{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:10:12Z","timestamp":1780056612815,"version":"3.54.0"},"reference-count":53,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Delays in the treatment of proven invasive fungal disease have been shown to be harmful. However, empiric treatment for all patients at risk of infection has not demonstrated benefit. This study evaluates the effects of a micafungin stewardship initiative on the duration of therapy and clinical outcomes at the University of Mississippi Medical Center in Jackson, Mississippi. This single-center quasi-experiment evaluated patients who received micafungin. Adult inpatients who received at least one treatment dose of micafungin in the pre-intervention (1 October 2020 to 30 September 2021) or post-intervention (1 October 2021 to 30 April 2022) groups were included. Patients were placed on micafungin for prophylaxis and those who required definitive micafungin therapy were excluded. An algorithm was used to provide real-time recommendations in order to assess change in the treatment days of micafungin therapy. A total of 282 patients were included (141 pre-group versus 141 post-group). Over 80% of the patients included in the study were in an intensive care unit, and other baseline characteristics were similar. The median number of treatment days with micafungin was 4 [IQR 3-6] in the pre-group and 3 [IQR 2-6] in the post-group (p = 0.005). Other endpoints, such as time to discontinuation or de-escalation, hospital mortality, and hospital length of stay, were not significantly different between the groups. An antifungal stewardship initiative can be an effective way to decrease unnecessary empiric antifungal therapy for patients who are at risk of invasive fugal disease.<\/jats:p>","DOI":"10.3390\/antibiotics12020193","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T01:57:57Z","timestamp":1674007077000},"page":"193","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of an Antifungal Stewardship Initiative Targeting Micafungin at an Academic Medical Center"],"prefix":"10.3390","volume":"12","author":[{"given":"J. Myles","family":"Keck","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Cretella","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, MS 39216, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8635-0137","authenticated-orcid":false,"given":"Kayla R.","family":"Stover","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, University of Mississippi School of Pharmacy, Jackson, MS 39216, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie L.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, University of Mississippi School of Pharmacy, Jackson, MS 39216, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8411-3111","authenticated-orcid":false,"given":"Katie E.","family":"Barber","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, University of Mississippi School of Pharmacy, Jackson, MS 39216, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8758-3696","authenticated-orcid":false,"given":"Tulip A.","family":"Jhaveri","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, MS 39216, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prakhar","family":"Vijayvargiya","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, MS 39216, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zerelda Esquer","family":"Garrigos","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, MS 39216, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2037-2616","authenticated-orcid":false,"given":"Mary Joyce B.","family":"Wingler","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of Mississippi Medical Center, Jackson, MS 39216, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Taei, M., Chadeganipour, M., and Mohammadi, R. (2019). An alarming rise of non-albicans Candida species and uncommon yeasts in the clinical samples; a combination of various molecular techniques for identification of etiologic agents. BMC Res. Notes, 12.","DOI":"10.1186\/s13104-019-4811-1"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1093\/jac\/dkr394","article-title":"Antifungal use influences Candida species distribution and susceptibility in the intensive care unit","volume":"66","author":"Fournier","year":"2011","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s12281-014-0209-7","article-title":"Epidemiology of Echinocandin Resistance in Candida","volume":"8","author":"Grossman","year":"2014","journal-title":"Curr. Fungal Infect. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1097\/CCM.0000000000004371","article-title":"Key Takeaways From the U.S. CDC\u2019s 2019 Antibiotic Resistance Threats Report for Frontline Providers","volume":"48","author":"Kadri","year":"2020","journal-title":"Crit. Care Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.idc.2015.10.012","article-title":"Antifungal Agents: Spectrum of Activity, Pharmacology, and Clinical Indications","volume":"30","author":"Nett","year":"2016","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"18026","DOI":"10.1038\/nrdp.2018.26","article-title":"Invasive candidiasis","volume":"4","author":"Pappas","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13054-020-2766-1","article-title":"Risk factors for candidemia: A prospective matched case-control study","volume":"24","author":"Poissy","year":"2020","journal-title":"Crit. Care"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1093\/jac\/dky270","article-title":"Trends in antifungal use in US hospitals, 2006\u20132012","volume":"73","author":"Vallabhaneni","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2147\/TCRM.S40160","article-title":"Epidemiology and risk factors for invasive candidiasis","volume":"10","author":"Yapar","year":"2014","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1093\/cid\/cit006","article-title":"Finding the \u201cMissing 50%\u201d of Invasive Candidiasis: How Nonculture Diagnostics Will Improve Understanding of Disease Spectrum and Transform Patient