{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T07:20:34Z","timestamp":1789888834160,"version":"4.0.1"},"reference-count":21,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Public Health, Aarhus University","award":["17-12-1981"],"award-info":[{"award-number":["17-12-1981"]}]},{"name":"Skibsreder Per Henriksen, R. og hustrus fond","award":["17-12-1981"],"award-info":[{"award-number":["17-12-1981"]}]},{"name":"Region Midtjyllands Sundhedsvidenskabelige Forskningsfond","award":["17-12-1981"],"award-info":[{"award-number":["17-12-1981"]}]},{"name":"Christian Larsen og dommer Ellen Larsens Legat","award":["17-12-1981"],"award-info":[{"award-number":["17-12-1981"]}]},{"name":"Helga og Peter Kornings Fond","award":["17-12-1981"],"award-info":[{"award-number":["17-12-1981"]}]},{"name":"Beckett-Fonden","award":["17-12-1981"],"award-info":[{"award-number":["17-12-1981"]}]},{"name":"Fonden for L\u00e6gevidenskabens Fremme","award":["17-12-1981"],"award-info":[{"award-number":["17-12-1981"]}]},{"name":"Danish Ministry of Higher Education and Science","award":["17-12-1981"],"award-info":[{"award-number":["17-12-1981"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Mycobacterium marinum infections are rare, and they can be difficult to diagnose and treat. This may lead to further spread of the infection and complications, such as tenosynovitis, pyomyositis, and osteomyelitis. A 40-year-old previously healthy man presented with tenosynovitis of the extensor tendons on the second phalanx of his right hand. He was initially treated with steroid injections without any effect. Followingly, ulceration and an abscess developed on the dorsal site of the hand. At this point, it came to the physician\u2019s knowledge that the patient had been cleaning an aquarium before onset of symptoms. After progression to massive tenosynovitis, the patient was admitted and underwent multiple surgical debridements. Briefly, after the first surgery, an interferon-\u03b3 release assay was positive, and treatment for M. marinum with rifampicin and azithromycin was initiated after eight months of symptoms. Later, a surgical biopsy showed acid-fast bacilli, and a polymerase chain reaction confirmed the diagnosis of M. marinum. In this case story, we highlight the difficulties of diagnosing and managing this complicated infection, describe the considerable morbidity associated with it, and suggest that local tissue concentrations could be useful to improve clinical outcomes, as these concentrations are potentially suboptimal.<\/jats:p>","DOI":"10.3390\/antibiotics12030629","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T03:07:57Z","timestamp":1679540877000},"page":"629","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Mycobacterium marinum: A Challenging Cause of Protracted Tenosynovitis"],"prefix":"10.3390","volume":"12","author":[{"given":"Pernille Grand","family":"Moestrup","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Aarhus University Hospital, DK-8200 Aarhus N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4530-2075","authenticated-orcid":false,"given":"Maiken","family":"Stilling","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Aarhus University Hospital, DK-8200 Aarhus N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2534-2942","authenticated-orcid":false,"given":"Christian Morberg","family":"Wejse","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Aarhus University Hospital, DK-8200 Aarhus N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2965-6348","authenticated-orcid":false,"given":"Victor Naestholt","family":"Dahl","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Aarhus University Hospital, DK-8200 Aarhus N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1001\/archinte.162.15.1746","article-title":"Sixty-three cases of Mycobacterium marinum infection: Clinical features, treatment, and antibiotic susceptibility of causative isolates","volume":"162","author":"Aubry","year":"2002","journal-title":"Arch. 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