{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T11:06:50Z","timestamp":1785755210445,"version":"3.56.0"},"reference-count":215,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T00:00:00Z","timestamp":1658102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Minciencias","award":["2105-905-87457"],"award-info":[{"award-number":["2105-905-87457"]}]},{"name":"Minciencias","award":["80740-458-2021"],"award-info":[{"award-number":["80740-458-2021"]}]},{"name":"Minciencias","award":["ING-PHD-42-2021"],"award-info":[{"award-number":["ING-PHD-42-2021"]}]},{"DOI":"10.13039\/501100010628","name":"Universidad de La Sabana and Clinica Universidad de La Sabana\u2014the Biomedical Campus Call","doi-asserted-by":"publisher","award":["2105-905-87457"],"award-info":[{"award-number":["2105-905-87457"]}],"id":[{"id":"10.13039\/501100010628","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010628","name":"Universidad de La Sabana and Clinica Universidad de La Sabana\u2014the Biomedical Campus Call","doi-asserted-by":"publisher","award":["80740-458-2021"],"award-info":[{"award-number":["80740-458-2021"]}],"id":[{"id":"10.13039\/501100010628","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010628","name":"Universidad de La Sabana and Clinica Universidad de La Sabana\u2014the Biomedical Campus Call","doi-asserted-by":"publisher","award":["ING-PHD-42-2021"],"award-info":[{"award-number":["ING-PHD-42-2021"]}],"id":[{"id":"10.13039\/501100010628","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Acne vulgaris is a multifactorial disease that remains under-explored; up to date it is known that the bacterium Cutibacterium acnes is involved in the disease occurrence, also associated with a microbial dysbiosis. Antibiotics have become a mainstay treatment generating the emergence of antibiotic-resistant bacteria. In addition, there are some reported side effects of alternative treatments, which indicate the need to investigate a different therapeutic approach. Natural products continue to be an excellent option, especially those extracted from actinobacteria, which represent a prominent source of metabolites with a wide range of biological activities, particularly the marine actinobacteria, which have been less studied than their terrestrial counterparts. Therefore, this systematic review aimed to identify and evaluate the potential anti-infective activity of metabolites isolated from marine actinobacteria strains against bacteria related to the development of acne vulgaris disease. It was found that there is a variety of compounds with anti-infective activity against Staphylococcus aureus and Staphylococcus epidermidis, bacteria closely related to acne vulgaris development; nevertheless, there is no report of a compound with antibacterial activity or quorum-sensing inhibition toward C. acnes, which is a surprising result. Since two of the most widely used antibiotics for the treatment of acne targeting C. acnes were obtained from actinobacteria of the genus Streptomyces, this demonstrates a great opportunity to pursue further studies in this field, considering the potential of marine actinobacteria to produce new anti-infective compounds.<\/jats:p>","DOI":"10.3390\/antibiotics11070965","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T11:32:23Z","timestamp":1658143943000},"page":"965","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Marine Actinobacteria a New Source of Antibacterial Metabolites to Treat Acne Vulgaris Disease\u2014A Systematic Literature Review"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1811-5274","authenticated-orcid":false,"given":"Maria Clara","family":"De La Hoz-Romo","sequence":"first","affiliation":[{"name":"Doctoral Program of Biosciences, School of Engineering, Universidad de La Sabana, Ch\u00eda 140013, Colombia"},{"name":"Bioprospecting Research Group, School of Engineering, Universidad de La Sabana, Ch\u00eda 140013, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9588-9935","authenticated-orcid":false,"given":"Luis","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Doctoral Program of Biosciences, School of Engineering, Universidad de La Sabana, Ch\u00eda 140013, Colombia"},{"name":"Bioprospecting Research Group, School of Engineering, Universidad de La Sabana, Ch\u00eda 140013, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2188-5453","authenticated-orcid":false,"given":"Luisa","family":"Villamil","sequence":"additional","affiliation":[{"name":"Doctoral Program of Biosciences, School of Engineering, Universidad de La Sabana, Ch\u00eda 140013, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15029","DOI":"10.1038\/nrdp.2015.29","article-title":"Acne vulgaris","volume":"1","author":"Tuchayi","year":"2015","journal-title":"Nat. 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