{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:21:42Z","timestamp":1793305302697,"version":"4.5.0"},"reference-count":103,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Iuliu Ha\u0163ieganu University of Medicine and Pharmacy Cluj-Napoca, Rom\u00e2nia","award":["35192\/17.12.2021"],"award-info":[{"award-number":["35192\/17.12.2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Periodontitis is one of the most common oral polymicrobial infectious diseases induced by the complex interplay between the altered subgingival microbiota and the host\u2019s dysregulated immune-inflammatory response, leading to the initiation of progressive and irreversible destruction of the periodontal tissues and eventually to tooth loss. The main goal of cause-related periodontal therapy is to eliminate the dysbiotic subgingival biofilm in order to arrest local inflammation and further periodontal tissue breakdown. Because, in some cases, subgingival mechanical instrumentation has limited efficiency in achieving those goals, various adjunctive therapies, mainly systemic and locally delivered antimicrobials, have been proposed to augment its effectiveness. However, most adjunctive antimicrobials carry side effects; therefore, their administration should be precociously considered. HybenX\u00ae (HY) is a commercial therapeutical agent with decontamination properties, which has been studied for its effects in treating various oral pathological conditions, including periodontitis. This review covers the current evidence regarding the treatment outcomes and limitations of conventional periodontal therapies and provides information based on the available experimental and clinical studies related to the HY mechanism of action and effects following its use associated with subgingival instrumentation and other types of dental treatments.<\/jats:p>","DOI":"10.3390\/antibiotics12030456","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T03:29:48Z","timestamp":1677468588000},"page":"456","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A Local Desiccant Antimicrobial Agent as an Alternative to Adjunctive Antibiotics in the Treatment of Periodontitis: A Narrative Review"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5590-6692","authenticated-orcid":false,"given":"Iulia C.","family":"Micu","sequence":"first","affiliation":[{"name":"Department of Periodontology, Faculty of Dental Medicine, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy Cluj-Napoca, Victor Babe\u015f St., No. 15, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandrina","family":"Muntean","sequence":"additional","affiliation":[{"name":"Department of Pedodontics, Faculty of Dental Medicine, Iuliu Ha\u021bieganu University of Medicine and Pharmacy Cluj-Napoca, Avram Iancu St., No. 31, 400117 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0649-9426","authenticated-orcid":false,"given":"Alexandra","family":"Roman","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dental Medicine, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy Cluj-Napoca, Victor Babe\u015f St., No. 15, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0218tefan I.","family":"Stratul","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Anton Sculean Research Center of Periodontal and Peri-Implant Diseases, Faculty of Dental Medicine, Victor Babe\u0219 University of Medicine and Pharmacy Timi\u0219oara, Bulevardul Revolu\u021biei din 1989, No.9, 300230 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7919-7381","authenticated-orcid":false,"given":"Em\u00f6ke","family":"Pall","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, M\u0103n\u0103\u0219tur St., No. 3-5, 400372 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea","family":"Ciurea","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dental Medicine, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy Cluj-Napoca, Victor Babe\u015f St., No. 15, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8452-6410","authenticated-orcid":false,"given":"Andrada","family":"Soanc\u0103","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Faculty of Dental Medicine, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy Cluj-Napoca, Victor Babe\u015f St., No. 15, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Negucioiu","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Faculty of Dental Medicine, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy Cluj-Napoca, Clinicilor St., No. 32, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0360-016X","authenticated-orcid":false,"given":"Lucian","family":"Barbu Tudoran","sequence":"additional","affiliation":[{"name":"Electron Microscopy Center, Department of Molecular Biology and Biotechnologies, Faculty of Biology and Geology, Babe\u015f-Bolyai University, Clinicilor St., No. 5-7, 400006 Cluj-Napoca, Romania"},{"name":"Electron Microscopy Integrated Laboratory (LIME), National Institute for Research and Development of Isotopic and Molecular Technologies, Institutul Na\u021bional de Cercetare-Dezvoltare pentru Tehnologii Izotopice \u0219i Moleculare, 67-103 Donath St., 400293 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada G.","family":"Delean","sequence":"additional","affiliation":[{"name":"Department of Cariology, Endodontics and Oral Pathology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, Mo\u021bilor St., No. 33, 400001 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/prd.12297","article-title":"The role of inflammation and genetics in periodontal disease","volume":"83","author":"Loos","year":"2020","journal-title":"Periodontol. 2000"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/prd.12393","article-title":"The oral microbiome: Role of key organisms and complex networks in oral health and disease","volume":"87","author":"Sedghi","year":"2021","journal-title":"Periodontol. 2000"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/jcpe.13290","article-title":"Treatment of stage I-III periodontitis-The EFP S3 level clinical practice guideline","volume":"47","author":"Sanz","year":"2020","journal-title":"J. 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