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(Spain)","award":["PTDC\/CVT-CVT\/28469\/2017"],"award-info":[{"award-number":["PTDC\/CVT-CVT\/28469\/2017"]}]},{"name":"VISAVET Health Surveillance Centre (Spain)","award":["2017-HW-LS-1"],"award-info":[{"award-number":["2017-HW-LS-1"]}]},{"name":"VISAVET Health Surveillance Centre (Spain)","award":["2018027"],"award-info":[{"award-number":["2018027"]}]},{"name":"VISAVET Health Surveillance Centre (Spain)","award":["PID2021-125136OB-I00"],"award-info":[{"award-number":["PID2021-125136OB-I00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Antimicrobial resistance (AMR) is one of the top public health threats nowadays. Among the most important AMR pathogens, Escherichia coli resistant to extended spectrum cephalosporins (ESC-EC) is a perfect example of the One Health problem due to its global distribution in animal, human, and environmental sources and its resistant phenotype, derived from the carriage of plasmid-borne extended-spectrum and AmpC \u03b2-lactamases, which limits the choice of effective antimicrobial therapies. The epidemiology of ESC-EC infection is complex as a result of the multiple possible sources involved in its transmission, and its study would require databases ideally comprising information from animal (livestock, companion, wildlife), human, and environmental sources. Here, we present the steps taken to assemble a database with phenotypic and genetic information on 10,763 ESC-EC isolates retrieved from multiple sources provided by 13 partners located in eight European countries, in the frame of the DiSCoVeR Joint Research project funded by the One Health European Joint Programme (OH-EJP), along with its strengths and limitations. This database represents a first step to help in the assessment of different geographical and temporal trends and transmission dynamics in animals and humans. The work performed highlights aspects that should be considered in future international efforts, such as the one presented here.<\/jats:p>","DOI":"10.3390\/antibiotics12030552","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T03:02:08Z","timestamp":1678417328000},"page":"552","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Building an International One Health Strain Level Database to Characterise the Epidemiology of AMR Threats: ESBL\u2014AmpC Producing E. coli as An Example\u2014Challenges and Perspectives"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8370-7911","authenticated-orcid":false,"given":"Sara","family":"Perestrelo","sequence":"first","affiliation":[{"name":"Department of Biological Safety, German Federal Institute for Risk Assessment, 10589 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5139-3268","authenticated-orcid":false,"given":"Ana","family":"Amaro","sequence":"additional","affiliation":[{"name":"Laboratory of Bacteriology and Micology, National Institute of Agrarian and Veterinary Research, National Reference for Animal Health, 2780-157 Oeiras, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S. M.","family":"Brouwer","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Host Pathogen Interaction & Diagnostics, Wageningen Bioveterinary Research, Part of Wageningen University & Research, 8221 Lelystad, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2064-2046","authenticated-orcid":false,"given":"Lurdes","family":"Clemente","sequence":"additional","affiliation":[{"name":"Laboratory of Bacteriology and Micology, National Institute of Agrarian and Veterinary Research, National Reference for Animal Health, 2780-157 Oeiras, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8794-0542","authenticated-orcid":false,"given":"Ana Sofia","family":"Ribeiro Duarte","sequence":"additional","affiliation":[{"name":"National Food Institute, Technical University of Denmark, 2800 Kongens Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2966-2713","authenticated-orcid":false,"given":"Annemarie","family":"Kaesbohrer","sequence":"additional","affiliation":[{"name":"Department of Biological Safety, German Federal Institute for Risk Assessment, 10589 Berlin, Germany"},{"name":"Veterinary Public Health and Epidemiology, University of Veterinary Medicine, 1210 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Karp\u00ed\u0161kov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Public Health, Medical Faculty, Masaryk University, 625 000 Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3558-9260","authenticated-orcid":false,"given":"Vicente","family":"Lopez-Chavarrias","sequence":"additional","affiliation":[{"name":"VISAVET Health Surveillance Centre, Universidad Complutense, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dearbh\u00e1ile","family":"Morris","sequence":"additional","affiliation":[{"name":"Antimicrobial Resistance and Microbial Ecology Group, School of Medicine, University of Galway, H91 TK33 Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre","family":"Prendergast","sequence":"additional","affiliation":[{"name":"Backweston Laboratory Campus, Department of Agriculture, Food and the Marine, W23 X3PH Celbridge, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9219-4222","authenticated-orcid":false,"given":"Angela","family":"Pista","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Gastrointestinal Infections, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge, Avenida Padre Cruz, 1649-016 Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonor","family":"Silveira","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Gastrointestinal Infections, Department of Infectious Diseases, National Institute of Health Doutor Ricardo Jorge, Avenida Padre Cruz, 1649-016 Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5666-9510","authenticated-orcid":false,"given":"Magdalena","family":"Skar\u017cy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Microbiology, National Veterinary Research Institute, 24-100 Pulawy, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemarie","family":"Slowey","sequence":"additional","affiliation":[{"name":"Backweston Laboratory Campus, Department of Agriculture, Food and the Marine, W23 X3PH Celbridge, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kees T.","family":"Veldman","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Host Pathogen Interaction & Diagnostics, Wageningen Bioveterinary Research, Part of Wageningen University & Research, 8221 Lelystad, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8155-7614","authenticated-orcid":false,"given":"Magdalena","family":"Zaj\u0105c","sequence":"additional","affiliation":[{"name":"Department of Microbiology, National Veterinary Research Institute, 24-100 Pulawy, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3722-5935","authenticated-orcid":false,"given":"Catherine","family":"Burgess","sequence":"additional","affiliation":[{"name":"Food Safety Department, Teagasc Food Research Centre Ashtown, D15 DY05 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8999-9417","authenticated-orcid":false,"given":"Julio","family":"Alvarez","sequence":"additional","affiliation":[{"name":"VISAVET Health Surveillance Centre, Universidad Complutense, 28040 Madrid, Spain"},{"name":"Department of Animal Health, Faculty of Veterinary Medicine, Universidad Complutense, Avda. Puerta de Hierro S\/N, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,10]]},"reference":[{"key":"ref_1","unstructured":"WHO (2023, January 15). Ten Threats to Global Health in 2019. Available online: https:\/\/www.who.int\/news-room\/spotlight\/ten-threats-to-global-health-in-2019."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"EclinicalMedicine (2021). Antimicrobial resistance: A top ten global public health threat. EClinicalMedicine, 41, 101221.","DOI":"10.1016\/j.eclinm.2021.101221"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: A systematic analysis","volume":"399","author":"Murray","year":"2022","journal-title":"Lancet"},{"key":"ref_4","unstructured":"ECDC (2016). 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