{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:03:38Z","timestamp":1792789418930,"version":"4.5.0"},"reference-count":45,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the European Union\u2019s Horizon 2020 research and innovation program","award":["857287"],"award-info":[{"award-number":["857287"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Honey is widely used in traditional medicine and modern wound healing biomaterial research as a broad-spectrum antimicrobial, anti-inflammatory and antioxidant agent. The study\u2019s objectives were to evaluate the antibacterial activity and polyphenolic profiles of 40 monofloral honey samples collected from beekeepers in the territory of Latvia. The antimicrobial and antifungal activity of Latvian honey samples were compared with commercial Manuka honey and the honey analogue sugar solutions\u2013carbohydrate mixture and tested against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, clinical isolates Extended-Spectrum Beta-Lactamases produced Escherichia coli, Methicillin-resistant Staphylococcus aureus and Candida albicans. Antimicrobial activity was evaluated with the well-diffusion method (80% honey solution w\/v) and microdilution method. The honey samples with the highest antimicrobial potential were tested to prevent biofilm development and activity against a preformed biofilm. The principal component analysis of the antimicrobial properties of honey samples vs. polyphenolic profile was performed. Eleven honey samples exhibited antibacterial activity to all investigated bacteria. The antibacterial effect of the samples was most significant on the Gram-positive bacteria compared to the studied Gram-negative bacteria. Latvian honey presents promising potential for use in wound healing biomaterials, opening the possibility of achieving long-term antibacterial effects.<\/jats:p>","DOI":"10.3390\/antibiotics12050816","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T02:50:00Z","timestamp":1682563800000},"page":"816","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Antimicrobial and Antibiofilm Properties of Latvian Honey against Causative Agents of Wound Infections"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4044-8750","authenticated-orcid":false,"given":"Ingus","family":"Skadi\u0146\u0161","sequence":"first","affiliation":[{"name":"Baltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, LV-1658 Riga, Latvia"},{"name":"Department of Biology and Microbiology, Riga Stradi\u0146\u0161 University, LV-1007 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4384-8541","authenticated-orcid":false,"given":"Kri\u0161s D\u0101vids","family":"Labsv\u0101rds","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, University of Latvia, LV-1004 Riga, Latvia"},{"name":"Institute of Food Safety, Animal Health and Environment \u201cBIOR\u201d, LV-1076 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9772-7665","authenticated-orcid":false,"given":"Andra","family":"Grava","sequence":"additional","affiliation":[{"name":"Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Faculty of Materials Science and Applied Chemistry, Institute of General Chemical Engineering, Riga Technical University, LV-1007 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhaleh","family":"Amirian","sequence":"additional","affiliation":[{"name":"Baltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, LV-1658 Riga, Latvia"},{"name":"Department of Pharmaceutical Chemistry, Riga Stradi\u0146\u0161 University, LV-1007 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura El\u012bna","family":"Tomsone","sequence":"additional","affiliation":[{"name":"Institute of Food Safety, Animal Health and Environment \u201cBIOR\u201d, LV-1076 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9027-8895","authenticated-orcid":false,"given":"J\u0101nis","family":"Ru\u0161ko","sequence":"additional","affiliation":[{"name":"Institute of Food Safety, Animal Health and Environment \u201cBIOR\u201d, LV-1076 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1440-798X","authenticated-orcid":false,"given":"Arturs","family":"Viksna","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, University of Latvia, LV-1004 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9144-8799","authenticated-orcid":false,"given":"Dace","family":"Bandere","sequence":"additional","affiliation":[{"name":"Baltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, LV-1658 Riga, Latvia"},{"name":"Department of Pharmaceutical Chemistry, Riga Stradi\u0146\u0161 University, LV-1007 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1194-0746","authenticated-orcid":false,"given":"Agnese","family":"Brangule","sequence":"additional","affiliation":[{"name":"Baltic Biomaterials Centre of Excellence, Headquarters at Riga Technical University, LV-1658 Riga, Latvia"},{"name":"Department of Pharmaceutical Chemistry, Riga Stradi\u0146\u0161 University, LV-1007 Riga, Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S2221-1691(11)60016-6","article-title":"Honey: Its medicinal property and antibacterial activity","volume":"1","author":"Mandal","year":"2011","journal-title":"Asian Pac. 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