{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T03:01:37Z","timestamp":1760151697143,"version":"build-2065373602"},"reference-count":105,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:00:00Z","timestamp":1650585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Ocular surgery encompasses a wide range of procedures, including surgery of the tear ducts, eyelid, cornea and conjunctiva, lens, ocular muscle, and vitreoretinal and iris surgery. Operations are also performed for the removal of tumors, repairs of ocular trauma and, finally, corneal transplantation. Antibiotic prophylaxis for the prevention of surgical site infections (SSIs) in ocular surgery is a complex field in which shared lines of action are absent. In light of the scarcity of shared evidence in the use of ocular antimicrobial prophylaxis for the pediatric population, this consensus document aims to provide clinicians with a series of recommendations on antimicrobial prophylaxis for patients of neonatal and pediatric age undergoing eye surgery. The following scenarios are considered: (1) intraocular surgery; (2) extraocular surgery; (3) ocular trauma; (4) ocular neoplasm; (5) ocular surface transplantations; (6) corneal grafts. This work has been made possible by the multidisciplinary contribution of experts belonging to the most important Italian scientific societies and represents, in our opinion, the most complete and up-to-date collection of recommendations regarding clinical actions in the peri-operative environment in eye surgery. The application of uniform and shared protocols aims to improve surgical practice, through the standardization of procedures, with a consequent reduction of SSIs, also limiting the phenomenon of antimicrobial resistance.<\/jats:p>","DOI":"10.3390\/antibiotics11050561","type":"journal-article","created":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T08:14:06Z","timestamp":1650701646000},"page":"561","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Surgical Antimicrobial Prophylaxis in Patients of Neonatal and Pediatric Age Subjected to Eye Surgery: A RAND\/UCLA Appropriateness Method Consensus Study"],"prefix":"10.3390","volume":"11","author":[{"given":"Sonia","family":"Bianchini","sequence":"first","affiliation":[{"name":"Pediatric Clinic, University Hospital, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Morini","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Guglielmo da Saliceto Hospital, 29121 Piacenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Nicoletti","sequence":"additional","affiliation":[{"name":"Pediatric Clinic, University Hospital, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Monaco","sequence":"additional","affiliation":[{"name":"Pediatric Clinic, University Hospital, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Rigotti","sequence":"additional","affiliation":[{"name":"Pediatric Clinic, Azienda Ospedaliera Universitaria Integrata, 37134 Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3196-2435","authenticated-orcid":false,"given":"Caterina","family":"Caminiti","sequence":"additional","affiliation":[{"name":"Clinical and Epidemiological Research Unit, University Hospital of Parma, 43126 Parma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Conti","sequence":"additional","affiliation":[{"name":"Pediatric ICU and Trauma Center, Fondazione Policlinico Universitario A. 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Infect."},{"key":"ref_2","unstructured":"Fitch, K., Bernstein, S.J., and Aguilar, M.D. (2001). The RAND\/UCLA Adeguateness Method User\u2019s Manual, The RAND Corporation."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1136\/bmj.309.6956.730","article-title":"Some observations on attempts to measure appropriateness of care","volume":"309","author":"Hicks","year":"1994","journal-title":"BMJ"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/08820538.2017.1353826","article-title":"Postoperative Endophthalmitis: A Review of Risk Factors, Prophylaxis, Incidence, Microbiology, Treatment, and Outcomes","volume":"33","author":"Rahmani","year":"2018","journal-title":"Semin. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.4103\/ijo.IJO_961_17","article-title":"Antibiotic prophylaxis in cataract surgery\u2014An evidence-based approach","volume":"65","author":"Haripriya","year":"2017","journal-title":"Indian J. Ophthalmol."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Huang, J., Wang, X., Chen, X., Song, Q., Liu, W., and Lu, L. (2016). Perioperative Antibiotics to Prevent Acute Endophthalmitis after Ophthalmic Surgery: A Systematic Review and Meta-Analysis. