{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:37:15Z","timestamp":1790696235105,"version":"4.1.0"},"reference-count":40,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CAPES-Coordination for the Improvement of Higher Education Personnel, Brazil","award":["#001"],"award-info":[{"award-number":["#001"]}]},{"name":"CAPES-Coordination for the Improvement of Higher Education Personnel, Brazil","award":["# 311368\/2019-0"],"award-info":[{"award-number":["# 311368\/2019-0"]}]},{"name":"CAPES-Coordination for the Improvement of Higher Education Personnel, Brazil","award":["# 313647\/2021-6"],"award-info":[{"award-number":["# 313647\/2021-6"]}]},{"name":"CNPq-National Council for Scientific and Technological Development, Brazil","award":["#001"],"award-info":[{"award-number":["#001"]}]},{"name":"CNPq-National Council for Scientific and Technological Development, Brazil","award":["# 311368\/2019-0"],"award-info":[{"award-number":["# 311368\/2019-0"]}]},{"name":"CNPq-National Council for Scientific and Technological Development, Brazil","award":["# 313647\/2021-6"],"award-info":[{"award-number":["# 313647\/2021-6"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>The effect of systemic antibiotics on the microbial profile of extracrevicular sites after periodontal treatment is currently the subject of research. This study evaluated the microbiological effects on different oral cavity sites of scaling and root planing (SRP) combined with antimicrobial chemical control in the treatment of periodontitis. Sixty subjects were randomly assigned to receive SRP alone or combined with metronidazole (MTZ) + amoxicillin (AMX) for 14 days, with or without chlorhexidine mouth rinse (CHX) for 60 days. Microbiological samples were evaluated by checkerboard DNA\u2013DNA hybridization until 180 days post therapy. The adjunctive use of antibiotics plus CHX significantly reduced the mean proportions of red complex species from subgingival biofilm and saliva (p &lt; 0.05). Furthermore, the analysis of all intraoral niches showed a significantly lower mean proportion of the red complex species in the same group. In conclusion, the concomitant use of antimicrobial chemical control (systemic and local) demonstrated a beneficial effect on the composition of the oral microbiota.<\/jats:p>","DOI":"10.3390\/antibiotics12050847","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T03:24:32Z","timestamp":1683257072000},"page":"847","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Systemic Antibiotics and Chlorhexidine Associated with Periodontal Therapy: Microbiological Effect on Intraoral Surfaces and Saliva"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4500-9872","authenticated-orcid":false,"given":"Stella de Noronha Campos","family":"Mendes","sequence":"first","affiliation":[{"name":"Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07090-023, SP, Brazil"},{"name":"Department of Dentistry, Federal University of Piaui, Teresina 64049-550, PI, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Machado","family":"Esteves","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07090-023, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Alethusa Velloso","family":"Mendes","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07090-023, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2293-3392","authenticated-orcid":false,"given":"Magda","family":"Feres","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07090-023, SP, Brazil"},{"name":"Department of Oral Medicine, Infection, and Immunity, Division of Periodontology, Harvard School of Dental Medicine, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalia","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07090-023, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2988-9205","authenticated-orcid":false,"given":"Tamires Szeremeske","family":"de Miranda","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07090-023, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1971-0195","authenticated-orcid":false,"given":"Jamil Awad","family":"Shibli","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07090-023, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciene Cristina","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07090-023, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/jcpe.13547","article-title":"Pocket closure and residual pockets after non-surgical periodontal therapy: A systematic review and meta-analysis","volume":"49","author":"Citterio","year":"2022","journal-title":"J. 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