{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:02:43Z","timestamp":1787752963396,"version":"build-2784847793"},"reference-count":60,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>The predictors of intestinal carriage of vancomycin-resistant Enterococcus spp. (VRE) among high-risk patients in the counties of the Southeast Europe Region are insufficiently investigated, yet they could be of key importance in infection control. The aim of the study was to identify risk factors associated with fecal VRE colonization among high-risk inpatients in university hospitals in Serbia. The study comprised 268 inpatients from three university hospitals. Data on patient demographics and clinical characteristics, length of hospital stay, therapy, and procedures were obtained from medical records. Chi-squared tests and univariate and multivariate logistic regressions were performed. Compared to the hemodialysis departments, stay in the geriatric departments, ICUs, and haemato-oncology departments increased the risk for VRE colonization 7.6, 5.4, and 5.5 times, respectively. Compared to inpatients who were hospitalized 48 h before stool sampling for VRE isolation, inpatients hospitalized 3\u20137, 8\u201315, and longer than 16 days before sampling had 5.0-, 4.7-, and 6.6-fold higher risk for VRE colonization, respectively. The use of cephalosporins and fluoroquinolones increased the risk for VRE colonization by 2.2 and 1.9 times, respectively. The age \u2265 65 years increased the risk for VRE colonization 2.3 times. In comparison to the University Clinical Centre of Serbia, the hospital stays at Zemun and Zvezdara University Medical Centres were identified as a protector factors. The obtained results could be valuable in predicting the fecal VRE colonization status at patient admission and consequent implementation of infection control measures targeting at-risk inpatients where VRE screening is not routinely performed.<\/jats:p>","DOI":"10.3390\/antibiotics11091228","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T20:52:25Z","timestamp":1663015945000},"page":"1228","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Predictors of Vancomycin-Resistant Enterococcus spp. Intestinal Carriage among High-Risk Patients in University Hospitals in Serbia"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5759-3527","authenticated-orcid":false,"given":"Ana","family":"Janjusevic","sequence":"first","affiliation":[{"name":"Institute of Virology, Vaccines and Sera \u201cTorlak\u201d, 11152 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1515-1824","authenticated-orcid":false,"given":"Ivana","family":"Cirkovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Institute of Microbiology and Immunology, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2941-9246","authenticated-orcid":false,"given":"Rajna","family":"Minic","sequence":"additional","affiliation":[{"name":"Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, 11129 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran","family":"Stevanovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Clinic for Infectious and Tropical Diseases, University Clinical Centre of Serbia, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4893-1683","authenticated-orcid":false,"given":"Ivan","family":"Soldatovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Institute of Medical Statistics, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biljana","family":"Mihaljevic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Institute of Hematology, University Clinical Centre of Serbia, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Vidovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Institute of Hematology, University Clinical Centre of Serbia, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ljiljana","family":"Markovic Denic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Institute of Epidemiology, 11129 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,9]]},"reference":[{"key":"ref_1","unstructured":"Gilmore, M.S., Clewell, D.B., Ike, Y., and Shankar, N. (2014). Enterococcus Diversity, Origins in Nature, and Gut Colonization. Enterococci: From Commensals to Leading Causes of Drug Resistant Infection, Eye and Ear Infirmary."},{"key":"ref_2","unstructured":"European Centre for Disease Prevention and Control (2022, July 27). Antimicrobial Resistance in the EU\/EEA (EARS-Net), Available online: https:\/\/www.ecdc.europa.eu\/en\/publications-data\/surveillance-antimicrobial-resistance-europe-2019."},{"key":"ref_3","unstructured":"European Centre for Disease Prevention and Control (2022, July 27). Surveillance of Antimicrobial Resistance in Europe. ECDC: Stockholm, Sweden, Available online: https:\/\/www.ecdc.europa.eu\/en\/publications-data\/surveillance-antimicrobial-resistance-europe-2020."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S1473-3099(17)30753-3","article-title":"Discovery, research, and development of new antibiotics: The WHO priority list of antibiotic-resistant bacteria and tuberculosis","volume":"18","author":"Tacconelli","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"ref_5","unstructured":"Tacconelli, E., and Margin, N. (2022, July 27). Global Priority List of Antibiotic-Resistant Bacteria to Guide Research, Discovery, and Development of new Antibiotics. World Haelth Organization: Geneva, Switzerland, Available online: http:\/\/www.cdc.gov\/drugresistance\/threat-report-2013."