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0166141"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000089197","article-title":"Reduction of endophthalmitis rate after cataract surgery with preoperative 5% povidone-iodine","volume":"212","author":"Trinavarat","year":"2006","journal-title":"Dermatology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1089\/jop.2006.22.54","article-title":"Risk of endophthalmitis after cataract surgery using different protocols for povidone- iodine preoperative disinfection","volume":"22","author":"Wu","year":"2006","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1016\/j.jcrs.2009.06.038","article-title":"Preoperative topical moxifloxacin 0.5% and povidone\u2013iodine 5.0% versus povidone\u2013iodine 5.0% alone to reduce bacterial colonization in the conjunctival sac","volume":"35","author":"Lang","year":"2009","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jcrs.2014.04.040","article-title":"Incidence of postoperative endophthalmitis from 1990 to 2009 using povidone-iodine but no intracameral antibiotics at a single academic institution","volume":"41","author":"Nentwich","year":"2015","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/ICU.0000000000000445","article-title":"Intracameral antibiotics during cataract surgery: Evidence and barriers","volume":"29","author":"Haripriya","year":"2018","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jhin.2018.02.005","article-title":"Bacteriology and cefuroxime resistance in endophthalmitis following cataract surgery before and after the introduction of prophylactic intracameral cefuroxime: A retrospective single-centre study","volume":"101","author":"Friling","year":"2019","journal-title":"J. Hosp. Infect."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jcrs.2014.05.038","article-title":"Reevaluating intracameral cefuroxime as a prophylaxis against endophthalmitis after cataract surgery in India","volume":"41","author":"Sharma","year":"2015","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.ophtha.2006.11.025","article-title":"Endophthalmitis after cataract surgery: A nationwide prospective study evaluating incidence in relation to incision type and location","volume":"114","author":"Wejde","year":"2007","journal-title":"Ophthalmology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jcrs.2018.10.044","article-title":"Safety and efficacy of intracameral moxifloxacin for prevention of post-cataract endophthalmitis: Randomized controlled clinical trial","volume":"45","author":"Melega","year":"2019","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/aos.12684","article-title":"Antibiotic prevention of postcataract endophthalmitis: A systematic review and meta-analysis","volume":"93","author":"Kessel","year":"2015","journal-title":"Acta Ophthalmol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1136\/bjophthalmol-2017-311051","article-title":"Comparative analysis of the safety and efficacy of intracameral cefuroxime, moxifloxacin and vancomycin at the end of cataract surgery: A meta-analysis","volume":"102","author":"Bowen","year":"2018","journal-title":"Br. J. Ophthalmol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"188","DOI":"10.5301\/EJO.2011.8434","article-title":"Phacoemulsificator and sterile drapes contamination during cataract surgery: A microbiological study","volume":"22","author":"Balestrazzi","year":"2012","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1136\/bjo.2006.112060","article-title":"Pharmacokinetics of vancomycin following intracameral bolus injection in patients undergoing phacoemulsification cataract surgery","volume":"91","author":"Murphy","year":"2007","journal-title":"Br. J. Ophthalmol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.jcrs.2017.04.028","article-title":"Endophthalmitis prophylaxis by intracameral antibiotics: In vitro model comparing vancomycin, cefuroxime, and moxifloxacin","volume":"43","author":"Libre","year":"2017","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ophtha.2015.08.039","article-title":"Comparative Effectiveness of Antibiotic Prophylaxis in Cataract Surgery","volume":"123","author":"Herrinton","year":"2016","journal-title":"Ophthalmology"},{"key":"ref_22","first-page":"15","article-title":"Infectious postoperative endophthalmitis after cataract surgery performed over 7 years. The role of azithromycin versus ciprofloxacin eye drops","volume":"31","author":"Grau","year":"2018","journal-title":"Rev. Esp. Quimioter."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jcrs.2006.02.021","article-title":"ESCRS study of prophylaxis of postoperative endophthalmitis after cataract surgery: Preliminary report of principal results from a European multicenter study","volume":"32","author":"Barry","year":"2006","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.jcrs.2009.01.004","article-title":"United Kingdom survey of antibiotic prophylaxis practice after publication of the ESCRS Endophthalmitis Study","volume":"35","author":"Gore","year":"2009","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jcrs.2013.11.002","article-title":"Adoption of intracameral antibiotic prophylaxis of endophthalmitis following cataract surgery: Update on the ESCRS Endophthalmitis Study","volume":"40","author":"Barry","year":"2014","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e143","DOI":"10.5301\/ejo.5000841","article-title":"Author\u2019s reply to comments to: Adherence to European Society for Cataract and Refractive Surgery recommendations among Italian cataract surgeons: A survey","volume":"26","author":"Grosso","year":"2016","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_27","first-page":"CD006364","article-title":"Perioperative