{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:54:40Z","timestamp":1793019280404,"version":"4.5.0"},"reference-count":19,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Taiwan Ministry of Science and Technology","award":["MOST 106-2314-B-182A-041"],"award-info":[{"award-number":["MOST 106-2314-B-182A-041"]}]},{"name":"the Taiwan Ministry of Science and Technology","award":["CMRPG3 K1681"],"award-info":[{"award-number":["CMRPG3 K1681"]}]},{"name":"Chang Gung Memorial Hospital","award":["MOST 106-2314-B-182A-041"],"award-info":[{"award-number":["MOST 106-2314-B-182A-041"]}]},{"name":"Chang Gung Memorial Hospital","award":["CMRPG3 K1681"],"award-info":[{"award-number":["CMRPG3 K1681"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Staphylococcus lugdunensis endophthalmitis is an uncommon intraocular infection with potentially visually devastating consequences. S. lugdunensis endophthalmitis have been reported following cataract surgery, trauma, intravitreal injections of anti-vascular endothelial growth factor agents and dexamethasone implant. We report four cases of postoperative S. lugdunensis endophthalmitis after cataract extraction (three patients) and combined pars plana vitrectomy and cataract extraction (one patient). The onset of presentation of endophthalmitis was acute (within 2 weeks) in two patients, subacute (2 to 6 weeks) in one patient, and chronic (more than 6 weeks) in one patient. All patients had presenting visual acuity (VA) of hand motions or worse and were treated with pars plana vitrectomy with intravitreal antibiotics. The final VA was 20\/50 in two patients, 4\/200 in one patient with pre-existing myopic maculopathy, and no light perception in one patient with retinal detachment. In antibiotic susceptibility testing, S. lugdunensis isolates were resistant to penicillin (3\/4, 75%), but all were susceptible to vancomycin, oxacillin, teicoplanin, tigecycline, and sulfamethoxazole-trimethoprim. S. lugdunensis may be associated with acute or chronic endophthalmitis. Favorable visual outcomes can be achieved with prompt diagnosis and management.<\/jats:p>","DOI":"10.3390\/antibiotics11111485","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T09:59:37Z","timestamp":1666778377000},"page":"1485","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Staphylococcus lugdunensis Endophthalmitis: Case Series and Literature Review"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4994-8391","authenticated-orcid":false,"given":"Kuan-Jen","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou branch, Taoyuan 333, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3436-2582","authenticated-orcid":false,"given":"Ming-Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou branch, Taoyuan 333, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew S. H.","family":"Tsai","sequence":"additional","affiliation":[{"name":"Singapore National Eye Centre, Singapore 168751, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Chin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou branch, Taoyuan 333, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan 333, Taiwan"},{"name":"Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung 204, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou branch, Taoyuan 333, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Chun","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou branch, Taoyuan 333, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan 333, Taiwan"},{"name":"Department of Ophthalmology, Chang Gung Memorial Hospital, Keelung 204, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.survophthal.2018.02.003","article-title":"Management of bacterial postoperative endophthalmitis and the role of vitrectomy","volume":"63","author":"Clarke","year":"2018","journal-title":"Surv. Ophthalmol."},{"key":"ref_2","first-page":"2399","article-title":"Preventive factors, diagnosis, and management of injection-related endophthalmitis: A literature review","volume":"260","author":"Singh","year":"2022","journal-title":"Graefe\u2032s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0002-9394(14)71959-2","article-title":"Spectrum and susceptibilities of microbiologic isolates in the Endophthalmitis Vitrectomy Study","volume":"122","author":"Han","year":"1996","journal-title":"Am. J. Ophthalmol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1001\/archopht.1997.01100150359008","article-title":"The source of coagulase-negative staphylococci in the Endophthalmitis Vitrectomy Study. A comparison of eyelid and intraocular isolates using pulsed-field gel