{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:55:13Z","timestamp":1787507713418,"version":"build-2736575974"},"reference-count":31,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T00:00:00Z","timestamp":1653350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Few data are available on infectious complications in critically ill patients with different viral infections. We performed a retrospective monocentric study including all of the patients admitted to the intensive care unit (ICU) with confirmed COVID-19 (as of 13 March 2020) or Influenza A and\/or B infections (as of 1 January 2015) until 20 April 2020. Coinfection and secondary infections (occurring within and after 48 h from admission, respectively) were recorded. Fifty-seven COVID-19 and 55 Influenza patients were included. Co-infections were documented in 13\/57 (23%) COVID-19 patients vs. 40\/55 (73%) Influenza patients (p &lt; 0.001), most of them being respiratory (9\/13, 69% vs. 35\/40, 88%; p = 0.13) and of bacterial origin (12\/13, 92% vs. 29\/40, 73%; p = 0.25). Invasive aspergillosis infections were observed only in Influenza patients (8\/55, 15%). The COVID-19 and Influenza patients presented 1 (0\u20134) vs. 0 (0\u20134) secondary infections (p = 0.022), with comparable sites being affected (lungs: 35\/61, 57% vs. 13\/31, 42%; p = 0.16) and causative pathogens occurring (Gram-negative bacteria: 51\/61, 84% vs. 23\/31, 74%; p &gt; 0.99). The COVID-19 patients had longer ICU lengths of stay (15 (\u201365) vs. 5 (1\u201389) days; p = 0.001), yet the two groups had comparable mortality rates (20\/57, 35% vs. 23\/55, 41%; p = 0.46). We report fewer co-infections but more secondary infections in the ICU COVID-19 patients compared to the Influenza patients. Most of the infectious complications were respiratory and of bacterial origin.<\/jats:p>","DOI":"10.3390\/antibiotics11060704","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T22:04:06Z","timestamp":1653429846000},"page":"704","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Retrospective, Monocentric Study Comparing Co and Secondary Infections in Critically Ill COVID-19 and Influenza Patients"],"prefix":"10.3390","volume":"11","author":[{"given":"Diane","family":"Marcoux","sequence":"first","affiliation":[{"name":"Clinic of Infectious Diseases, HUB-Erasme Hospital, 1070 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Etienne","sequence":"additional","affiliation":[{"name":"Department of Pneumology, HUB-Erasme Hospital, 1070 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Van Muylem","sequence":"additional","affiliation":[{"name":"Department of Pneumology, HUB-Erasme Hospital, 1070 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa Gouvea","family":"Bogossian","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, HUB-Erasme Hospital, 1070 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1706-6869","authenticated-orcid":false,"given":"Nicolas","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Laboratoire Hospitalier Universitaire de Bruxelles-Universitair Laboratorium Brussel (LHUB-ULB), Universit\u00e9 Libre de Bruxelles, 1070 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Silvio","family":"Taccone","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, HUB-Erasme Hospital, 1070 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6961-6039","authenticated-orcid":false,"given":"Maya","family":"Hites","sequence":"additional","affiliation":[{"name":"Clinic of Infectious Diseases, HUB-Erasme Hospital, 1070 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,24]]},"reference":[{"key":"ref_1","unstructured":"(2021, August 22). 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