{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:55:02Z","timestamp":1792788902688,"version":"4.5.0"},"reference-count":82,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Council","award":["110-2314-B-075A-011"],"award-info":[{"award-number":["110-2314-B-075A-011"]}]},{"name":"National Science and Technology Council","award":["TCVGH-1113901D"],"award-info":[{"award-number":["TCVGH-1113901D"]}]},{"name":"National Science and Technology Council","award":["TCVGH-1113901C"],"award-info":[{"award-number":["TCVGH-1113901C"]}]},{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["110-2314-B-075A-011"],"award-info":[{"award-number":["110-2314-B-075A-011"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH-1113901D"],"award-info":[{"award-number":["TCVGH-1113901D"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH-1113901C"],"award-info":[{"award-number":["TCVGH-1113901C"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Animals have been identified as potential reservoirs and vectors of resistance genes, with studies showing that Gram-negative bacteria can acquire resistance through the horizontal transmission of resistance genes on plasmids. It is important to understand the distribution of antimicrobial-resistant bacteria and their drug-resistant genes in animals. Previous review articles mostly focused on a single bacterium or a single animal. Our objective is to compile all ESBL-producing bacteria isolated from various animals in recent years and provide a comprehensive viewpoint. Using a thorough PubMed literature search spanning from 1 January 2020 to 30 June 2022, studies exploring extended-spectrum beta-lactamase (ESBL) producing bacteria in animals were included. ESBL-producing bacteria are present in animals from various countries around the world. The most common sources of these bacteria were farm animals, and the most frequently isolated bacteria were Escherichia coli and Klebsiella pneumoniae. The most detected ESBL genes were blaTEM, blaSHV, and blaCTX-M. The presence of ESBL-producing bacteria in animals highlights the importance of the One Health approach to address the issue of antibiotic resistance. Further research is needed to better understand the epidemiology and mechanisms of the spread of ESBL-producing bacteria in animal populations and their potential impact on human and animal health.<\/jats:p>","DOI":"10.3390\/antibiotics12040661","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T04:37:15Z","timestamp":1679978235000},"page":"661","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Extended-Spectrum \u03b2-Lactamases (ESBL) Producing Bacteria in Animals"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2098-8872","authenticated-orcid":false,"given":"Chien-Hao","family":"Tseng","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Taichung Veterans General Hospital, Taichung 40705, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Taichung Veterans General Hospital, Taichung 40705, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8006-4917","authenticated-orcid":false,"given":"Po-Yu","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Taichung Veterans General Hospital, Taichung 40705, Taiwan"},{"name":"Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung 40227, Taiwan"},{"name":"Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 40227, Taiwan"},{"name":"Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung 40227, Taiwan"},{"name":"Genomic Center for Infectious Diseases, Taichung Veterans General Hospital, Taichung 40705, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"ref_1","unstructured":"Antimicrobial Resistance Collaborators (2022). Global burden of bacterial antimicrobial resistance in 2019: A systematic analysis. Lancet, 399, 629\u2013655."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Darwich, L., Vidal, A., Seminati, C., Albamonte, A., Casado, A., Lopez, F., Molina-Lopez, R.A., and Migura-Garcia, L. (2019). High prevalence and diversity of extended-spectrum beta-lactamase and emergence of OXA-48 producing Enterobacterales in wildlife in Catalonia. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0210686"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"550","DOI":"10.3389\/fmicb.2018.00550","article-title":"Prevalence and Characterization of Multi-Drug-Resistant Gram-Negative Bacilli Isolated from Lebanese Poultry: A Nationwide Study","volume":"9","author":"Dandachi","year":"2018","journal-title":"Front. Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e316","DOI":"10.1016\/S2542-5196(17)30141-9","article-title":"Restricting the use of antibiotics in food-producing animals and its associations with antibiotic resistance in food-producing animals and human beings: A systematic review and meta-analysis","volume":"1","author":"Tang","year":"2017","journal-title":"Lancet Planet Health"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"dlab092","DOI":"10.1093\/jacamr\/dlab092","article-title":"Extended-spectrum beta-lactamases: An update on their characteristics, epidemiology and detection","volume":"3","author":"Castanheira","year":"2021","journal-title":"JAC Antimicrob. Resist."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1080\/23744235.2019.1654127","article-title":"Risk factors for community acquired urinary tract infections caused by extended spectrum beta-lactamase (ESBL) producing Escherichia coli in children: A case control study","volume":"51","author":"Zhu","year":"2019","journal-title":"Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cmi.2019.05.013","article-title":"Estimating the association between antibiotic exposure and colonization with extended-spectrum beta-lactamase-producing Gram-negative bacteria using machine learning methods: A multicentre, prospective cohort study","volume":"26","author":"Tacconelli","year":"2020","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1128\/CMR.18.4.657-686.2005","article-title":"Extended-spectrum beta-lactamases: A clinical update","volume":"18","author":"Paterson","year":"2005","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jgar.2022.05.021","article-title":"Genomic characterization of ESBL\/AmpC-producing and high-risk clonal lineages of Escherichia coli and Klebsiella pneumoniae in imported dogs with shelter and stray background","volume":"30","author":"Johansson","year":"2022","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1111\/jam.15469","article-title":"Incidence and molecular characterization of ESBL-producing and colistin-resistant Escherichia coli isolates recovered from healthy food-producing animals in Pakistan","volume":"133","author":"Shafiq","year":"2022","journal-title":"J. Appl. Microbiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"119367","DOI":"10.1016\/j.envpol.2022.119367","article-title":"A walk on the wild side: Wild ungulates as potential reservoirs of multi-drug resistant bacteria and genes, including Escherichia coli harbouring CTX-M beta-lactamases","volume":"306","author":"Torres","year":"2022","journal-title":"Environ. Pollut."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"936843","DOI":"10.3389\/fmicb.2022.936843","article-title":"Within-farm dynamics of ESBL-producing Escherichia coli in dairy cattle: Resistance profiles and molecular characterization by long-read whole-genome sequencing","volume":"13","author":"Tello","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"154814","DOI":"10.1016\/j.scitotenv.2022.154814","article-title":"Occurrence of multidrug resistant Gram-negative bacteria and resistance genes in semi-aquatic wildlife\u2014Trachemys scripta, Neovison vison and Lutra lutra\u2014As sentinels of environmental health","volume":"830","author":"Mengistu","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"109453","DOI":"10.1016\/j.vetmic.2022.109453","article-title":"Clonal and plasmid-mediated flow of ESBL\/AmpC genes in Escherichia coli in a commercial laying hen farm","volume":"270","author":"Aldea","year":"2022","journal-title":"Vet. Microbiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1292\/jvms.22-0018","article-title":"Characterization of multi-resistant Shigella species isolated from raw cow milk and milk products","volume":"84","author":"Elkenany","year":"2022","journal-title":"J. Vet. Med. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"866674","DOI":"10.3389\/fmicb.2022.866674","article-title":"Changes in Fecal Carriage of Extended-Spectrum Beta-Lactamase Producing Enterobacterales in Dutch Veal Calves by Clonal Spread of Klebsiella pneumoniae","volume":"13","author":"Kant","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1089\/fpd.2021.0101","article-title":"Prevalence of Antimicrobial Resistant and Extended-Spectrum Beta-Lactamase-producing Escherichia coli in Dairy Cattle Farms in East Tennessee","volume":"19","author":"Gelalcha","year":"2022","journal-title":"Foodborne Pathog. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/zph.12922","article-title":"Zoonotic bacteria in clinically healthy goats in petting zoo settings of zoological gardens in Germany","volume":"69","author":"Gottling","year":"2022","journal-title":"Zoonoses Public Health"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s42770-022-00700-w","article-title":"Non-diarrhoeic pigs as source of highly virulent and multidrug-resistant non-typhoidal Salmonella","volume":"53","author":"Karabasanavar","year":"2022","journal-title":"Braz. J. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s11259-021-09876-2","article-title":"Diversity of bacterial pathogens and their antimicrobial resistance profile among commensal rodents in Qatar","volume":"46","author":"Islam","year":"2022","journal-title":"Vet. Res. Commun."