{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:20:20Z","timestamp":1789507220638,"version":"build-2803163510"},"reference-count":71,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T00:00:00Z","timestamp":1643155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["5SC1CA190504"],"award-info":[{"award-number":["5SC1CA190504"]}]},{"name":"NIH","award":["1R21CA240997-01A1"],"award-info":[{"award-number":["1R21CA240997-01A1"]}]},{"DOI":"10.13039\/100000001","name":"NSF","doi-asserted-by":"publisher","award":["1757365"],"award-info":[{"award-number":["1757365"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH RISE","award":["5R25GM061151-17"],"award-info":[{"award-number":["5R25GM061151-17"]}]},{"name":"NSF STC","award":["1231306"],"award-info":[{"award-number":["1231306"]}]},{"name":"Puerto Rico Science, Technology &amp; Research Trust Science Communication and Living Expenses Grant","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"University of Puerto Rico R\u00edo Piedras FIPI","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"University of Puerto Rico R\u00edo Piedras PBMA","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"NIH MARC","award":["5T34GM007821-40S1"],"award-info":[{"award-number":["5T34GM007821-40S1"]}]},{"name":"NSF CHE","award":["1626103"],"award-info":[{"award-number":["1626103"]}]},{"name":"Wellcome Trust (UK)","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"The University of Queensland (Australia)","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Due to the rapid mutation of pathogenic microorganisms, drug-resistant superbugs have evolved. Antimicrobial-resistant germs may share their resistance genes with other germs, making them untreatable. The search for more combative antibiotic compounds has led researchers to explore metal-based strategies centered on perturbing the bioavailability of essential metals in microbes and examining the therapeutic potential of metal complexes. Given the limited knowledge on the application of titanium(IV), in this work, eight Ti(IV) complexes and some of their corresponding ligands were screened by the Community for Open Antimicrobial Drug Discovery for antimicrobial activity. The compounds were selected for evaluation because of their low cytotoxic\/antiproliferative behavior against a human non-cancer cell line. At pH 7.4, these compounds vary in terms of their solution stability and ligand exchange lability; therefore, an assessment of their solution behavior provides some insight regarding the importance of the identity of the metal compound to the antimicrobial therapeutic potential. Only one compound, Ti(deferasirox)2, exhibited promising inhibitory activity against the Gram-positive bacteria methicillin-resistant Staphylococcus aureus and minimal toxicity against human cells. The ability of this compound to undergo transmetalation with labile Fe(III) sources and, as a consequence, inhibit Fe bioavailability and ribonucleotide reductase is evaluated as a possible mechanism for its antibiotic effect.<\/jats:p>","DOI":"10.3390\/antibiotics11020158","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T11:02:53Z","timestamp":1643194973000},"page":"158","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Exploring Titanium(IV) Complexes as Potential Antimicrobial Compounds"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1062-301X","authenticated-orcid":false,"given":"Israel","family":"Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Puerto Rico-R\u00edo Piedras Campus, San Juan 00925, Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1646-9722","authenticated-orcid":false,"given":"Lauren","family":"Fern\u00e1ndez-Vega","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Puerto Rico-R\u00edo Piedras Campus, San Juan 00925, Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea N.","family":"Maser-Figueroa","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Puerto Rico-R\u00edo Piedras Campus, San Juan 00925, Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branlee","family":"Sang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Puerto Rico-R\u00edo Piedras Campus, San Juan 00925, Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Gonz\u00e1lez-Pag\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Puerto Rico-R\u00edo Piedras Campus, San Juan 00925, Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur D.","family":"Tinoco","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Puerto Rico-R\u00edo Piedras Campus, San Juan 00925, Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9654","DOI":"10.1039\/C9DT00642G","article-title":"Copper potentiates azole antifungal activity in a way that does not involve complex formation","volume":"48","author":"Hunsaker","year":"2019","journal-title":"Dalton Trans."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1021\/acsinfecdis.8b00037","article-title":"Copper Influences the Antibacterial Outcomes of a \u03b2-Lactamase-Activated Prochelator against Drug-Resistant Bacteria","volume":"4","author":"Jackson","year":"2018","journal-title":"ACS Infect. 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