{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:58:06Z","timestamp":1760785086447,"version":"build-2065373602"},"reference-count":35,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"THERMO FISHER SCIENTIFIC (BRAHMS GmbH, Hennigsdorf, Germany)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Mid-regional proadrenomedullin (MR-proADM) protects against endothelial permeability and has been associated with prognosis in bacterial sepsis. As endothelial dysfunction is central in the pathophysiology of severe SARS-CoV-2 infection, we sought to evaluate MR-proADM both as a prognostic biomarker and as a marker of bacterial superinfection. Consecutive patients admitted to the ICU for severe SARS-CoV-2 pneumonia were prospectively included and serum was bio-banked on days 1, 3, and 7. MR-proADM levels were measured blindly from clinical outcomes in batches at the end of follow-up. Among the 135 patients included between April 2020 and May 2021, 46 (34.1%) had died at day 60. MR-proADM levels on days 1, 3, and 7 were significantly higher in day-60 non-survivors. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve (0.744, p &lt; 0.001) of day-1 MR-proADM compared favorably with the AUC ROC curve of day-1 procalcitonin (0.691, p &lt; 0.001). Serial MR-proADM measurements on days 3 and 7 may add prognostic information. After adjusting for CRP, LDH, and lymphocyte values, day-1 MR-proADM remained significantly associated with day-60 mortality. MR-proADM concentrations were significantly higher in patients with respiratory superinfections (on days 3 and 7) and bloodstream infections (on days 1, 3, and 7) than in patients without infection. Our results suggest that MR-proADM is a good predictor of outcome in severe SARS-CoV-2 infection and could be a useful tool to assess bacterial superinfection in COVID-19 patients.<\/jats:p>","DOI":"10.3390\/antibiotics11091166","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T21:01:31Z","timestamp":1661806891000},"page":"1166","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Mid-Regional Pro-Adrenomedullin as a Prognostic Factor for Severe COVID-19 ARDS"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6379-1928","authenticated-orcid":false,"given":"Etienne","family":"de Montmollin","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9, INSERM, UMR 1137, IAME, 75018 Paris, France"},{"name":"Medical and Infectious Diseases Intensive Care Unit, APHP, Bichat-Claude Bernard Hospital, 75018 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8203-1243","authenticated-orcid":false,"given":"Katell","family":"Peoc\u2019h","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9, INSERM, UMRs 1149, CRI, 75018 Paris, France"},{"name":"Biochemistry Department, APHP, Bichat-Claude Bernard Hospital, 75018 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Marzouk","sequence":"additional","affiliation":[{"name":"Medical and Infectious Diseases Intensive Care Unit, APHP, Bichat-Claude Bernard Hospital, 75018 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Ruckly","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9, INSERM, UMR 1137, IAME, 75018 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1105-4667","authenticated-orcid":false,"given":"Paul-Henri","family":"Wicky","sequence":"additional","affiliation":[{"name":"Medical and Infectious Diseases Intensive Care Unit, APHP, Bichat-Claude Bernard Hospital, 75018 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliette","family":"Patrier","sequence":"additional","affiliation":[{"name":"Medical and Infectious Diseases Intensive Care Unit, APHP, Bichat-Claude Bernard Hospital, 75018 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Jaquet","sequence":"additional","affiliation":[{"name":"Medical and Infectious Diseases Intensive Care Unit, APHP, Bichat-Claude Bernard Hospital, 75018 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0245-309X","authenticated-orcid":false,"given":"Romain","family":"Sonneville","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9, INSERM, UMR 1137, IAME, 75018 Paris, France"},{"name":"Medical and Infectious Diseases Intensive Care Unit, APHP, Bichat-Claude Bernard Hospital, 75018 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lila","family":"Bouadma","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9, INSERM, UMR 1137, IAME, 75018 Paris, France"},{"name":"Medical and Infectious Diseases Intensive Care Unit, APHP, Bichat-Claude Bernard Hospital, 75018 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6063-7383","authenticated-orcid":false,"given":"Jean-Fran\u00e7ois","family":"Timsit","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris Cit\u00e9, INSERM, UMR 1137, IAME, 75018 Paris, France"},{"name":"Medical and Infectious Diseases Intensive Care Unit, APHP, Bichat-Claude Bernard Hospital, 75018 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"key":"ref_1","unstructured":"WHO (2022, August 22). 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