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In particular, Candida albicans exhibits several virulence factors that facilitate yeast colonization in humans. In this sense, the photodynamic inactivation of yeasts is a promising new alternative to eliminate fungal infections. Herein, the photodynamic activity sensitized by a free-base chlorin (TPCF16) and its complexes with Zn(II) (ZnTPCF16) and Pd(II) (PdTPCF16) was investigated in order to eliminate C. albicans under different forms of cell cultures. A decrease in cell survival of more than 5 log was found in planktonic cells incubated with 5 \u03bcM TPCF16 or ZnTPCF16 upon 15 min of white-light irradiation. The mechanism of action mainly involved a type II pathway in the inactivation of C. albicans cells. In addition, the photodynamic action induced by these chlorins was able to suppress the growth of C. albicans in a culture medium. These photosensitizers were also effective to photoinactivate C. albicans pseudohyphae suspended in PBS. Furthermore, the biofilms of C. albicans that incorporated the chlorins during the proliferation stage were completely eradicated using 5 \u03bcM TPCF16 or ZnTPCF16 after 60 min of light irradiation. The studies indicated that these chlorins are effective photosensitizing agents to eliminate C. albicans as planktonic cells, pseudohyphae, and biofilms.<\/jats:p>","DOI":"10.3390\/antibiotics12010105","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T01:36:17Z","timestamp":1673228177000},"page":"105","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Photoinactivation of Planktonic Cells, Pseudohyphae, and Biofilms of Candida albicans Sensitized by a Free-Base Chlorin and Its Metal Complexes with Zn(II) and Pd(II)"],"prefix":"10.3390","volume":"12","author":[{"given":"Paula V.","family":"Cordero","sequence":"first","affiliation":[{"name":"IDAS-CONICET, Departamento de Qu\u00edmica, Facultad de Ciencias Exactas, F\u00edsico-Qu\u00edmicas y Naturales, Universidad Nacional de R\u00edo Cuarto, Ruta Nacional 36 Km 601, R\u00edo Cuarto X5804BYA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1051-3390","authenticated-orcid":false,"given":"Mar\u00eda G.","family":"Alvarez","sequence":"additional","affiliation":[{"name":"IDAS-CONICET, Departamento de Qu\u00edmica, Facultad de Ciencias Exactas, F\u00edsico-Qu\u00edmicas y Naturales, Universidad Nacional de R\u00edo Cuarto, Ruta Nacional 36 Km 601, R\u00edo Cuarto X5804BYA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4680-1087","authenticated-orcid":false,"given":"Edwin J.","family":"Gonzalez Lopez","sequence":"additional","affiliation":[{"name":"IDAS-CONICET, Departamento de Qu\u00edmica, Facultad de Ciencias Exactas, F\u00edsico-Qu\u00edmicas y Naturales, Universidad Nacional de R\u00edo Cuarto, Ruta Nacional 36 Km 601, R\u00edo Cuarto X5804BYA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0667-3906","authenticated-orcid":false,"given":"Daniel A.","family":"Heredia","sequence":"additional","affiliation":[{"name":"IDAS-CONICET, Departamento de Qu\u00edmica, Facultad de Ciencias Exactas, F\u00edsico-Qu\u00edmicas y Naturales, Universidad Nacional de R\u00edo Cuarto, Ruta Nacional 36 Km 601, R\u00edo Cuarto X5804BYA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8901-7543","authenticated-orcid":false,"given":"Edgardo N.","family":"Durantini","sequence":"additional","affiliation":[{"name":"IDAS-CONICET, Departamento de Qu\u00edmica, Facultad de Ciencias Exactas, F\u00edsico-Qu\u00edmicas y Naturales, Universidad Nacional de R\u00edo Cuarto, Ruta Nacional 36 Km 601, R\u00edo Cuarto X5804BYA, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.mib.2021.05.005","article-title":"Cutaneous and subcutaneous fungal infections: Recent developments on host-fungus interactions","volume":"62","author":"Ma","year":"2021","journal-title":"Curr. 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