{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:26:34Z","timestamp":1794324394962,"version":"4.9.0"},"reference-count":74,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T00:00:00Z","timestamp":1688688000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific Research Deanship at the University of Hail, Saudi Arabia","award":["MDR 22010"],"award-info":[{"award-number":["MDR 22010"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Broccoli, Brassica oleracea var. italica, has recently gained considerable attention due to its remarkable nutritional composition and numerous health benefits. In this review, the nutritional aspects of broccoli are examined, highlighting its rich nutrient content and essential bioactive compounds. The cruciferous vegetable broccoli is a rich source of several important nutrients, including fiber, vitamins (A, C, and K), minerals (calcium, potassium, and iron), and antioxidants. It has also been shown to contain bioactive compounds such as glucosinolates, sulforaphane, and indole-3-carbinol, all of which have been shown to have significant health-promoting effects. These chemicals are known to have potent antioxidant, anti-inflammatory, and anticancer effects. This review article aims to comprehensively examine the diverse spectrum of nutrients contained in broccoli and explore its medicinal potential to promote human health.<\/jats:p>","DOI":"10.3390\/antibiotics12071157","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T01:41:36Z","timestamp":1688694096000},"page":"1157","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":105,"title":["Broccoli: A Multi-Faceted Vegetable for Health: An In-Depth Review of Its Nutritional Attributes, Antimicrobial Abilities, and Anti-inflammatory Properties"],"prefix":"10.3390","volume":"12","author":[{"given":"Rahamat Unissa","family":"Syed","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia"},{"name":"Medical and Diagnostic Research Centre, University of Hail, Hail 55473, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4860-0166","authenticated-orcid":false,"given":"Sivakumar Sivagurunathan","family":"Moni","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6031-4154","authenticated-orcid":false,"given":"Mohammed Khaled Bin","family":"Break","sequence":"additional","affiliation":[{"name":"Medical and Diagnostic Research Centre, University of Hail, Hail 55473, Saudi Arabia"},{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weam M. A.","family":"Khojali","sequence":"additional","affiliation":[{"name":"Medical and Diagnostic Research Centre, University of Hail, Hail 55473, Saudi Arabia"},{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia"},{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Omdurman Islamic University, Al Khartoum 14415, Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3581-0877","authenticated-orcid":false,"given":"Mohammed","family":"Jafar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 34212, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maali D.","family":"Alshammari","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Abdelsalam","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soha","family":"Taymour","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khetam Saad Mutni","family":"Alreshidi","sequence":"additional","affiliation":[{"name":"College of Pharmacy, University of Hail, Hail 81442, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal Mohamed","family":"Elhassan Taha","sequence":"additional","affiliation":[{"name":"Substance Abuse and Toxicology Research Centre, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2077-1278","authenticated-orcid":false,"given":"Syam","family":"Mohan","sequence":"additional","affiliation":[{"name":"Substance Abuse and Toxicology Research Centre, Jazan University, Jazan 45142, Saudi Arabia"},{"name":"Center for Transdisciplinary Research, Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai 602105, India"},{"name":"School of Health Sciences, University of Petroleum and Energy Studies, Dehradun 248007, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,7]]},"reference":[{"key":"ref_1","first-page":"100","article-title":"In vitro antibacterial activities of Broccoli (Brassica oleracea L. var italica) against food borne bacteria","volume":"3","author":"Sibi","year":"2013","journal-title":"J. Appl. Pharm. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Siomos, A.S., Koularmanis, K., and Tsouvaltzis, P. (2022). The Impacts of the Emerging Climate Change on Broccoli (Brassica oleracea L. var. italica Plenck.) Crop. Horticulturae, 8.","DOI":"10.3390\/horticulturae8111032"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/jam.13629","article-title":"Antimicrobial activity of broccoli (Brassica oleracea var. italica) cultivar avenger against pathogenic bacteria, phytopathogenic filamentous fungi and yeast","volume":"124","author":"Bideshi","year":"2018","journal-title":"J. Appl. Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S1607-551X(09)70264-5","article-title":"Antimicrobi-al effect of extracts of cruciferous vegetables","volume":"20","author":"Hu","year":"2004","journal-title":"Kaohsiung J. Med. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3746\/pnf.2015.20.1.8","article-title":"Antioxidant and anticancer activities of broccoli by-products from different cultivars and maturity stages at harvest","volume":"20","author":"Hwang","year":"2015","journal-title":"Prev. Nutr. Food Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1177\/1082013211433073","article-title":"An overview of health-promoting compounds of broccoli (Brassica oleracea var. italica) and the effect of processing","volume":"18","author":"Mahn","year":"2012","journal-title":"Food Sci. Technol. Int."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1021\/acs.jafc.6b00559","article-title":"Antiamnesic effect of broccoli (Brassica oleracea var. italica) leaves on amyloid beta (A\u03b2) 1-42-induced learning and memory impairment","volume":"64","author":"Park","year":"2016","journal-title":"J. Agric. Food Chem."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1039\/C4FO01209G","article-title":"Impact of boiling on phytochemicals and antioxidant activity of green vegetables con-sumed in the Mediterranean diet","volume":"6","author":"Vinha","year":"2015","journal-title":"Food Funct."},{"key":"ref_9","first-page":"696","article-title":"Broccoli: The green beauty: A review","volume":"7","author":"Owis","year":"2015","journal-title":"J. Pharm. Sci. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1017\/S0007114514001937","article-title":"Global assessment of select phytonutrient intakes by level of fruit and vegetable consumption","volume":"112","author":"Mary","year":"2014","journal-title":"Br. J. Nutr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1017\/S0007114512005417","article-title":"Relationship of lycopene intake and consumption of tomato products to incident CVD","volume":"110","author":"Jacques","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_12","unstructured":"Booth, S. (2023, May 01). Health Benefits of Broccoli. Available online: https:\/\/www.webmd.com\/food-recipes\/health-benefits-broccoli."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Barber, T.M., Kabisch, S., Pfeiffer, A.F.H., and Weickert, M.O. (2020). The Health Benefits of Dietary Fibre. Nutrients, 12.","DOI":"10.3390\/nu12103209"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13765-022-00700-2","article-title":"Antioxidant and antiproliferative activities of solvent fractions of broccoli (Brassica oleracea L.) sprout","volume":"65","author":"Kim","year":"2022","journal-title":"Appl. Biol. Chem."},{"key":"ref_15","first-page":"e13414","article-title":"The value of bioactive compounds of cruciferous vegetables (Brassica) as antimicrobials and antioxidants: A review","volume":"44","year":"2020","journal-title":"J. Food Biochem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1002\/mc.20774","article-title":"Broccoli-derived phytochemicals indole-3-carbinol and 3,3\u2019-diindolylmethane exerts concentration-dependent pleiotropic effects on prostate cancer cells: Comparison with other cancer preventive phytochemicals","volume":"51","author":"Wang","year":"2012","journal-title":"Mol. Carcinog."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Tang, G.-Y., Meng, X., Li, Y., Zhao, C.-N., Liu, Q., and Li, H.-B. (2017). Effects of Vegetables on Cardiovascular Diseases and Related Mechanisms. Nutrients, 9.","DOI":"10.3390\/nu9080857"},{"key":"ref_18","first-page":"741","article-title":"Nutrients for the aging eye","volume":"8","author":"Rasmussen","year":"2013","journal-title":"Clin. Interv. Aging"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Mahn, A., and Castillo, A. (2021). Potential of Sulforaphane as a Natural Immune System Enhancer: A Review. Molecules, 26.","DOI":"10.3390\/molecules26030752"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4629383","DOI":"10.1155\/2018\/4629383","article-title":"Vitamin K and Bone Metabolism: A Review of the Latest Evidence in Preclinical Studies","volume":"2018","author":"Akbari","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"ref_21","unstructured":"Farha, A. (2023, May 01). Broccoli for Weight Loss\u2014Here\u2019s How It Can Help. Available online: https:\/\/www.healthifyme.com\/blog\/broccoli-for-weight-loss\/."