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1086\/533452","article-title":"Federal Funding for the Study of Antimicrobial Resistance in Nosocomial Pathogens: No ESKAPE","volume":"197","author":"Rice","year":"2008","journal-title":"J. Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3201\/eid1001.020790","article-title":"Vancomycin- resistant Enterococcus faecalis in Serbia","volume":"10","author":"Stosovic","year":"2004","journal-title":"Emerg. Infect. Dis."},{"key":"ref_8","unstructured":"WHO Regional Office for Europe\/European Centre for Disease Prevention and Control (2022, July 27). Antimicrobial Resistance Surveillance in Europe 2022\u20132020 data. WHO Regional Office for Europe: Copenhagen, Denmark, Available online: https:\/\/www.ecdc.europa.eu\/sites\/default\/files\/documents\/ECDC-WHO-AMR-report.pdf."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13756-020-00770-1","article-title":"Enterococcus faecium: From microbiological insights to practical recommendations for infection control and diagnostics","volume":"9","author":"Zhou","year":"2020","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"ref_10","unstructured":"(2022, July 27). Recommendations for Preventing the Spread of Vancomycin Resistance Recommendations of the Hospital Infection Control Practices Advisory Committee (HICPAC), Available online: https:\/\/www.cdc.gov\/MMwr\/preview\/mmwrhtml\/00039349.htm."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/Spectrum.00356-21","article-title":"Development and validation of a tool for the prediction of vancomycin-resistant enterococci colonization persistence\u2014The PREVENT score","volume":"9","author":"Boeing","year":"2021","journal-title":"Microbiol Spectr."},{"key":"ref_12","unstructured":"Gilmore, M.S., Clewell, D.B., Ike, Y., and Shankar, N. (2014). Enterococcal Disease, Epidemiology, and Implications for Treatment. Enterococci: From Commensals to Leading Causes of Drug Resistant Infection, Eye and Ear Infirmary."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1089\/mdr.2017.0147","article-title":"Vancomycin-Resistant Enterococci: A Review of Antimicrobial Resistance Mechanisms and Perspectives of Human and Animal Health","volume":"24","author":"Ahmed","year":"2018","journal-title":"Microb. Drug Resist."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"529","DOI":"10.4065\/81.4.529","article-title":"Vancomycin-resistant enterococci: Colonization, infection, detection, and treatment","volume":"81","author":"Zirakzadeh","year":"2006","journal-title":"Mayo Clin. Proc."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Pan, S., Wang, J., Chen, Y., Chang, Y., Chen, M., and Chang, C. (2012). Incidence of and Risk Factors for Infection or Colonization of Vancomycin-Resistant Enterococci in Patients in the Intensive Care Unit Acute renal failure. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0047297"},{"key":"ref_16","first-page":"686","article-title":"Vancomycin-Resistant Entrococci colonization in chronic hemodialysis patients and its risk factors in southern. Iran","volume":"14","author":"Shaghaghian","year":"2012","journal-title":"Red Crescent Med. J."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Gudiol, C., Ayats, J., Camoez, M., Dom\u00ednguez, M., Garc\u00eda-Vidal, C., Bodro, M., Ardanuy, C., Obed, M., Arnan, M., and Antonio, M. (2013). Increase in Bloodstream Infection Due to Vancomycin- Susceptible Enterococcus faecium in Cancer Patients: Risk Factors, Molecular Epidemiology and Outcomes. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0074734"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1086\/519932","article-title":"Outcomes for and Risk Factors Associated With Vancomycin-Resistant Enterococcus faecalis and Vancomycin-Resistant Enterococcus faecium Bacteremia in Cancer Patients","volume":"28","author":"Ghanem","year":"2007","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1089\/sur.2008.9955","article-title":"Vancomycin-resistant enterococcus: Risk factors, surveillance, infections, and treatment","volume":"9","author":"Mazuski","year":"2008","journal-title":"Surg. Infect."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"504S","DOI":"10.1378\/chest.123.5_suppl.504S","article-title":"Vancomycin-resistant enterococci: A road map on how to prevent the emergence and transmission of antimicrobial resistance","volume":"123","author":"DeLisle","year":"2003","journal-title":"Chest"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1128\/JCM.00211-16","article-title":"Resistance Mechanisms, Epidemiology, and Approaches to Screening","volume":"54","author":"Faron","year":"2016","journal-title":"J. Clin. Microbiol."},{"key":"ref_22","unstructured":"The World Bank Group (2022, July 27). Serbia. Available online: https:\/\/data.worldbank.org\/country\/serbia?view=chart."