{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:54:21Z","timestamp":1792101261916,"version":"4.4.0"},"reference-count":73,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004787","name":"The Research Council","doi-asserted-by":"publisher","award":["BFP\/RGP\/CBS\/21\/002"],"award-info":[{"award-number":["BFP\/RGP\/CBS\/21\/002"]}],"id":[{"id":"10.13039\/501100004787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>In the current study, methanol (ADAM) extracts and their fractions, including chloroform (ADAC), ethyl acetate (ADAE), n-hexane (ADAH), and aqueous (ADAA) fractions, were prepared from aerial parts of Anogeissus dhofarica and evaluated for phytochemical assessment, high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) analysis, and in vitro bioassays. The qualitative analysis determined that, except alkaloids, all the representative groups were found to be present in the analyzed samples. Samples under quantitative study displayed the highest amount of total phenolic contents in the ADAE fraction, while total flavonoid contents were highest in the ADAM extract. The ADAM extract was subjected to HR-ESI-MS to identify the chemical constituents that presented twenty-two bioactive ingredients, outlined for the first time from A. dhofarica, mainly contributed by sub-class flavanones. In the case of antimicrobial activity, the ADAE extract revealed an effective zone of inhibition (ZOI) against the Gram-positive bacterial strain (Staphylococcus aureus) with an MIC value of 0.78 \u00b1 0.3 mg\/mL, while the ADAA extract exhibited higher ZOI (34 \u00b1 0.12 mm) against the fungal strain Candida kruzei with an MIC of 0.78 mg\/mL. In the DPPH (2,2-diphenyl-1-picrylhydrazyl) analysis, the ADAE extract exhibited a maximum scavenging potential with an IC50 of 9.8 \u00b1 1.2 \u03bcg\/mL, succeeded by the ADAM extract with an IC50 of 17.4 \u00b1 0.4 \u03bcg\/mL free radical scavenging capability. In the antidiabetic assessment, the ADAE extract was the most effective, with an IC50 of 6.40 \u00b1 0.1 \u03bcg\/mL, while the same extract demonstrated prominent activity with 30.8% viability and an IC50 of 6.2 \u00b1 0.3 \u03bcg\/mL against breast cancer cell lines. The brine shrimp lethality assay demonstrated a correlation with the in vitro cytotoxicity assay, showing the ADAE extract as the most active, with a 70% mortality rate and an LC50 of 300.1 \u03bcg\/mL. In conclusion, all the tested samples, especially the ADAE and ADAM extracts, have significant capabilities for the investigated activities that could be due to the presence of the bioactive compounds.<\/jats:p>","DOI":"10.3390\/antibiotics12020354","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T02:32:07Z","timestamp":1675909927000},"page":"354","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Evaluation of Antiproliferative, Antimicrobial, Antioxidant, Antidiabetic and Phytochemical Analysis of Anogeissus dhofarica A. J. Scott"],"prefix":"10.3390","volume":"12","author":[{"given":"Rabia","family":"Maqsood","sequence":"first","affiliation":[{"name":"Natural & Medical Sciences Research Center, University of Nizwa, Nizwa 616, Oman"},{"name":"Department of Chemistry, University of Okara, Okara 56300, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faizullah","family":"Khan","sequence":"additional","affiliation":[{"name":"Natural & Medical Sciences Research Center, University of Nizwa, Nizwa 616, Oman"},{"name":"Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Ullah","sequence":"additional","affiliation":[{"name":"Natural & Medical Sciences Research Center, University of Nizwa, Nizwa 616, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajmal","family":"Khan","sequence":"additional","affiliation":[{"name":"Natural & Medical Sciences Research Center, University of Nizwa, Nizwa 616, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habib","family":"Al-Jahdhami","sequence":"additional","affiliation":[{"name":"Natural & Medical Sciences Research Center, University of Nizwa, Nizwa 616, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javid","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences & Chemistry, College of Arts and Sciences, University of Nizwa, Nizwa 616, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afaf","family":"M. Weli","sequence":"additional","affiliation":[{"name":"School of Pharmacy, College of Pharmacy and Nursing, University of Nizwa, Nizwa 616, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danial","family":"Maqsood","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Lahore, Lahore 54590, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4879-2663","authenticated-orcid":false,"given":"Shaikh Mizanoor","family":"Rahman","sequence":"additional","affiliation":[{"name":"Natural & Medical Sciences Research Center, University of Nizwa, Nizwa 616, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1697-7580","authenticated-orcid":false,"given":"Amjad","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Okara, Okara 56300, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1563-225X","authenticated-orcid":false,"given":"Najeeb Ur","family":"Rehman","sequence":"additional","affiliation":[{"name":"Natural & Medical Sciences Research Center, University of Nizwa, Nizwa 616, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0815-5942","authenticated-orcid":false,"given":"Ahmed","family":"Al-Harrasi","sequence":"additional","affiliation":[{"name":"Natural & Medical Sciences Research Center, University of Nizwa, Nizwa 616, Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.3906\/bot-1405-93","article-title":"Phytochemical importance of medicinal plants as potential sources of anticancer agents","volume":"38","author":"Raina","year":"2014","journal-title":"Turk. 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