{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T01:02:26Z","timestamp":1792544546953,"version":"4.5.0"},"reference-count":15,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:00:00Z","timestamp":1667865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by painful nodules, abscesses, and fistulas, localized to the areas of the folds where apocrine glands are present: the armpits, groin, inframammary region, and genital or perineal region. The management is still challenging, and it includes mainly systemic antibiotics, immunosuppressors, and biologic agents. Antibiotics are frequently used in the management of HS for their anti-inflammatory, immunomodulatory, and antimicrobial properties, but no data have been reported regarding the use of dalbavancin in HS. The aim of our practice was to evaluate efficacy, flare, and disease-free survival after dalbavancin therapy in a selected population with HS. We report the experience of the Ancona Dermatology Clinic in treating HS flare-ups with dalbavancin and its rationale for use. Our observation shows that the use of dalbavancin is an effective and well-tolerated treatment for the management of Hurley stage II-III HS; currently, dalbavancin should be considered as a supportive therapy for selected patients.<\/jats:p>","DOI":"10.3390\/antibiotics11111573","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T10:49:51Z","timestamp":1667904591000},"page":"1573","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Effect of Dalbavancin in Moderate to Severe Hidradenitis Suppurativa"],"prefix":"10.3390","volume":"11","author":[{"given":"Elisa","family":"Molinelli","sequence":"first","affiliation":[{"name":"Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60121 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Sapigni","sequence":"additional","affiliation":[{"name":"Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60121 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3856-4122","authenticated-orcid":false,"given":"Giovanni Marco","family":"D\u2019Agostino","sequence":"additional","affiliation":[{"name":"Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60121 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Brisigotti","sequence":"additional","affiliation":[{"name":"Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60121 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0091-4067","authenticated-orcid":false,"given":"Giulio","family":"Rizzetto","sequence":"additional","affiliation":[{"name":"Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60121 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Bobyr","sequence":"additional","affiliation":[{"name":"Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60121 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Cirioni","sequence":"additional","affiliation":[{"name":"Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60121 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Giacometti","sequence":"additional","affiliation":[{"name":"Clinic of Infectious Diseases, Department of Biochemical Sciences and Public Health, Polytechnic University of the Marche Region, 60121 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Brescini","sequence":"additional","affiliation":[{"name":"Clinic of Infectious Diseases, Department of Biochemical Sciences and Public Health, Polytechnic University of the Marche Region, 60121 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mazzanti","sequence":"additional","affiliation":[{"name":"Clinic of Infectious Diseases, Department of Biochemical Sciences and Public Health, Polytechnic University of the Marche Region, 60121 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Offidani","sequence":"additional","affiliation":[{"name":"Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60121 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriana","family":"Simonetti","sequence":"additional","affiliation":[{"name":"Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, 60121 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/jdv.15827","article-title":"Hidradenitis suppurativa in a prepubertal case series: A call for specific guidelines","volume":"33","author":"Offidani","year":"2019","journal-title":"J. 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