{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:22:27Z","timestamp":1787761347932,"version":"build-2784847793"},"reference-count":75,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Skin and soft tissue infections caused by Staphylococcus aureus (S. aureus) cover a wide spectrum of diseases in neonates, including staphylococcal scalded skin syndrome (SSSS). We describe a representative case of SSSS in neonatal twins, which despite recurrence showed a mild clinical disease course. This case was part of a small outbreak on a neonatal intensive care unit and therefore exemplifies the existence of neonatal outbreaks with skin and soft tissue infections by S. aureus. Diagnosis is generally based on the clinical picture and response to antibiotics, but can be aided by histology and cultures. Sequence-based molecular techniques are available to evaluate typing and virulence of S. aureus in outbreak or surveillance settings. The pillars of treatment are antibiotics and supportive care. Methicillin resistance remains a topic of concern, especially in outbreak settings. Our overview of numerous outbreaks of neonatal S. aureus skin infections underlines the importance of outbreak management strategies, including screening to identify the source of the outbreak, and limiting exposure through hygienic measures and establishment of physical boundaries.<\/jats:p>","DOI":"10.3390\/antibiotics12010038","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T04:42:47Z","timestamp":1672116167000},"page":"38","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Staphylococcal Scalded Skin Syndrome in Neonates: Case Series and Overview of Outbreaks"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7923-1690","authenticated-orcid":false,"given":"Charlotte M.","family":"Nusman","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Emma Children\u2019s Hospital, Amsterdam University Medical Centers, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6164-4289","authenticated-orcid":false,"given":"Charlotte","family":"Blokhuis","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Emma Children\u2019s Hospital, Amsterdam University Medical Centers, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5232-8206","authenticated-orcid":false,"given":"Dasja","family":"Pajkrt","sequence":"additional","affiliation":[{"name":"Department of Paediatric Infectious Disease, Emma Children\u2019s Hospital, Amsterdam University Medical Centers, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douwe H.","family":"Visser","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Emma Children\u2019s Hospital, Amsterdam University Medical Centers, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/bjd.16097","article-title":"Epidemiology of staphylococcal scalded skin syndrome in U.S. children","volume":"178","author":"Staiman","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/j.0022-202X.2005.23642.x","article-title":"Epidemiology of staphylococcal scalded skin syndrome in Germany","volume":"124","author":"Mockenhaupt","year":"2005","journal-title":"J. Investig. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"E514","DOI":"10.1111\/1469-0691.12053","article-title":"Epidemiological data of staphylococcal scalded skin syndrome in France from 1997 to 2007 and microbiological characteristics of Staphylococcus aureus associated strains","volume":"18","author":"Lamand","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_4","first-page":"296","article-title":"Staphylococcal scalded skin syndrome in the Czech Republic: An epidemiological study","volume":"38","author":"Brychta","year":"2011","journal-title":"Burns"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1172\/JCI0215766","article-title":"Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome","volume":"110","author":"Hanakawa","year":"2002","journal-title":"J. Clin. Investig."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s12519-018-0150-x","article-title":"Staphylococcal-scalded skin syndrome: Evaluation, diagnosis, and management","volume":"14","author":"Leung","year":"2018","journal-title":"World J. Pediatr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1128\/CMR.12.2.224","article-title":"Clinical, microbial, and biochemical aspects of the exfoliative toxins causing staphylococcal scalded-skin syndrome","volume":"12","author":"Ladhani","year":"1999","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1128\/jcm.27.3.504-506.1989","article-title":"Synthetic exfoliative toxin A and B DNA probes for detection of toxigenic Staphylococcus aureus strains","volume":"27","author":"Rifai","year":"1989","journal-title":"J. Clin. Microbiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/pde.12114","article-title":"Staphylococcal scalded skin syndrome in neonates: An 8-year retrospective study in a single institution","volume":"31","author":"Li","year":"2013","journal-title":"Pediatr. Dermatol."