Care","volume":"56","author":"Clancy","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Clancy, C.J., and Nguyen, M.H. (2018). Non-Culture Diagnostics for Invasive Candidiasis: Promise and Unintended Consequences. J. Fungi, 4.","DOI":"10.3390\/jof4010027"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jmii.2014.06.009","article-title":"A systematic review and meta-analysis of diagnostic accuracy of serum 1,3-\u03b2-d-glucan for invasive fungal infection: Focus on cutoff levels","volume":"48","author":"He","year":"2015","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1093\/cid\/ciq206","article-title":"\u03b2-D-Glucan Assay for the Diagnosis of Invasive Fungal Infections: A Meta-analysis","volume":"52","author":"Karageorgopoulos","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1136\/bmj.a301","article-title":"Refeeding syndrome: What it is, and how to prevent and treat it","volume":"336","author":"Mehanna","year":"2008","journal-title":"BMJ"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1093\/cid\/cis200","article-title":"Performance of Candida Real-time Polymerase Chain Reaction, -D-Glucan Assay, and Blood Cultures in the Diagnosis of Invasive Candidiasis","volume":"54","author":"Nguyen","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1086\/432470","article-title":"Multicenter Clinical Evaluation of the (1\u21923) \u03b2-D-Glucan Assay as an Aid to Diagnosis of Fungal Infections in Humans","volume":"41","author":"Alexander","year":"2005","journal-title":"Clin. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1164\/rccm.201211-2069OC","article-title":"\u03b2-Glucan Antigenemia Anticipates Diagnosis of Blood Culture\u2013Negative Intraabdominal Candidiasis","volume":"188","author":"Tissot","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1086\/504810","article-title":"Time to Initiation of Fluconazole Therapy Impacts Mortality in Patients with Candidemia: A Multi-Institutional Study","volume":"43","author":"Garey","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1128\/AAC.49.9.3640-3645.2005","article-title":"Delaying the Empiric Treatment of Candida Bloodstream Infection until Positive Blood Culture Results Are Obtained: A Potential Risk Factor for Hospital Mortality","volume":"49","author":"Morrell","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1128\/AAC.00945-09","article-title":"Effect of Antifungal Therapy Timing on Mortality in Cancer Patients with Candidemia","volume":"54","author":"Taur","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1164\/rccm.201409-1701OC","article-title":"Failure of Empirical Systemic Antifungal Therapy in Mechanically Ventilated Critically Ill Patients","volume":"191","author":"Bailly","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/01.CCM.0000298158.12101.41","article-title":"Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008","volume":"36","author":"Dellinger","year":"2008","journal-title":"Crit. Care Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/civ933","article-title":"Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America","volume":"62","author":"Pappas","year":"2015","journal-title":"Clin. Infect. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1093\/cid\/cit136","article-title":"Increasing Echinocandin Resistance in Candida glabrata: Clinical Failure Correlates With Presence of FKS Mutations and Elevated Minimum Inhibitory Concentrations","volume":"56","author":"Alexander","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1080\/21505594.2022.2123325","article-title":"Distribution and antifungal susceptibility pattern of Candida species from mainland China: A systematic analysis","volume":"13","author":"Bilal","year":"2022","journal-title":"Virulence"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3314\/mmj.22.003","article-title":"Antifungal Stewardship Task Shifting Required of Pharmacists","volume":"63","author":"Ebihara","year":"2022","journal-title":"Med. Mycol. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e474","DOI":"10.1111\/ijd.15495","article-title":"The increasing problem of treatment-resistant fungal infections: A call for antifungal stewardship programs","volume":"60","author":"Gupta","year":"2021","journal-title":"Int. J. Dermatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"S175","DOI":"10.1093\/infdis\/jiaa394","article-title":"Core Recommendations for Antifungal Stewardship: A Statement of the Mycoses Study Group Education and Research Consortium","volume":"222","author":"Johnson","year":"2020","journal-title":"J. Infect. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"100047","DOI":"10.1016\/j.infpip.2020.100047","article-title":"Antifungal stewardship in critical care: Implementing a diagnostics-driven care pathway in the management of invasive candidiasis","volume":"2","author":"Hare","year":"2020","journal-title":"Infect. Prev. Pract."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1513\/AnnalsATS.202003-188ST","article-title":"Antibiotic Stewardship in the Intensive Care Unit. An Official American Thoracic Society Workshop Report in Collaboration with the AACN, CHEST, CDC, and SCCM","volume":"17","author":"Wunderink","year":"2020","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/cid\/cis494","article-title":"Is the \u201clow-hanging fruit\u201d worth picking for antimicrobial stewardship programs?","volume":"55","author":"Goff","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.cmi.2019.08.007","article-title":"How to start an antimicrobial stewardship programme in a hospital","volume":"26","author":"Mendelson","year":"2019","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/jac\/dkaa409","article-title":"Establishing essential metrics for antifungal stewardship in hospitals: The results of an international Delphi survey","volume":"76","author":"Khanina","year":"2020","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e0062921","DOI":"10.1128\/AAC.00629-21","article-title":"Implementation of Pharmacist-Driven Antifungal Stewardship Program in a Tertiary Care