},{"key":"ref_22","unstructured":"Megan, M. (2023, May 01). The Different Ways That Prebiotics and Fiber Affect the Gut Microbiota. Available online: https:\/\/www.gutmicrobiotaforhealth.com\/the-different-ways-that-prebiotics-and-fiber-affect-the-gut-microbiota\/."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"405","DOI":"10.4103\/jomfp.JOMFP_126_19","article-title":"Sulforaphane in broccoli: The green chemoprevention!! Role in cancer prevention and therapy","volume":"24","author":"Nandini","year":"2020","journal-title":"J. Oral Maxillofac. Pathol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s11357-019-00061-7","article-title":"Sulforaphane-role in aging and neurodegeneration","volume":"41","author":"Chondrogianni","year":"2019","journal-title":"Geroscience"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.clnu.2018.03.006","article-title":"Effects of long-term consumption of broccoli sprouts on inflammatory markers in overweight subjects","volume":"38","author":"Pilar","year":"2019","journal-title":"Clin. Nutr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3746\/pnf.2014.19.2.089","article-title":"Antioxidant and Anti-inflammatory Activities of Broccoli Florets in LPS-stimulated RAW 264.7 Cells","volume":"19","author":"Hwang","year":"2014","journal-title":"Prev. Nutr. Food Sci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"822895","DOI":"10.3389\/fimmu.2022.822895","article-title":"Sulforaphane Exerts Beneficial Immunomodulatory Effects on Liver Tissue via a Nrf2 Pathway-Related Mechanism in a Murine Model of Hemorrhagic Shock and Resuscitation","volume":"13","author":"Liang","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Zuo, L., Prather, E.R., Stetskiv, M., Garrison, D.E., Meade, J.R., Peace, T.I., and Zhou, T. (2019). Inflammaging and Oxidative Stress in Human Diseases: From Molecular Mechanisms to Novel Treatments. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20184472"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","article-title":"ROS function in redox signaling and oxidative stress","volume":"24","author":"Schieber","year":"2014","journal-title":"Curr. Biol."},{"key":"ref_30","first-page":"35","article-title":"Chapter Two\u2014Involvement of Cytochrome P450 in Reactive Oxygen Species Formation and Cancer","volume":"7","author":"Eugene","year":"2015","journal-title":"Adv. Pharmacol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.mib.2015.01.004","article-title":"Diagnosing oxidative stress in bacteria: Not as easy as you might think","volume":"24","author":"James","year":"2015","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Abdal Dayem, A., Hossain, M.K., Lee, S.B., Kim, K., Saha, S.K., Yang, G.-M., Choi, H.Y., and Cho, S.-G. (2017). The Role of Reactive Oxygen. Species (ROS) in the Biological Activities of Metallic Nanoparticles. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18010120"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/j.imbio.2013.04.019","article-title":"Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK\/AP-1 and IKK\/NF-\u03baB-induced inflammatory mediators production in RAW 264.7 cells","volume":"18","author":"Endale","year":"2013","journal-title":"Immunobiology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive oxygen species in inflammation and tissue injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid. Redox. Signal"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/ijc.33588","article-title":"Cancer statistics for the year 2020: An overview","volume":"149","author":"Ferlay","year":"2021","journal-title":"Int. J. Cancer"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s00217-016-2764-3","article-title":"Glucoraphenin, sulforaphene, and antiproliferative capacity of radish sprouts in germinating and thermal processes","volume":"243","author":"Li","year":"2017","journal-title":"Eur. Food Res. Technol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1021\/np800233q","article-title":"Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 Xenografts in vivo","volume":"71","author":"Liang","year":"2008","journal-title":"J. Nat. Prod."