{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:54:33Z","timestamp":1790117673668,"version":"4.0.1"},"reference-count":11,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001823","name":"M\u0160MT","doi-asserted-by":"publisher","award":["MUNI\/A\/1336\/2022"],"award-info":[{"award-number":["MUNI\/A\/1336\/2022"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001823","name":"M\u0160MT","doi-asserted-by":"publisher","award":["65269705"],"award-info":[{"award-number":["65269705"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MH CZ-DRO FNBr","award":["MUNI\/A\/1336\/2022"],"award-info":[{"award-number":["MUNI\/A\/1336\/2022"]}]},{"name":"MH CZ-DRO FNBr","award":["65269705"],"award-info":[{"award-number":["65269705"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Mucormycosis is an opportunistic infection affecting mainly immunocompromised hosts. Infection in immunocompetent patients is rare, but may occur typically in trauma or burn victims. We report on a previously healthy young man suffering devastating trauma from an agricultural accident with the subsequent development of a multifocal mucormycosis. Diagnosis was achieved by cultures obtained from non-healing wounds, some of them even covered by a macroscopic mold formation. Specific treatment was initiated soon after the preliminary results indicated mucormycosis. Aggressive surgical therapy, with concomitant use of systemic posaconazole and topical amphotericin B in a combination treatment, led to the elimination of the fungal infection. The remaining deep tissue defects were consequently reconstructed by a muscle flap and skin graft autotransplantation with a good overall outcome, which would not have been possible without the complete remission of mucormycosis. This case study presents the successful use of a combination treatment with systemic posaconazole and topical amphotericin B and underlines the importance of timely and aggressive surgical therapy.<\/jats:p>","DOI":"10.3390\/antibiotics12101489","type":"journal-article","created":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T01:42:12Z","timestamp":1695865332000},"page":"1489","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Mucormycosis in a Severe Trauma Patient Treated with a Combination of Systemic Posaconazole and Topical Amphotericin B\u2014Case Report"],"prefix":"10.3390","volume":"12","author":[{"given":"Filip","family":"Keller","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Masaryk University and University Hospital, 625 00 Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Antoni","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Masaryk University and University Hospital, 625 00 Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Minarcikova","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Masaryk University and University Hospital, 625 00 Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9364-5470","authenticated-orcid":false,"given":"Ondrej","family":"Hrdy","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Masaryk University and University Hospital, 625 00 Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Gal","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine, Masaryk University and University Hospital, 625 00 Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/mmy\/myx101","article-title":"Challenges in the diagnosis and treatment of mucormycosis","volume":"56","author":"Skiada","year":"2018","journal-title":"Med. Mycol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/j.burns.2014.03.013","article-title":"Mucormycosis attributed mortality: A seven-year review of surgical and medical management","volume":"408","author":"Mitchell","year":"2014","journal-title":"Burns"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.burns.2022.05.012","article-title":"Mucormycosis following burn injuries: A systematic review","volume":"49","author":"Dang","year":"2023","journal-title":"Burns"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1093\/cid\/cir866","article-title":"Epidemiology and clinical manifestations of mucormycosis","volume":"54","author":"Petrikkos","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e405","DOI":"10.1016\/S1473-3099(19)30312-3","article-title":"Global guideline for the diagnosis and management of mucormycosis: An initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium","volume":"19","author":"Cornely","year":"2019","journal-title":"Lancet Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Akers, K.S., Rowan, M.P., Niece, K.L., Graybill, J.C., Mende, K., Chung, K.K., and Murray, C.K. (2015). Antifungal wound penetration of amphotericin and voriconazole in combat-related injuries: Case report. BMC Infect. Dis., 15.","DOI":"10.1186\/s12879-015-0918-8"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Borman, A.M., Fraser, M., Patterson, Z., Palmer, M.D., and Johnson, E.M. (2021). In Vitro Antifungal Drug Resistance Profiles of Clinically Relevant Members of the Mucorales (Mucoromycota) Especially with the Newer Triazoles. J. Fungi, 2.","DOI":"10.3390\/jof7040271"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/jac\/49.suppl_1.37","article-title":"Amphotericin B nephrotoxicity","volume":"49","author":"Deray","year":"2002","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"101007","DOI":"10.1016\/j.mycmed.2020.101007","article-title":"Mucormycosis treatment: Recommendations, latest advances, and perspectives","volume":"30","author":"Brunet","year":"2020","journal-title":"J. Mycol. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/S1473-3099(16)00071-2","article-title":"VITAL and FungiScope Mucormycosis Investigators. Isavuconazole treatment for mucormycosis: A single-arm open-label trial and case-control analysis","volume":"16","author":"Marty","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.cmi.2016.03.029","article-title":"Initial use of combination treatment does not impact survival of 106 patients with haematologic malignancies and mucormycosis: A propensity score analysis","volume":"22","author":"Kyvernitakis","year":"2016","journal-title":"Clin. Microbiol. 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