developed by Evidence Prime, Inc.). Available online: Gradepro.Org."},{"key":"ref_33","unstructured":"Sch\u00fcnemann, H., Bro\u017cek, J., Guyatt, G., and Oxman, A. (2021, May 01). GRADE Handbook for Grading Quality of Evidence and Strength of Recommendations. Updated October 2013, Available online: Guidelinedevelopment.Org\/Handbook."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1002\/bjs.10281","article-title":"Randomized Clinical Trial of Oral and Intravenous vs. Intravenous Antibiotic Prophylaxis for Laparoscopic Colorectal Resection","volume":"103","author":"Ikeda","year":"2016","journal-title":"Br. J. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1097\/SLA.0000000000001581","article-title":"Oral and Parenteral Versus Parenteral Antibiotic Prophylaxis in Elective Laparoscopic Colorectal Surgery (JMTO PREV 07-01): A Phase 3, Multicenter, Open-Label, Randomized Trial","volume":"263","author":"Hata","year":"2016","journal-title":"Ann. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1007\/s005950170006","article-title":"Impact of Oral Antimicrobial Prophylaxis on Surgical Site Infection and Methicillin-Resistant Staphylococcus Aureus Infection after Elective Colorectal Surgery. Results of a Prospective Randomized Trial","volume":"31","author":"Ishida","year":"2001","journal-title":"Surg. Today"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/bjs.11117","article-title":"Randomized Clinical Trial of Selective Decontamination of the Digestive Tract in Elective Colorectal Cancer Surgery (SELECT Trial)","volume":"106","author":"Abis","year":"2019","journal-title":"Br. J. Surg."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00384-020-03544-8","article-title":"Prevention of Anastomotic Leak in Rectal Cancer Surgery with Local Antibiotic Decontamination: A Prospective, Randomized, Double-Blind, Placebo-Controlled Single Center Trial","volume":"35","author":"Schardey","year":"2020","journal-title":"Int. J. Colorectal. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s00595-006-3410-7","article-title":"Randomized Clinical Trial Comparing Intravenous Antimicrobial Prophylaxis Alone with Oral and Intravenous Antimicrobial Prophylaxis for the Prevention of a Surgical Site Infection in Colorectal Cancer Surgery","volume":"37","author":"Kobayashi","year":"2007","journal-title":"Surg. Today"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1007\/BF00295902","article-title":"Comparison of cefotaxime plus metronidazole vs. cefoxitin for prevention of wound infection after abdominal surgery","volume":"19","author":"Kow","year":"1995","journal-title":"World J. Surg."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1179\/joc.2002.14.4.366","article-title":"Amoxicillin\/clavulanic acid vs. cefotaxime for antimicrobial prophylaxis in abdominal surgery: A randomized trial","volume":"14","author":"Tonelli","year":"2002","journal-title":"J. Chemother."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0002-9610(02)01125-X","article-title":"A comparison of the prophylactic efficacy of ceftriaxone and cefotaxime in abdominal surgery","volume":"185","author":"Woodfield","year":"2003","journal-title":"Am. J. Surg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/DCR.0000000000000524","article-title":"Comparing Mechanical Bowel Preparation With Both Oral and Systemic Antibiotics Versus Mechanical Bowel Preparation and Systemic Antibiotics Alone for the Prevention of Surgical Site Infection After Elective Colorectal Surgery: A Meta-Analysis of Randomized Controlled Clinical Trials","volume":"59","author":"Chen","year":"2016","journal-title":"Dis. Colon. Rectum."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1097\/SLA.0000000000001125","article-title":"Oral Antibiotic Bowel Preparation Significantly Reduces Surgical Site Infection Rates and Readmission Rates in Elective Colorectal Surgery","volume":"261","author":"Morris","year":"2015","journal-title":"Ann. Surg."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/SLA.0000000000002567","article-title":"Efficacy of Preoperative Oral Antibiotic Prophylaxis for the Prevention of Surgical Site Infections in Patients With Crohn Disease: A Randomized Controlled Trial","volume":"269","author":"Uchino","year":"2019","journal-title":"Ann. Surg."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1213\/ANE.0000000000003746","article-title":"Enhanced Recovery Pathways: Looking Into the Future","volume":"128","author":"Joshi","year":"2019","journal-title":"Anesth. Analg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1007\/s00464-014-3814-1","article-title":"Iatrogenic ureteral injury in colorectal cancer surgery: A nationwide study comparing laparoscopic and open approaches","volume":"29","author":"Andersen","year":"2015","journal-title":"Surg. Endosc."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.amjsurg.2015.06.006","article-title":"Urinary tract infection after surgery for colorectal malignancy: Risk factors and complications","volume":"211","author":"Sheka","year":"2016","journal-title":"Am. J. Surg."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Smolarek, S., Shalaby, M., Angelucci, G.P., Missori, G., Capuano, I., Franceschilli, L., Quaresima, S., Di Lorenzo, N., and Sileri, P. (2016). Small-Bowel Obstruction Secondary to Adhesions After Open or Laparoscopic Colorectal Surgery. JSLS, 20.","DOI":"10.4293\/JSLS.2016.00073"},{"key":"ref_50","first-page":"1789","article-title":"Defunctioning Ileostomy Is a Key Risk Factor for Small Bowel Obstruction After Colorectal Cancer Resection","volume":"38","author":"Eto","year":"2018","journal-title":"Anticancer Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1001\/archsurg.134.2.170","article-title":"Selective decontamination of the digestive tract in surgical patients: A systematic 597 review of the evidence","volume":"134","author":"Nathens","year":"1999","journal-title":"Arch. Surg."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/10543400500406553","article-title":"Quasi-empirical Bayes methodology for improving meta-analysis","volume":"16","author":"Saleh","year":"2006","journal-title":"J. Biopharm. Stat."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"c365","DOI":"10.1136\/bmj.c365","article-title":"The impact of outcome reporting bias in randomised controlled trials on a cohort of systematic reviews","volume":"15","author":"Kirkham","year":"2010","journal-title":"BMJ"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/DCR.0b013e31819a5e45","article-title":"Surgical Site Infections in a \u201cHigh Outlier\u201d Institution: Are Colorectal Surgeons to Blame?","volume":"52","author":"Wick","year":"2009","journal-title":"Dis. Colon. Rectum."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.jamcollsurg.2010.07.025","article-title":"Surgical Site Infection in Colorectal Surgery: A Review of the Nonpharmacologic Tools of Prevention","volume":"211","author":"Murray","year":"2010","journal-title":"J. Am. Coll. Surg."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1097\/01.sla.0000219017.78611.49","article-title":"Elective Colon and Rectal Surgery Differ in Risk Factors for Wound Infection: Results of Prospective Surveillance","volume":"244","author":"Konishi","year":"2006","journal-title":"Ann. Surg."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/11\/1\/21\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:53:10Z","timestamp":1760169190000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/11\/1\/21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,24]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["antibiotics11010021"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics11010021","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,24]]}}}