{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:46:42Z","timestamp":1788191202293,"version":"build-2803163510"},"reference-count":45,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T00:00:00Z","timestamp":1679616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Investigator Sponsored Research (ISR)-Pfizer","award":["69333487"],"award-info":[{"award-number":["69333487"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>The addition of Biofire\u00ae FilmArray\u00ae Blood Culture Identification panel 2 (BCID2) to the antimicrobial stewardship program (ASP) could improve outcomes in bloodstream infections (BSI) of patients with febrile neutropenia (FN). A pre- and post-quasi-experimental single-center study was conducted at a reference hospital in Peru. Three groups were considered: patients with BSI before ASP intervention (control group), patients with BSI after ASP intervention (group 1), and patients with BSI after ASP intervention plus BCID2 PCR Panel implementation (group 2). Overall, 93 patients were identified (32 control, 30 group 1, 31 group 2). The median time to effective therapy was significantly shorter in group 2 compared to group 1 and control group, respectively (3.75 vs. 10 h, p = 0.004; 3.75 vs. 19 h, p &lt; 0.001). No significant differences in terms of relapse of bacteremia, in-hospital mortality (all cause), and 30-day-all-cause hospital readmission between the three study periods were found. The appropriateness of empirical antimicrobial use, adding or change, and the following de-escalation or discontinuation was significant when the two intervention periods were compared with the control group (p &lt; 0.001). In addition to the lack of local studies documenting the microbiological profile of FN episodes, adding syndromic panels-based testing could allow for the consolidation of ASP strategies.<\/jats:p>","DOI":"10.3390\/antibiotics12040648","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T08:43:03Z","timestamp":1679647383000},"page":"648","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Impact of Adding a Rapid PCR-Based Blood Culture Identification Panel to the Antimicrobial Stewardship Program of Patients with Febrile Neutropenia in a Peruvian Referral Hospital"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3823-4737","authenticated-orcid":false,"given":"Giancarlo","family":"P\u00e9rez-Lazo","sequence":"first","affiliation":[{"name":"Escuela de Medicina, Universidad C\u00e9sar Vallejo, Piura 20001, Peru"},{"name":"Division of Infectious 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Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Castillo-C\u00f3rdova","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Z\u00e1rate-Tantale\u00e1n","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Morales-Castillo","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia Joanna","family":"P\u00e1ucar-Miranda","sequence":"additional","affiliation":[{"name":"Clinical Pathology Department, Guillermo Almenara Irigoyen 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Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Guerrero-Arismendiz","sequence":"additional","affiliation":[{"name":"Clinical Hematology Service, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee","family":"Eyzaguirre-Zapata","sequence":"additional","affiliation":[{"name":"Clinical Hematology Service, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima 15033, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7023-3190","authenticated-orcid":false,"given":"Miguel Angel","family":"Aguilar-Luis","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n e Innovaci\u00f3n de la Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0051-4189","authenticated-orcid":false,"given":"Johanna","family":"Martins-Luna","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n e Innovaci\u00f3n de la Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilmer","family":"Silva-Caso","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n e Innovaci\u00f3n de la Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"v111","DOI":"10.1093\/annonc\/mdw325","article-title":"Management of febrile neutropaenia: ESMO Clinical Practice 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