{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:31:07Z","timestamp":1787027467280,"version":"build-2736575974"},"reference-count":29,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Gangneung Asan Hospital Medical Institute and the Asan Foundation","award":["2018\u2013C10"],"award-info":[{"award-number":["2018\u2013C10"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>An increase in the rate of complications after prostate biopsy (PB) due to increased antibiotic-resistant bacteria is a global issue. We report the safety of aztreonam as a prophylactic antibiotic in patients undergoing PB. We investigated the complication rates according to several antibiotic regimens, including aztreonam. We hypothesized that PB complications increased following a rise in antibiotic-resistant bacteria. We examined the annual rates of complications among patients in our hospital (clinical cohort) and the Korea Health Insurance Review and Assessment Service (HIRA) cohort. Data regarding complications, hospitalization, emergency room (ER) visits, and febrile urinary tract infections occurring within 2 weeks after PB were recorded. The rate of complications was significantly lower in patients who received oral quinolone and intravenous aztreonam than in those who received oral quinolone. The complication rates did not increase throughout the study period. Additionally, 1754 patients from the HIRA cohort were included. The rates of complications, hospitalizations, and ER visits did not increase among these patients. Oral quinolone combined with intravenous aztreonam reduced the rate of febrile complications compared to quinolone alone and was safe to use after PB. Therefore, we recommend intravenous aztreonam with oral quinolone as a prophylactic antibiotic regimen before PB.<\/jats:p>","DOI":"10.3390\/antibiotics11030312","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T10:00:40Z","timestamp":1645783240000},"page":"312","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Recent Trends in Prostate Biopsy Complication Rates and the Role of Aztreonam in Periprocedural Antimicrobial Prophylaxis\u2014A Nationwide Population-Based Study from Korea"],"prefix":"10.3390","volume":"11","author":[{"given":"Wook","family":"Nam","sequence":"first","affiliation":[{"name":"Department of Urology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung 25440, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Uk","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Kyu","family":"Chae","sequence":"additional","affiliation":[{"name":"Department of Urology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung 25440, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihye","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Ajou College of Medicine, Ajou University Hospital, Suwon 16499, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Gwun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Urology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung 25440, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Yeon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Urology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung 25440, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seokjoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Catholic Kwandong University College of Medicine, Gangneung 25601, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Urology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung 25440, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"431","DOI":"10.4143\/crt.2019.139","article-title":"Prediction of cancer incidence and mortality in Korea, 2019","volume":"51","author":"Jung","year":"2019","journal-title":"Cancer Res. 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