{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:26:02Z","timestamp":1790479562648,"version":"4.1.0"},"reference-count":39,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,8]],"date-time":"2022-01-08T00:00:00Z","timestamp":1641600000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"project &quot;InnateFun&quot;","award":["promotional reference ANR-16-IFEC-0003-05"],"award-info":[{"award-number":["promotional reference ANR-16-IFEC-0003-05"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Candidiasis, caused by the opportunistic yeast Candida albicans, is the most common fungal infection today. Resistance of C. albicans to current antifungal drugs has emerged over the past decade leading to the need for novel antifungal agents. Our aim was to select new antifungal compounds by library-screening methods and to assess their antifungal effects against C. albicans. After screening 90 potential antifungal compounds from JUNIA, a chemical library, two compounds, 1-(4-chlorophenyl)-4-((4-chlorophenyl)amino)-3,6-dimethylpyridin-2(1H)-one (PYR) and (Z)-N-(2-(4,6-dimethoxy-1,3,5-triazin-2-yl)vinyl)-4-methoxyaniline (TRI), were identified as having potential antifungal activity. Treatment with PYR and TRI resulted in a significant reduction of C. albicans bioluminescence as well as the number of fungal colonies, indicating rapid fungicidal activity. These two compounds were also effective against clinically isolated fluconazole- or caspofungin-resistant C. albicans strains. PYR and TRI had an inhibitory effect on Candida biofilm formation and reduced the thickness of the mannan cell wall. In a Caenorhabditis elegans infection model, PYR and TRI decreased the mortality of nematodes infected with C. albicans and enhanced the expression of antimicrobial genes that promote C. albicans elimination. Overall, PYR and TRI showed antifungal properties against C. albicans by exerting fungicidal activities and enhancing the antimicrobial gene expression of Caenorhabditis elegans.<\/jats:p>","DOI":"10.3390\/antibiotics11010072","type":"journal-article","created":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T20:29:26Z","timestamp":1641760166000},"page":"72","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Two New Compounds Containing Pyridinone or Triazine Heterocycles Have Antifungal Properties against Candida albicans"],"prefix":"10.3390","volume":"11","author":[{"given":"Laura","family":"Mena","sequence":"first","affiliation":[{"name":"UMR 8576\u2014UGSF\u2014Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle, Centre National de la Recherche Scientifique, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1285, University of Lille, F-59000 Lille, France"},{"name":"Medicine Faculty, University of Lille, F-59000 Lille, France"},{"name":"CHU Lille, Service de Parasitologie Mycologie, P\u00f4le de Biologie Pathologie G\u00e9n\u00e9tique, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1486-7206","authenticated-orcid":false,"given":"Muriel","family":"Billamboz","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, CHU Lille, Institut Pasteur de Lille, U1167\u2014RID-AGE\u2014Facteurs de Risque et D\u00e9terminants Mol\u00e9culaires des Maladies Li\u00e9es au Vieillissement, University of Lille, F-59000 Lille, France"},{"name":"JUNIA, Health and Environment, Laboratory of Sustainable Chemistry and Health, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogatien","family":"Charlet","sequence":"additional","affiliation":[{"name":"UMR 8576\u2014UGSF\u2014Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle, Centre National de la Recherche Scientifique, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1285, University of Lille, F-59000 Lille, France"},{"name":"Medicine Faculty, University of Lille, F-59000 Lille, France"},{"name":"CHU Lille, Service de Parasitologie Mycologie, P\u00f4le de Biologie Pathologie G\u00e9n\u00e9tique, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9rang\u00e8re","family":"Despr\u00e8s","sequence":"additional","affiliation":[{"name":"UMR 8576\u2014UGSF\u2014Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle, Centre National de la Recherche Scientifique, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1285, University of Lille, F-59000 Lille, France"},{"name":"Medicine Faculty, University of Lille, F-59000 Lille, France"},{"name":"CHU Lille, Service de Parasitologie Mycologie, P\u00f4le de Biologie Pathologie G\u00e9n\u00e9tique, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1577-7325","authenticated-orcid":false,"given":"Boualem","family":"Sendid","sequence":"additional","affiliation":[{"name":"UMR 8576\u2014UGSF\u2014Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle, Centre National de la Recherche Scientifique, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale U1285, University of Lille, F-59000 Lille, France"},{"name":"Medicine Faculty, University of Lille, F-59000 Lille, France"},{"name":"CHU Lille, Service de Parasitologie Mycologie, P\u00f4le de Biologie Pathologie G\u00e9n\u00e9tique, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6468-4331","authenticated-orcid":false,"given":"Alina","family":"Ghinet","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, CHU Lille, Institut Pasteur de Lille, U1167\u2014RID-AGE\u2014Facteurs de Risque et D\u00e9terminants Mol\u00e9culaires des Maladies Li\u00e9es au Vieillissement, University of Lille, F-59000 Lille, France"},{"name":"JUNIA, Health and Environment, Laboratory of Sustainable Chemistry and Health, F-59000 Lille, France"},{"name":"Faculty of Chemistry, \u2018Alexandru Ioan Cuza\u2019 University of Iasi, Bd. 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