{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T16:49:09Z","timestamp":1793638149998,"version":"4.5.1"},"reference-count":248,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T00:00:00Z","timestamp":1678492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R21AI153646"],"award-info":[{"award-number":["R21AI153646"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["COCR22RBG005"],"award-info":[{"award-number":["COCR22RBG005"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NJCCR","award":["R21AI153646"],"award-info":[{"award-number":["R21AI153646"]}],"id":[{"id":"https:\/\/ror.org\/01etkt338","id-type":"ROR","asserted-by":"crossref"}]},{"name":"NJCCR","award":["COCR22RBG005"],"award-info":[{"award-number":["COCR22RBG005"]}],"id":[{"id":"https:\/\/ror.org\/01etkt338","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>The pathogenic bacterium Staphylococcus\u00a0aureus is the most common pathogen isolated in skin-and-soft-tissue infections (SSTIs) in the United States. Most S. aureus SSTIs are caused by the epidemic clone USA300 in the USA. These infections can be serious; in 2019, SSTIs with S.\u00a0aureus were associated with an all-cause, age-standardized mortality rate of 0.5 globally. Clinical presentations of S. aureus SSTIs vary from superficial infections with local symptoms to monomicrobial necrotizing fasciitis, which can cause systemic manifestations and may lead to serious complications or death. In order to cause skin infections, S.\u00a0aureus employs a host of virulence factors including cytolytic proteins, superantigenic factors, cell wall-anchored proteins, and molecules used for immune evasion. The immune response to S.\u00a0aureus SSTIs involves initial responders such as keratinocytes and neutrophils, which are supported by dendritic cells and T-lymphocytes later during infection. Treatment for S.\u00a0aureus SSTIs is usually oral therapy, with parenteral therapy reserved for severe presentations; it ranges from cephalosporins and penicillin agents such as oxacillin, which is generally used for methicillin-sensitive S.\u00a0aureus (MSSA), to vancomycin for methicillin-resistant S.\u00a0aureus (MRSA). Treatment challenges include adverse effects, risk for Clostridioides\u00a0difficile infection, and potential for antibiotic resistance.<\/jats:p>","DOI":"10.3390\/antibiotics12030557","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T05:36:21Z","timestamp":1678685781000},"page":"557","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":262,"title":["Clinical Impact of Staphylococcus aureus Skin and Soft Tissue Infections"],"prefix":"10.3390","volume":"12","author":[{"given":"Matthew S.","family":"Linz","sequence":"first","affiliation":[{"name":"Department of Pathology, Immunology and Laboratory Medicine, Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ 07103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5016-6565","authenticated-orcid":false,"given":"Arun","family":"Mattappallil","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Services, University Hospital, Newark, NJ 07103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Finkel","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Rutgers New Jersey Medical School, Newark, NJ 07103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7304-3392","authenticated-orcid":false,"given":"Dane","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Pathology, Immunology and Laboratory Medicine, Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ 07103, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S1473-3099(05)70295-4","article-title":"The role of nasal carriage in Staphylococcus aureus infections","volume":"5","author":"Wertheim","year":"2005","journal-title":"Lancet Infect. 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