{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:54:30Z","timestamp":1790351670760,"version":"4.1.0"},"reference-count":205,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Antimicrobial resistance (AMR) is one of the top global health threats of the 21th century. Recent studies are increasingly reporting the rise in extended-spectrum beta-lactamases producing Enterobacteriaceae (ESBLs-Ent) in dairy cattle and humans in the USA. The causes of the increased prevalence of ESBLs-Ent infections in humans and commensal ESBLs-Ent in dairy cattle farms are mostly unknown. However, the extensive use of beta-lactam antibiotics, especially third-generation cephalosporins (3GCs) in dairy farms and human health, can be implicated as a major driver for the rise in ESBLs-Ent. The rise in ESBLs-Ent, particularly ESBLs-Escherichia coli and ESBLs-Klebsiella species in the USA dairy cattle is not only an animal health issue but also a serious public health concern. The ESBLs-E. coli and -Klebsiella spp. can be transmitted to humans through direct contact with carrier animals or indirectly through the food chain or via the environment. The USA Centers for Disease Control and Prevention reports also showed continuous increase in community-associated human infections caused by ESBLs-Ent. Some studies attributed the elevated prevalence of ESBLs-Ent infections in humans to the frequent use of 3GCs in dairy farms. However, the status of ESBLs-Ent in dairy cattle and their contribution to human infections caused by ESBLs-producing enteric bacteria in the USA is the subject of further study. The aims of this review are to give in-depth insights into the status of ESBL-Ent in the USA dairy farms and its implication for public health and to highlight some critical research gaps that need to be addressed.<\/jats:p>","DOI":"10.3390\/antibiotics11101313","type":"journal-article","created":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T21:23:27Z","timestamp":1664313807000},"page":"1313","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Extended-Spectrum Beta-Lactamases Producing Enterobacteriaceae in the USA Dairy Cattle Farms and Implications for Public Health"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4845-715X","authenticated-orcid":false,"given":"Benti Deresa","family":"Gelalcha","sequence":"first","affiliation":[{"name":"Department of Animal Science, University of Tennessee, Knoxville, TN 37996, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2108-8905","authenticated-orcid":false,"given":"Oudessa","family":"Kerro Dego","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of Tennessee, Knoxville, TN 37996, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"key":"ref_1","unstructured":"Antimicrobial Resistance Collaborators (2022). Global burden of bacterial antimicrobial resistance in 2019: A systematic analysis. Lancet, 399, 629\u2013655."},{"key":"ref_2","unstructured":"O\u2019Neill, J. (2014). Antimicrobial Resistance: Tackling a Crisis for the Health and Wealth of Nations, Wellcome Trust."},{"key":"ref_3","unstructured":"CDC (2022, January 25). Antimicrobial Resistance Threats Report, Available online: https:\/\/www.cdc.gov\/DrugResistance\/Biggest-Threats.html#cam."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0140-6736(15)00473-0","article-title":"Understanding the mechanisms and drivers of antimicrobial resistance","volume":"387","author":"Holmes","year":"2016","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.3168\/jds.2018-15224","article-title":"Quantification of antibiotic use on dairy farms in Pennsylvania","volume":"102","author":"Redding","year":"2019","journal-title":"J. Dairy Sci."},{"key":"ref_6","unstructured":"FDA (2019). Summary Report on Antimicrobials Sold or Distributed for Use in Food-Producing Animals."},{"key":"ref_7","unstructured":"WHO (2022, August 28). Critically Important Antimicrobials for Human Medicine. In Proceedings of the 6th Revision 2018, Ranking of medically Important Antimicrobials for Risk Management of Antimicrobial Resistance Due to non-Human Use. Available online: https:\/\/www.who.int\/publications\/i\/item\/9789241515528."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/lam.13419","article-title":"Use of critically important antimicrobial classes early in life may adversely impact bacterial resistance profiles during adult years: Potential co-selection for plasmid-borne fluoroquinolone and macrolide resistance via extendedspectrum beta-lactam use in dairy cattle","volume":"72","author":"Taylor","year":"2020","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_9","unstructured":"Bahrani-Mougeot, F.K., and Ansonetti, P.J.S. (2009). Encyclopedia of Microbiology, Elsevier. [3rd ed.]."},{"key":"ref_10","unstructured":"U.S. Department of Health and Human Services Food and Drug Administration Center for Veterinary Medicine (2022, August 28). #152 Guidance for Industry, Evaluating the Safety of Antimicrobial New Animal Drugs with Regard to Their Microbiological Effects on Bacteria of Human Health Concern, Available online: https:\/\/www.fda.gov\/files\/animal%20&%20veterinary\/published\/CVM-GFI--152-Evaluating-the-Safety-of-Antimicrobial-New-Animal-Drugs-with-Regard-to-Their-Microbiological-Effects-on-Bacteria-of-Human-Health-Concern.pdf."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e01017","DOI":"10.1128\/mBio.01017-13","article-title":"Diverse antibiotic resistance genes in dairy cow manure","volume":"5","author":"Wichmann","year":"2014","journal-title":"MBio"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Catry, B., Dewulf, J., Maes, D., Pardon, B., Callens, B., Vanrobaeys, M., Opsomer, G., De Kruif, A., and Haesebrouck, F. (2016). Effect of Antimicrobial Consumption and Production Type on Antibacterial Resistance in the Bovine Respiratory and Digestive Tract. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0146488"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/sj.embor.7400731","article-title":"The gut flora as a forgotten organ","volume":"7","author":"Shanahan","year":"2006","journal-title":"Embo Rep."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Bennani, H., Mateus, A., Mays, N., Eastmure, E., St\u00e4rk, K.D.C., and H\u00e4sler, B. (2020). Overview of Evidence of Antimicrobial Use and Antimicrobial Resistance in the Food Chain. Antibiotics, 9.","DOI":"10.3390\/antibiotics9020049"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1017\/ice.2015.239","article-title":"Increasing Incidence of Extended-Spectrum beta-Lactamase-Producing Escherichia coli in Community Hospitals throughout the Southeastern United States","volume":"37","author":"Thaden","year":"2016","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/1040841X.2020.1715339","article-title":"Prevalence of extended-spectrum b-lactamases in the local farm environment and livestock: Challenges to mitigate antimicrobial resistance","volume":"46","author":"Lee","year":"2020","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_17","unstructured":"USDA (2018). Dairy 14 Part III. Health and Management Practices on U.S. Dairy Operations, 2014, USDA-APHIS-VS-CEAHNAHMS, Fort Collins, CO, USA."