{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:27:09Z","timestamp":1787657229807,"version":"build-2736575974"},"reference-count":69,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T00:00:00Z","timestamp":1653004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008273","name":"Novartis Foundation","doi-asserted-by":"publisher","award":["18A059"],"award-info":[{"award-number":["18A059"]}],"id":[{"id":"10.13039\/100008273","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008273","name":"Novartis Foundation","doi-asserted-by":"publisher","award":["D43 TW007393"],"award-info":[{"award-number":["D43 TW007393"]}],"id":[{"id":"10.13039\/100008273","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fogarty International Center of the US National Institutes of Health","award":["18A059"],"award-info":[{"award-number":["18A059"]}]},{"name":"Fogarty International Center of the US National Institutes of Health","award":["D43 TW007393"],"award-info":[{"award-number":["D43 TW007393"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>E. coli that produce extended-spectrum \u03b2-lactamases (ESBLs) are major multidrug-resistant bacteria. In Peru, only a few reports have characterised the whole genome of ESBL enterobacteria. We aimed to confirm the identity and antimicrobial resistance (AMR) profile of two ESBL isolates from dog faeces and drinking water of rural Andean households and determine serotype, phylogroup, sequence type (ST)\/clonal complex (CC), pathogenicity, virulence genes, ESBL genes, and their plasmids. To confirm the identity and AMR profiles, we used the VITEK\u00ae2 system. Whole-genome sequencing (WGS) and bioinformatics analysis were performed subsequently. Both isolates were identified as E. coli, with serotypes -:H46 and O9:H10, phylogroups E and A, and ST\/CC 5259\/- and 227\/10, respectively. The isolates were ESBL-producing, carbapenem-resistant, and not harbouring carbapenemase-encoding genes. Isolate 1143 ST5259 harboured the astA gene, encoding the EAST1 heat-stable toxin. Both genomes carried ESBL genes (blaEC-15, blaCTX-M-8, and blaCTX-M-55). Nine plasmids were detected, namely IncR, IncFIC(FII), IncI, IncFIB(AP001918), Col(pHAD28), IncFII, IncFII(pHN7A8), IncI1, and IncFIB(AP001918). Finding these potentially pathogenic bacteria is worrisome given their sources and highlights the importance of One-Health research efforts in remote Andean communities.<\/jats:p>","DOI":"10.3390\/antibiotics11050692","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T04:27:22Z","timestamp":1653020842000},"page":"692","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Whole-Genome Characterisation of ESBL-Producing E. coli Isolated from Drinking Water and Dog Faeces from Rural Andean Households in Peru"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9288-1794","authenticated-orcid":false,"given":"Maria Luisa","family":"Medina-Pizzali","sequence":"first","affiliation":[{"name":"Research Unit in Integral Development, Environment and Health, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima 15102, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apoorva","family":"Venkatesh","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland"},{"name":"University of Basel, 4001 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maribel","family":"Riveros","sequence":"additional","affiliation":[{"name":"School of Medicine, Universidad Peruana Cayetano Heredia, Lima 15102, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5735-4614","authenticated-orcid":false,"given":"Diego","family":"Cuicapuza","sequence":"additional","affiliation":[{"name":"Laboratory of Microbial Genomics, Department of Cellular and Molecular Sciences, School of Science and Philosophy, Universidad Peruana Cayetano Heredia, Lima 15102, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8918-7689","authenticated-orcid":false,"given":"Gabriela","family":"Salmon-Mulanovich","sequence":"additional","affiliation":[{"name":"Research Unit in Integral Development, Environment and Health, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima 15102, Peru"},{"name":"Institute for Earth, Nature and Energy, Pontificia Universidad Cat\u00f3lica del Per\u00fa, Lima 15088, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"M\u00e4usezahl","sequence":"additional","affiliation":[{"name":"Research Unit in Integral Development, Environment and Health, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima 15102, Peru"},{"name":"Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland"},{"name":"University of Basel, 4001 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3523-1725","authenticated-orcid":false,"given":"Stella M.","family":"Hartinger","sequence":"additional","affiliation":[{"name":"Research Unit in Integral Development, Environment and Health, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima 15102, Peru"},{"name":"Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, 4123 Allschwil, Switzerland"},{"name":"University of Basel, 4001 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global Burden of Bacterial Antimicrobial Resistance in 2019: A Systematic Analysis","volume":"399","author":"Murray","year":"2022","journal-title":"Lancet"},{"key":"ref_2","unstructured":"Caballero, B., Finglas, P., and Toldr\u00e1, F. 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