{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T23:22:28Z","timestamp":1770420148905,"version":"3.49.0"},"reference-count":23,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Background: Ceftazidime\/avibactam is a new cephalosporin\/beta-lactamase inhibitor combination approved in 2015 by the FDA for the treatment of complicated intra-abdominal and urinary tract infection, hospital-acquired pneumoniae and Gram-negative infections with limited treatment options. Methods: In this retrospective study, we evaluate the efficacy of ceftazidime\/avibactam treatment in 81 patients with Gram-negative infection treated in our center from January 2018 to December 2019. The outcome evaluated was 30-days survival or relapse of infection after the first positive blood culture. Results: the majority of patients were 56 male (69%), with median age of 67. Charlson\u2019s Comorbidity Index was &gt;3 in 58 patients. In total, 46% of the patients were admitted into the medical unit, 41% in the ICU, and 14% in the surgical ward. Of the patients, 78% had nosocomial infections, and 22% had healthcare-related infections. The clinical failure rate was 35%: 13 patients died within 30 days from the onset of infection. The outcome was influenced by the clinical condition of the patients: solid organ transplantation (p = 0.003) emerged as an independent predictor of mortality; non-survival patients most frequently had pneumonia (p = 0.009) or mechanical ventilation (p = 0.049). Conclusion: Ceftazidime\u2013avibactam showed high efficacy in infections caused by MDR Gram-negative pathogens with limited therapeutic options.<\/jats:p>","DOI":"10.3390\/antibiotics11030321","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T20:09:57Z","timestamp":1646078997000},"page":"321","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Ceftazidime\u2013Avibactam for the Treatment of Multidrug-Resistant Pathogens: A Retrospective, Single Center Study"],"prefix":"10.3390","volume":"11","author":[{"given":"Maria","family":"Di Pietrantonio","sequence":"first","affiliation":[{"name":"Infectious Diseases Clinic, Ospedali Riuniti Umberto I, Via Conca 71, 60126 Ancona, Torrette, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Brescini","sequence":"additional","affiliation":[{"name":"Infectious Diseases Clinic, Ospedali Riuniti Umberto I, Via Conca 71, 60126 Ancona, Torrette, Italy"},{"name":"Department of Biomedical Sciences and Public Health, Polytechnic University of Marche Medical School, Via Tronto 10\/a, 60020 Ancona, Torrette, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Candi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Polytechnic University of Marche Medical School, Via Tronto 10\/a, 60126 Ancona, Torrette, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0772-0214","authenticated-orcid":false,"given":"Morroni","family":"Gianluca","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Public Health, Polytechnic University of Marche Medical School, Via Tronto 10\/a, 60020 Ancona, Torrette, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Pallotta","sequence":"additional","affiliation":[{"name":"Infectious Diseases Clinic, Ospedali Riuniti Umberto I, Via Conca 71, 60126 Ancona, Torrette, Italy"},{"name":"Faculty of Medicine, Polytechnic University of Marche Medical School, Via Tronto 10\/a, 60126 Ancona, Torrette, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Mazzanti","sequence":"additional","affiliation":[{"name":"Infectious Diseases Clinic, Ospedali Riuniti Umberto I, Via Conca 71, 60126 Ancona, Torrette, Italy"},{"name":"Department of Biomedical Sciences and Public Health, Polytechnic University of Marche Medical School, Via Tronto 10\/a, 60020 Ancona, Torrette, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Mantini","sequence":"additional","affiliation":[{"name":"Infectious Diseases Clinic, Ospedali Riuniti Umberto I, Via Conca 71, 60126 Ancona, Torrette, Italy"},{"name":"Faculty of Medicine, Polytechnic University of Marche Medical School, Via Tronto 10\/a, 60126 Ancona, Torrette, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca","family":"Candelaresi","sequence":"additional","affiliation":[{"name":"Infectious Diseases Clinic, Ospedali Riuniti Umberto I, Via Conca 71, 60126 Ancona, Torrette, Italy"},{"name":"Faculty of Medicine, Polytechnic University of Marche Medical School, Via Tronto 10\/a, 60126 Ancona, Torrette, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Olivieri","sequence":"additional","affiliation":[{"name":"Infectious Diseases Clinic, Ospedali Riuniti Umberto