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1089\/fpd.2021.0101","article-title":"Prevalence of Antimicrobial Resistant and Extended-Spectrum Beta-Lactamase-producing Escherichia coli in Dairy Cattle Farms in East Tennessee","volume":"19","author":"Gelalcha","year":"2022","journal-title":"Foodborne Pathog. Dis"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.4103\/0974-777X.68531","article-title":"Extended-spectrum beta-lactamases in Gram Negative Bacteria","volume":"2","author":"Rawat","year":"2010","journal-title":"J. Glob. Infect. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.vetmic.2016.01.023","article-title":"Mechanisms of cephalosporin resistance in indicator Escherichia coli isolated from food animals","volume":"194","author":"Lalak","year":"2016","journal-title":"Vet. Microbiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1089\/fpd.2018.2524","article-title":"Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae in Dairy Farm Environments: A New Zealand Perspective","volume":"16","author":"Collis","year":"2019","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/nyas.12023","article-title":"Proliferation and significance of clinically relevant beta-lactamases","volume":"1277","author":"Bush","year":"2013","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"de Been, M., Lanza, V.F., de Toro, M., Scharringa, J., Dohmen, W., Du, Y., Hu, J., Lei, Y., Li, N., and Tooming-Klunderud, A. (2014). Dissemination of Cephalosporin Resistance Genes between Escherichia coli Strains from Farm Animals and Humans by Specific Plasmid Lineages. PLoS Genet., 10.","DOI":"10.1371\/journal.pgen.1004776"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Afema, J.A., Ahmed, S., Besser, T.E., Jones, L.P., Sischo, W.M., and Davis, M.A. (2018). Molecular Epidemiology of Dairy Cattle-Associated Escherichia coli Carrying blaCTX-M Genes in Washington State. Appl. Environ. Microbiol., 84.","DOI":"10.1128\/AEM.02430-17"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"538","DOI":"10.3928\/0090-4481-19941001-07","article-title":"Salmonella, Shigella, and Campylobacter: Common bacterial causes of infectious diarrhea","volume":"23","author":"Stutman","year":"1994","journal-title":"Pediatr. Ann."},{"key":"ref_26","first-page":"5","article-title":"Antimicrobial therapy of salmonelloses--current state and perspectives","volume":"48","author":"Stoycheva","year":"2006","journal-title":"Folia Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1089\/fpd.2010.0615","article-title":"CTX-M-type extended-spectrum beta-lactamases present in Escherichia coli from the feces of cattle in Ohio, United States","volume":"7","author":"Wittum","year":"2010","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2460\/ajvr.70.3.389","article-title":"Identification of Escherichia coli and Salmonella enterica organisms with reduced susceptibility to ceftriaxone from fecal samples of cows in dairy herds","volume":"70","author":"Heider","year":"2009","journal-title":"Am. J. Vet. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1001\/jama.284.24.3151","article-title":"Emergence of domestically acquired ceftriaxone-resistant Salmonella infections associated with AmpC beta-lactamase","volume":"284","author":"Dunne","year":"2000","journal-title":"JAMA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1093\/jtm\/taw102","article-title":"The ecology of extended-spectrum beta-lactamases (ESBLs) in the developed world","volume":"24","author":"Doi","year":"2017","journal-title":"J. Travel. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1574-6976.2008.00105.x","article-title":"The penicillin-binding proteins: Structure and role in peptidoglycan biosynthesis","volume":"32","author":"Sauvage","year":"2008","journal-title":"FEMS Microbiol. Rev."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Bush, K., and Bradford, P.A. (2016). beta-Lactams and beta-Lactamase Inhibitors: An Overview. Cold Spring Harb. Perspect. Med., 6.","DOI":"10.1101\/cshperspect.a025247"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.drup.2012.12.001","article-title":"Extended-spectrum cephalosporin-resistant Gram-negative organisms in livestock: An emerging problem for human health?","volume":"16","author":"Seiffert","year":"2013","journal-title":"Drug Resist. Updates"},{"key":"ref_34","unstructured":"Letourneau, A.R. (2022, August 28). Beta-Lactam Antibiotics: Mechanisms of Action and Resistance and Adverse Effects. Available online: https:\/\/www.uptodate.com\/contents\/beta-lactam-antibiotics-mechanisms-of-action-and-resistance-and-adverse-effects."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"King, D.T., Sobhanifar, S., and Strynadka, N.C.J. (2017). The Mechanisms of Resistance to \u03b2-Lactam Antibiotics. Handbook of Antimicrobial Resistance, Springer.","DOI":"10.1007\/978-1-4939-0694-9_10"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1128\/AAC.01009-09","article-title":"Updated functional classification of beta-lactamases","volume":"54","author":"Bush","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/jac\/45.6.783","article-title":"Analysis of the effects of \u221242 and \u221232 ampC promoter mutations in clinical isolates of Escherichia coli hyperproducing ampC","volume":"45","author":"Caroff","year":"2000","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1093\/jac\/dkx146","article-title":"Global epidemiology of CTX-M beta-lactamases: Temporal and geographical shifts in genotype","volume":"72","author":"Bevan","year":"2017","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1128\/CMR.14.4.933-951.2001","article-title":"Extended-spectrum beta-lactamases in the 21st century: Characterization, epidemiology, and detection of this important resistance threat","volume":"14","author":"Bradford","year":"2001","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1128\/CMR.18.4.657-686.2005","article-title":"Extended-spectrum beta-lactamases: A clinical update","volume":"18","author":"Paterson","year":"2005","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Castanheira, M., Simner, P.J., and Bradford, P.A. (2021). Extended-spectrum \u03b2-lactamases: An update on their characteristics, epidemiology and detection. JAC Antimicrob. Resist., 16.","DOI":"10.1093\/jacamr\/dlab092"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Bradford, P.A., Bonomo, R.A., Bush, K., Carattoli, A., Feldgarden, M., Haft, D.H., Ishii, Y., Jacoby, G.A., Klimke, W., and Palzkill, T. (2022). Consensus on beta-Lactamase Nomenclature. Antimicrob. Agents Chemother., 66.","DOI":"10.1128\/aac.00333-22"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/oxfordjournals.bmb.a071942","article-title":"\u03b2-LACTAMASES","volume":"40","author":"Medeiros","year":"1984","journal-title":"Br. Med. Bull."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s10156-013-0640-7","article-title":"The ABCD\u2019s of beta-lactamase nomenclature","volume":"19","author":"Bush","year":"2013","journal-title":"J. Infect. Chemother."