{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:52:31Z","timestamp":1760151151137,"version":"build-2065373602"},"reference-count":55,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T00:00:00Z","timestamp":1644969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>During pregnancy, there is a state of immune tolerance that predisposes them to viral infection, causing maternal-fetal vulnerability to the adverse effects of COVID-19. Bacterial coinfections significantly increase the mortality rate for COVID-19. However, it is known that all drugs, including antibiotics, will enter the fetal circulation in a variable degree despite the role of the placenta as a protective barrier and can cause teratogenesis or other malformations depending on the timing of exposure to the drug. Also, it is important to consider the impact of the indiscriminate use of antibiotics during pregnancy can alter both the maternal and fetal-neonatal microbiota, generating future repercussions in both. In the present study, the literature for treating bacterial coinfections in pregnant women with COVID-19 is reviewed. In turn, we present the findings in 50 pregnant women hospitalized diagnosed with SARS-CoV-2 without previous treatment with antibiotics; moreover, a bacteriological culture of sample types was performed. Seven pregnant women had coinfection with Staphylococcus haemolyticus, Staphylococcus epidermidis, Streptococcus agalactiae, Escherichia coli ESBL +, biotype 1 and 2, Acinetobacter jahnsonii, Enterococcus faecium, and Clostridium difficile. When performing the antibiogram, resistance to multiple drugs was found, such as macrolides, aminoglycosides, sulfa, dihydrofolate reductase inhibitors, beta-lactams, etc. The purpose of this study was to generate more scientific evidence on the better use of antibiotics in these patients. Because of this, it is important to perform an antibiogram to prevent abuse of empirical antibiotic treatment with antibiotics in pregnant women diagnosed with SARS-CoV-2.<\/jats:p>","DOI":"10.3390\/antibiotics11020252","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T20:26:41Z","timestamp":1645043201000},"page":"252","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Does the Fetus Limit Antibiotic Treatment in Pregnant Patients with COVID-19?"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0729-0031","authenticated-orcid":false,"given":"Tito","family":"Ram\u00edrez-Lozada","sequence":"first","affiliation":[{"name":"Servicio de Ginecolog\u00eda y Obstetricia, Hospital Regional de Alta Especialidad de Ixtapaluca, Ixtapaluca 56530, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Concepci\u00f3n","family":"Loranca-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Hospital General de Zona No. 53, Los Reyes, Instituto Mexicano del Seguro Social (IMSS), Carr Federal M\u00e9xico-Puebla Km 17.5, Villa de la Paz, Rinc\u00f3n de los Reyes, Los Reyes Acaquilpan 56400, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2145-5971","authenticated-orcid":false,"given":"Claudia Erika","family":"Fuentes-Venado","sequence":"additional","affiliation":[{"name":"Servicio de Medicina F\u00edsica y Rehabilitaci\u00f3n, Hospital General de Zona No. 197 IMSS, Texcoco 56108, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9939-0771","authenticated-orcid":false,"given":"Carmen","family":"Rodr\u00edguez-Cerdeira","sequence":"additional","affiliation":[{"name":"Efficiency, Quality, and Costs in Health Services Research Group (EFISALUD), Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36213 Vigo, Spain"},{"name":"Dermatology Department, Hospital Vithas Ntra. Sra. de F\u00e1tima, 36206 Vigo, Spain"},{"name":"Campus Universitario, University of Vigo, 36310 Vigo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0433-8116","authenticated-orcid":false,"given":"Esther","family":"Ocharan-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6529-1502","authenticated-orcid":false,"given":"Marvin A.","family":"Soriano-Urs\u00faa","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0787-044X","authenticated-orcid":false,"given":"Eunice D.","family":"Farf\u00e1n-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8571-4111","authenticated-orcid":false,"given":"Edwin","family":"Ch\u00e1vez-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Doctorado en Ciencias en Biomedicina y Biotecnolog\u00eda Molecular, Escuela Nacional de Ciencias Biol\u00f3gicas, IPN, Mexico City 07738, Mexico"},{"name":"Unidad de Investigaci\u00f3n, Hospital Regional de Alta Especialidad de Ixtapaluca, Estado de Mexico 56530, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X\u00f3chitl","family":"Ram\u00edrez-Maga\u00f1a","sequence":"additional","affiliation":[{"name":"Servicio de Ginecolog\u00eda y Obstetricia, Hospital Regional de Alta Especialidad de Ixtapaluca, Ixtapaluca 56530, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maura","family":"Robledo-Cayetano","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n, Hospital Regional de Alta Especialidad de Ixtapaluca, Estado de Mexico 56530, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8449-0806","authenticated-orcid":false,"given":"Marco A.","family":"Loza-Mej\u00eda","sequence":"additional","affiliation":[{"name":"Design, Isolation, and Synthesis of Bioactive Molecules Research Group, Chemical Sciences School, Universidad La Salle-M\u00e9xico, Benjam\u00edn Franklin 45, Mexico City 06140, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8706-7301","authenticated-orcid":false,"given":"Ivonne Areli Garcia","family":"Santa-Olalla","sequence":"additional","affiliation":[{"name":"Subdirecci\u00f3n de Enfermer\u00eda, Hospital Regional de Alta Especialidad de Ixtapaluca, Ixtapaluca 56530, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6637-4978","authenticated-orcid":false,"given":"Oscar Uriel","family":"Torres-Paez","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n, Hospital Regional de Alta Especialidad de Ixtapaluca, Estado de Mexico 56530, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5210-5395","authenticated-orcid":false,"given":"Rodolfo","family":"Pinto-Almaz\u00e1n","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"},{"name":"Non-Communicable Disease Research Group, Facultad Mexicana de Medicina, Universidad La Salle-M\u00e9xico, Las Fuentes 17, Tlalpan Centro I, Tlalpan, Mexico City 14000, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7298-158X","authenticated-orcid":false,"given":"Erick","family":"Mart\u00ednez-Herrera","sequence":"additional","affiliation":[{"name":"Efficiency, Quality, and Costs in Health Services Research Group (EFISALUD), Galicia Sur Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36213 Vigo, Spain"},{"name":"Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,16]]},"reference":[{"key":"ref_1","unstructured":"(2021, December 01). 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