{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:18:07Z","timestamp":1787764687339,"version":"build-2784847793"},"reference-count":34,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Diabetic foot infections (DFIs) are one of the causes of hospitalization in diabetic patients and, when this occurs, empirical antibiotic therapy is necessary. We have conducted a retrospective study of patients with DFI that required hospitalization to evaluate microbiologic profile and the susceptibility pattern of these infections. We evaluated 320 patients, of which 223 (69.7%) were male with a media age of 71 years with 276 isolates. Gram-positive bacteria were responsible for 188 (68.1%) of the isolates, while Gram-negative bacilli were responsible for 88 (31.9%). E. faecalis was the most prevalent pathogen, followed by S. aureus and coagulase negative Staphylococci. Among Gram-negative pathogens, P. aeruginosa was the most prevalent agent. Regarding the susceptibility profile, we found ampicillin-sensitive enterococci in 89% of the cases, oxacillin-sensitive S. aureus in 47%, but in coagulase-negative staphylococci, oxacillin was sensible only in 20%. The susceptibility profile of Gram-negatives was very good with 76% susceptibility of P. aeruginosa to ceftazidime and meropenem. The other prevalent Enterobacterales had great susceptibility to ceftazidime, piperacillin-tazobactam and 100% susceptibility to meropenem, with the exception of K. pneumoniae, which had 75% susceptibility to meropenem. Knowledge of microbiological profile and susceptibility patterns of patients with DFIs is useful to guide empirical therapy.<\/jats:p>","DOI":"10.3390\/antibiotics11081125","type":"journal-article","created":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T21:05:51Z","timestamp":1661115951000},"page":"1125","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Microbiology of Diabetic Foot Infections in a Tertiary Care Hospital in S\u00e3o Paulo, Brazil"],"prefix":"10.3390","volume":"11","author":[{"given":"Amanda Thurler","family":"Palomo","sequence":"first","affiliation":[{"name":"Vascular Surgery Department of Hospital do Servidor P\u00fablico Estadual de S\u00e3o Paulo, S\u00e3o Paulo 04029-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula Maia","family":"Pires","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department of Hospital do Servidor P\u00fablico Estadual de S\u00e3o Paulo, S\u00e3o Paulo 04029-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Fernando","family":"Matielo","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department of Hospital do Servidor P\u00fablico Estadual de S\u00e3o Paulo, S\u00e3o Paulo 04029-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7646-5208","authenticated-orcid":false,"given":"Rafael","family":"de Athayde Soares","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department of Hospital do Servidor P\u00fablico Estadual de S\u00e3o Paulo, S\u00e3o Paulo 04029-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiano","family":"Pecego","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department of Hospital do Servidor P\u00fablico Estadual de S\u00e3o Paulo, S\u00e3o Paulo 04029-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Sacilotto","sequence":"additional","affiliation":[{"name":"Vascular Surgery Department of Hospital do Servidor P\u00fablico Estadual de S\u00e3o Paulo, S\u00e3o Paulo 04029-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Inacio","family":"de Paula","sequence":"additional","affiliation":[{"name":"Microbiology Department of Hospital do Servidor P\u00fablico Estadual de S\u00e3o Paulo, S\u00e3o Paulo 04029-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nair","family":"Hosino","sequence":"additional","affiliation":[{"name":"Microbiology Department of Hospital do Servidor P\u00fablico Estadual de S\u00e3o Paulo, S\u00e3o Paulo 04029-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"de Melo Gamba","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department of Hospital do Servidor P\u00fablico Estadual de S\u00e3o Paulo, S\u00e3o Paulo 04029-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cibele Lefreve","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department of Hospital do Servidor P\u00fablico Estadual de S\u00e3o Paulo, S\u00e3o Paulo 04029-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela K. S.","family":"Paraskevopoulos","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department of Hospital do Servidor P\u00fablico Estadual de S\u00e3o Paulo, S\u00e3o Paulo 04029-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto","family":"Yamaguti","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department of Hospital do Servidor P\u00fablico Estadual de S\u00e3o Paulo, S\u00e3o Paulo 04029-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Silva","family":"de Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department of Hospital do Servidor P\u00fablico Estadual de S\u00e3o Paulo, S\u00e3o Paulo 04029-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Figueiredo","family":"Costa","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department of Hospital das Cl\u00ednicas, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-220, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7282-5453","authenticated-orcid":false,"given":"Tha\u00eds","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department of Hospital do Servidor P\u00fablico Estadual de S\u00e3o Paulo, S\u00e3o Paulo 04029-000, Brazil"},{"name":"Infectious Diseases Department of Hospital das Cl\u00ednicas, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-220, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,19]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2022, August 14). 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