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1469-0691.2007.01857.x","article-title":"Defining an extended-spectrum beta-lactamase","volume":"14","author":"Livermore","year":"2008","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1469-0691.2007.01854.x","article-title":"Evolution of extended-spectrum beta-lactamases by mutation","volume":"14","author":"Gniadkowski","year":"2008","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1128\/jb.138.3.657-662.1979","article-title":"Types of beta-lactamase determined by plasmids in gram-negative bacteria","volume":"138","author":"Matthew","year":"1979","journal-title":"J. Bacteriol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1586\/eri.12.110","article-title":"Extraintestinal pathogenic Escherichia coli: An update on antimicrobial resistance, laboratory diagnosis and treatment","volume":"10","author":"Pitout","year":"2012","journal-title":"Expert Rev. Anti Infect"},{"key":"ref_49","unstructured":"NCBI (2022, July 05). Reference Gene Catalog, Available online: https:\/\/www.ncbi.nlm.nih.gov\/pathogens\/refgene\/#gene_family:(blaSHV\/blaTEM."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"5715","DOI":"10.1128\/JCM.42.12.5715-5721.2004","article-title":"Phenotypic and molecular detection of CTX-M-beta-lactamases produced by Escherichia coli and Klebsiella spp.","volume":"42","author":"Pitout","year":"2004","journal-title":"J. Clin. Microbiol."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Hussain, H.I., Aqib, A.I., Seleem, M.N., Shabbir, M.A., Hao, H., Iqbal, Z., Kulyar, M.F., Zaheer, T., and Li, K. (2021). Genetic basis of molecular mechanisms in beta-lactam resistant gram-negative bacteria. Microb. Pathog., 158.","DOI":"10.1016\/j.micpath.2021.105040"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1128\/AAC.32.8.1243","article-title":"Novel plasmid-mediated Beta-lactamase from Escherichia coli that inactivates oxyimino-cephalosporins","volume":"32","author":"Matsumoto","year":"1988","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3389\/fmicb.2012.00110","article-title":"CTX-M Enzymes: Origin and Diffusion","volume":"3","author":"Canton","year":"2012","journal-title":"Front. Microbiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1093\/jac\/dks026","article-title":"Molecular epidemiology of extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae over a 10 year period in Calgary, Canada","volume":"67","author":"Peirano","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1473-3099(08)70041-0","article-title":"Extended-spectrum beta-lactamase-producing Enterobacteriaceae: An emerging public-health concern","volume":"8","author":"Pitout","year":"2008","journal-title":"Lancet Infect. Dis."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AAC.48.1.1-14.2004","article-title":"Growing group of extended-spectrum beta-lactamases: The CTX-M enzymes","volume":"48","author":"Bonnet","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"4403","DOI":"10.1128\/AEM.00463-15","article-title":"Recent Emergence of Escherichia coli with Cephalosporin Resistance Conferred by bla(CTX-M) on Washington State Dairy Farms","volume":"81","author":"Davis","year":"2015","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ijmm.2013.02.008","article-title":"CTX-M-type beta-lactamases: A successful story of antibiotic resistance","volume":"303","author":"Arena","year":"2013","journal-title":"Int. J. Med. Microbiol."},{"key":"ref_59","unstructured":"NCBI (2022, July 05). Reference Gene Catalog, Available online: https:\/\/www.ncbi.nlm.nih.gov\/pathogens\/refgene\/#gene_family:(blaCTX-M)."},{"key":"ref_60","unstructured":"USDA(United States Department of Agriculture) (2016). Dairy 2014, Milk Quality, Milking Procedures, and Mastitis in the United States, 2014, USDA\u2013APHIS\u2013VS\u2013CEAH\u2013NAHMS."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/zph.12773","article-title":"Antimicrobial Use Quantification in Adult Dairy Cows\u2014Part 3\u2014Use Measured by Standardized Regimens and Grams on 29 Dairies in the United States","volume":"67","author":"Schrag","year":"2020","journal-title":"Zoonoses Public Health"},{"key":"ref_62","unstructured":"FDA (2022, August 28). Animal Drugs. In: U.S. Food & Drug Administration, Animal Drugs., Available online: https:\/\/animaldrugsatfda.fda.gov\/adafda\/views\/#\/search."},{"key":"ref_63","unstructured":"FDA (2022, June 30). Extralabel Use and Antimicrobials, Available online: https:\/\/www.fda.gov\/animal-veterinary\/antimicrobial-resistance\/extralabel-use-and-antimicrobials."},{"key":"ref_64","unstructured":"FDA (2022, July 03). Cephalosporin Order of Prohibition Questions and Answers, Available online: https:\/\/www.fda.gov\/animal-veterinary\/antimicrobial-resistance\/cephalosporin-order-prohibition-questions-and-answers."},{"key":"ref_65","unstructured":"Arnold, M. (2022, July 03). The U.S. Food and Drug Administration (FDA) and Cephalosporin Use: How Will This New Rule Affect KY Dairy Producers?. Available online: https:\/\/afs.ca.uky.edu\/dairy\/us-food-and-drug-administration-fda-and-cephalosporin-use-how-will-new-rule-affect-ky-dairy."},{"key":"ref_66","unstructured":"FDA (2022, July 15). Cephalosporin use in cattle. Available online: https:\/\/www.mda.state.mn.us\/sites\/default\/files\/inline-files\/Cephalosporin.pdf."},{"key":"ref_67","unstructured":"(2022, July 03). Zoetis Services, LLC Zoetis United States Website. Available online: https:\/\/www.zoetisus.com\/."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Ekakoro, J.E., Caldwell, M., Strand, E.B., and Okafor, C.C. (2018). Drivers of Antimicrobial Use Practices among Tennessee Dairy Cattle Producers. Vet. Med. Int., 2018.","DOI":"10.1155\/2018\/1836836"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/zph.12766","article-title":"Antimicrobial use quantification in adult dairy cows\u2014Part 1\u2014Standardized regimens as a method for describing antimicrobial use","volume":"67","author":"Schrag","year":"2020","journal-title":"Zoonoses Public Health"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3168\/jds.S0022-0302(07)72626-7","article-title":"Treatment practices and quantification of antimicrobial drug usage in conventional and organic dairy farms in Wisconsin","volume":"90","author":"Pol","year":"2007","journal-title":"J. Dairy Sci."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"75","DOI":"10.14202\/vetworld.2016.75-79","article-title":"Episodes of clinical mastitis and its relationship with duration of treatment and seasonality in crossbred cows maintained in organized dairy farm","volume":"9","author":"Kumar","year":"2016","journal-title":"Vet. World"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.3168\/jds.S0022-0302(05)72979-9","article-title":"A survey on antibiotic usage in dairy herds in Pennsylvania","volume":"88","author":"Sawant","year":"2005","journal-title":"J. Dairy Sci."},{"key":"ref_73","unstructured":"U.S. Food & Drug Administration (2022, August 28). Antimicrobial Use and Resistance in Animal Agriculture in the United States 2016\u20132019, Available online: https:\/\/www.fda.gov\/media\/159544\/download."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1056\/NEJM200004273421703","article-title":"Ceftriaxone-resistant salmonella infection acquired by a child from cattle","volume":"342","author":"Fey","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"ref_75","unstructured":"Food and Drug Administration, Center for Veteinary Medicine (2022, August 28). 2020 Summary Report on Animicrobials sold or Distributed for Use in Food-Producing Animals, Available online: https:\/\/www.fda.gov\/media\/154820\/download."