antibiotics for prevention of acute endophthalmitis after cataract surgery","volume":"2","author":"Gower","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ophtha.2021.10.006","article-title":"American Academy of Ophthalmology Preferred Practice Pattern Cataract\/Anterior Segment Panel. Cataract in the Adult Eye Preferred Practice Pattern","volume":"129","author":"Miller","year":"2022","journal-title":"Ophthalmology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/ICU.0000000000000216","article-title":"A review of preoperative manoeuvres for prophylaxis of endophthalmitis in intraocular surgery: Topical application of antibiotics, disinfectants, or both?","volume":"27","author":"Grzybowski","year":"2016","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/j.jcrs.0000000000000757","article-title":"Antibiotic prophylaxis of postoperative endophthalmitis after cataract surgery: Results of the 2014 ASCRS member survey","volume":"48","author":"Chang","year":"2022","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e249","DOI":"10.1542\/neo.21-4-e249","article-title":"Strategies to Prevent Severe Retinopathy of Prematurity: A 2020 Update and Meta-analysis","volume":"21","author":"Raghuveer","year":"2020","journal-title":"Neoreviews"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.preteyeres.2017.09.002","article-title":"Pathophysiology, screening and treatment of ROP: A multi-disciplinary perspective","volume":"62","author":"Gole","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1007\/s12098-017-2404-3","article-title":"An Update on Retinopathy of Prematurity (ROP)","volume":"84","author":"Dogra","year":"2017","journal-title":"Indian J. Pediatr."},{"key":"ref_34","unstructured":"American Academy of Ophthalmology (2019). Chapter 9: Infectious Diseases of The External Eye: Basic Concepts and Viral Infections. In: Weisenthal RW, Daly MK, de Freitas, D., Feder RS, editors. BCSC 2019\u20132020: External Disease and Cornea. Am. Acad. Ophthalmol., 65, 120."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.joms.2017.01.025","article-title":"Antibiotic Prophylaxis in Blepharoplasty: Review of the Current Literature","volume":"75","author":"Ferneini","year":"2017","journal-title":"J. Oral. Maxillofac. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Yazici, B., and Meyer, D.R. (2002). Selective antibiotic use to prevent postoperative wound infection after external dacryocystorhinostomy. Ophthal. Plast. Reconstr. Surg., 18.","DOI":"10.1097\/00002341-200209000-00003"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"382","DOI":"10.4103\/ijo.IJO_616_18","article-title":"Oral versus single intravenous bolus dose antibiotic prophylaxis against postoperative surgical site infection in external dacryocystorhinostomy for primary acquired nasolacrimal duct obstruction\u2014A randomized study","volume":"67","author":"Sheth","year":"2019","journal-title":"Indian J. Ophthalmol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/IOP.0b013e3181d644cf","article-title":"Study on the effectiveness of antibiotic prophylaxis in external dacryocystorhinostomy: A review of 697 cases","volume":"26","author":"Gibelalde","year":"2010","journal-title":"Ophthal. Plast Reconstr. Surg."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3109\/01676830.2011.569630","article-title":"Postoperative infection rate after dacryocystorhinostomy without the use of systemic antibiotic prophylaxis","volume":"31","author":"Dulku","year":"2012","journal-title":"Orbit"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/ICU.0000000000000507","article-title":"Infection following strabismus surgery","volume":"29","author":"Schnall","year":"2018","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3928\/01913913-20110920-01","article-title":"Suture contamination in strabismus surgery","volume":"49","author":"Eustis","year":"2012","journal-title":"J. Pediatr. Ophthalmol. Strabismus."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jaapos.2014.02.014","article-title":"Dual application versus single application of povidone-iodine in reducing surgical site contamination during strabismus surgery","volume":"18","author":"Benson","year":"2014","journal-title":"J. AAPOS"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.jaapos.2007.10.005","article-title":"Postoperative povidone-iodine prophylaxis in strabismus surgery","volume":"12","author":"Koederitz","year":"2008","journal-title":"J. AAPOS"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3928\/01913913-20190808-01","article-title":"Strabismus Surgery Infection Prophylaxis and Timing of First Postoperative Visit","volume":"56","author":"DeBenedictis","year":"2019","journal-title":"J. Pediatr. Ophthalmol. Strabismus."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1111\/jpc.15531","article-title":"Epidemiology, aetiology and outcome of paediatric ocular trauma in Sydney","volume":"57","author":"Liu","year":"2021","journal-title":"J. Paediatr. Child Health"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3928\/01913913-20100308-06","article-title":"Major pediatric ocular trauma in Taiwan","volume":"47","author":"Liu","year":"2010","journal-title":"J. Pediatr. Ophthalmol. Strabismus."