{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:40:27Z","timestamp":1793313627599,"version":"4.5.0"},"reference-count":56,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Background: Infection by SARS-CoV-2 has unquestionably had an impact on the health of patients with chronic respiratory airway diseases, such as COPD and asthma, but little information is available about its impact on patients with bronchiectasis. The objective of the present study was to analyze the effect of the SARS-CoV-2 pandemic on the state of health, characteristics, and clinical severity (including the number and severity of exacerbations) of patients with non-cystic fibrosis bronchiectasis. Methods: This study was multicenter, observational, and ambispective (with data collected before and during the SARS-CoV-2 pandemic), and included 150 patients diagnosed with non-cystic fibrosis bronchiectasis. Results: A significant drop was observed in the number and severity of the exacerbations (57% in all exacerbations and 50% in severe exacerbations) in the E-FACED and BSI multidimensional scores, in the pandemic, compared with the pre-pandemic period. There was also a drop in the percentage of sputum samples positive for pathogenic microorganisms in general (from 58% to 44.7%) and, more specifically, Pseudomonas aeruginosa (from 23.3% to 13.3%) and Haemophilus influenzae (from 21.3% to 14%). Conclusions: During the SARS-CoV-2 period, a significant reduction was observed in the exacerbations, severity, and isolations of pathogenic microorganisms in patients with bronchiectasis.<\/jats:p>","DOI":"10.3390\/antibiotics11081096","type":"journal-article","created":{"date-parts":[[2022,8,14]],"date-time":"2022-08-14T21:09:06Z","timestamp":1660511346000},"page":"1096","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Impact of the SARS-CoV-2 Virus Pandemic on Patients with Bronchiectasis: A Multicenter Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7379-8848","authenticated-orcid":false,"given":"Adri\u00e1n","family":"Mart\u00ednez-Vergara","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria La Princesa, Hospital Universitario La Princesa, 28006 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7094-0848","authenticated-orcid":false,"given":"Rosa M\u00aa","family":"Gir\u00f3n Moreno","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria La Princesa, Hospital Universitario La Princesa, 28006 Madrid, Spain"},{"name":"Facultad de Medicina, Universidad Aut\u00f3noma de Madrid, 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6912-7400","authenticated-orcid":false,"given":"Casilda","family":"Olveira","sequence":"additional","affiliation":[{"name":"Hospital Regional Universitario de M\u00e1laga, 29010 Malaga, Spain"},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga (IBIMA), Universidad de M\u00e1laga, 29016 Malaga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9997-5048","authenticated-orcid":false,"given":"Mar\u00eda","family":"Victoria Gir\u00f3n","sequence":"additional","affiliation":[{"name":"Hospital Regional Universitario de M\u00e1laga, 29010 Malaga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0284-6643","authenticated-orcid":false,"given":"Adri\u00e1n","family":"Pel\u00e1ez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria La Princesa, Hospital Universitario La Princesa, 28006 Madrid, Spain"},{"name":"Facultad de Medicina, Universidad Aut\u00f3noma de Madrid, 28049 Madrid, Spain"},{"name":"CIBER de Enfermedades Respiratorias, ISCIII, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Ancochea","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria La Princesa, Hospital Universitario La Princesa, 28006 Madrid, Spain"},{"name":"Facultad de Medicina, Universidad Aut\u00f3noma de Madrid, 28049 Madrid, Spain"},{"name":"CIBER de Enfermedades Respiratorias, ISCIII, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2121-7554","authenticated-orcid":false,"given":"Grace","family":"Oscullo","sequence":"additional","affiliation":[{"name":"Hospital Universitario y Polit\u00e9cnico La Fe, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7321-1891","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Mart\u00ednez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"CIBER de Enfermedades Respiratorias, ISCIII, 28029 Madrid, Spain"},{"name":"Hospital Universitario y Polit\u00e9cnico La Fe, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arbres.2020.10.021","article-title":"CIBERESUCICOVID: A strategic project for a better understanding and clinical management of COVID-19 in critical patients","volume":"57","author":"Torres","year":"2021","journal-title":"Arch Bronconeumol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.arbres.2020.05.038","article-title":"Factors Associated to Hospital Admission in a Care Protocol in COVID-19","volume":"56","author":"Golpe","year":"2020","journal-title":"Arch Bronconeumol."},{"key":"ref_3","first-page":"55","article-title":"Thrombotic Risk and Covid-19: Review of Current Evidence for a Better Diagnostic and Therapeutic Approach","volume":"57","author":"Oscullo","year":"2021","journal-title":"Arch. 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