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3168\/jdsc.2020-0031","article-title":"Antimicrobial resistance in Klebsiella species from milk specimens submitted for bovine mastitis testing at the Wisconsin Veterinary Diagnostic Laboratory, 2008\u20132019","volume":"2","author":"Fuenzalida","year":"2021","journal-title":"JDS Commun."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1128\/AAC.45.7.2054-2059.2001","article-title":"Effect of abolishment of the use of antimicrobial agents for growth promotion on occurrence of antimicrobial resistance in fecal enterococci from food animals in Denmark","volume":"45","author":"Aarestrup","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.prevetmed.2005.01.013","article-title":"Animal and farm influences on the dynamics of antibiotic resistance in faecal Escherichia coli in young calves","volume":"69","author":"Berge","year":"2005","journal-title":"Prev. Vet. Med."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1128\/AEM.71.3.1184-1192.2005","article-title":"Acquisition of resistance to extended-spectrum cephalosporins by Salmonella enterica subsp. enterica serovar Newport and Escherichia coli in the turkey poult intestinal tract","volume":"71","author":"Poppe","year":"2005","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Fan, S., Foster, D., Miller, W., Osborne, J., and Kathariou, S. (2021). Impact of Ceftiofur Administration in Steers on the Prevalence and Antimicrobial Resistance of Campylobacter spp.. Microorganisms, 9.","DOI":"10.3390\/microorganisms9020318"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Beyi, A.F., Brito-Goulart, D., Hawbecker, T., Ruddell, B., Hassall, A., Dewell, R., Dewell, G., Sahin, O., Zhang, Q., and Plummer, P.J. (2021). Enrofloxacin Alters Fecal Microbiota and Resistome Irrespective of Its Dose in Calves. Microorganisms, 9.","DOI":"10.3390\/microorganisms9102162"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Beyi, A.F., Brito-Goulart, D., Hawbecker, T., Slagel, C., Ruddell, B., Hassall, A., Dewell, R., Dewell, G., Sahin, O., and Zhang, Q. (2021). Danofloxacin Treatment Alters the Diversity and Resistome Profile of Gut Microbiota in Calves. Microorganisms, 9.","DOI":"10.3390\/microorganisms9102023"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Guri, A., Flaks-Manov, N., Ghilai, A., Hoshen, M., Rimon, O.F., Ciobotaro, P., and Zimhony, O. (2020). Risk factors for third-generation cephalosporin resistant Enterobacteriaceae in gestational urine cultures: A retrospective cohort study based on centralized electronic health records. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0226515"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Foster, D.M., Jacob, M.E., Farmer, K.A., Callahan, B., Theriot, C.M., Kathariou, S., Cernicchiaro, N., Prange, T., and Papich, M.G. (2019). Ceftiofur formulation differentially affects the intestinal drug concentration, resistance of fecal Escherichia coli, and the microbiome of steers. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0223378"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"5426","DOI":"10.3168\/jds.2013-7756","article-title":"Treatments of clinical mastitis occurring in cows on 51 large dairy herds in Wisconsin","volume":"97","author":"Oliveira","year":"2014","journal-title":"J. Dairy Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.2460\/javma.2003.222.1582","article-title":"Antimicrobial resistance of bacteria isolated from dairy cow milk samples submitted for bacterial culture: 8,905 samples (1994\u20132001)","volume":"222","author":"Makovec","year":"2003","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1089\/fpd.2010.0730","article-title":"Impact of Antibiotic Use in Adult Dairy Cows on Antimicrobial Resistance of Veterinary and Human Pathogens: A Comprehensive Review","volume":"8","author":"Oliver","year":"2011","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1089\/fpd.2017.2362","article-title":"Antimicrobial Resistance of Staphylococcus aureus Isolates from Dairy Cows and Genetic Diversity of Resistant Isolates","volume":"15","author":"Abdi","year":"2018","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Abdi, R.D., Gillespie, B.E., Ivey, S., Pighetti, G.M., Almeida, R.A., and Dego, O.K. (2021). Antimicrobial Resistance of Major Bacterial Pathogens from Dairy Cows with High Somatic Cell Count and Clinical Mastitis. Animals, 11.","DOI":"10.3390\/ani11010131"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.3168\/jds.2019-16778","article-title":"Invited review: Fate of antibiotic residues, antibiotic-resistant bacteria, and antibiotic resistance genes in US dairy manure management systems","volume":"103","author":"Oliver","year":"2020","journal-title":"J. Dairy Sci."},{"key":"ref_91","unstructured":"Dego, O.K. (2021). Antimicrobial Usage for the Management of Mastitis in the USA: Impacts on Antimicrobial Resistance and Potential Alternative Approaches. Mastitis in Dairy Cattle, Sheep and Goats, Intech Open."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"9001","DOI":"10.3168\/jds.2016-11134","article-title":"Prevalence and risk factors for extended-spectrum beta-lactamase- and AmpC-producing Escherichia coli in dairy farms","volume":"99","author":"Gonggrijp","year":"2016","journal-title":"J. Dairy Sci."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00284-015-0958-8","article-title":"Control of Bovine Mastitis: Old and Recent Therapeutic Approaches","volume":"72","author":"Gomes","year":"2016","journal-title":"Curr. Microbiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"6915","DOI":"10.3168\/jds.2013-6544","article-title":"The effect of internal teat sealant products (Teatseal and Orbeseal) on intramammary infection, clinical mastitis, and somatic cell counts in lactating dairy cows: A meta-analysis","volume":"96","author":"Rabiee","year":"2013","journal-title":"J. Dairy Sci."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3109\/1040841X.2012.691460","article-title":"Epidemiology and genetics of CTX-M extended-spectrum beta-lactamases in Gram-negative bacteria","volume":"39","author":"Zhao","year":"2013","journal-title":"Crit. Rev. Microbiol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"633","DOI":"10.3389\/fmicb.2019.00633","article-title":"The Role of Plasmids in the Multiple Antibiotic Resistance Transfer in ESBLs-Producing Escherichia coli Isolated From Wastewater Treatment Plants","volume":"10","author":"Li","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Partridge, S.R., Kwong, S.M., Firth, N., and Jensen, S.O. (2018). MMobile Genetic Elements Associated with Antimicrobial Resistance. Clin. Microbiol. Rev., 31.","DOI":"10.1128\/CMR.00088-17"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1007\/s40265-019-01180-3","article-title":"Extended-Spectrum \u03b2-Lactamase-Producing Enterobacteriaceae: Update on Molecular Epidemiology and Treatment Options","volume":"79","author":"Peirano","year":"2019","journal-title":"Drugs"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1128\/AAC.49.1.447-450.2005","article-title":"ISEcp1B-mediated transposition of blaCTX-M in Escherichia coli","volume":"49","author":"Poirel","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1128\/AAC.50.4.1282-1286.2006","article-title":"In vitro analysis of ISEcp1B-mediated mobilization of naturally occurring beta-lactamase gene blaCTX-M of Kluyvera ascorbata","volume":"50","author":"Lartigue","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1128\/CMR.00116-14","article-title":"The role of epidemic resistance plasmids and international high-risk clones in the spread of multidrug-resistant Enterobacteriaceae","volume":"28","author":"Mathers","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/1469-0691.12719","article-title":"The difficult-to-control spread of carbapenemase producers among Enterobacteriaceae worldwide. Clinical microbiology and infection","volume":"20","author":"Nordmann","year":"2014","journal-title":"Eur. Soc. Clin. Microbiol. Infect. Dis."