{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:53:04Z","timestamp":1792803184715,"version":"4.5.0"},"reference-count":26,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Taiwan University Hospital","award":["110-T07"],"award-info":[{"award-number":["110-T07"]}],"id":[{"id":"https:\/\/ror.org\/03nteze27","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Taiwan University Hospital","award":["110-S5053"],"award-info":[{"award-number":["110-S5053"]}],"id":[{"id":"https:\/\/ror.org\/03nteze27","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Taiwan University Hospital","award":["CMRPG3G1851"],"award-info":[{"award-number":["CMRPG3G1851"]}],"id":[{"id":"https:\/\/ror.org\/03nteze27","id-type":"ROR","asserted-by":"crossref"}]},{"name":"National Taiwan University Hospital","award":["107-2314-B-182A-131-MY3"],"award-info":[{"award-number":["107-2314-B-182A-131-MY3"]}],"id":[{"id":"https:\/\/ror.org\/03nteze27","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["110-T07"],"award-info":[{"award-number":["110-T07"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["110-S5053"],"award-info":[{"award-number":["110-S5053"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG3G1851"],"award-info":[{"award-number":["CMRPG3G1851"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["107-2314-B-182A-131-MY3"],"award-info":[{"award-number":["107-2314-B-182A-131-MY3"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science and Technology, R.O.C","award":["110-T07"],"award-info":[{"award-number":["110-T07"]}]},{"name":"Ministry of Science and Technology, R.O.C","award":["110-S5053"],"award-info":[{"award-number":["110-S5053"]}]},{"name":"Ministry of Science and Technology, R.O.C","award":["CMRPG3G1851"],"award-info":[{"award-number":["CMRPG3G1851"]}]},{"name":"Ministry of Science and Technology, R.O.C","award":["107-2314-B-182A-131-MY3"],"award-info":[{"award-number":["107-2314-B-182A-131-MY3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Background: The contemporary guidelines have recommended multiple antimicrobial therapies along with oral macrolides for the treatment of Mycobacterium abscessus complex lung disease (MABC-LD). However, there is little evidence supporting the parenteral tigecycline-containing regimens against MABC-LD. Therefore, we conducted this study to evaluate the effect of intravenous tigecycline-containing regimens on the treatment of MABC-LD. Methods: A retrospective study was conducted in 6 medical centers. Patients with MABC-LD that were followed up at \u226512 months were enrolled. Mycobacterium abscessus subspecies were identified by hsp65, rpoB, secA1 gene PCR, and sequencing. Antimicrobial susceptibility was determined for 34 patients using broth microdilution methods following the Clinical and Laboratory Standards Institute (CLSI) guideline. The microbiology and treatment outcomes were defined as either success or failure. The impacts of tigecycline and amikacin were adjusted for age, comorbidities, surgical resection, and radiologic scores. Results: During the study period, seventy-one patients were enrolled for final analysis. The microbiology failure rate was 61% (43\/71) and the treatment failure rate was 62% (44\/71). For M. abscessus complex, 97% (33\/34) of tigecycline MIC were \u22641 mg\/L. Amikacin also demonstrated great susceptibility (94.1%; 32\/34). Treatment with regimens containing tigecycline plus amikacin provided better microbiology success (adjusted OR 17.724; 95% CI 1.227\u2013267.206) and treatment success (adjusted OR 14.085; 95% CI 1.103\u2013166.667). Conclusion: The outcome of MABC-LD is always unsatisfactory. Treatment regimens with oral macrolide in combination with tigecycline and amikacin were correlated with increased microbiology success and less treatment failure.<\/jats:p>","DOI":"10.3390\/antibiotics11050571","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T21:16:28Z","timestamp":1650921388000},"page":"571","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Treatment Outcome in Patients with Mycobacterium abscessus Complex Lung Disease: The Impact of Tigecycline and Amikacin"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7814-4723","authenticated-orcid":false,"given":"Jeng-How","family":"Yang","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University College of Medicine, No. 5, Fuxing St., Guishan Dist., Taoyuan City 33302, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0304-4258","authenticated-orcid":false,"given":"Ping-Huai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Far-Eastern Memorial Hospital, New Taipei City 30010, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7400-6996","authenticated-orcid":false,"given":"Sheng-Wei","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Medicine, National Yang-Ming University, Taipei 22000, Taiwan"},{"name":"Department of Chest Medicine, Taipei Veterans General Hospital, Taipei 11267, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6380-3527","authenticated-orcid":false,"given":"Yu-Feng","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, E-Da Hospital, Kaohsiung City 82445, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9002-7255","authenticated-orcid":false,"given":"Chung-Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin County 64041, Taiwan"},{"name":"College of Medicine, National Taiwan University, Taipei 10607, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5839-8670","authenticated-orcid":false,"given":"Ho-Sheng","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, E-Da Hospital, Kaohsiung City 82445, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Chung","family":"Shu","sequence":"additional","affiliation":[{"name":"College of Medicine, National Taiwan University, Taipei 10607, Taiwan"},{"name":"Department of Internal Medicine, National Taiwan University Hospital, No. 7, Chung Shan South Road, Taipei 10002, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6710-3432","authenticated-orcid":false,"given":"Ting-Shu","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University College of Medicine, No. 5, Fuxing St., Guishan Dist., Taoyuan City 33302, Taiwan"},{"name":"School of Medicine, Chang Gung University, No. 259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 33302, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1164\/rccm.200604-571ST","article-title":"An official ATS\/IDSA statement: Diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases","volume":"175","author":"Griffith","year":"2007","journal-title":"Am. 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