{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:26:29Z","timestamp":1792625189663,"version":"4.5.0"},"reference-count":43,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T00:00:00Z","timestamp":1651276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Clindamycin is an antibiotic with high bioavailability and appropriate bone diffusion, often proposed as an alternative in guidelines for C. acnes prosthetic joint infections. We aimed to evaluate the efficacy of clindamycin in the treatment of C. acnes shoulder implant joint infections (SIJI). Methods: A retrospective analysis was conducted at the University Hospital of Nice (France) between 2010 and 2019. We included patients with one shoulder implant surgical procedure and at least one C. acnes positive sample. We selected the C. acnes SIJI according to French and international recommendations. The primary endpoint was favorable outcome of C. acnes SIJI treatment after at least 1-year follow-up in the clindamycin group compared to another therapeutic group. Results: Forty-eight SIJI were identified and 33 were treated with clindamycin, among which 25 were treated with monotherapy. The median duration of clindamycin antibiotherapy was 6 weeks. The average follow-up was 45 months; one patient was lost to follow-up. Twenty-seven patients out of 33 (82%) were cured with clindamycin, compared to 9\/12 (75%) with other antibiotics. The rate of favorable outcomes increased to 27\/31 (87%) with clindamycin and to 9\/10 (90%) for other antibiotics when no septic revision strategies were excluded (P = 1.00). Conclusions: The therapeutic strategy based on one- or two-stage revision associated with 6 weeks of clindamycin seems to be effective.<\/jats:p>","DOI":"10.3390\/antibiotics11050608","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T05:44:07Z","timestamp":1651297447000},"page":"608","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clindamycin Efficacy for Cutibacterium acnes Shoulder Device-Related Infections"],"prefix":"10.3390","volume":"11","author":[{"given":"Audrey","family":"Courduri\u00e9","sequence":"first","affiliation":[{"name":"Infectious Diseases Department, Universit\u00e9 C\u00f4te d\u2019Azur, CHU Nice, 06202 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0064-5525","authenticated-orcid":false,"given":"Romain","family":"Lotte","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Universit\u00e9 C\u00f4te d\u2019Azur, CHU Nice, 06202 Nice, France"},{"name":"INSERM, C3M, 06204 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Ruimy","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Universit\u00e9 C\u00f4te d\u2019Azur, CHU Nice, 06202 Nice, France"},{"name":"INSERM, C3M, 06204 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Cauhape","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Universit\u00e9 C\u00f4te d\u2019Azur, CHU Nice, 06202 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Carles","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Universit\u00e9 C\u00f4te d\u2019Azur, CHU Nice, 06202 Nice, France"},{"name":"INSERM, C3M, 06204 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2228-7084","authenticated-orcid":false,"given":"Marc-Olivier","family":"Gauci","sequence":"additional","affiliation":[{"name":"Institut Universitaire Locomoteur & Sport (IULS), Unit\u00e9 de Recherche Clinique C\u00f4te d\u2019Azur (UR2CA), H\u00f4pital Pasteur 2 CHU de Nice, Universit\u00e9 C\u00f4te D\u2019Azur, 06000 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Boileau","sequence":"additional","affiliation":[{"name":"ICR-Institut de Chirurgie R\u00e9paratrice Locomoteur et Sports\u2013Groupe KANTYS, 06000 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Courjon","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, Universit\u00e9 C\u00f4te d\u2019Azur, CHU Nice, 06202 Nice, France"},{"name":"INSERM, C3M, 06204 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Chebili, F. 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