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12941-021-00423-0","article-title":"Intestinal carriage of vancomycin-resistant Enterococcus spp. among high-risk patients in university hospitals in Serbia: First surveillance report","volume":"20","author":"Janjusevic","year":"2021","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2047-2994-1-31","article-title":"Prevalence and risk factors for VRE colonisation in a tertiary hospital in Melbourne, Australia: A cross sectional study","volume":"1","author":"Karki","year":"2012","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jiph.2016.04.010","article-title":"Factors associated with Vancomycin-resistant Enterococcus acquisition during a large outbreak","volume":"10","author":"Djembi","year":"2017","journal-title":"J. Infect. Public Health"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"134","DOI":"10.11622\/smedj.2016158","article-title":"Factors associated with prolonged length of stay in older patients","volume":"58","author":"Toh","year":"2017","journal-title":"Singapore Med. J."},{"key":"ref_27","first-page":"7","article-title":"Factores asociados con estancia hospitalaria prolongada en una unidad geri\u00e1trica de agudos","volume":"46","year":"2020","journal-title":"Acta M\u00e9dica Colomb."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1503\/cmaj.1031189","article-title":"Clostridium difficile-associated diarrhea in adults","volume":"171","author":"Poutanen","year":"2004","journal-title":"CMAJ"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ofid\/ofw246","article-title":"Colonization with vancomycin-resistant enterococci and risk for bloodstream infection among patients with malignancy: A systematic review and meta-analysis","volume":"4","author":"Alevizakos","year":"2017","journal-title":"Open Forum Infect. Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1001\/archsurg.133.12.1343","article-title":"Third-generation cephalosporins and vancomycin as risk factors for postoperative vancomycin-resistant enterococcus infection","volume":"133","author":"Dahms","year":"1998","journal-title":"Arch. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/jac\/dkg271","article-title":"European survey of vancomycin-resistant enterococci in at-risk hospital wards and in vitro susceptibility testing of ramoplanin against these isolates","volume":"51","author":"Goossens","year":"2003","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.leukres.2018.06.013","article-title":"Factors associated with a prolonged hospital stay during induction chemotherapy in newly diagnosed high risk pediatric acute lymphoblastic leukemia","volume":"71","author":"Warrick","year":"2018","journal-title":"Leuk. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s11899-013-0171-4","article-title":"Febrile neutropenia in hematologic malignancies","volume":"8","author":"Keng","year":"2013","journal-title":"Curr. Hematol. Malig. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1007\/s00277-017-3098-3","article-title":"Diagnosis and empirical treatment of fever of unknown origin (FUO) in adult neutropenic patients: Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)","volume":"96","author":"Heinz","year":"2017","journal-title":"Ann. Hematol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12890-017-0552-x","article-title":"Rates and risk factors associated with hospitalization for pneumonia with ICU admission among adults","volume":"17","author":"Storms","year":"2017","journal-title":"BMC Pulm. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1007\/s00134-021-06502-2","article-title":"Critical illness in patients with hematologic malignancy: A population-based cohort study","volume":"47","author":"Ferreyro","year":"2021","journal-title":"Intensive Care Med."},{"key":"ref_37","first-page":"1","article-title":"Predictors of intensive care unit admission in patients with hematologic malignancy","volume":"10","author":"Vijenthira","year":"2020","journal-title":"Natureresearch"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/CCM.0000000000001429","article-title":"Predictors of ICU Admission in Patients With Cancer and the Related Characteristics and Outcomes: A 5-Year Registry-Based Study","volume":"44","author":"Hawari","year":"2016","journal-title":"Crit. Care Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1046\/j.1523-1755.2001.00955.x","article-title":"Vancomycin-resistant enterococci colonization in patients at seven hemodialysis centers","volume":"60","author":"Tokars","year":"2001","journal-title":"Kidney Int."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jhin.2014.09.002","article-title":"Controlling the spread of vancomycin-resistant enterococci. Is active screening worthwhile?","volume":"88","author":"Humphreys","year":"2014","journal-title":"J. Hosp. Infect."