{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T13:21:55Z","timestamp":1778160115795,"version":"3.51.4"},"reference-count":59,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"S\u00e3o Paulo Research Foundation (FAPESP)","award":["2019\/07295-2"],"award-info":[{"award-number":["2019\/07295-2"]}]},{"name":"S\u00e3o Paulo Research Foundation (FAPESP)","award":["2597"],"award-info":[{"award-number":["2597"]}]},{"name":"S\u00e3o Paulo Research Foundation (FAPESP)","award":["310068\/2020-7"],"award-info":[{"award-number":["310068\/2020-7"]}]},{"name":"Coordination of Superior Level Staff Improvement","award":["2019\/07295-2"],"award-info":[{"award-number":["2019\/07295-2"]}]},{"name":"Coordination of Superior Level Staff Improvement","award":["2597"],"award-info":[{"award-number":["2597"]}]},{"name":"Coordination of Superior Level Staff Improvement","award":["310068\/2020-7"],"award-info":[{"award-number":["310068\/2020-7"]}]},{"name":"National Council for Scientific and Technological Development\/CNPQ","award":["2019\/07295-2"],"award-info":[{"award-number":["2019\/07295-2"]}]},{"name":"National Council for Scientific and Technological Development\/CNPQ","award":["2597"],"award-info":[{"award-number":["2597"]}]},{"name":"National Council for Scientific and Technological Development\/CNPQ","award":["310068\/2020-7"],"award-info":[{"award-number":["310068\/2020-7"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Irritation and biofilm adhesion are complaints associated with ocular prosthesis use. This study aimed to evaluate the effects of prosthesis repolishing on several conditions of anophthalmic volunteers. Participants were divided into two groups: intervention (IG, n = 10) and nonintervention (NIG, n = 6) groups. The anophthalmic cavity, contralateral eye, and prosthesis surface were evaluated at initial, day 15, and day 30 after repolishing. Microbiological analysis (colony-forming units), exfoliative cytology (conjunctiva inflammatory cells), sensory analysis (quantitative mechanical sensory test), tear production (Schirmer\u2019s test), and conjunctival inflammation (clinical evaluation) were performed. Nonparametric tests were used to compare groups in the initial period and to analyze periods for the IG (p &lt; 0.05). More microorganisms were formed in the anophthalmic socket and prosthesis than in the contralateral eye in the initial period. For IG, the anophthalmic cavity exhibited more microorganisms and inflammatory clinical signs in the initial period than at 15 and 30 after repolishing. The prosthesis showed greater accumulations of total bacteria and Candida albicans in the initial period than at 15 and 30 days after repolishing. The anophthalmic cavity had more palpebral inflammation than the contralateral eye. In conclusion, repolishing reduced the number of microorganisms and inflammatory signs over time.<\/jats:p>","DOI":"10.3390\/antibiotics11111486","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T20:37:58Z","timestamp":1666903078000},"page":"1486","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Inflammation Level and a Microbiological Analysis of the Anophthalmic Cavities of Unilateral Ocular Prosthesis Users: A Blind, Randomized Observational Study"],"prefix":"10.3390","volume":"11","author":[{"given":"Paulo Augusto","family":"Penitente","sequence":"first","affiliation":[{"name":"Department of Dental Materials and Prosthodontics, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0164-1788","authenticated-orcid":false,"given":"Emily Vivianne Freitas","family":"Da Silva","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, School of Dentistry, University of S\u00e3o Paulo, S\u00e3o Paulo 0508-000, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3800-3050","authenticated-orcid":false,"given":"Marcelo Coelho","family":"Goiato","sequence":"additional","affiliation":[{"name":"Department of Dental Materials and Prosthodontics, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, S\u00e3o Paulo, Brazil"},{"name":"Oral Oncology Center, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba Dental School, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena Louise Pontes","family":"Mani\u00e7oba","sequence":"additional","affiliation":[{"name":"Department of Dental Materials and Prosthodontics, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5508-3825","authenticated-orcid":false,"given":"Victor Gustavo Balera","family":"Brito","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, S\u00e3o Paulo State University (UNESP), School of Dentistry, Ara\u00e7atuba 16015-050, S\u00e3o Paulo, Brazil"},{"name":"Multicenter Postgraduate Program in Physiological Sciences, Brazilian Society of Physiology, S\u00e3o Paulo State University (UNESP), School of Dentistry, Ara\u00e7atuba 16015-050, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina Helga Leal","family":"T\u00farcio","sequence":"additional","affiliation":[{"name":"Department of Dental Materials and Prosthodontics, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alana Semenzin","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Dental Materials and Prosthodontics, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, S\u00e3o Paulo, Brazil"},{"name":"Oral Oncology Center, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba Dental School, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna Egumi","family":"Nagay","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba 13414-903, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6297-6154","authenticated-orcid":false,"given":"Daniela Micheline","family":"Dos Santos","sequence":"additional","affiliation":[{"name":"Department of Dental Materials and Prosthodontics, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, S\u00e3o Paulo, Brazil"},{"name":"Oral Oncology Center, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba Dental School, S\u00e3o Paulo State University (UNESP), Ara\u00e7atuba 16015-050, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1590\/S1678-77572010000600018","article-title":"Chromatic stability of acrylic resins of artificial eyes submitted to accelerated aging and polishing","volume":"18","author":"Goiato","year":"2010","journal-title":"J. Appl. Oral Sci."