{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T14:59:58Z","timestamp":1788361198186,"version":"build-2803163510"},"reference-count":115,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Methicillin-resistant Staphylococcus aureus (MRSA) has evolved vast antibiotic resistance. These strains contain numerous virulence factors facilitating the development of severe infections. Considering the costs, side effects, and time duration needed for the synthesis of novel drugs, seeking efficient alternative approaches for the eradication of drug-resistant bacterial agents seems to be an unmet requirement. Nickel nanoparticles (NiNPs) have been applied as prognostic and therapeutic cheap agents to various aspects of biomedical sciences. Their antibacterial effects are exerted via the disruption of the cell membrane, the deformation of proteins, and the inhibition of DNA replication. NiNPs proper traits include high-level chemical stability and binding affinity, ferromagnetic properties, ecofriendliness, and cost-effectiveness. They have outlined pleomorphic and cubic structures. The combined application of NiNPs with CuO, ZnO, and CdO has enhanced their anti-MRSA effects. The NiNPs at an approximate size of around 50 nm have exerted efficient anti-MRSA effects, particularly at higher concentrations. NiNPs have conferred higher antibacterial effects against MRSA than other nosocomial bacterial pathogens. The application of green synthesis and low-cost materials such as albumin and chitosan enhance the efficacy of NPs for therapeutic purposes.<\/jats:p>","DOI":"10.3390\/antibiotics11091208","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T20:52:03Z","timestamp":1662583923000},"page":"1208","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Nickel Nanoparticles: Applications and Antimicrobial Role against Methicillin-Resistant Staphylococcus aureus Infections"],"prefix":"10.3390","volume":"11","author":[{"given":"Elham","family":"Zarenezhad","sequence":"first","affiliation":[{"name":"Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa 7461686688, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein T.","family":"Abdulabbas","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Techniques, Faculty of Health and Medical Techniques, Imam Ja\u2019afar Al-Sadiq University, Al Muthanna 9647555434, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahrokh","family":"Marzi","sequence":"additional","affiliation":[{"name":"Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa 7461686688, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esraa","family":"Ghazy","sequence":"additional","affiliation":[{"name":"Department of pharmacy, Al-Rasheed University College, Baghdad 9643675544, Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Ekrahi","sequence":"additional","affiliation":[{"name":"Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa 7461686688, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Pezeshki","sequence":"additional","affiliation":[{"name":"Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa 7461686688, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdolmajid","family":"Ghasemian","sequence":"additional","affiliation":[{"name":"Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa 7461686688, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5105-4637","authenticated-orcid":false,"given":"Amira A.","family":"Moawad","sequence":"additional","affiliation":[{"name":"Friedrich-Loeffler-Institut (Federal Research Institute for Animal Health), Institute of Bacterial Infections and Zoonoses, Naumburger Str. 96a, 07743 Jena, Germany"},{"name":"Animal Health Research Institute, Agriculture Research Center (ARC), Giza 12618, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/cid\/ciy024","article-title":"The Clinical Utility of Methicillin-Resistant Staphylococcus aureus (MRSA) Nasal Screening to Rule Out MRSA Pneumonia: A Diagnostic Meta-analysis With Antimicrobial Stewardship Implications","volume":"67","author":"Parente","year":"2018","journal-title":"Clin. 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