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s11259-021-09857-5","article-title":"Pathotyping and antimicrobial susceptibility testing of Escherichia coli isolates from neonatal calves","volume":"46","author":"Khawaskar","year":"2022","journal-title":"Vet. Res. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1080\/09603123.2021.1885632","article-title":"Molecular characterization of quinolone resistance and antimicrobial resistance profiles of Klebsiella pneumoniae and Escherichia coli isolated from human and broiler chickens","volume":"32","author":"Haeili","year":"2022","journal-title":"Int. J. Environ. Health Res."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Aklilu, E., Harun, A., and Singh, K.K.B. (2022). Molecular characterization of bla(NDM), bla(OXA-48), mcr-1 and bla(TEM-52) positive and concurrently carbapenem and colistin resistant and extended spectrum beta-lactamase producing Escherichia coli in chicken in Malaysia. BMC Vet. Res., 18.","DOI":"10.1186\/s12917-022-03292-7"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"846116","DOI":"10.3389\/fmicb.2022.846116","article-title":"High-Frequency Detection of fosA3 and bla (CTX-M-55) Genes in Escherichia coli From Longitudinal Monitoring in Broiler Chicken Farms","volume":"13","author":"Baptista","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"11786361211063619","DOI":"10.1177\/11786361211063619","article-title":"Molecular Characterization of ESBLs and QnrS Producers from Selected Enterobacteriaceae Strains Isolated from Commercial Poultry Production Systems in Kiambu County, Kenya","volume":"15","author":"Ndukui","year":"2022","journal-title":"Microbiol. Insights"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Su, X., Yan, X., Li, Y., Zhang, D., Li, L., Geng, Y., Su, F., Yue, C., Hou, R., and Liu, S. (2022). Identification of extended-spectrum beta-lactamase (CTX-M)-producing Klebsiella pneumoniae belonging to ST37, ST290, and ST2640 in captive giant pandas. BMC Vet. Res., 18.","DOI":"10.1186\/s12917-022-03276-7"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"882422","DOI":"10.3389\/fmicb.2022.882422","article-title":"High Prevalence of bla (CTXM-1)\/IncI1-Igamma\/ST3 Plasmids in Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Isolates Collected from Domestic Animals in Guadeloupe (French West Indies)","volume":"13","author":"Gruel","year":"2022","journal-title":"Front. Microbiol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Mahmoud, S.F., Fayez, M., Swelum, A.A., Alswat, A.S., Alkafafy, M., Alzahrani, O.M., Alsunaini, S.J., Almuslem, A., Al Amer, A.S., and Yusuf, S. (2022). Genetic Diversity, Biofilm Formation, and Antibiotic Resistance of Pseudomonas aeruginosa Isolated from Cow, Camel, and Mare with Clinical Endometritis. Vet. Sci., 9.","DOI":"10.3390\/vetsci9050239"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1007\/s00248-021-01803-x","article-title":"Detection of bla(TEM), bla(CTX-M), bla(CMY), and bla(SHV) Genes Among Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Isolated from Migratory Birds Travelling to Bangladesh","volume":"83","author":"Islam","year":"2022","journal-title":"Microb. Ecol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e0003621","DOI":"10.1128\/spectrum.00036-21","article-title":"First Report of Extended-Spectrum beta-Lactamase (bla(CTX-M1)) and Colistin Resistance Gene mcr-1 in E. coli of Lineage ST648 from Cockroaches in Tunisia","volume":"10","author":"Landolsi","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1093\/jac\/dkac041","article-title":"Comparative phylogenomics of ESBL-, AmpC- and carbapenemase-producing Klebsiella pneumoniae originating from companion animals and humans","volume":"77","author":"Drapeau","year":"2022","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Belas, A., Marques, C., Menezes, J., da Gama, L.T., Cavaco-Silva, P., and Pomba, C. (2022). ESBL\/pAmpC-Producing Escherichia coli Causing Urinary Tract Infections in Non-Related Companion Animals and Humans. Antibiotics, 11.","DOI":"10.3390\/antibiotics11050559"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"869314","DOI":"10.3389\/fcimb.2022.869314","article-title":"Extended-Spectrum ss-Lactamase-Producing Escherichia coli among Humans, Beef Cattle, and Abattoir Environments in Nigeria","volume":"12","author":"Aworh","year":"2022","journal-title":"Front. Cell Infect. Microbiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e1269","DOI":"10.1002\/mbo3.1269","article-title":"Antimicrobial resistance profiles of Escherichia coli and prevalence of extended-spectrum beta-lactamase-producing Enterobacteriaceae in calves from organic and conventional dairy farms in