},{"key":"ref_103","first-page":"273","article-title":"Intercontinental emergence of Escherichia coli clone O25: H4-ST131 producing CTX-M-15","volume":"61","author":"Blanco","year":"2008","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.3389\/fmicb.2017.02318","article-title":"CTX-M-15-Producing E. coli Isolates from Food Products in Germany Are Mainly Associated with an IncF-Type Plasmid and Belong to Two Predominant Clonal E. coli Lineages","volume":"8","author":"Irrgang","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.ijmm.2013.02.001","article-title":"Plasmids and the spread of resistance","volume":"303","author":"Carattoli","year":"2013","journal-title":"Int. J. Med. Microbiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.3389\/fmicb.2019.01394","article-title":"Dissemination of Multidrug-Resistant Commensal Escherichia coli in Feedlot Lambs in Southeastern Brazil","volume":"10","author":"Gozi","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1093\/jac\/dkq347","article-title":"Replicon sequence typing of IncF plasmids carrying virulence and resistance determinants","volume":"65","author":"Villa","year":"2010","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"195","DOI":"10.12688\/f1000research.10609.1","article-title":"Escherichia coli ST131: A multidrug-resistant clone primed for global domination","volume":"6","author":"Pitout","year":"2017","journal-title":"F1000Research"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1093\/jac\/dks143","article-title":"Replicon sequence typing of IncF plasmids and the genetic environments of blaCTX-M-15 indicate multiple acquisitions of blaCTX-M-15 in Escherichia coli and Klebsiella pneumoniae isolates from South Korea","volume":"67","author":"Shin","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.mib.2006.08.011","article-title":"The CTX-M beta-lactamase pandemic","volume":"9","author":"Canton","year":"2006","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1128\/AEM.02770-05","article-title":"Molecular epidemiology of ceftiofur-resistant Escherichia coli isolates from dairy calves","volume":"72","author":"Donaldson","year":"2006","journal-title":"Appl. Env. Microbiol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"360","DOI":"10.14202\/vetworld.2020.360-363","article-title":"Antimicrobial resistance pattern of extended-spectrum beta-lactamase-producing Escherichia coli isolated from fecal samples of piglets and pig farm workers of selected organized farms of India","volume":"13","author":"Tamta","year":"2020","journal-title":"Vet. World"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.3389\/fmicb.2018.01756","article-title":"Molecular Characterization of Extended-Spectrum beta-Lactamase-Producing Multidrug Resistant Escherichia coli From Swine in Northwest China","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Badr, H., Reda, R.M., Hagag, N.M., Kamel, E., Elnomrosy, S.M., Mansour, A.I., Shahein, M.A., Ali, S.F., and Ali, H.R. (2022). Multidrug-Resistant and Genetic Characterization of Extended-Spectrum Beta-Lactamase-Producing E. coli Recovered from Chickens and Humans in Egypt. Animals, 12.","DOI":"10.3390\/ani12030346"},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Carey, A.M., Capik, S.F., Giebel, S., Nickodem, C., Pi\u00f1eiro, J.M., Scott, H.M., Vinasco, J., and Norman, K.N. (2022). Prevalence and Profiles of Antibiotic Resistance Genes mph(A) and qnrB in Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli Isolated from Dairy Calf Feces. Microorganisms, 10.","DOI":"10.3390\/microorganisms10020411"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1128\/AAC.44.10.2777-2783.2000","article-title":"Animal and human multidrug-resistant, cephalosporin-resistant salmonella isolates expressing a plasmid-mediated CMY-2 AmpC beta-lactamase","volume":"44","author":"Winokur","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/infdis\/162.2.460","article-title":"A novel chromosomal TEM derivative and alterations in outer membrane proteins together mediate selective ceftazidime resistance in Escherichia coli","volume":"162","author":"Weber","year":"1990","journal-title":"J. Infect. Dis."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1128\/AAC.35.9.1697","article-title":"More extended-spectrum beta-lactamases","volume":"35","author":"Jacoby","year":"1991","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1128\/AAC.47.7.2382-2383.2003","article-title":"Discovery of CTX-M-like extended-spectrum beta-lactamases in Escherichia coli isolates from five US States","volume":"47","author":"Moland","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1089\/mdr.2015.0259","article-title":"Antimicrobial-Resistant Fecal Bacteria from Ceftiofur-Treated and Nonantimicrobial-Treated Comingled Beef Cows at a Cow-Calf Operation","volume":"22","author":"Agga","year":"2016","journal-title":"Microb. Drug Resist."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1128\/AEM.70.1.318-323.2004","article-title":"Use of antibiotic susceptibility patterns and pulsed-field gel electrophoresis to compare historic and contemporary isolates of multi-drug-resistant Salmonella enterica subsp enterica serovar Newport","volume":"70","author":"Berge","year":"2004","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Yang, Y., Higgins, C.H., Rehman, I., Galvao, K.N., Brito, I.L., Bicalho, M.L., Song, J., Wang, H., and Bicalho, R.C. (2019). Genomic Diversity, Virulence, and Antimicrobial Resistance of Klebsiella pneumoniae Strains from Cows and Humans. Appl. Environ. Microbiol., 85.","DOI":"10.1128\/AEM.02654-18"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e03206","DOI":"10.1016\/j.heliyon.2020.e03206","article-title":"Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in cattle production\u2014A threat around the world","volume":"6","year":"2020","journal-title":"Heliyon"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1089\/fpd.2017.2310","article-title":"Prevalence and Transmission of Antimicrobial Resistance in a Vertically Integrated Veal Calf Production System","volume":"14","author":"Hutchinson","year":"2017","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Davidson, K.E., Byrne, B.A., Pires, A.F.A., Magdesian, K.G., and Pereira, R.V. (2018). Antimicrobial resistance trends in fecal Salmonella isolates from northern California dairy cattle admitted to a veterinary teaching hospital, 2002\u20132016. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0199928"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"4552","DOI":"10.1128\/AEM.00373-12","article-title":"Variable within- and between-Herd Diversity of CTX-M Cephalosporinase-Bearing Escherichia coli Isolates from Dairy Cattle","volume":"78","author":"Mollenkopf","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ijantimicag.2007.03.013","article-title":"Prevalence, distribution and characterisation of ceftiofur resistance in Salmonella enterica isolated from animals in the USA from 1999 to 2003","volume":"30","author":"Frye","year":"2007","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_128","first-page":"2","article-title":"Phenotypic Antimicrobial Resistance Profiles of E. coli and Enterococcus from Dairy Cattle in Different Management Units on a Central California Dairy","volume":"7","author":"Li","year":"2018","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_129","unstructured":"Cao, H. (2015). Antimicrobial Resistance of Salmonella and E. coli from Pennsylvania Dairy Herds, University of Maryland."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.3168\/jds.2009-2093","article-title":"The incidence of salmonellosis among dairy herds in the northeastern United States","volume":"92","author":"Cummings","year":"2009","journal-title":"J. Dairy Sci."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4315\/0362-028X-71.1.27","article-title":"Prevalence of multidrug-resistant Salmonella on commercial dairies utilizing a single heifer raising facility","volume":"71","author":"Edrington","year":"2008","journal-title":"J. Food Prot."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.prevetmed.2006.12.001","article-title":"Prevalence of antimicrobial resistance among Salmonella on midwest and northeast USA dairy farms","volume":"79","author":"Ray","year":"2007","journal-title":"Prev. Vet. Med."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1128\/AEM.02588-10","article-title":"Genotypic-Phenotypic Discrepancies between Antibiotic Resistance Characteristics of Escherichia coli Isolates from Calves in Management Settings with High and Low Antibiotic Use","volume":"77","author":"Davis","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_134","unstructured":"NARMS (2022, July 20). Global Resistome Data, Available online: https:\/\/www.fda.gov\/animal-veterinary\/national-antimicrobial-resistance-monitoring-system\/global-resistome-data."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/eva.12185","article-title":"Antibiotics in agriculture and the risk to human health: How worried should we be?","volume":"8","author":"Chang","year":"2015","journal-title":"Evol. Appl."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1289\/ehp.10191","article-title":"Elevated risk of carrying gentamicin-resistant Escherichia coli among U.S. poultry workers","volume":"115","author":"Price","year":"2007","journal-title":"Environ. Health Perspect."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"7538","DOI":"10.3168\/jds.2012-6078","article-title":"Characterization of clinical mastitis occurring in cows on 50 large dairy herds in Wisconsin","volume":"96","author":"Oliveira","year":"2013","journal-title":"J. Dairy Sci."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1128\/JCM.00941-10","article-title":"CTX-M1 ESBL-producing Klebsiella pneumoniae subsp. pneumoniae isolated from cases of bovine mastitis","volume":"48","author":"Locatelli","year":"2010","journal-title":"J. Clin. Microbiol."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.3201\/eid1911.121470","article-title":"CTX-M \u03b2-Lactamase\u2013producing Klebsiella pneumoniae in Suburban New York City, New York, USA","volume":"19","author":"Wang","year":"2013","journal-title":"Emerg. Infect. Dis."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1017\/ice.2017.156","article-title":"Incidence of Extended-Spectrum beta-Lactamase (ESBL)-Producing Escherichia coli and Klebsiella Infections in the United States: A Systematic Literature Review","volume":"38","author":"McDanel","year":"2017","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/2047-2994-3-9","article-title":"Changing epidemiology of infections due to extended spectrum beta-lactamase producing bacteria","volume":"3","author":"Kassakian","year":"2014","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"ref_142","first-page":"137","article-title":"Occurrence and characterization of resistance to extended-spectrum cephalosporins mediated by beta-lactamase CMY-2 in Salmonella isolated from food-producing animals in Canada","volume":"66","author":"Allen","year":"2002","journal-title":"Can. J. Vet. Res."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1056\/NEJM197609092951103","article-title":"Changes in intestinal flora of farm personnel after introduction of a tetracycline-supplemented feed on a farm","volume":"295","author":"Levy","year":"1976","journal-title":"N. Engl. J. Med."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1056\/NEJM199905203402001","article-title":"Quinolone-resistant Campylobacter jejuni infections in Minnesota, 1992\u20131998 Investigation Team","volume":"340","author":"Smith","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1128\/AAC.45.10.2716-2722.2001","article-title":"Evidence for transfer of CMY-2 AmpC beta-lactamase plasmids between Escherichia coli and Salmonella isolates from food animals and humans","volume":"45","author":"Winokur","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1089\/fpd.2016.2180","article-title":"Ceftriaxone-Resistant Nontyphoidal Salmonella from Humans, Retail Meats, and Food Animals in the United States, 1996\u20132013","volume":"14","author":"Iwamoto","year":"2017","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_147","doi-asserted-by":"crossref","unstructured":"Reeves, P.R., Liu, B., Zhou, Z., Li, D., Guo, D., Ren, Y., Clabots, C., Lan, R., Johnson, J.R., and Wang, L. (2011). Rates of mutation and host transmission for an Escherichia coli clone over 3 years. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0026907"},{"key":"ref_148","unstructured":"Kantele, A., Kuenzli, E., Dunn, S.J., Dance, D.A., Newton, P.N., Davong, V., Mero, S., Pakkanen, S.H., Neumayr, A., and Hatz, C. (2022). Real-time sampling of travelers shows intestinal colonization by multidrug-resistant bacteria to be a dynamic process with multiple transient acquisitions. bioRxiv, 827915."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/j.cmi.2020.09.019","article-title":"Quantifying the transmission of antimicrobial resistance at the human and livestock interface with genomics","volume":"26","author":"Wee","year":"2020","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1007\/s40572-016-0089-9","article-title":"Recent Research Examining Links Among Klebsiella pneumoniae from Food, Food Animals, and Human Extraintestinal Infections","volume":"3","author":"Davis","year":"2016","journal-title":"Curr. Environ. Health Rep."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1093\/cid\/civ273","article-title":"Extensive Household Outbreak of Urinary Tract Infection and Intestinal Colonization due to Extended-Spectrum \u03b2-Lactamase-Producing Escherichia coli Sequence Type 131","volume":"61","author":"Madigan","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2147\/IDR.S48820","article-title":"Horizontal gene transfer in the human gastrointestinal tract: Potential spread of antibiotic resistance genes","volume":"7","author":"Huddleston","year":"2014","journal-title":"Infect. Drug Resist."