{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:41:33Z","timestamp":1788518493043,"version":"build-2803163510"},"reference-count":122,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Government of the Russian Federation","award":["075-15-2022-1124"],"award-info":[{"award-number":["075-15-2022-1124"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Limosilactobacillus fermentum strain 3872 (LF3872) was originally isolated from the breast milk of a healthy woman during lactation and the breastfeeding of a child. The high-quality genome sequencing of LF3872 was performed, and a gene encoding a unique bacteriocin was discovered. It was established that the bacteriocin produced by LF3872 (BLF3872) belongs to the family of cell-wall-degrading proteins that cause cell lysis. The antibacterial properties of LF3872 were studied using test cultures of antibiotic-resistant Gram-positive and Gram-negative pathogens. Gram-positive pathogens (Staphylococcus aureus strain 8325-4 and S. aureus strain IIE CI-SA 1246) were highly sensitive to the bacteriolytic action of LF3872. Gram-negative pathogens (Escherichia coli, Salmonella strains, and Campylobacter jejuni strains) were more resistant to the bacteriolytic action of LF3872 compared to Gram-positive pathogens. LF3872 is a strong co-aggregator of Gram-negative pathogens. The cell-free culture supernatant of LF3872 (CSLF3872) induced cell damage in the Gram-positive and Gram-negative test cultures and ATP leakage. In the in vitro experiments, it was found that LF3872 and Actigen prebiotic (Alltech Inc., Nicholasville, KY, USA) exhibited synergistic anti-adhesive activity against Gram-negative pathogens. LF3872 has immunoregulatory properties: it inhibited the lipopolysaccharide-induced production of proinflammatory cytokines IL-8, IL-1\u03b2, and TNF-\u03b1 in a monolayer of Caco-2 cells; inhibited the production of IL-12 and stimulated the production of IL-10 in immature human dendritic cells; and stimulated the production of TGF-\u03b2, IFN-\u03b3, and IgA in the immunocompetent cells of intestinal Peyer\u2019s patches (PPs) in mice. These results indicate the possibility of creating a synbiotic based on LF3872 and a prebiotic derived from Saccharomyces cerevisiae cell wall components. Such innovative drugs and biologically active additives are necessary for the implementation of a strategy to reduce the spread of antibiotic-resistant strains of socially significant animal and human infections.<\/jats:p>","DOI":"10.3390\/antibiotics11101437","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T20:32:23Z","timestamp":1666211543000},"page":"1437","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Limosilactobacillus fermentum Strain 3872: Antibacterial and Immunoregulatory Properties and Synergy with Prebiotics against Socially Significant Antibiotic-Resistant Infections of Animals and Humans"],"prefix":"10.3390","volume":"11","author":[{"given":"Vyacheslav M.","family":"Abramov","sequence":"first","affiliation":[{"name":"Federal Service for Veterinary and Phytosanitary Surveillance (Rosselkhoznadzor), Federal State Budgetary Institution \u201cThe Russian State Center for Animal Feed and Drug Standardization and Quality\u201d (FGBU VGNKI), 123022 Moscow, Russia"},{"name":"Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor V.","family":"Kosarev","sequence":"additional","affiliation":[{"name":"Federal Service for Veterinary and Phytosanitary Surveillance (Rosselkhoznadzor), Federal State Budgetary Institution \u201cThe Russian State Center for Animal Feed and Drug Standardization and Quality\u201d (FGBU VGNKI), 123022 Moscow, Russia"},{"name":"Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health, 117997 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4859-7219","authenticated-orcid":false,"given":"Andrey V.","family":"Machulin","sequence":"additional","affiliation":[{"name":"Skryabin 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I.","family":"Deryusheva","sequence":"additional","affiliation":[{"name":"Institute for Biological Instrumentation, Federal Research Center \u201cPushchino Scientific Center for Biological Research of Russian Academy of Science\u201d, Russian Academy of Science, 142290 Pushchino, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4539-5192","authenticated-orcid":false,"given":"Tatiana N.","family":"Abashina","sequence":"additional","affiliation":[{"name":"Skryabin Institute of Biochemistry and Physiology of Microorganisms, Federal Research Center \u201cPushchino Scientific Center for Biological Research of Russian Academy of Science\u201d, Russian Academy of Science, 142290 Pushchino, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almira D.","family":"Donetskova","sequence":"additional","affiliation":[{"name":"NRC Institute of Immunology FMBA of Russia, 115522 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander N.","family":"Panin","sequence":"additional","affiliation":[{"name":"Federal Service for Veterinary and Phytosanitary Surveillance (Rosselkhoznadzor), Federal State Budgetary Institution \u201cThe Russian State Center for Animal Feed and Drug Standardization and Quality\u201d (FGBU VGNKI), 123022 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0825-7930","authenticated-orcid":false,"given":"Vyacheslav G.","family":"Melnikov","sequence":"additional","affiliation":[{"name":"Gabrichevsky Research Institute for Epidemiology and Microbiology, 125212 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliya E.","family":"Suzina","sequence":"additional","affiliation":[{"name":"Skryabin Institute of Biochemistry and Physiology of Microorganisms, Federal Research Center \u201cPushchino Scientific Center for Biological 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