Switzerland","volume":"11","author":"Hanni","year":"2022","journal-title":"Microbiologyopen"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1089\/vbz.2022.0004","article-title":"The Public Health Burden of Virulent Extended-Spectrum Beta-Lactamase-Producing Klebsiella pneumoniae Strains Isolated from Diseased Horses","volume":"22","author":"Samir","year":"2022","journal-title":"Vector-Borne Zoonotic Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"152861","DOI":"10.1016\/j.scitotenv.2021.152861","article-title":"Detection of NDM-5 and MCR-1 antibiotic resistance encoding genes in Enterobacterales in long-distance migratory bird species Ciconia ciconia, Algeria","volume":"814","author":"Loucif","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"152045","DOI":"10.1016\/j.scitotenv.2021.152045","article-title":"Long-term maintenance of multidrug-resistant Escherichia coli carried by vampire bats and shared with livestock in Peru","volume":"810","author":"Benavides","year":"2022","journal-title":"Sci. Total Environ."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1038\/s41598-022-06415-0","article-title":"Plasmid-mediated colistin resistance and ESBL production in Escherichia coli from clinically healthy and sick pigs","volume":"12","author":"Trongjit","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/jac\/dkp498","article-title":"Development of a set of multiplex PCR assays for the detection of genes encoding important beta-lactamases in Enterobacteriaceae","volume":"65","author":"Dallenne","year":"2010","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1093\/jac\/dkh070","article-title":"Antibiotic resistance genes, integrons and multiple antibiotic resistance in thirty-five serotypes of Salmonella enterica isolated from humans and animals in the UK","volume":"53","author":"Randall","year":"2004","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1093\/jac\/dku450","article-title":"Development and evaluation of a novel universal beta-lactamase gene subtyping assay for blaSHV, blaTEM and blaCTX-M using clinical and livestock-associated Escherichia coli","volume":"70","author":"Strauss","year":"2015","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1128\/AAC.01355-08","article-title":"Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital","volume":"53","author":"Gootz","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/jac\/dkm267","article-title":"Detection of OXA-2 group extended-spectrum-beta-lactamase-producing clinical isolates of Escherichia coli from India","volume":"60","author":"Bhattacharjee","year":"2007","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.jiph.2016.10.009","article-title":"Prevalence, antibiotic susceptibility and characterization of antibiotic resistant genes among carbapenem-resistant Gram-negative bacilli and yeast in intestinal flora of cancer patients in North Lebanon","volume":"10","author":"Christophy","year":"2017","journal-title":"J. Infect. Public Health"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1099\/jmm.0.005850-0","article-title":"Emergence of carbapenem-non-susceptible extended-spectrum beta-lactamase-producing Klebsiella pneumoniae isolates at the university hospital of Tubingen, Germany","volume":"58","author":"Grobner","year":"2009","journal-title":"J. Med. Microbiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.2147\/IDR.S202048","article-title":"Low prevalence of resistance genes in sheltered homeless population in Marseille, France, 2014\u20132018","volume":"12","author":"Ly","year":"2019","journal-title":"Infect. Drug Resist."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"7110","DOI":"10.1038\/s41598-021-86570-y","article-title":"Detection of extended spectrum beta-lactamase genes in Pseudomonas aeruginosa isolated from patients in rural Eastern Cape Province, South Africa","volume":"11","author":"Hosu","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1128\/AAC.42.6.1350","article-title":"beta-Lactamases responsible for resistance to expanded-spectrum cephalosporins in Klebsiella pneumoniae, Escherichia coli, and Proteus mirabilis isolates recovered in South Africa","volume":"42","author":"Pitout","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1128\/JCM.01943-07","article-title":"Molecular epidemiology of extended-spectrum beta-lactamases among Escherichia coli isolates collected in a Swedish hospital and its associated health care facilities from 2001 to 2006","volume":"46","author":"Fang","year":"2008","journal-title":"J. Clin. Microbiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/jac\/dki190","article-title":"Beta-Lactamases among extended-spectrum beta-lactamase (ESBL)-resistant Salmonella from poultry, poultry products and human patients in The