{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:33:14Z","timestamp":1760149994222,"version":"build-2065373602"},"reference-count":44,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["307672\/2019","E-26\/210.875\/2016","E-26\/210.110\/2018","E-26\/211.554\/2019","E-26\/200.952\/2021","001","408725\/2022-2"],"award-info":[{"award-number":["307672\/2019","E-26\/210.875\/2016","E-26\/210.110\/2018","E-26\/211.554\/2019","E-26\/200.952\/2021","001","408725\/2022-2"]}]},{"name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Apoio \u00e0 Ci\u00eancia","award":["307672\/2019","E-26\/210.875\/2016","E-26\/210.110\/2018","E-26\/211.554\/2019","E-26\/200.952\/2021","001","408725\/2022-2"],"award-info":[{"award-number":["307672\/2019","E-26\/210.875\/2016","E-26\/210.110\/2018","E-26\/211.554\/2019","E-26\/200.952\/2021","001","408725\/2022-2"]}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)","award":["307672\/2019","E-26\/210.875\/2016","E-26\/210.110\/2018","E-26\/211.554\/2019","E-26\/200.952\/2021","001","408725\/2022-2"],"award-info":[{"award-number":["307672\/2019","E-26\/210.875\/2016","E-26\/210.110\/2018","E-26\/211.554\/2019","E-26\/200.952\/2021","001","408725\/2022-2"]}]},{"name":"CNPq\/MCTI\/CT-Sa\u00fade","award":["307672\/2019","E-26\/210.875\/2016","E-26\/210.110\/2018","E-26\/211.554\/2019","E-26\/200.952\/2021","001","408725\/2022-2"],"award-info":[{"award-number":["307672\/2019","E-26\/210.875\/2016","E-26\/210.110\/2018","E-26\/211.554\/2019","E-26\/200.952\/2021","001","408725\/2022-2"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Streptococcus pyogenes is known to be associated with a variety of infections, from pharyngitis to necrotizing fasciitis (flesh-eating disease). S. pyogenes of the ST62\/emm87 lineage is recognized as one of the most frequently isolated lineages of invasive infections caused by this bacterium, which may be involved in hospital outbreaks and cluster infections. Despite this, comparative genomic and phylogenomic studies have not yet been carried out for this lineage. Thus, its virulence and antimicrobial susceptibility profiles are mostly unknown, as are the genetic relationships and evolutionary traits involving this lineage. Previously, a strain of S. pyogenes ST62\/emm87 (37\u201397) was characterized in our lab for its ability to generate antibiotic-persistent cells, and therapeutic failure in severe invasive infections caused by this bacterial species is well-reported in the scientific literature. In this work, we analyzed genomic and phylogenomic characteristics and evaluated the virulence and resistance profiles of ST62\/emm87 S. pyogenes from Brazil and international sources. Here we show that strains that form this lineage (ST62\/emm87) are internationally spread, involved in invasive outbreaks, and share important virulence profiles with the most common emm types of S. pyogenes, such as emm1, emm3, emm12, and emm69, which are associated with most invasive infections caused by this bacterial species in the USA and Europe. Accordingly, the continued increase of ST62\/emm87 in severe S. pyogenes diseases should not be underestimated.<\/jats:p>","DOI":"10.3390\/antibiotics12101530","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T08:07:12Z","timestamp":1697011632000},"page":"1530","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Streptococcus pyogenes Lineage ST62\/emm87: The International Spread of This Potentially Invasive Lineage"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8637-6110","authenticated-orcid":false,"given":"Caroline Lopes","family":"Martini","sequence":"first","affiliation":[{"name":"Departamento de Microbiologia M\u00e9dica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5540-5740","authenticated-orcid":false,"given":"Deborah Nascimento Santos","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia M\u00e9dica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice Slotfeldt","family":"Viana","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia M\u00e9dica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul Joseph","family":"Planet","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA"},{"name":"Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8229-6957","authenticated-orcid":false,"given":"Agnes Marie S\u00e1","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia M\u00e9dica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil"},{"name":"Programa de P\u00f3s-gradua\u00e7\u00e3o em Patologia, Faculdade de Medicina, Universidade Federal, Fluminense, Niter\u00f3i 24220-900, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernadete Teixeira","family":"Ferreira-Carvalho","sequence":"additional","affiliation":[{"name":"Departamento de Microbiologia M\u00e9dica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"201991","DOI":"10.1098\/rsos.201991","article-title":"A brief review on Group A Streptococcus pathogenesis and vaccine development","volume":"8","author":"Castro","year":"2021","journal-title":"R. 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