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.arcped.2020.01.002","article-title":"Pediatric ocular trauma: Characteristics and outcomes among a French cohort (2007\u20132016)","volume":"27","author":"Boret","year":"2020","journal-title":"Arch. Pediatr."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Puod\u017eiuvien\u0117, E., Jok\u016bbauskien\u0117, G., Vieversyt\u0117, M., and Asselineau, K. (2018). A five-year retrospective study of the epidemiological characteristics and visual outcomes of pediatric ocular trauma. BMC Ophthalmol., 18.","DOI":"10.1186\/s12886-018-0676-7"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"10020","DOI":"10.1038\/s41598-020-67315-9","article-title":"Incidence and seasonality of major ocular trauma: A nationwide population-based study","volume":"10","author":"Kwon","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1136\/bjo.86.8.920","article-title":"The aetiology of perforating ocular injuries in children","volume":"86","author":"Thompson","year":"2002","journal-title":"Br. J. Ophthalmol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Awidi, A., and Kraus, C.L. (2019). A comparison of ocular trauma scores in a pediatric population. BMC Res. Notes, 12.","DOI":"10.1186\/s13104-019-4602-8"},{"key":"ref_52","first-page":"59","article-title":"Pediatric ocular trauma in Taiwan","volume":"31","author":"Lee","year":"2008","journal-title":"Chang Gung Med. J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/sj.eye.6702332","article-title":"Vitreoretinal surgery after childhood ocular trauma","volume":"21","author":"Sheard","year":"2007","journal-title":"Eye"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e1263","DOI":"10.1542\/peds.2005-1950","article-title":"Pediatric eye injury-related hospitalizations in the United States","volume":"117","author":"Brophy","year":"2006","journal-title":"Pediatrics"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/eye.2008.32","article-title":"Open globe injuries in children: Factors predictive of a poor final visual acuity","volume":"23","author":"Gupta","year":"2009","journal-title":"Eye"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1177\/1120672120902033","article-title":"Firework-inflicted ocular trauma in children and adults in an urban German setting","volume":"31","author":"Lenglinger","year":"2021","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"216","DOI":"10.4103\/0974-2700.166663","article-title":"Pediatric open globe injury: A review of the literature","volume":"8","author":"Li","year":"2015","journal-title":"J. Emerg. Trauma. Shock."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1097\/TA.0b013e31825eeac9","article-title":"Effect of penetrating and blunt ocular trauma on the outcome of traumatic cataract in children in northern India","volume":"73","author":"Ram","year":"2012","journal-title":"J. Trauma. Acute Care Surg."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.survophthal.2015.05.003","article-title":"Animal-inflicted ocular and adnexal injuries in children: A systematic review","volume":"60","author":"Yardley","year":"2015","journal-title":"Surv. Ophthalmol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"130","DOI":"10.4103\/0974-620X.57313","article-title":"Vidi, vini, vinci: External ophthalmomyiasis infection that occurred, and was diagnosed and treated in a single day: A rare case report","volume":"2","author":"Thakur","year":"2009","journal-title":"Oman. J. Ophthalmol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/00006565-200206000-00024","article-title":"A comparison of dog bite injuries in younger and older children treated in a pediatric emergency department","volume":"18","author":"Bernardo","year":"2002","journal-title":"Pediatr. Emerg. Care"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0896-1549(02)00007-X","article-title":"The Ocular Trauma Score (OTS)","volume":"15","author":"Kuhn","year":"2002","journal-title":"Ophthalmol. Clin. N. Am."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/eye.2010.211","article-title":"A new ocular trauma score in pediatric penetrating eye injuries","volume":"25","author":"Acar","year":"2011","journal-title":"Eye"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1055\/a-1194-5104","article-title":"Comparison of the Ocular Trauma Score and Pediatric Ocular Trauma Score as Two Prognostic Models in Pediatric Open Globe Injuries","volume":"238","author":"Pahor","year":"2021","journal-title":"Klin. Monbl. Augenheilkd."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1136\/bjo.85.4.388","article-title":"The Bhaktapur eye study: Ocular trauma and antibiotic prophylaxis for the prevention of corneal ulceration in Nepal","volume":"85","author":"Upadhyay","year":"2001","journal-title":"Br. J. Ophthalmol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1097\/00006982-199212031-00002","article-title":"Systemic antibiotic prophylaxis in penetrating ocular injuries. An experimental study","volume":"12","author":"Alfaro","year":"1992","journal-title":"Retina"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1080\/01676830.2018.1470190","article-title":"Dog bite injuries of the eye and ocular adnexa","volume":"38","author":"Erickson","year":"2019","journal-title":"Orbit"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Lou, B., Lin, L., Tan, J., Yang, Y., Yuan, Z., and Lin, X. (2016). Survey of Intraocular Antibiotics Prophylaxis Practice after Open Globe Injury in China. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0156856"},{"key":"ref_69","first-page":"921","article-title":"Prise en compte du potentiel t\u00e9notoxique des fluoroquinolones dans le choix d\u2019une antibioprophylaxie chirurgicale en ophtalmologie [Tenotoxic potential of fluoroquinolones in the choice of surgical antibiotic prophylaxis in ophthalmology]","volume":"25","author":"Pouzaud","year":"2002","journal-title":"J. Fr. Ophtalmol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.ajo.2008.10.023","article-title":"Low rate of endophthalmitis in a large series of open globe injuries","volume":"147","author":"Andreoli","year":"2009","journal-title":"Am. J. Ophthalmol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1177\/112067211002000128","article-title":"Risk factors for culture-positive endophthalmitis after repair of open globe injuries","volume":"20","author":"Osman","year":"2010","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1089\/jop.2016.0051","article-title":"Use of Intravenous Vancomycin and Cefepime in Preventing Endophthalmitis After Open Globe Injury","volume":"32","author":"Huang","year":"2016","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e361","DOI":"10.1111\/aos.13531","article-title":"Prophylactic intravitreal antibiotics reduce the risk of post-traumatic endophthalmitis after repair of open globe injuries","volume":"96","author":"Abouammoh","year":"2018","journal-title":"Acta Ophthalmol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.mcna.2021.02.005","article-title":"Ocular Oncology-Primary and Metastatic Malignancies","volume":"105","author":"Williams","year":"2021","journal-title":"Med. Clin. N. Am."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.clp.2020.12.001","article-title":"Neonatal Retinoblastoma","volume":"48","author":"Lin","year":"2021","journal-title":"Clin. Perinatol."},{"key":"ref_76","unstructured":"Blaney, S.M., Adamson, P.C., and Helman, L.J. (2020). Retinoblastoma. Pizzo and Poplack. Pedaitric Oncology, Ringgold Inc.. [8th ed.]."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1001\/jamaophthalmol.2013.8001","article-title":"Retinoblastoma incidence patterns in the US Surveillance, Epidemiology, and End Results program","volume":"132","author":"Wong","year":"2014","journal-title":"JAMA Ophthalmol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"15021","DOI":"10.1038\/nrdp.2015.21","article-title":"Retinoblastoma","volume":"1","author":"Dimaras","year":"2015","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1542\/peds.112.6.1248","article-title":"Screening for retinoblastoma: Presenting signs as prognosticators of patient and ocular survival","volume":"112","author":"Abramson","year":"2003","journal-title":"Pediatrics"},{"key":"ref_80","first-page":"117","article-title":"Photoleukocoria with smartphone photographs","volume":"11","year":"2018","journal-title":"Int. Med. Case Rep. J."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ophtha.2012.07.067","article-title":"Lesions simulating retinoblastoma (pseudoretinoblastoma) in 604 cases: Results based on age at presentation","volume":"120","author":"Shields","year":"2013","journal-title":"Ophthalmology"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.siny.2012.04.003","article-title":"Retinoblastoma in the perinatal and neonatal child","volume":"17","author":"Gombos","year":"2012","journal-title":"Semin. Fetal. Neonatal. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1001\/jamaophthalmol.2015.3108","article-title":"Treatment of Retinoblastoma in 2015: Agreement and Disagreement","volume":"133","author":"Abramson","year":"2015","journal-title":"JAMA Ophthalmol."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Gobin, Y.P., Dunkel, I.J., Marr, B.P., Francis, J.H., Brodie, S.E., and Abramson, D.H. (2012). Combined, sequential intravenous and intra-arterial chemotherapy (bridge chemotherapy) for young infants with retinoblastoma. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0044322"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1200\/JCO.2011.36.9744","article-title":"Carboplatin-associated ototoxicity in children with retinoblastoma","volume":"30","author":"Qaddoumi","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/pbc.22467","article-title":"Comparison of two methods for carboplatin dosing in children with retinoblastoma","volume":"55","author":"Allen","year":"2010","journal-title":"Pediatr. Blood Cancer"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/IAE.0000000000001275","article-title":"Ocular pharmacology of chemotherapy for retinoblastoma","volume":"37","author":"Schaiquevich","year":"2017","journal-title":"Retina"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1001\/jamaophthalmol.2016.5544","article-title":"Clinical