{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T19:41:39Z","timestamp":1779392499547,"version":"3.53.1"},"reference-count":66,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,6,18]],"date-time":"2023-06-18T00:00:00Z","timestamp":1687046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Incentive for Research of the Universidad Peruana de Ciencias Aplicadas","award":["N\u00ba UPC-C007-2020"],"award-info":[{"award-number":["N\u00ba UPC-C007-2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>(1) Background: Acinetobacter baumannii has become the most important pathogen responsible for nosocomial infections in health systems. It expresses several resistance mechanisms, including the production of \u03b2-lactamases, changes in the cell membrane, and the expression of efflux pumps. (2) Methods: A. baumannii was detected by PCR amplification of the blaOXA-51-like gene. Antimicrobial susceptibility to fluoroquinolones and aminoglycosides was assessed using the broth microdilution technique according to 2018 CLSI guidelines. Efflux pump system activity was assessed by the addition of a phenylalanine\u2013arginine beta-naphthylamide (PA\u03b2N) inhibitor. (3) Results: A total of nineteen A. baumannii clinical isolates were included in the study. In an overall analysis, in the presence of PA\u03b2N, amikacin susceptibility rates changed from 84.2% to 100%; regarding tobramycin, they changed from 68.4% to 84.2%; for nalidixic acid, they changed from 73.7% to 79.0%; as per ciprofloxacin, they changed from 68.4% to 73.7%; and, for levofloxacin, they stayed as 79.0% in both groups. (4) Conclusions: The addition of PA\u03b2N demonstrated a decrease in the rates of resistance to antimicrobials from the family of quinolones and aminoglycosides. Efflux pumps play an important role in the emergence of multidrug-resistant A. baumannii strains, and their inhibition may be useful as adjunctive therapy against this pathogen.<\/jats:p>","DOI":"10.3390\/antibiotics12061071","type":"journal-article","created":{"date-parts":[[2023,6,19]],"date-time":"2023-06-19T01:31:14Z","timestamp":1687138274000},"page":"1071","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of Phenylalanine\u2013Arginine Beta-Naphthylamide on the Values of Minimum Inhibitory Concentration of Quinolones and Aminoglycosides in Clinical Isolates of Acinetobacter baumannii"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9243-8872","authenticated-orcid":false,"given":"Stefany","family":"Plasencia-Rebata","sequence":"first","affiliation":[{"name":"Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5673-5477","authenticated-orcid":false,"given":"Saul","family":"Levy-Blitchtein","sequence":"additional","affiliation":[{"name":"Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"},{"name":"Microbiology Department, Vall d\u2019Hebron University Hospital, 08034 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juana","family":"del Valle-Mendoza","sequence":"additional","affiliation":[{"name":"Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"},{"name":"Laboratorio de Biomedicina, Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"},{"name":"Instituto de Investigaci\u00f3n Nutricional, Lima 15024, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilmer","family":"Silva-Caso","sequence":"additional","affiliation":[{"name":"Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"},{"name":"Laboratorio de Biomedicina, Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"},{"name":"Instituto de Investigaci\u00f3n Nutricional, Lima 15024, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Pe\u00f1a-Tuesta","sequence":"additional","affiliation":[{"name":"Laboratorio de Biomedicina, Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"},{"name":"Instituto de Investigaci\u00f3n Nutricional, Lima 15024, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Vicente Taboada","sequence":"additional","affiliation":[{"name":"National Institute of Neoplastic Diseases, Lima 15024, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Barreda Bola\u00f1os","sequence":"additional","affiliation":[{"name":"National Institute of Neoplastic Diseases, Lima 15024, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7023-3190","authenticated-orcid":false,"given":"Miguel Angel","family":"Aguilar-Luis","sequence":"additional","affiliation":[{"name":"Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"},{"name":"Laboratorio de Biomedicina, Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima 15023, Peru"},{"name":"Instituto de Investigaci\u00f3n Nutricional, Lima 15024, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S1473-3099(08)70279-2","article-title":"Current control and treatment of multidrug-resistant Acinetobacter baumannii infections","volume":"8","author":"Karageorgopoulos","year":"2008","journal-title":"Lancet Infect. 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