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.tiv.2016.08.005","article-title":"Toxicity analysis of ocular prosthesis acrylic resin with or without pigment incorporation in human conjunctival cell line","volume":"36","author":"Goiato","year":"2016","journal-title":"Toxicol. In Vitro"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1097\/SCS.0000000000003370","article-title":"Survey of ocular prosthetics rehabilitation in the united kingdom, part 1: Anophthalmic patients\u2019 aetiology, opinions, and attitudes","volume":"28","author":"Hatamleh","year":"2017","journal-title":"J. Craniofac. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.prosdent.2016.06.001","article-title":"Effect of different methods of polymerizing ocular prosthesis acrylic resin on a human conjunctival cell line","volume":"116","author":"Goiato","year":"2016","journal-title":"J. Prosthet. Dent."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3109\/01676830.2014.881395","article-title":"Fabrication techniques for ocular prostheses: An overview","volume":"33","author":"Goiato","year":"2014","journal-title":"Orbit"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1600-0501.2006.01353.x","article-title":"Effect of material character-istics and\/or surface topography on biofilm development","volume":"17","author":"Teughels","year":"2006","journal-title":"Clin. Oral Implant. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4103\/ejd.ejd_50_18","article-title":"In vitro evaluation of microbial adhesion on the different surface roughness of acrylic resin specific for ocular prosthesis","volume":"12","author":"Andreotti","year":"2018","journal-title":"Eur. J. Dent."},{"key":"ref_8","first-page":"154","article-title":"Comparative study of bacterial and fungal floras of contracted sockets and fellow eyes","volume":"16","author":"Dayal","year":"1984","journal-title":"Ann. Ophthalmol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Yoda, I., Koseki, H., Tomita, M., Shida, T., Horiuchi, H., Sakoda, H., and Osaki, M. (2014). Effect of sur-face roughness of biomaterials on Staphylococcus epidermidis adhesion. BMC Microbiol., 2.","DOI":"10.1186\/s12866-014-0234-2"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1097\/ICO.0000000000000639","article-title":"Fungal infections after boston type 1 keratoprosthesis implantation: Literature review and in vitro antifungal activity of hypochlorous acid","volume":"34","author":"Odorcic","year":"2015","journal-title":"Cornea"},{"key":"ref_11","first-page":"707","article-title":"A survey of prosthetic eye wearers to investigate mucoid discharge","volume":"6","author":"Pine","year":"2012","journal-title":"Clin. Ophthalmol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/00004397-199103120-00015","article-title":"The contact lens patient and ocular allergies","volume":"31","author":"Donshik","year":"1991","journal-title":"Int. Ophthalmol. Clin."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/01.IOP.0000148410.70798.95","article-title":"Conjunctival cytology features of giant papillary conjunctivitis associated with ocular prostheses","volume":"21","author":"Chang","year":"2005","journal-title":"Ophthalmic Plast. Reconstr. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.jtos.2020.03.007","article-title":"Giant papillary conjunctivitis: A review","volume":"18","author":"Kenny","year":"2020","journal-title":"Ocul. Surf."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.1167\/iovs.06-0817","article-title":"Exposure to a controlled adverse environment impairs the ocular surface of subjects with minimally symptomatic dry eye","volume":"48","author":"Stern","year":"2007","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.ophtha.2013.11.036","article-title":"Environmental factors affect the risk of dry eye syndrome in a United States veteran population","volume":"121","author":"Galor","year":"2014","journal-title":"Ophthalmology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.ajo.2014.01.001","article-title":"Dry eye exacerbation in patients exposed to desiccating stress under controlled environmental conditions","volume":"157","author":"Stern","year":"2014","journal-title":"Am. J. Ophthalmol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.clae.2005.12.006","article-title":"The effect of short term contact lens wear on the tear film and ocular surface characteristics of tolerant and intolerant wearers","volume":"29","author":"Glasson","year":"2006","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/01.ICL.0000072825.23491.59","article-title":"In vivo dehydration of silicone hydrogel contact lenses","volume":"29","author":"Morgan","year":"2003","journal-title":"Eye Contact Lens"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1167\/iovs.03-1185","article-title":"Effect of environmental condi-tions on tear dynamics in soft contact lens