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1111\/j.1745-7254.2007.00679.x","article-title":"Discovery, and development of sulforaphane as a cancer chemo preventive phytochemical","volume":"28","author":"Zhang","year":"2007","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_39","first-page":"82","article-title":"Modulation of drug metabolizing enzymes by dietary doses of sulforaphane; role in its anti-hypertensive and anti-oxidant effect in spontaneously hypertensive rats","volume":"6","author":"Fawzy","year":"2016","journal-title":"J. Clin. Toxicol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1089\/jmf.2012.2559","article-title":"Potential Efficacy of Broccoli Sprouts as a Unique Supplement for Management of Type 2 Diabetes and Its Complications","volume":"16","author":"Bahadoran","year":"2013","journal-title":"J. Med. Food"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"5615","DOI":"10.1021\/jf900549c","article-title":"Modulation of Phase II Enzymes by Sulforaphane: Implications for Its Cardioprotective Potential","volume":"57","author":"Angeloni","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5743","DOI":"10.1021\/jf010809a","article-title":"Comparison of the bioactivity of two glucoraphanin hydrolysis products found in broccoli, sulforaphane and sulforaphane nitrile","volume":"49","author":"Matusheski","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1270\/jsbbs.64.48","article-title":"Glucosinolate metabolism, functionality and breeding for the improvement of Brassicaceae vegetables","volume":"64","author":"Ishida","year":"2014","journal-title":"Breed Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s12272-020-01225-2","article-title":"Sulforaphane as an anticancer molecule: Mechanisms of action, synergistic effects, enhancement of drug safety, and delivery systems","volume":"43","author":"Kamal","year":"2020","journal-title":"Arch. Pharm. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1038\/s41416-020-1025-1","article-title":"Broccoli extract increases drug-mediated cytotoxicity towards cancer stem cells of head and neck squamous cell carcinoma","volume":"123","author":"Elkashty","year":"2020","journal-title":"Br. J. Cancer"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41523-022-00402-4","article-title":"Sulforaphane suppresses metastasis of triple-negative breast cancer cells by targeting the RAF\/MEK\/ERK pathway","volume":"8","author":"Zhang","year":"2022","journal-title":"NPJ Breast Cancer"},{"key":"ref_47","unstructured":"Schnekenburger, M., and Diederich, M. (2015). Epigenetic Cancer Therapy, Elsevier."},{"key":"ref_48","unstructured":"Derkay, C.S., and Faust, R.A. (2015). Cummings Pediatric Otolaryngology, Elsevier."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1007\/s12291-013-0375-3","article-title":"Vitamin C in disease prevention and cure: An overview","volume":"28","author":"Chambial","year":"2013","journal-title":"Indian J. Clin. Biochem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"89","DOI":"10.59566\/IJBS.2008.4089","article-title":"Free radicals, antioxidants in disease and health","volume":"4","author":"He","year":"2008","journal-title":"Int. J. Biomed. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4103\/0973-7847.194044","article-title":"Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid","volume":"10","author":"Arulmoli","year":"2016","journal-title":"Pharmacogn. Rev."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.1007\/s13197-019-03952-x","article-title":"The importance of antioxidants and place in today\u2019s scientific and technological studies","volume":"56","author":"Zehiroglu","year":"2019","journal-title":"J. Food Sci. Technol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Soundararajan, P., and Kim, J.S. (2018). Anti-Carcinogenic Glucosinolates in Cruciferous Vegetables and Their Antagonistic Effects on Prevention of Cancers. Molecules, 23.","DOI":"10.3390\/molecules23112983"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"767975","DOI":"10.3389\/fphar.2021.767975","article-title":"Glucosinolates from Cruciferous Vegetables and Their Potential Role in Chronic Disease: Investigating the Preclinical and Clinical Evidence","volume":"12","author":"Connolly","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Kamal, R.M., Abdull Razis, A.F., Mohd Sukri, N.S., Perimal, E.K., Ahmad, H., Patrick, R., Djedaini-Pilard, F., Mazzon, E., and Rigaud, S. (2022). Beneficial Health Effects of Glucosinolates-Derived Isothiocyanates on Cardiovascular and Neurodegenerative Diseases. Molecules, 27.","DOI":"10.3390\/molecules27030624"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Mitsiogianni, M., Koutsidis, G., Mavroudis, N., Trafalis, D.T., Botaitis, S., Franco, R., Zoumpourlis, V., Amery, T., Galanis, A., and Pappa, A. (2019). The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents. Antioxidants, 8.","DOI":"10.3390\/antiox8040106"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3390\/nu5041169","article-title":"Dietary Sources of Lutein and Zeaxanthin Carotenoids and Their Role in Eye Health","volume":"5","author":"Akhtar","year":"2013","journal-title":"Nutrients"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Crupi, P., Faienza, M.F., Naeem, M.Y., Corbo, F., Clodoveo, M.L., and Muraglia, M. (2023). Overview of the Potential Beneficial Effects of Carotenoids on Consumer Health and Well-Being. Antioxidants, 12.","DOI":"10.3390\/antiox12051069"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Kieliszek, M. (2019). Selenium\u2013Fascinating Microelement, Properties and Sources in Food. Molecules, 24.","DOI":"10.3390\/molecules24071298"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s10787-020-00690-x","article-title":"Selenium and selenoproteins: It\u2019s role in regulation of inflammation","volume":"28","author":"Hariharan","year":"2020","journal-title":"Inflammopharmacology"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"He, W.