{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:30:07Z","timestamp":1789986607366,"version":"4.0.1"},"reference-count":52,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T00:00:00Z","timestamp":1667606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"COLCIENCIAS 807\u20132018","award":["Code 120380763646, contract RC N\u00b0 715\u20132018"],"award-info":[{"award-number":["Code 120380763646, contract RC N\u00b0 715\u20132018"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Antimicrobial peptides (AMPs) are considered to be a valuable source for the identification and\/or design of promising candidates for the development of antifungal treatments, since they have advantages such as lower tendency to induce resistance, ease of production, and high purity and safety. Bovine lactoferricin (LfcinB) and Buforin II (BFII) are AMPs to which great antimicrobial potential has been attributed. The minimum motives with antimicrobial activity derived from LfcinB and BFII are RRWQWR and RLLR, respectively. Nine chimeras containing the minimum motives of both peptides were synthesized and their antifungal activity against fluconazole (FLC)-sensitive and resistant C. albicans, C. glabrata, and C. auris strains was evaluated. The results showed that peptides C9: (RRWQWR)2K-Ahx-RLLRRRLLR and C6: KKWQWK-Ahx-RLLRRLLR exhibited the greatest antifungal activity against two strains of C. albicans, a FLC-sensitive reference strain and a FLC-resistant clinical isolate; no medically significant results were observed with the other chimeras evaluated (MIC ~200 \u03bcg\/mL). The chimera C6 was also active against sensitive and resistant strains of C. glabrata and C. auris. The combination of branched polyvalent chimeras together with FLC showed a synergistic effect against C. albicans. In addition to exhibiting antifungal activity against reference strains and clinical isolates of Candida spp., they also showed antibacterial activity against both Gram-positive and Gram-negative bacteria, suggesting that these chimeras exhibit a broad antimicrobial spectrum and can be considered to be promising molecules for therapeutic applications.<\/jats:p>","DOI":"10.3390\/antibiotics11111561","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T02:43:51Z","timestamp":1667789031000},"page":"1561","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Chimeric Peptides Derived from Bovine Lactoferricin and Buforin II: Antifungal Activity against Reference Strains and Clinical Isolates of Candida spp."],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9122-678X","authenticated-orcid":false,"given":"Katherine","family":"Aguirre-Guataqui","sequence":"first","affiliation":[{"name":"Human Proteomics and Mycosis Unit, Infectious Diseases Research Group, Department of Microbiology, Carrera 7 # 43-82 Lab 404 Building 52, Pontificia Universidad Javeriana, Bogot\u00e1 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateo","family":"M\u00e1rquez-Torres","sequence":"additional","affiliation":[{"name":"Bacteriology Department, Universidad Colegio Mayor de Cundinamarca, Bogot\u00e1 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9081-0546","authenticated-orcid":false,"given":"H\u00e9ctor Manuel","family":"Pineda-Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Synthesis and Application of Peptide Molecules Faculty of Sciences, Universidad Nacional of Colombia, Bogot\u00e1 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4788-8150","authenticated-orcid":false,"given":"Yerly","family":"Vargas-Casanova","sequence":"additional","affiliation":[{"name":"Human Proteomics and Mycosis Unit, Infectious Diseases Research Group, Department of Microbiology, Carrera 7 # 43-82 Lab 404 Building 52, Pontificia Universidad Javeriana, Bogot\u00e1 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0743-6857","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Ceballos-Garzon","sequence":"additional","affiliation":[{"name":"MEDiS, INRAE, Universit\u00e9 Clermont Auvergne, 63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6915-8488","authenticated-orcid":false,"given":"Zuly Jenny","family":"Rivera-Monroy","sequence":"additional","affiliation":[{"name":"Synthesis and Application of Peptide Molecules Faculty of Sciences, Universidad Nacional of Colombia, Bogot\u00e1 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6882-4397","authenticated-orcid":false,"given":"Javier Eduardo","family":"Garc\u00eda-Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Synthesis and Application of Peptide Molecules Faculty of Sciences, Universidad Nacional of Colombia, Bogot\u00e1 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1302-5429","authenticated-orcid":false,"given":"Claudia Marcela","family":"Parra-Giraldo","sequence":"additional","affiliation":[{"name":"Human Proteomics and Mycosis Unit, Infectious Diseases Research Group, Department of Microbiology, Carrera 7 # 43-82 Lab 404 Building 52, Pontificia Universidad Javeriana, Bogot\u00e1 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"18026","DOI":"10.1038\/nrdp.2018.26","article-title":"Invasive candidiasis","volume":"4","author":"Pappas","year":"2018","journal-title":"Nat. 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