wearers","volume":"45","author":"Maruyama","year":"2004","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/eye.2013.97","article-title":"Ocular pros-theses in the last century: A retrospective analysis of 8018 patients","volume":"27","author":"Modugno","year":"2013","journal-title":"Eye"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"438","DOI":"10.5935\/0034-7280.20160088","article-title":"Comparative study between phenol red thread test and the Schirmer\u2019s test in the diagnosis of dry eyes syndrome","volume":"75","author":"Ghislandi","year":"2016","journal-title":"Rev. Bras. Oftalmol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/lam.12830","article-title":"Microbiological analysis of conjunctival secretion in anophthalmic cavity, contralateral eye and ocular prosthesis of patients with maxillofacial abnormalities","volume":"66","author":"Guiotti","year":"2018","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1590\/S1678-77572007000100008","article-title":"Evaluation of ocular prosthesis biofilm and anophthalmic cavity contamination after use of three cleansing solutions","volume":"15","author":"Paranhos","year":"2007","journal-title":"J. Appl. Oral Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5967","DOI":"10.1016\/j.biomaterials.2012.05.031","article-title":"Biofilm for-mation in Staphylococcus implant infections: A review of molecular mechanisms and implications for biofilm-resistant materials","volume":"33","author":"Arciola","year":"2012","journal-title":"Biomaterials"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.clae.2015.06.003","article-title":"Recommendations for post-adaption care of an ocular prosthesis: A review","volume":"38","author":"Amigo","year":"2015","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"718017","DOI":"10.1155\/2009\/718017","article-title":"Influence of surface properties on the adhesion of Staphylococcus epidermidis to acrylic and silicone","volume":"2009","author":"Sousa","year":"2009","journal-title":"Int. J. Biomater."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e20180779","DOI":"10.1590\/1678-7757-2018-0779","article-title":"The effect of nanodiamonds on candida albicans adhesion and surface characteristics of PMMA denture base material\u2014An in vitro study","volume":"27","author":"Fouda","year":"2019","journal-title":"J. Appl. Oral Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1741-2358.2012.00642.x","article-title":"Effect of different disinfectants on the microhardness and roughness of acrylic resins for ocular prosthesis","volume":"30","author":"Moreno","year":"2013","journal-title":"Gerodontology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1076\/ocii.11.3.223.17350","article-title":"Tear eotaxin levels in giant papillary conjunctivitis associated with ocular prosthesis","volume":"11","author":"Sarac","year":"2003","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"78","DOI":"10.29252\/ibj.23.1.78","article-title":"Influence of preparation and exposure periods of eluates from oc-ular prosthesis acrylic resin in human conjunctival cell line","volume":"23","author":"Goiato","year":"2019","journal-title":"Iran. Biomed. J."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1523\/JNEUROSCI.21-06-01868.2001","article-title":"Upregulation of dorsal root ganglion (alpha)2(delta) calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats","volume":"21","author":"Luo","year":"2001","journal-title":"J. Neurosci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1089\/107999000312441","article-title":"Interleukin-6 levels in tears of contact lens wearers","volume":"20","author":"Schultz","year":"2000","journal-title":"J. Interf. Cytokine Res."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/ICL.0b013e3182482910","article-title":"Elevated tear interleukin-6 and interleukin-8 levels associated with silicone hydrogel and conventional hydrogel contact lens wear","volume":"38","author":"Poyraz","year":"2012","journal-title":"Eye Contact Lens"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.ico.0000167877.11687.7e","article-title":"Assessment of stromal keratocytes and tear film inflammatory mediators during extended wear of contact lenses","volume":"25","author":"Kallinikos","year":"2006","journal-title":"Cornea"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.pain.2006.10.010","article-title":"Brain activity related to temporal summation of cfiber evoked pain","volume":"129","author":"Staud","year":"2007","journal-title":"Pain"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/0006-8993(94)90288-7","article-title":"Descending modulation of central neural plasticity in the formalin pain test","volume":"666","author":"Vaccarino","year":"1994","journal-title":"Brain Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0006-8993(96)00631-2","article-title":"Participation of central descending noci-cep-tive facilitatory systems in secondary hyperalgesia produced by mustard oil","volume":"737","author":"Urban","year":"1996","journal-title":"Brain Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/(SICI)1097-0339(199708)17:2<88::AID-DC2>3.0.CO;2-K","article-title":"Brush technique in ocular surface cytology","volume":"17","author":"Varinli","year":"1997","journal-title":"Diagn. Cytopathol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ijom.2012.05.028","article-title":"Psychosocial impact on anophthalmic patients wearing ocular prosthesis","volume":"42","author":"Goiato","year":"2013","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.jpain.2009.09.014","article-title":"Translation to portuguese and validation of the Douleur Neuropathique 4 questionnaire","volume":"11","author":"Santos","year":"2010","journal-title":"J. Pain."