I, Via Conca 71, 60126 Ancona, Torrette, Italy"},{"name":"Faculty of Medicine, Polytechnic University of Marche Medical School, Via Tronto 10\/a, 60126 Ancona, Torrette, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Ginevri","sequence":"additional","affiliation":[{"name":"Infectious Diseases Clinic, Ospedali Riuniti Umberto I, Via Conca 71, 60126 Ancona, Torrette, Italy"},{"name":"Faculty of Medicine, Polytechnic University of Marche Medical School, Via Tronto 10\/a, 60126 Ancona, Torrette, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Cesaretti","sequence":"additional","affiliation":[{"name":"Infectious Diseases Clinic, Ospedali Riuniti Umberto I, Via Conca 71, 60126 Ancona, Torrette, Italy"},{"name":"Faculty of Medicine, Polytechnic University of Marche Medical School, Via Tronto 10\/a, 60126 Ancona, Torrette, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sefora","family":"Castelletti","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Ospedali Riuniti Umberto I, Via Conca 71, 60126 Ancona, Torrette, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Cocci","sequence":"additional","affiliation":[{"name":"Hospital Pharmacy, Ospedali Riuniti Umberto I, Via Conca 71, 60126 Ancona, Torrette, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosaria G.","family":"Polo","sequence":"additional","affiliation":[{"name":"Hospital Pharmacy, Ospedali Riuniti Umberto I, Via Conca 71, 60126 Ancona, Torrette, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Cerutti","sequence":"additional","affiliation":[{"name":"Anesthesia and Transplant Surgical Intensive Care Unit, Ospedali Riuniti Umberto I, Via Conca 71, 60126 Ancona, Torrette, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oriana","family":"Simonetti","sequence":"additional","affiliation":[{"name":"Clinic of Dermatology, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Via Conca 71, 60126 Ancona, Torrete, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Cirioni","sequence":"additional","affiliation":[{"name":"Infectious Diseases Clinic, Ospedali Riuniti Umberto I, Via Conca 71, 60126 Ancona, Torrette, Italy"},{"name":"Department of Biomedical Sciences and Public Health, Polytechnic University of Marche Medical School, Via Tronto 10\/a, 60020 Ancona, Torrette, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Tavio","sequence":"additional","affiliation":[{"name":"Infectious Diseases, Ospedali Riuniti Umberto I, Via Conca 71, 60126 Ancona, Torrette, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Giacometti","sequence":"additional","affiliation":[{"name":"Infectious Diseases Clinic, Ospedali Riuniti Umberto I, Via Conca 71, 60126 Ancona, Torrette, Italy"},{"name":"Department of Biomedical Sciences and Public Health, Polytechnic University of Marche Medical School, Via Tronto 10\/a, 60020 Ancona, Torrette, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Barchiesi","sequence":"additional","affiliation":[{"name":"Department of 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Basic Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1093\/jac\/dkx393","article-title":"Ceftazidime\/avibactam alone or in combination with aztreonam against colistin-resistant and carbapenemase-producing Klebsiella pneumoniae","volume":"73","author":"Jayol","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.ijantimicag.2015.05.003","article-title":"Ceftolozane\/tazobactam and ceftazidime\/avibactam: Two novel \u03b2-lactam\/\u03b2-lactamase inhibitor combination agents for the treatment of resistant Gram-negative bacterial infections","volume":"46","author":"Liscio","year":"2015","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.1007\/s11033-020-05651-9","article-title":"Metallo-\u00df-lactamases: A review","volume":"47","author":"Behzadi","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"ref_6","unstructured":"(2022, January 01). Available online: https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/zavicefta-epar-product-information_en.pdf."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/14787210.2018.1429912","article-title":"Novel \u03b2-lactam\/\u03b2-lactamase inhibitors versus alternative antibiotics for the treatment of complicated intra-abdominal infection and complicated urinary tract infection: A meta-analysis of randomized controlled trials","volume":"16","author":"Chen","year":"2018","journal-title":"Expert Rev. Anti-Infect. Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/jac\/dku351","article-title":"\u03b2-Lactam\/\u03b2-lactamase inhibitors versus carbapenems for the treatment of sepsis: Systematic review and meta-analysis of randomized controlled trials","volume":"70","author":"Shiber","year":"2015","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.2174\/1381612825999190619130216","article-title":"Antimicrobial Agents and Urinary Tract Infections","volume":"25","author":"Issakhanian","year":"2019","journal-title":"Curr. Pharm. Des."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/cid\/ciy492","article-title":"Efficacy of Ceftazidime-Avibactam Salvage Therapy in Patients With Infections Caused by Klebsiella pneumoniae Carbapenemase\u2013producing K. pneumoniae","volume":"68","author":"Tumbarello","year":"2019","journal-title":"Clin. Infect. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1007\/s40121-021-00506-7","article-title":"Clinical and Microbiological Outcomes of Ceftazidime-Avibactam Treatment in Adults with Gram-Negative Bacteremia: A Subset Analysis from the Phase 3 Clinical Trial Program","volume":"10","author":"Mazuski","year":"2021","journal-title":"Infect. Dis. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e00883-17","DOI":"10.1128\/AAC.00883-17","article-title":"Ceftazidime-Avibactam Is Superior to Other Treatment Regimens against Carbapenem-Resistant Klebsiella pneumoniae Bacteremia","volume":"61","author":"Shields","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"106075","DOI":"10.1016\/j.ijantimicag.2020.106075","article-title":"Ceftazidime-avibactam in the treatment of infections caused by KPC-producing Klebsiella pneumoniae: Factors associated with clinical efficacy in a single-center cohort","volume":"56","author":"Gallo","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1017\/ice.2017.197","article-title":"Carbapenem resistance, initial antibiotic therapy, and mortality in Klebsiella pneumoniae bacteremia: A systematic review and meta-analysis","volume":"38","author":"Kohler","year":"2017","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.3201\/eid2007.121004","article-title":"Deaths attributable to carbapenem-resistant Enterobacteriaceae infections","volume":"20","author":"Falagas","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1093\/cid\/ciw684","article-title":"The effectiveness and safety of high-dose colistin: Prospective cohort study","volume":"63","author":"Benattar","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Barchiesi, F., Montalti, R., Castelli, P., Nicolini, D., Staffolani, S., Mocchegiani, F., Fiorentini, A., Manso, E., and Vivarelli, M. (2016). Carbapenem-resistant Klebsiella pneumoniae influences the outcome of early infections in liver transplant recipients. BMC Infect. Dis., 16.","DOI":"10.1186\/s12879-016-1876-5"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1111\/ajt.12424","article-title":"Epidemiology and molecular characterization of bacteremia due to carbapenem-resistant Klebsiella pneumoniae in transplant recipients","volume":"13","author":"Clancy","year":"2013","journal-title":"Am. J. Transplant."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Villegas, M.V., Pallares, C.J., and Escand\u00f3n-Vargas, K. (2016). Characterization and clinical impact of bloodstream infection caused by carbapenemase-producing Enterobacteriaceae in seven Latin American Countries. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0154092"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"5603","DOI":"10.2147\/IDR.S342163","article-title":"Ceftazidime-Avibactam as Salvage Treatment for Infections Due to Carbapenem-Resistant Klebsiella pneumoniae in Liver Transplantation Recipients","volume":"14","author":"Chen","year":"2021","journal-title":"Infect. Drug Resist."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J. Chronic Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA"},{"key":"ref_23","unstructured":"The European Committee on Antimicrobial Susceptibility Testing (2022, January 01). Breakpoint Tables for Interpretation of MICs and Zone Diameters. Available online: https:\/\/www.eucast.org\/fileadmin\/src\/media\/PDFs\/EUCAST_files\/Breakpoint_tables\/v_12.0_Breakpoint_Tables.pdf."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/11\/3\/321\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:29:12Z","timestamp":1760135352000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/11\/3\/321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,28]]},"references-count":23,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["antibiotics11030321"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics11030321","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,28]]}}}