electrophoresis","volume":"115","author":"Bannerman","year":"1997","journal-title":"Arch. Ophthalmol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0025-6196(11)64220-1","article-title":"Prosthetic joint infection due to Staphylococcus lugdunensis","volume":"75","author":"Sampathkumar","year":"2000","journal-title":"Mayo Clin. Proc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1128\/CMR.00036-07","article-title":"From clinical microbiology to infection pathogenesis: How daring to be different works for Staphylococcus lugdunensis","volume":"21","author":"Frank","year":"2008","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1128\/JCM.00847-16","article-title":"Clinical Features, Outcomes, and Molecular Characteristics of Community- and Health Care-Associated Staphylococcus lugdunensis Infections","volume":"54","author":"Yeh","year":"2016","journal-title":"J. Clin. Microbiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1128\/JCM.02499-06","article-title":"Acute postoperative endophthalmitis caused by Staphylococcus lugdunensis","volume":"45","author":"Chiquet","year":"2007","journal-title":"J. Clin. Microbiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/ICB.0b013e3182a85a4f","article-title":"Staphylococcus lugdunensis endophthalmitis after intravitreal injection: A case series","volume":"8","author":"Kashani","year":"2014","journal-title":"Retin. Cases Brief Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"424","DOI":"10.4103\/ijo.IJO_720_18","article-title":"Staphylococcus lugdunensis endophthalmitis following dexamethasone intravitreal implant","volume":"67","author":"Salceanu","year":"2019","journal-title":"Indian J. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"657","DOI":"10.12669\/pjms.38.3.4738","article-title":"Investigation of Staphylococcus lugdunensis and Selected Coagulase Negative Staphylococci Isolated from Blood Culture bottles and Determination of their Sensitivities to Antibiotics","volume":"38","author":"Veliev","year":"2022","journal-title":"Pak. J. Med. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"64","DOI":"10.4103\/0974-9233.171784","article-title":"Incidence of Endophthalmitis after Intravitreal Bevacizumab using Aliquots Prepared On-site in 2 Operating Rooms in Kuwait","volume":"23","author":"Wani","year":"2016","journal-title":"Middle East Afr. J. Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ajoc.2017.12.006","article-title":"Acute-onset endophthalmitis caused by Staphylococcus lugdunensis","volume":"9","author":"Garoon","year":"2018","journal-title":"Am. J. Ophthalmol. Case Rep."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Xu, S., and Zhang, H. (2022). Bacteriological profile of conjunctiva bacterial Flora in Northeast China: A hospital-based study. BMC Ophthalmol., 22.","DOI":"10.1186\/s12886-022-02441-8"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1469-0691.2009.02813.x","article-title":"Staphylococcus lugdunensis in several niches of the normal skin flora","volume":"16","author":"Bieber","year":"2010","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e00205-20","DOI":"10.1128\/CMR.00205-20","article-title":"Staphylococcus lugdunensis: A Skin Commensal with Invasive Pathogenic Potential","volume":"34","author":"Heilbronner","year":"2021","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1080\/09273948.2020.1814343","article-title":"Retinal Vasculitis and Posterior Pole Preretinal Exudates in Exogenous Bacterial Endophthalmitis: Management and Visual Outcomes","volume":"30","author":"Chen","year":"2022","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1136\/bjophthalmol-2015-307722","article-title":"Endophthalmitis caused by Gram-positive organisms with reduced vancomycin susceptibility: Literature review and options for treatment","volume":"100","author":"Relhan","year":"2016","journal-title":"Br. J. Ophthalmol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"15878","DOI":"10.1038\/s41598-021-95458-w","article-title":"Susceptibility of bacterial endophthalmitis isolates to vancomycin, ceftazidime, and amikacin","volume":"11","author":"Chen","year":"2021","journal-title":"Sci. Rep."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/11\/11\/1485\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:03:32Z","timestamp":1760144612000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/11\/11\/1485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,26]]},"references-count":19,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["antibiotics11111485"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics11111485","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,26]]}}}