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1590\/S0004-27492006000400002","article-title":"Questionnaire of the psychosocial profile of the patient with anophthalmia with indication of ocular prosthesis","volume":"69","author":"Nicodemo","year":"2006","journal-title":"Arq. Bras. Oftalmol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1755-3768.2010.02039.x","article-title":"The eye amputated\u2013consequences of eye amputation with em-phasis on clinical aspects, phantom eye syndrome and quality of life","volume":"88","author":"Rasmussen","year":"2010","journal-title":"Acta Ophthalmol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"18186","DOI":"10.1021\/acsami.9b03311","article-title":"Visible-light-induced photocatalytic and antibacterial activity of TiO2 codoped with nitrogen and bismuth: New perspectives to control implant-biofilm-related diseases","volume":"11","author":"Nagay","year":"2019","journal-title":"ACS Appl. Mater. Interfaces."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1444-0938.2012.00754.x","article-title":"The development of measurement tools for prosthetic eye research","volume":"96","author":"Pine","year":"2013","journal-title":"Clin. Exp. Optom."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jtos.2019.03.010","article-title":"Neutrophil extracellular traps (NETs) contribute to pathological changes of ocular graft-vs.-host disease (oGVHD) dry eye: Implications for novel biomarkers and therapeutic strategies","volume":"17","author":"An","year":"2019","journal-title":"Ocul. Surf."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/eye.1996.12","article-title":"Impression cytology of the conjunctival epithelium in patients with vernal conjunctivitis","volume":"10","author":"Aragona","year":"1996","journal-title":"Eye"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/112067219700700104","article-title":"Conjunctival scrapings and impression cytology in chronic conjunctivitis. Correlation with microbiology","volume":"7","author":"Cvenkel","year":"1997","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s004200000203","article-title":"Ocular dis-comfort and conjunctival alterations in operating room workers. A single-institution pilot study","volume":"74","author":"Fenga","year":"2001","journal-title":"Int. Arch. Occup."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.2147\/OPTH.S95242","article-title":"Tear film osmolarity and dry eye disease: A review of the literature","volume":"9","author":"Potvin","year":"2015","journal-title":"Clin. Ophthalmol."},{"key":"ref_51","first-page":"45","article-title":"Schirmer\u2019s test","volume":"24","author":"Stevens","year":"2011","journal-title":"Community Eye Health J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s12974-019-1656-4","article-title":"Chronic dry eye induced corneal hypersensitivity, neuroinflammatory responses, and synaptic plasticity in the mouse trigeminal brainstem","volume":"16","author":"Fakih","year":"2019","journal-title":"J Neuroinflamm."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ejp.1287","article-title":"Reproducibility of quantitative sensory testing applied to musculoskeletal orofacial region: Site and sex differences","volume":"23","author":"Costa","year":"2019","journal-title":"Eur. J. Pain"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.archoralbio.2015.02.027","article-title":"Effect of topical anaesthesia in patients with persistent dentoalveolar pain disorders: A quan-titative sensory testing evaluation","volume":"60","author":"Porporatti","year":"2015","journal-title":"Arch. Oral Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/01.ajp.0000210950.01503.72","article-title":"Quantifying allodynia in patients suffering from unilateral neuropathic pain using von frey monofilaments","volume":"23","author":"Keizer","year":"2007","journal-title":"Clin. J. Pain"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.clinph.2008.11.010","article-title":"Ethnic differences regarding sensory, pain, and reflex responses in the trigeminal region","volume":"120","author":"Komiyama","year":"2009","journal-title":"Clin. Neurophysiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/jopr.12925","article-title":"The effect of a continuous mechanical polishing protocol on surface roughness, biofilm adhesion, and color stability of acrylic resin artificial teeth","volume":"28","author":"Barreto","year":"2019","journal-title":"J. Prosthodont."},{"key":"ref_58","first-page":"796","article-title":"Effect of a continuous mechanical polishing protocol on the color stainability, microhardness, mass, and surface roughness of denture base acrylic resin","volume":"21","author":"Melo","year":"2020","journal-title":"J. Prosthet. Dent."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"271","DOI":"10.4103\/0974-9233.134694","article-title":"Fabrication of a custom ocular prosthesis","volume":"21","author":"Sethi","year":"2014","journal-title":"Middle East Afr. J. Ophthalmol."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/11\/11\/1486\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:03:53Z","timestamp":1760144633000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/11\/11\/1486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,27]]},"references-count":59,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["antibiotics11111486"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics11111486","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,27]]}}}