},{"key":"ref_10","first-page":"e36","article-title":"Neonatal staphylococcal scalded skin syndrome in a breastfed neonate","volume":"34","author":"Fertitta","year":"2019","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1111\/j.1651-2227.2004.tb00859.x","article-title":"Congenital staphylococcal scalded skin syndrome in a premature infant","volume":"93","author":"Haveman","year":"2004","journal-title":"Acta Paediatr."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1365-2133.2011.10515.x","article-title":"Mild staphylococcal scalded skin syndrome: An underdiagnosed clinical disorder","volume":"166","author":"Hubiche","year":"2011","journal-title":"Br. J. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1097\/PCC.0b013e3181b80dd2","article-title":"Neonate twin with staphylococcal scalded skin syndrome from a renal source","volume":"11","author":"Norbury","year":"2010","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1111\/1346-8138.13206","article-title":"Case of bullous impetigo with enormous bulla developing into staphylococcal scalded skin syndrome","volume":"43","author":"Bae","year":"2015","journal-title":"J. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1128\/JCM.43.4.1890-1893.2005","article-title":"Clinical manifestations of staphylococcal scalded-skin syndrome depend on serotypes of exfoliative toxins","volume":"43","author":"Yamasaki","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e110","DOI":"10.1111\/pde.13380","article-title":"A rare presentation of congenital syphilis: Pemphigus syphiliticus in a newborn infant with extensive desquamation of the extremities","volume":"35","author":"Wang","year":"2018","journal-title":"Pediatr. Dermatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1136\/adc.2006.103515","article-title":"Syphilis is on the increase: The implications for child health","volume":"93","author":"Chakraborty","year":"2008","journal-title":"Arch. Dis. Child."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s10096-010-0900-8","article-title":"A review of diagnostic tests for congenital syphilis in newborns","volume":"29","author":"Herremans","year":"2010","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"296","DOI":"10.3389\/fmed.2018.00296","article-title":"Diagnosis of Autoimmune Blistering Diseases","volume":"5","author":"Witte","year":"2018","journal-title":"Front. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.15537\/smj.2015.9.12270","article-title":"Pemphigus and pregnancy. Analysis and summary of case reports over 49 years","volume":"36","author":"Lin","year":"2015","journal-title":"Saudi Med. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1046\/j.1460-9592.2002.00768.x","article-title":"Epidermolysis bullosa in children: Pathophysiology, anaesthesia and pain management","volume":"12","author":"Frca","year":"2002","journal-title":"Paediatr. Anaesth"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.1093\/nar\/23.21.4407","article-title":"AFLP: A new technique for DNA fingerprinting","volume":"23","author":"Vos","year":"1995","journal-title":"Nucleic Acids Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.mimet.2007.01.013","article-title":"Comparison of multilocus sequence typing (MLST), pulsed-field gel electrophoresis (PFGE), and amplified fragment length polymorphism (AFLP) for genetic typing of Staphylococcus aureus","volume":"69","author":"Melles","year":"2007","journal-title":"J. Microbiol. Methods"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/S0140-6736(00)04403-2","article-title":"Whole genome sequencing of meticillin-resistant Staphylococcus aureus","volume":"357","author":"Kuroda","year":"2001","journal-title":"Lancet"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1473-3099(12)70276-1","article-title":"Use of whole-genome sequencing for outbreak investigations","volume":"13","author":"Diep","year":"2013","journal-title":"Lancet Infect. Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"20380","DOI":"10.2807\/ese.18.04.20380-en","article-title":"Overview of molecular typing methods for outbreak detection and epidemiological surveillance","volume":"18","author":"Sabat","year":"2013","journal-title":"Eurosurveillance"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.pedneo.2011.02.008","article-title":"Panton-Valentine leukocidin in the pathogenesis of community-associated methicillin-resistant Staphylococcus aureus infection","volume":"52","author":"Lo","year":"2011","journal-title":"Pediatr. Neonatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1146\/annurev-biochem-060614-034516","article-title":"Mechanisms of Methicillin Resistance in Staphylococcus aureus","volume":"84","author":"Peacock","year":"2015","journal-title":"Annu. Rev. Biochem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.meegid.2008.07.007","article-title":"The evolution of Staphylococcus aureus","volume":"8","author":"Deurenberg","year":"2008","journal-title":"Infect. Genet. Evol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1073\/pnas.95.6.3140","article-title":"Multilocus sequence typing: A portable approach to the identification of clones within populations of pathogenic microorganisms","volume":"95","author":"Maiden","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/BF01586186","article-title":"Molecular typing of methicillin-resistant Staphylococcus aureus on the basis of protein A gene polymorphism","volume":"15","author":"Bunschoten","year":"1996","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e22","DOI":"10.3346\/jkms.2021.36.e22","article-title":"Antimicrobial Resistance and Molecular Analysis of Staphylococcus aureus in Staphylococcal Scalded Skin Syndrome among Children in Korea","volume":"36","author":"Choi","year":"2021","journal-title":"J. Korean Med. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/pde.14014","article-title":"Antibiotic sensitivity and clinical outcomes in staphylococcal scalded skin syndrome","volume":"37","author":"Wang","year":"2019","journal-title":"Pediatr. Dermatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/pde.12195","article-title":"Antibiotic sensitivity and resistance patterns in pediatric staphylococcal scalded skin syndrome","volume":"31","author":"Braunstein","year":"2013","journal-title":"Pediatr. Dermatol."},{"key":"ref_35","first-page":"149","article-title":"Staphylococcal scalded skin syndrome: An epidemiological and clinical review of 84 cases","volume":"38","author":"Pope","year":"2020","journal-title":"Pediatr. Dermatol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1440-1754.2008.01316.x","article-title":"Staphylococcal scalded skin syndrome in an extremely premature neonate: A case report with a brief review of literature","volume":"44","author":"Kapoor","year":"2008","journal-title":"J. Paediatr. Child Health"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00431-014-2414-3","article-title":"Exfoliative toxin A staphylococcal scalded skin syndrome in preterm infants","volume":"174","author":"Saida","year":"2014","journal-title":"Eur. J. Pediatr."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Kong, C., Neoh, H.-M., and Nathan, S. (2016). Targeting Staphylococcus aureus Toxins: A Potential form of Anti-Virulence Therapy. Toxins, 8.","DOI":"10.3390\/toxins8030072"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e134","DOI":"10.1055\/s-0037-1603971","article-title":"Recurrent Staphylococcal Scalded Skin Syndrome in an Extremely Low-Birth-Weight Neonate","volume":"07","author":"Davidson","year":"2017","journal-title":"Am. J. Perinatol. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"7313","DOI":"10.4076\/1752-1947-3-7313","article-title":"Recurring staphylococcal scalded skin syndrome in a very low birth weight infant: A case report","volume":"3","author":"Duijsters","year":"2009","journal-title":"J. Med. Case Rep."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0140-6736(60)91693-7","article-title":"Acquisition of staphylococci by newborns. Direct versus indirect transmission","volume":"2","author":"Wolinsky","year":"1960","journal-title":"Lancet"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1086\/501216","article-title":"Management of outbreaks of methicillin-resistant Staphylococcus aureus infection in the neonatal intensive care unit: A consensus statement","volume":"27","author":"Gerber","year":"2006","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Rao, G.G., Batura, R., Nicholl, R., Coogan, F., Patel, B., Bassett, P., and Kearns, A.M. (2019). Outbreak report of investigation and control of an outbreak of Panton-Valentine Leukocidin-positive methicillin-sensitive Staphylococcus aureus (PVL-MSSA) infection in neonates and mothers. BMC Infect. Dis., 19.","DOI":"10.1186\/s12879-019-3802-0"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s15010-017-1084-2","article-title":"An outbreak of skin infections in neonates due to a Staphylococcus aureus strain