Hospital","volume":"65","author":"Kara","year":"2021","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1469-0691.2012.03891.x","article-title":"A non-compulsory stewardship programme for the management of antifungals in a university-affiliated hospital","volume":"19","author":"Juan","year":"2013","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1093\/jac\/dkv040","article-title":"Introduction of an antifungal stewardship programme targeting high-cost antifungals at a tertiary hospital in Cambridge, England","volume":"70","author":"Micallef","year":"2015","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/s15010-013-0431-1","article-title":"A 6-year antifungal stewardship programme in a teaching hospital","volume":"41","author":"Mondain","year":"2013","journal-title":"Infection"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"83","DOI":"10.7326\/0003-4819-149-2-200807150-00004","article-title":"Empirical fluconazole versus placebo for intensive care unit patients: A randomized trial","volume":"149","author":"Schuster","year":"2008","journal-title":"Ann. Intern. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1001\/jama.2016.14655","article-title":"Empirical Micafungin Treatment and Survival Without Invasive Fungal Infection in Adults With ICU-Acquired Sepsis, Candida Colonization, and Multiple Organ Failure: The EMPIRICUS Randomized Clinical Trial","volume":"316","author":"Timsit","year":"2016","journal-title":"JAMA"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41579-022-00720-1","article-title":"Tackling the emerging threat of antifungal resistance to human health","volume":"20","author":"Fisher","year":"2022","journal-title":"Nat. Rev. Genet."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Wang, Q., Li, Y., Cai, X., Li, R., Zheng, B., Yang, E., Liang, T., Yang, X., Wan, Z., and Liu, W. (2021). Two Sequential Clinical Isolates of Candida glabrata with Multidrug-Resistance to Posaconazole and Echinocandins. Antibiotics, 10.","DOI":"10.3390\/antibiotics10101217"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Hanson, K.E., Pfeiffer, C.D., Lease, E.D., Balch, A.H., Zaas, A.K., Perfect, J.R., and Alexander, B.D. (2012). \u03b2-D-glucan surveillance with preemptive anidulafungin for invasive candidiasis in intensive care unit patients: A randomized pilot study. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0042282"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"5828","DOI":"10.1038\/s41598-020-62276-5","article-title":"Rapid Identification of Candida Species in Candidemia Directly from Blood Samples Using Imperfect Match Probes","volume":"10","author":"Higashi","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1590\/s1678-9946202062025","article-title":"Performance of a new Candida anti-mannan IgM and IgG assays in the diagnosis of candidemia","volume":"62","author":"Meng","year":"2020","journal-title":"Rev. Inst. Med. Trop. S\u00e3o Paulo"},{"key":"ref_45","first-page":"251","article-title":"Comparative analysis of simulated candidemia using two different blood culture systems and the rapid identification of Candida albicans","volume":"41","author":"Park","year":"2011","journal-title":"Ann. Clin. Lab. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Sawai, T., Nakao, T., Yamaguchi, S., Yoshioka, S., Matsuo, N., Suyama, N., Yanagihara, K., and Mukae, H. (2017). Detection of high serum levels of \u03b2-D-Glucan in disseminated nocardial infection: A case report. BMC Infect. Dis., 17.","DOI":"10.1186\/s12879-017-2370-4"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1093\/cid\/ciab1028","article-title":"High False-Positive Rate of (1,3)-\u03b2-D-Glucan in Onco-Hematological Patients Receiving Immunoglobulins and Therapeutic Antibodies","volume":"75","author":"Tschopp","year":"2022","journal-title":"Clin. Infect. Dis."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Zheng, S., Ng, T.Y., Li, H., Tan, A.L., Tan, T.T., and Tan, B.H. (2016). A dedicated fungal culture medium is useful in the diagnosis of fungemia: A retrospective cross-sectional study. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0164668"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e28906","DOI":"10.1097\/MD.0000000000028906","article-title":"A quality improvement initiative to improve the appropriateness of candidemia management by the implementation of a comprehensive candidemia care bundle at a tertiary care hospital in South India: Results of a quasi-experimental study","volume":"101","author":"Moni","year":"2022","journal-title":"Medicine"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s40588-016-0039-1","article-title":"Antifungal Stewardship: An Emerging Practice in Antimicrobial Stewardship","volume":"3","author":"Andruszko","year":"2016","journal-title":"Curr. Clin. Microbiol. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"106409","DOI":"10.1016\/j.ijantimicag.2021.106409","article-title":"Antimicrobial stewardship in the ICU in COVID times: The known unknowns","volume":"58","author":"Schouten","year":"2021","journal-title":"Int. J. Antimicrob. Agents"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"102353","DOI":"10.1016\/j.bjid.2022.102353","article-title":"Increased incidence of candidemia in critically ill patients during the Coronavirus Disease 2019 (COVID-19) pandemic","volume":"26","author":"Kolonitsiou","year":"2022","journal-title":"Braz. J. Infect. Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)\u2014A metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J. Biomed. Inform."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/12\/2\/193\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:08:31Z","timestamp":1760119711000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/12\/2\/193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,17]]},"references-count":53,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["antibiotics12020193"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics12020193","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,17]]}}}