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1089\/fpd.2005.2.115","article-title":"Foodborne pathogens in milk and the dairy farm environment: Food safety and public health implications","volume":"2","author":"Oliver","year":"2005","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1089\/fpd.2009.0302","article-title":"Food safety hazards associated with consumption of raw milk","volume":"6","author":"Oliver","year":"2009","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1089\/fpd.2021.0103","article-title":"Regulation Mechanisms of Virulence Genes in Enterohemorrhagic Escherichia coli","volume":"19","author":"Gelalcha","year":"2022","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"957","DOI":"10.3201\/eid2306.151603","article-title":"Outbreak-Related Disease Burden Associated with Consumption of Unpasteurized Cow\u2019s Milk and Cheese, United States, 2009\u20132014","volume":"23","author":"Costard","year":"2017","journal-title":"Emerg. Infect. Dis."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3201\/eid1803.111370","article-title":"Nonpasteurized dairy products, disease outbreaks, and state laws\u2014United States, 1993\u20132006","volume":"18","author":"Langer","year":"2012","journal-title":"Emerg Infect. Dis."},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Manyi-Loh, C., Mamphweli, S., Meyer, E., and Okoh, A. (2018). Antibiotic Use in Agriculture and Its Consequential Resistance in Environmental Sources: Potential Public Health Implications. Molecules, 23.","DOI":"10.3390\/molecules23040795"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1089\/fpd.2006.3.222","article-title":"Public Health Significance of Antimicrobial-Resistant Gram-Negative Bacteria in Raw Bulk Tank Milk","volume":"3","author":"Straley","year":"2006","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_160","first-page":"1191","article-title":"Drug-Resistant Infections from Raw Milk","volume":"319","author":"Kuehn","year":"2018","journal-title":"JAMA"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3201\/eid2101.140447","article-title":"Increased outbreaks associated with nonpasteurized milk, United States, 2007\u20132012","volume":"21","author":"Mungai","year":"2015","journal-title":"Emerg. Infect. Dis."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1086\/517310","article-title":"A prolonged outbreak of Escherichia coli O157:H7 infections caused by commercially distributed raw milk","volume":"176","author":"Keene","year":"1997","journal-title":"J. Infect. Dis."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4014\/jmb.0908.08007","article-title":"A brief overview of Escherichia coli O157:H7 and its plasmid O157","volume":"20","author":"Lim","year":"2010","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1038\/s41598-017-03724-7","article-title":"Local immunization impacts the response of dairy cows to Escherichia coli mastitis, Local immunization impacts the response of dairy cows to Escherichia coli mastitis","volume":"7","author":"Herry","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4142\/jvs.2014.15.1.1","article-title":"An overview of calf diarrhea\u2014Infectious etiology, diagnosis, and intervention","volume":"15","author":"Cho","year":"2014","journal-title":"J. Vet. Sci."},{"key":"ref_166","unstructured":"Scripps Local Media (2022, August 28). Some Dairy Farmers Are Turning to Unpasteurized Milk. Available online: https:\/\/fox13now.com\/2020\/01\/27\/some-dairy-farmers-are-turning-to-unpasteurized-milk\/."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1001\/jama.281.19.1805","article-title":"Two outbreaks of multidrug-resistant Salmonella serotype typhimurium DT104 infections linked to raw-milk cheese in Northern California","volume":"281","author":"Cody","year":"1999","journal-title":"JAMA"},{"key":"ref_168","unstructured":"United States Department of Agriculture, Animal and Plant Health Inspection Service (1996). Economic Opportunities for Dairy Cow Culling Management Options."},{"key":"ref_169","unstructured":"National Agricultural Statistics Service (NASS), Agricultural Statistics Board, United States Department of Agriculture (USDA) (2022, August 28). Livestock Slaughter, Available online: https:\/\/www.nass.usda.gov\/Publications\/Todays_Reports\/reports\/lstk0122.pdf."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"405","DOI":"10.20506\/rst.16.2.1022","article-title":"Meat from dairy cows: Possible microbiological hazards and risks","volume":"16","author":"Troutt","year":"1997","journal-title":"Rev. Sci. Tech."},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"443","DOI":"10.15585\/mmwr.mm6715a2","article-title":"Protracted Outbreak of Salmonella Newport Infections Linked to Ground Beef: Possible Role of Dairy Cows\u201421 States, 2016\u20132017","volume":"67","author":"Marshall","year":"2018","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2460\/javma.228.4.585","article-title":"Long-term persistence of multi-drug-resistant Salmonella enterica serovar Newport in two dairy herds","volume":"228","author":"Cobbold","year":"2006","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1056\/NEJM198703053161001","article-title":"Chloramphenicol-Resistant Salmonella-Newport Traced through Hamburger to Dairy Farms\u2014A Major Persisting Source of Human Salmonellosis in California","volume":"316","author":"Spika","year":"1987","journal-title":"N. Engl. J. Med."},{"key":"ref_174","unstructured":"Centers for Disease Control and Prevention (CDC) (2019). Outbreak of E. coli Infections Linked to Ground Beef."},{"key":"ref_175","unstructured":"Centers for Disease Control and Prevention (CDC) (2008). Multistate Outbreak of E. coli O157:H7 Infections Linked to Ground Beef from Kroger\/Nebraska Ltd., (FINAL UPDATE)."},{"key":"ref_176","unstructured":"Centers for Disease Control and Prevention (CDC) (2009). Multistate Outbreak of E. coli O157:H7 Infections Associated with Beef from Fairbanks Farms, (FINAL UPDATE)."},{"key":"ref_177","unstructured":"Centers for Disease Control and Prevention (CDC) (2014). Multistate Outbreak of Shiga Toxin-Producing Escherichia coli O157:H7 Infections Linked to Ground Beef."},{"key":"ref_178","unstructured":"Centers for Disease Control and Prevention (CDC) (2016). Multistate Outbreak of Shiga toxin-producing Escherichia coli O157:H7 Infections Linked to Beef Products Produced by Adams Farm."},{"key":"ref_179","unstructured":"Centers for Disease Control and Prevention (CDC) (2018). Outbreak of E. coli Infections Linked to Ground Beef, 2018."},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1128\/AAC.49.5.2137-2139.2005","article-title":"High Levels of Antimicrobial Coresistance among Extended-Spectrum- beta-Lactamase-Producing Enterobacteriaceae","volume":"49","author":"Schwaber","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13756-019-0552-0","article-title":"Distribution of quinolone resistance gene (qnr) in ESBL-producing Escherichia coli and Klebsiella spp. in Lome, Togo","volume":"8","author":"Salah","year":"2019","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"7644","DOI":"10.3168\/jds.2014-8521","article-title":"Effect of on-farm use of antimicrobial drugs on resistance in fecal Escherichia coli of preweaned dairy calves","volume":"97","author":"Pereira","year":"2014","journal-title":"J. Dairy Sci."