producing the exfoliative toxin A","volume":"46","author":"Tinelli","year":"2018","journal-title":"Infection"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13052-016-0323-y","article-title":"Rapid containment of nosocomial transmission of a rare community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) clone, responsible for the Staphylococcal Scalded Skin Syndrome (SSSS)","volume":"43","author":"Lamanna","year":"2017","journal-title":"Ital. J. Pediatr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jhin.2014.04.003","article-title":"Outbreak among healthy newborns due to a new variant of USA300-related meticillin-resistant Staphylococcus aureus","volume":"87","author":"Lee","year":"2014","journal-title":"J. Hosp. Infect."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jhin.2012.09.017","article-title":"Outbreak of skin and soft tissue infections in a hospital newborn nursery in Italy due to community-acquired meticillin-resistant Staphylococcus aureus USA300 clone","volume":"83","author":"Sanchini","year":"2013","journal-title":"J. Hosp. Infect."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"20880","DOI":"10.2807\/1560-7917.ES2014.19.33.20880","article-title":"Nosocomial outbreak of staphyloccocal scalded skin syndrome in neonates in England, December 2012 to March 2013","volume":"19","author":"Paranthaman","year":"2014","journal-title":"Eurosurveillance"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/j.1442-200X.2012.03673.x","article-title":"Nosocomial transmission of community-acquired methicillin-resistant Staphylococcus aureus in a well-infant nursery of a teaching hospital","volume":"54","author":"Alsubaie","year":"2012","journal-title":"Pediatr. Int."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1007\/s00431-010-1252-1","article-title":"Neonatal staphylococcal scalded skin syndrome: Clinical and outbreak containment review","volume":"169","author":"Neylon","year":"2010","journal-title":"Eur. J. Pediatr."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1017\/S0950268809002234","article-title":"Report of a hospital neonatal unit outbreak of community-associated methicillin-resistant Staphylococcus aureus","volume":"137","author":"Gould","year":"2009","journal-title":"Epidemiol. Infect."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s10482-009-9318-7","article-title":"Epidemiological investigation of nosocomial outbreak of staphylococcal skin diseases in neonatal ward","volume":"95","author":"Kurlenda","year":"2009","journal-title":"Antonie Van Leeuwenhoek"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"F40","DOI":"10.1136\/adc.2006.104026","article-title":"Methicillin-resistant Staphylococcus aureus infections among healthy full-term newborns","volume":"93","author":"James","year":"2008","journal-title":"Arch. Dis. Child. Fetal Neonatal. Ed."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jhin.2005.02.013","article-title":"Nosocomial outbreak of staphylococcal scalded skin syndrome in neonates: Epidemiological investigation and control","volume":"61","author":"Carbonne","year":"2005","journal-title":"J. Hosp. Infect."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1086\/501729","article-title":"An outbreak of pyodermas among neonates caused by ultrasound gel contaminated with methicillin-susceptible Staphylococcus aureus","volume":"21","author":"Weist","year":"2000","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/0196-6553(95)90042-X","article-title":"Use of 0.3% triclosan (Bacti-Stat) to eradicate an outbreak of methicillin-resistant Staphylococcus aureus in a neonatal nursery","volume":"23","author":"Zafar","year":"1995","journal-title":"Am. J. Infect. Control"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1017\/S0950268800057460","article-title":"A double outbreak of exfoliative toxin-producing strains of Staphylococcus aureus in a maternity unit","volume":"112","author":"Dave","year":"1994","journal-title":"Epidemiol. Infect."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0195-6701(90)90055-S","article-title":"Beta-lactamase-negative, methicillin-resistant Staphylococcus aureus in a newborn nursery: Report of an outbreak and laboratory investigations","volume":"16","author":"Richardson","year":"1990","journal-title":"J. Hosp. Infect."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0163-4453(88)96249-4","article-title":"Outbreak of staphylococcal scalded skin syndrome among neonates","volume":"16","author":"Dancer","year":"1988","journal-title":"J. Infect."