-J., Lv, C.-H., Chen, Z., Shi, M., Zeng, C.-X., Hou, D.-X., and Qin, S. (2023). The Regulatory Effect of Phytochemicals on Chronic Diseases by Targeting Nrf2-ARE Signaling Pathway. Antioxidants, 12.","DOI":"10.3390\/antiox12020236"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Ponnampalam, E.N., Kiani, A., Santhiravel, S., Holman, B.W.B., Lauridsen, C., and Dunshea, F.R. (2022). The importance of dietary antioxidants on oxidative stress, meat and milk production, and their preservative aspects in farm animals: Antioxidant action, animal health, and product quality\u2014Invited review. Animals, 12.","DOI":"10.3390\/ani12233279"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Manso, T., Lores, M., and de Miguel, T. (2022). Antimicrobial Activity of Polyphenols and Natural Polyphenolic Extracts on Clinical Isolates. Antibiotics, 11.","DOI":"10.3390\/antibiotics11010046"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Wang, X., Qi, Y., and Zheng, H. (2022). Dietary Polyphenol, Gut Microbiota, and Health Benefits. Antioxidants, 11.","DOI":"10.3390\/antiox11061212"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"460","DOI":"10.3390\/futurepharmacol2040030","article-title":"Preventing microbial infections with natural phenolic compounds","volume":"2","author":"Ecevit","year":"2022","journal-title":"Future Pharmacol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Herb, M., and Schramm, M. (2021). Functions of ROS in Macrophages and Antimicrobial Immunity. Antioxidants, 10.","DOI":"10.3390\/antiox10020313"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Juan, C.A., P\u00e9rez de la Lastra, J.M., Plou, F.J., and P\u00e9rez-Lebe\u00f1a, E. (2021). The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094642"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Bardel\u010d\u00edkov\u00e1, A., \u0160oltys, J., and Moj\u017ei\u0161, J. (2023). Oxidative Stress, Inflammation and Colorectal Cancer: An Overview. Antioxidants, 12.","DOI":"10.3390\/antiox12040901"},{"key":"ref_69","first-page":"5793817","article-title":"The Influence of Reactive Oxygen Species in the Immune System and Pathogenesis of Multiple Sclerosis","volume":"2020","author":"Tavassolifar","year":"2020","journal-title":"Autoimmune Dis."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Be\u0161lo, D., Golubi\u0107, N., Rastija, V., Agi\u0107, D., Karna\u0161, M., \u0160ubari\u0107, D., and Lu\u010di\u0107, B. (2023). Antioxidant Activity, Metabolism, and Bioavailability of Polyphenols in the Diet of Animals. Antioxidants, 12.","DOI":"10.3390\/antiox12061141"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"2716870","DOI":"10.1155\/2019\/2716870","article-title":"Sulforaphane: Its \u201cComing of Age\u201d as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease","volume":"2019","author":"Houghton","year":"2019","journal-title":"Oxidative Med. Cell Longev."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1055\/s-2008-1074520","article-title":"Growth inhibition of a spectrum of bacterial and fungal pathogens by sulforaphane, an isothiocyanate product found in broccoli and other cruciferous vegetables","volume":"74","author":"Johansson","year":"2008","journal-title":"Planta Med."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"T\u0159\u00edska, J., Bal\u00edk, J., Hou\u0161ka, M., Novotn\u00e1, P., Magner, M., Vrchotov\u00e1, N., H\u00edc, P., J\u00edlek, L., Thorov\u00e1, K., and \u0160nurkovi\u010d, P. (2021). Factors Influencing Sulforaphane Content in Broccoli Sprouts and Subsequent Sulforaphane Extraction. Foods, 10.","DOI":"10.3390\/foods10081927"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Golberg, K., Markus, V., Kagan, B.-e., Barzanizan, S., Yaniv, K., Teral\u0131, K., Kramarsky-Winter, E., Marks, R.S., and Kushmaro, A. (2022). Anti-Virulence Activity of 3,3\u2032-Diindolylmethane (DIM): A Bioactive Cruciferous Phytochemical with Accelerated Wound Healing Benefits. 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