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.3168\/jds.S0022-0302(01)74661-9","article-title":"Prevalence of foodborne pathogens in bulk tank milk","volume":"84","author":"Jayarao","year":"2001","journal-title":"J. Dairy Sci."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.3168\/jds.S0022-0302(99)75518-9","article-title":"A study on the prevalence of gram-negative bacteria in bulk tank milk","volume":"82","author":"Jayarao","year":"1999","journal-title":"J. Dairy Sci."},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.3168\/jds.S0022-0302(06)72318-9","article-title":"A survey of foodborne pathogens in bulk tank milk and raw milk consumption among farm families in Pennsylvania","volume":"89","author":"Jayarao","year":"2006","journal-title":"J. Dairy Sci."},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"713","DOI":"10.15585\/mmwr.mm6833a1","article-title":"Outbreak of Salmonella Newport Infections with Decreased Susceptibility to Azithromycin Linked to Beef Obtained in the United States and Soft Cheese Obtained in Mexico\u2014United States, 2018\u20132019","volume":"68","author":"Plumb","year":"2019","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.3168\/jds.2016-12084","article-title":"Prevalence, antimicrobial resistance, and molecular characterization of Campylobacter spp. in bulk tank milk and milk filters from US dairies","volume":"100","author":"Karns","year":"2017","journal-title":"J. Dairy Sci."},{"key":"ref_188","unstructured":"(2022, August 28). Centers for Disease Control and Prevention (CDC), Multistate Outbreak of Multidrug-Resistant Salmonella Heidelberg Infections Linked to Contact with Dairy Calves, Available online: https:\/\/www.cdc.gov\/salmonella\/heidelberg-11-16\/index.html."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1086\/379668","article-title":"Emergence of multidrug-resistant Salmonella enterica serotype Newport infections resistant to expanded-spectrum cephalosporins in the United States","volume":"188","author":"Gupta","year":"2003","journal-title":"J. Infect. Dis."},{"key":"ref_190","doi-asserted-by":"crossref","first-page":"547547","DOI":"10.1155\/2015\/547547","article-title":"Occurrence of Multidrug Resistant Extended Spectrum Beta-Lactamase-Producing Bacteria on Iceberg Lettuce Retailed for Human Consumption","volume":"2015","author":"Bhutani","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ijfoodmicro.2015.04.049","article-title":"Prevalence and characterization of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in ready-to-eat vegetables","volume":"207","author":"Kim","year":"2015","journal-title":"Int. J. Food Microbiol."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1002\/mnfr.200400030","article-title":"Occurrence of antibiotic-resistant enterobacteria in agricultural foodstuffs","volume":"48","author":"Boehme","year":"2004","journal-title":"Mol. Nutr. Food. Res."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1089\/fpd.2020.2792","article-title":"Prevalence of beta-Lactam Drug-Resistance Genes in Escherichia coli Contaminating Ready-to-Eat Lettuce","volume":"17","author":"Liao","year":"2020","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1089\/fpd.2018.2558","article-title":"Occurrence, Identification, and Antimicrobial Resistance Profiles of Extended-Spectrum and AmpC beta-Lactamase-Producing Enterobacteriaceae from Fresh Vegetables Retailed in Gauteng Province, South Africa","volume":"16","author":"Richter","year":"2019","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"e323","DOI":"10.1093\/cid\/ciz1182","article-title":"Shiga Toxin-Producing Escherichia coli Infections Associated With Romaine Lettuce-United States, 2018","volume":"71","author":"Bottichio","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1093\/jac\/dkv489","article-title":"Atypical epidemiology of CTX-M-15 among Enterobacteriaceae from a high diversity of non-clinical niches in Angola","volume":"71","author":"Ribeiro","year":"2016","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1086\/597399","article-title":"Multistate Outbreak of Escherichia coli O157:H7 Infection Associated with Consumption of Packaged Spinach, August-September 2006: The Wisconsin Investigation","volume":"48","author":"Wendel","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"939","DOI":"10.4315\/0362-028X.JFP-12-503","article-title":"Multistate outbreak of Escherichia coli O145 infections associated with romaine lettuce consumption, 2010","volume":"76","author":"Taylor","year":"2013","journal-title":"J. Food Prot."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1086\/515323","article-title":"An outbreak of Escherichia coli O157:H7 infections associated with leaf lettuce consumption","volume":"177","author":"Ackers","year":"1998","journal-title":"J. Infect. Dis."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.4315\/0362-028X.JFP-15-556","article-title":"Multistate Outbreak of Escherichia coli O157:H7 Infections Associated with Consumption of Fresh Spinach: United States, 2006","volume":"79","author":"Sharapov","year":"2016","journal-title":"J. Food Prot."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1128\/AEM.02506-10","article-title":"Extended-spectrum Beta-lactamase gene sequences in gram-negative saprophytes on retail organic and nonorganic spinach","volume":"77","author":"Raphael","year":"2011","journal-title":"Appl. Env. Microbiol."},{"key":"ref_202","doi-asserted-by":"crossref","unstructured":"Berman, H.F., and Riley, L.W. (2013). Identification of novel antimicrobial resistance genes from microbiota on retail spinach. BMC Microbiol., 13.","DOI":"10.1186\/1471-2180-13-272"},{"key":"ref_203","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.3201\/eid2610.191418","article-title":"Lessons Learned from a Decade of Investigations of Shiga Toxin-Producing Escherichia coli Outbreaks Linked to Leafy Greens, United States and Canada","volume":"26","author":"Marshall","year":"2020","journal-title":"Emerg. Infect. Dis."},{"key":"ref_204","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1089\/mdr.2018.0206","article-title":"Whole-Genome Sequence Analysis of CTX-M Containing Escherichia coli Isolates from Retail Meats and Cattle in the United States","volume":"24","author":"Tadesse","year":"2018","journal-title":"Microb. Drug Resist."},{"key":"ref_205","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1080\/09603123.2012.708916","article-title":"Prevalence of multiple antibiotic-resistant Gram-negative bacteria on bagged, ready-to-eat baby spinach","volume":"23","author":"Walia","year":"2013","journal-title":"Int. J. Environ. Health Res."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/11\/10\/1313\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:40:27Z","timestamp":1760143227000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/11\/10\/1313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,27]]},"references-count":205,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["antibiotics11101313"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics11101313","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,27]]}}}