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1128\/jcm.23.1.83-91.1986","article-title":"Importance of exfoliatin toxin A production by Staphylococcus aureus strains isolated from clustered epidemics of neonatal pustulosis","volume":"23","author":"Kaplan","year":"1986","journal-title":"J. Clin. Microbiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0195-6701(84)90007-0","article-title":"Analysis of an outbreak of staphylococcal scalded skin syndrome: Strategies for typing \u2018non-typable\u2019 strains","volume":"5","author":"Dowsett","year":"1984","journal-title":"J. Hosp. Infect."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1542\/peds.66.2.285","article-title":"Neonatal staphylococcal scalded skin syndrome: Massive outbreak due to an unusual phage type","volume":"66","author":"Curran","year":"1980","journal-title":"Pediatrics"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1001\/archpedi.1976.02120040043008","article-title":"Nursery outbreak of scalded-skin syndrome. Scarlatiniform rash due to phage group I Staphylococcus aureus","volume":"130","author":"Faden","year":"1976","journal-title":"Am. J. Dis. Child."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0140-6736(62)92036-6","article-title":"An outbreak of exfoliative dermatitis of the newborn (Ritter\u2019s disease) due to Staphylococcus aureus, phage-type 55\/71","volume":"1","author":"Benson","year":"1962","journal-title":"Lancet"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1136\/adc.36.186.214","article-title":"Two outbreaks of neonatal skin sepsis caused by Staphylococcus aureus, phage type 71","volume":"36","author":"Howells","year":"1961","journal-title":"Arch. Dis. Child."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00431-002-1080-z","article-title":"Staphylococcal scalded skin syndrome related to an exfoliative toxin A- and B-producing strain in preterm infants","volume":"161","author":"Plano","year":"2002","journal-title":"Eur. J. Pediatr."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"bcr0820114733","DOI":"10.1136\/bcr.08.2011.4733","article-title":"Staphylococcal scalded skin syndrome in a preterm newborn presenting within first 24 h of life","volume":"2011","author":"Arora","year":"2011","journal-title":"BMJ Case Rep."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00431-006-0291-0","article-title":"Exchange transfusion in a preterm infant with hyperbilirubinemia, staphylococcal scalded skin syndrome (SSSS) and sepsis","volume":"166","author":"Tenenbaum","year":"2006","journal-title":"Eur. J. Pediatr."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1891\/0730-0832.35.1.8","article-title":"Staphylococcal Scalded Skin Syndrome: A Case Review","volume":"35","author":"Hennigan","year":"2016","journal-title":"Neonatal Netw."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1590\/1516-3180.2013.79400715","article-title":"Staphylococcal scalded skin syndrome in a premature newborn caused by methicillin-resistant Staphylococcus aureus: Case report","volume":"133","author":"Horner","year":"2015","journal-title":"Sao Paulo Med. J."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1442-200X.2010.03246.x","article-title":"Staphylococcal scalded skin syndrome in an extremely low-birth-weight neonate: Molecular characterization and rapid detection by multiplex and real-time PCR of methicillin-resistant Staphylococcus aureus","volume":"53","author":"Shi","year":"2011","journal-title":"Pediatr. Int."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"416","DOI":"10.2340\/00015555-0447","article-title":"Staphylococcal scalded skin syndrome as a harbinger of late-onset staphylococcal septicaemia in a premature infant of very low birth weight","volume":"88","author":"Heimann","year":"2008","journal-title":"Acta Derm. Venereol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/sj.jp.7211599","article-title":"Diagnostic dilemma: Extremely low birth weight baby with staphylococcal scalded-skin syndrome or toxic epidermal necrolysis","volume":"26","author":"Coleman","year":"2006","journal-title":"J. Perinatol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"E16","DOI":"10.1542\/peds.108.1.e16","article-title":"Staphylococcal scalded-skin syndrome in a very low birth weight premature infant","volume":"108","author":"Makhoul","year":"2001","journal-title":"Pediatrics"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/j.1365-2133.2005.06337.x","article-title":"Netherton syndrome: Report of two Taiwanese siblings with staphylococcal scalded skin syndrome and mutation of SPINK5","volume":"152","author":"Chao","year":"2005","journal-title":"Br. J. 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