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1053\/j.ajkd.2004.04.038","article-title":"Evaluation of the prevalence and risk factors for colonization by vancomycin-resistant Enterococcus among patients on dialysis","volume":"44","author":"Barbosa","year":"2004","journal-title":"Am. J. Kidney Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1053\/j.ajkd.2014.05.016","article-title":"Vancomycin-resistant enterococci colonization among dialysis patients: A meta-analysis of prevalence, risk factors, and significance","volume":"65","author":"Zacharioudakis","year":"2015","journal-title":"Am. J. Kidney Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1469-0691.2007.01840.x","article-title":"Risk-factors and predictors of mortality in patients colonised with vancomycin-resistant enterococci","volume":"14","author":"Sakka","year":"2008","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1590\/S1413-86702006000300005","article-title":"Vancomycin-Resistant Enterococci, Colonizing the Intestinal Tract of Patients in a University Hospital in Greece","volume":"10","author":"Metallidis","year":"2006","journal-title":"Braz. J. Infect. Dis."},{"key":"ref_45","first-page":"6","article-title":"Screening for Intestinal Colonization with Vancomycin Resistant Enterococci and Associated Risk Factors among Patients Admitted to an Adult Intensive Care Unit of a Large Teaching Hospital","volume":"10","author":"Amberpet","year":"2016","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jhin.2005.06.018","article-title":"Risk factors for the acquisition of vancomycin-resistant enterococci during a single-strain outbreak at a major Australian teaching hospital","volume":"62","author":"McEvoy","year":"2006","journal-title":"J. Hosp. Infect."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1001\/archinte.159.13.1467","article-title":"Vancomycin-resistant enterococci in intensive care units: High frequency of stool carriage during a non-outbreak period","volume":"159","author":"Ostrowsky","year":"1999","journal-title":"Arch. Intern. Med."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Ofori-Asenso, R., Liew, D., M\u00e5rtensson, J., and Jones, D. (2020). The Frequency of, and Factors Associated with Prolonged Hospitalization: A Multicentre Study in Victoria, Australia. J. Clin. Med., 9.","DOI":"10.3390\/jcm9093055"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jhin.2018.06.003","article-title":"Estimating excess length of stay due to healthcare-associated infections: A systematic review and meta-analysis of statistical methodology","volume":"100","author":"Manoukian","year":"2018","journal-title":"J. Hosp. Infect."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1093\/jac\/48.4.463","article-title":"The problem with cephalosporins","volume":"48","author":"Dancer","year":"2001","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1093\/clinids\/23.5.1020","article-title":"Manipulation of a hospital antimicrobial formulary to control an outbreak of vancomycin-resistant enterococci","volume":"23","author":"Quale","year":"1996","journal-title":"Clin. Infect. Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.ijantimicag.2019.06.015","article-title":"Comparison of antibiotic treatment guidelines for urinary tract infections in 15 European countries: Results of an online survey","volume":"54","author":"Malmros","year":"2019","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"763","DOI":"10.2217\/ahe.09.74","article-title":"Community-acquired pneumonia in elderly patients","volume":"5","author":"Stupka","year":"2009","journal-title":"Aging Health"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1128\/JCM.01501-13","article-title":"Long-Term Carriage of Vancomycin-Resistant Enterococci in Patients Discharged from Hospitals: A 12-Year Retrospective","volume":"51","author":"Karki","year":"2013","journal-title":"J. Clin. Microbiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/S1473-3099(14)70780-7","article-title":"Global antibiotic consumption 2000 to 2010: An analysis of national pharmaceutical sales data","volume":"14","author":"Gandra","year":"2014","journal-title":"Lancet Infect. Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1469-0691.2009.02725.x","article-title":"Antibiotic consumption and link to resistance","volume":"15","author":"Goossens","year":"2009","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1080\/00365540310016646","article-title":"Antibiotic consumption, bacterial resistance and their correlation in a swiss university hospital and its adult intensive care units","volume":"35","author":"Loeffler","year":"2003","journal-title":"Scand. J. Infect. Dis."},{"key":"ref_58","unstructured":"Radonji\u0107, V. (2014). Promet i Potro\u0161nja Gotovih Lekova za Humanu Upotrebu u Republici Srbiji u 2013. godini, Skener Studio \u201cLazi\u0107\u201d."},{"key":"ref_59","unstructured":"Radonji\u0107, V. (2007). Promet i Potro\u0161nja Gotovih Lekova za Humanu Upotrebu u Republici Srbiji u 2006. godini, Helicon Publishing. Agencija za lekove i medicinska sredstva Srbije."},{"key":"ref_60","unstructured":"Vukajlovi\u0107, I., and Bogdanovi\u0107, M. (2019). Promet i Potro\u0161nja Gotovih Lekova za Humanu Upotrebu u Republici Srbiji u 2018. godini."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/11\/9\/1228\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:28:31Z","timestamp":1760142511000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/11\/9\/1228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,9]]},"references-count":60,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["antibiotics11091228"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics11091228","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,9]]}}}