{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T09:46:44Z","timestamp":1789897604749,"version":"4.0.1"},"reference-count":66,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Central Queensland University","award":["RSH\/4200"],"award-info":[{"award-number":["RSH\/4200"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Poultry production is among the most challenging industries for pathogen control. High animal density and abundance of faecal material demand strict biosecurity measures and continual vigilance in monitoring animal health parameters. Despite this vigilance, dealing with disease outbreaks is a part of farmers\u2019 routines. Phytogenic feed additives comprised of herbs, spices, essential oils, and oleoresins have potent antimicrobial and anti-inflammatory actions. Related studies are gaining substantial interest in human and animal health worldwide. In this study, a commercial blend phytogenic feed additive was supplemented to layers in an industrial free-range production system with 20,000 birds in both control and treatment groups. At the end of the trial, the ileum tissue was sampled for RNAseq transcriptomic analysis to study the host reaction to the supplement. Phytogenic supplement significantly inhibited four cholesterol-related pathways and reduced the Arteriosclerosis disease category towards improved cardiovascular health. The supplemented birds exhibited reduced disease susceptibility for 26 cancer categories with p-values in the range from 5.23 \u00d7 10\u22124 to 1.02 \u00d7 10\u221225. Major metabolic shifts in Lipid metabolism in combination with Carbohydrate metabolism have resulted in a decrease in the Obesity category, altering the ratio of fat and carbohydrate metabolism toward lower fat storage.<\/jats:p>","DOI":"10.3390\/antibiotics11101428","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:31:01Z","timestamp":1666053061000},"page":"1428","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Phytogenic Blend Improves Intestinal Health and Reduces Obesity, Diabetes, Cholesterol and Cancers: A Path toward Customised Supplementation"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8319-5007","authenticated-orcid":false,"given":"Sung J.","family":"Yu","sequence":"first","affiliation":[{"name":"Institute for Future Farming Systems, Central Queensland University, Rockhampton, QLD 4702, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadav S.","family":"Bajagai","sequence":"additional","affiliation":[{"name":"Institute for Future Farming Systems, Central Queensland University, Rockhampton, QLD 4702, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich","family":"Petranyi","sequence":"additional","affiliation":[{"name":"Institute for Future Farming Systems, Central Queensland University, Rockhampton, QLD 4702, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8665-6160","authenticated-orcid":false,"given":"Sara","family":"de las Heras-Saldana","sequence":"additional","affiliation":[{"name":"Animal Genetics and Breeding Unit, University of New England, Armidale, NSW 2351, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Thu Hao","family":"Van","sequence":"additional","affiliation":[{"name":"Institute for Future Farming Systems, Central Queensland University, Rockhampton, QLD 4702, Australia"},{"name":"School of Science, RMIT University, Bundoora West Campus, Bundoora, VIC 3083, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7019-4726","authenticated-orcid":false,"given":"Dragana","family":"Stanley","sequence":"additional","affiliation":[{"name":"Institute for Future Farming Systems, Central Queensland University, Rockhampton, QLD 4702, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ricke, S.C., Dittoe, D.K., and Richardson, K.E. 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