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Staphylococcaceae has been isolated from their gut and nasopharynx, but there is little information about Staphylococcaceae on bat skin. Therefore, this study aimed to decipher the Staphylococci species in bat skin and their antimicrobial susceptibility profile. One hundred and forty-seven skin swabs were collected from bats during the spring and summer of 2021 and 2022. Bats were captured in different areas of the Metropolitan Region of S\u00e3o Paulo, Brazil, according to the degree of anthropization: Area 1 (Forested), Area 2 (Rural), Area 3 (Residential-A), Area 4 (Slum-\u2013 up to two floors), Area 5 (Residential-B\u2014condo buildings), and Area 6 (Industrial). Swabs were kept in peptone water broth at 37 \u00b0C for 12 h when bacterial growth was streaked in Mannitol salt agar and incubated at 37 \u00b0C for 24 h. The disc-diffusion test evaluated antimicrobial susceptibility. Staphylococcaceae were isolated from 42.8% of bats, mostly from young, from the rural area, and during summer. M. sciuri was the most frequent species; S. aureus was also isolated. About 95% of isolates were resistant to at least one drug, and most strains were penicillin resistant. Eight isolates were methicillin resistant, and the mecA gene was detected in one isolate (S. haemolyticus). Antimicrobial resistance is a One Health issue that is not evaluated enough in bats. The results indicate that bats are carriers of clinically meaningful S. aureus and antimicrobial-resistant bacteria. Finally, the results suggest that we should intensify action plans to control the spread of resistant bacteria.<\/jats:p>","DOI":"10.3390\/antibiotics12020331","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T03:34:30Z","timestamp":1675654470000},"page":"331","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Bats Are Carriers of Antimicrobial-Resistant Staphylococcaceae in Their Skin"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6397-605X","authenticated-orcid":false,"given":"Nat\u00e1lia","family":"Carrillo Gaeta","sequence":"first","affiliation":[{"name":"Laboratory of Bacterial Zoonosis, Department of Preventive Veterinary Medicine and Animal Health, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-270, Brazil"},{"name":"Faculdades Integradas Campos Salles, S\u00e3o Paulo 05072-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Eduardo","family":"Cavalcante Brito","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology and Biostatistics, Department of Preventive Veterinary Medicine and Animal Health, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-270, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Maria","family":"Nunes Batista","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Zoonosis, Department of Preventive Veterinary Medicine and Animal Health, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-270, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Gagete Ver\u00edssimo de Mello","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology and Biostatistics, Department of Preventive Veterinary Medicine and Animal Health, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-270, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8241-7699","authenticated-orcid":false,"given":"Ricardo Augusto","family":"Dias","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology and Biostatistics, Department of Preventive Veterinary Medicine and Animal Health, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-270, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6444-9788","authenticated-orcid":false,"given":"Marcos B.","family":"Heinemann","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Zoonosis, Department of Preventive Veterinary Medicine and Animal Health, School of Veterinary Medicine and Animal Science, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-270, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.22207\/JPAM.14.SPL1.05","article-title":"Importance of Bats in Wildlife: Not Just Carriers of Pandemic SARS-CoV-2 and Other Viruses","volume":"14","author":"Patel","year":"2020","journal-title":"J. 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