Features Differentiating Benign From Malignant Conjunctival Tumors in Children","volume":"135","author":"Shields","year":"2017","journal-title":"JAMA Ophthalmol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1001\/archopht.122.2.167","article-title":"Conjunctival nevi: Clinical features and natural course in 410 consecutive patients","volume":"122","author":"Shields","year":"2004","journal-title":"Arch Ophthalmol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1038\/s41433-020-01273-4","article-title":"The natural history of conjunctival naevi in children and adolescents","volume":"35","author":"Negretti","year":"2021","journal-title":"Eye"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41409-022-01564-2","article-title":"Ocular graft-versus-host disease and dry eye disease after paediatric haematopoietic stem cell transplantation\u2013incidence and risk factors","volume":"57","author":"Jeppesen","year":"2022","journal-title":"Bone Marrow Transplant."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1080\/09273972.2021.1987925","article-title":"Treatment and prevention of ocular motility restrictions with amniotic membrane transplantation","volume":"29","author":"Monja","year":"2021","journal-title":"Strabismus"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jtos.2021.07.007","article-title":"Preliminary experience & rationale of primary allo Simple Limbal Epithelial Transplantation (SLET) following surgical excision of Ocular Surface Tumors","volume":"22","author":"Iyer","year":"2021","journal-title":"Ocul. Surf."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Patil, M., and Mehta, J.S. (2021). Long Term Outcomes of Surgical Excision of Giant Papillae with Mitomycin C and Amniotic Membrane Transplantation in the Treatment of Refractory Palpebral Vernal Keratoconjunctivitis. Medicina, 58.","DOI":"10.3390\/medicina58010019"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1016\/j.ophtha.2015.08.017","article-title":"Keratoplasty in the United States: A 10-Year Review from 2005 through 2014","volume":"122","author":"Park","year":"2015","journal-title":"Ophthalmology"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/ICU.0000000000000393","article-title":"Pediatric corneal transplants","volume":"28","author":"Trief","year":"2017","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/01.ICL.0000062460.03555.32","article-title":"Topical cyclosporine in pediatric keratoplasty","volume":"29","author":"Cosar","year":"2003","journal-title":"Eye Contact. Lens."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.ajo.2006.12.035","article-title":"Bacterial keratitis after primary pediatric penetrating keratoplasty","volume":"143","author":"Wagoner","year":"2007","journal-title":"Am. J. Ophthalmol."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.jpeds.2012.09.013","article-title":"A single-blinded randomized clinical trial comparing polymyxin B\u2013trimethoprim and moxifloxacin for treatment of acute conjunctivitis in children","volume":"162","author":"Williams","year":"2013","journal-title":"J. Pediatr."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1542\/peds.2016-2706","article-title":"The use of systemic and topical fluoroquinolones","volume":"138","author":"Jackson","year":"2016","journal-title":"Pediatrics"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2147\/OPTH.S100429","article-title":"Antibiotic prophylaxis: Different practice patterns within and outside the United States","volume":"10","author":"Schwartz","year":"2016","journal-title":"Clin Ophthalmol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/j.jcrs.2013.08.036","article-title":"Preparation of intracameral antibiotics for injection","volume":"39","author":"Nguyen","year":"2013","journal-title":"J. Cataract. Refract. Surg."},{"key":"ref_103","first-page":"CD010516","article-title":"Non-steroidal anti-inflammatory drugs versus corticosteroids for controlling inflammation after uncomplicated cataract surgery","volume":"7","author":"Juthani","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000317067","article-title":"Ketorolac plus tobramycin\/dexamethasone versus tobramycin\/dexamethasone after uneventful phacoemulsification surgery: A randomized controlled trial","volume":"225","author":"Chatziralli","year":"2011","journal-title":"Ophthalmologica"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.ajo.2008.07.027","article-title":"Are topical NSAIDs needed for routine cataract surgery?","volume":"146","author":"Kim","year":"2008","journal-title":"Am. J. Ophthalmol."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/11\/5\/561\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:58:53Z","timestamp":1760137133000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/11\/5\/561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,22]]},"references-count":105,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["antibiotics11050561"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics11050561","relation":{},"ISSN":["2079-6382"],"issn-type":[{"type":"electronic","value":"2079-6382"}],"subject":[],"published":{"date-parts":[[2022,4,22]]}}}