Netherlands","volume":"56","author":"Hasman","year":"2005","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"90144","DOI":"10.18632\/oncotarget.21496","article-title":"Characteristics and genetic diversity of multi-drug resistant extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli isolated from bovine mastitis","volume":"8","author":"Ali","year":"2017","journal-title":"Oncotarget"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1128\/JCM.42.6.2432-2437.2004","article-title":"SHV-12-like extended-spectrum-beta-lactamase-producing strains of Salmonella enterica serotypes Babelsberg and Enteritidis isolated in France among infants adopted from Mali","volume":"42","author":"Weill","year":"2004","journal-title":"J. Clin. Microbiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0378-1097(03)00306-9","article-title":"Simple and reliable multiplex PCR assay for detection of blaTEM, bla(SHV) and blaOXA-1 genes in Enterobacteriaceae","volume":"223","author":"Colom","year":"2003","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ijfoodmicro.2008.03.009","article-title":"Characterization of TEM-, SHV- and AmpC-type beta-lactamases from cephalosporin-resistant Enterobacteriaceae isolated from swine","volume":"124","author":"Rayamajhi","year":"2008","journal-title":"Int. J. Food Microbiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.1128\/AAC.05186-14","article-title":"Trends in susceptibility of Escherichia coli from intra-abdominal infections to ertapenem and comparators in the United States according to data from the SMART program, 2009 to 2013","volume":"59","author":"Lob","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ijid.2015.10.016","article-title":"Molecular epidemiology and characterization of multiple drug-resistant (MDR) clinical isolates of Acinetobacter baumannii","volume":"41","author":"Dashti","year":"2015","journal-title":"Int. J. Infect. Dis."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ijfoodmicro.2008.03.029","article-title":"Safety of raw meat and shellfish in Vietnam: An analysis of Escherichia coli isolations for antibiotic resistance and virulence genes","volume":"124","author":"Van","year":"2008","journal-title":"Int. J. Food Microbiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1089\/mdr.2006.12.192","article-title":"Molecular characterization and occurrence of extended-spectrum beta-lactamase resistance genes among Salmonella enterica serovar Corvallis from Thailand, Bulgaria, and Denmark","volume":"12","author":"Archambault","year":"2006","journal-title":"Microb. Drug Resist."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ejmhg.2013.05.002","article-title":"Detection of bla SHV and bla CTX-M genes in ESBL producing Klebsiella pneumoniae isolated from Egyptian patients with suspected nosocomial infections","volume":"14","author":"Ahmed","year":"2013","journal-title":"Egypt. J. Med. Hum. Genet."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Gundran, R.S., Cardenio, P.A., Villanueva, M.A., Sison, F.B., Benigno, C.C., Kreausukon, K., Pichpol, D., and Punyapornwithaya, V. (2019). Prevalence and distribution of bla(CTX-M), bla(SHV), bla(TEM) genes in extended- spectrum beta- lactamase- producing E. coli isolates from broiler farms in the Philippines. BMC Vet. Res., 15.","DOI":"10.1186\/s12917-019-1975-9"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1128\/AAC.49.4.1319-1322.2005","article-title":"Bla(CTX-M) genes in clinical Salmonella isolates recovered from humans in England and Wales from 1992 to 2003","volume":"49","author":"Batchelor","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"3724","DOI":"10.1128\/AAC.47.12.3724-3732.2003","article-title":"Prevalence and molecular epidemiology of CTX-M extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae in Russian hospitals","volume":"47","author":"Edelstein","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.1128\/AEM.02831-10","article-title":"Fecal carriage and shedding density of CTX-M extended-spectrum beta-lactamase-producing Escherichia coli in cattle, chickens, and pigs: Implications for environmental contamination and food production","volume":"77","author":"Horton","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/jac\/dki412","article-title":"Multiplex PCR for rapid detection of genes encoding CTX-M extended-spectrum (beta)-lactamases","volume":"57","author":"Woodford","year":"2006","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.3201\/eid1509.090567","article-title":"Salmonella enterica serovar Typhi with CTX-M beta-lactamase, Germany","volume":"15","author":"Pfeifer","year":"2009","journal-title":"Emerg. Infect. Dis."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Wetzker, W., Pfeifer, Y., Wolke, S., Haselbeck, A., Leistner, R., Kola, A., Gastmeier, P., and Salm, F. (2019). Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli Isolated from Flies in the Urban Center of Berlin, Germany. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16091530"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1469-0691.2007.01851.x","article-title":"Animal reservoirs for extended spectrum beta-lactamase producers","volume":"14","author":"Carattoli","year":"2008","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e03206","DOI":"10.1016\/j.heliyon.2020.e03206","article-title":"Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in cattle production\u2014A threat around the world","volume":"6","author":"Ferreira","year":"2020","journal-title":"Heliyon"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.3389\/fmicb.2017.01569","article-title":"From Farms to Markets: Gram-Negative Bacteria Resistant to Third-Generation Cephalosporins in Fruits and Vegetables in a Region of North Africa","volume":"8","author":"Granier","year":"2017","journal-title":"Front. Microbiol."},{"key":"ref_70","first-page":"1019","article-title":"ESBL-positive Enterobacteria isolates in drinking water","volume":"18","author":"Miwanda","year":"2012","journal-title":"Emerg. Infect. Dis."},{"key":"ref_71","unstructured":"World Health Organization (2021). WHO Integrated Global Surveillance on ESBL-Producing E. coli Using a \u201cOne Health\u201d Approach: Implementation and Opportunities."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1128\/CMR.14.4.933-951.2001","article-title":"Extended-spectrum beta-lactamases in the 21st century: Characterization, epidemiology, and detection of this important resistance threat","volume":"14","author":"Bradford","year":"2001","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e0103321","DOI":"10.1128\/JCM.01033-21","article-title":"Comparative Evaluation of Assays for Broad Detection of Molecular Resistance Mechanisms in Enterobacterales Isolates","volume":"59","author":"Garner","year":"2021","journal-title":"J. Clin. Microbiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3389\/fmicb.2013.00188","article-title":"Molecular characterization of bla ESBL-harboring conjugative plasmids identified in multi-drug resistant Escherichia coli isolated from food-producing animals and healthy humans","volume":"4","author":"Wang","year":"2013","journal-title":"Front. Microbiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1093\/jac\/dku206","article-title":"Nucleotide sequences of 16 transmissible plasmids identified in nine multidrug-resistant Escherichia coli isolates expressing an ESBL phenotype isolated from food-producing animals and healthy humans","volume":"69","author":"Wang","year":"2014","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"108566","DOI":"10.1016\/j.vetmic.2019.108566","article-title":"Molecular characterisation of multi-drug resistant Escherichia coli of bovine origin","volume":"242","author":"Anes","year":"2020","journal-title":"Vet. Microbiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jgar.2019.05.007","article-title":"Various Inc-type plasmids and lineages of Escherichia coli and Klebsiella pneumoniae spreading bla(CTX-M-15,)bla(CTX-M-1) and mcr-1 genes in camels in Tunisia","volume":"19","author":"Saidani","year":"2019","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"108601","DOI":"10.1016\/j.vetmic.2020.108601","article-title":"Genome analysis of enterobacteriaceae with non-wild type susceptibility to third-generation cephalosporins recovered from diseased dogs and cats in Europe","volume":"242","author":"Bertrand","year":"2020","journal-title":"Vet. Microbiol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1093\/jac\/dkx488","article-title":"Plasmids carrying antimicrobial resistance genes in Enterobacteriaceae","volume":"73","author":"Rozwandowicz","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1128\/JCM.01988-06","article-title":"Detection of extended-spectrum beta-lactamases among Enterobacteriaceae by use of semiautomated microbiology systems and manual detection procedures","volume":"45","author":"Wiegand","year":"2007","journal-title":"J. Clin. Microbiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_82","unstructured":"University of Alabama (2022, May 24). A Research Guide for Systematic Literature Reviews. Available online: https:\/\/guides.lib.ua.edu\/c.php?g=1135040&p=8286355."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/12\/4\/661\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:04:46Z","timestamp":1760123086000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/12\/4\/661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,28]]},"references-count":82,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2023,4]]}},"alternative-id":["antibiotics12040661"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics12040661","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,28]]}}}