{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:25:30Z","timestamp":1793384730235,"version":"4.5.0"},"reference-count":147,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T00:00:00Z","timestamp":1701648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>The skin microbiome is crucial in maintaining skin health, and its disruption is associated with various skin diseases. Prebiotics are non-digestible fibers and compounds found in certain foods that promote the activity and growth of beneficial bacteria in the gut or skin. On the other hand, live microorganisms, known as probiotics, benefit in sustaining healthy conditions when consumed in reasonable quantities. They differ from postbiotics, which are by-product compounds from bacteria that release the same effects as their parent bacteria. The human skin microbiome is vital when it comes to maintaining skin health and preventing a variety of dermatological conditions. This review explores novel strategies that use microbiome-targeted treatments to maintain and enhance overall skin health while managing various skin disorders. It is important to understand the dynamic relationship between these beneficial microorganisms and the diverse microbial communities present on the skin to create effective strategies for using probiotics on the skin. This understanding can help optimize formulations and treatment regimens for improved outcomes in skincare, particularly in developing solutions for various skin problems.<\/jats:p>","DOI":"10.3390\/antibiotics12121698","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T12:15:14Z","timestamp":1701692114000},"page":"1698","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Innovative Approaches for Maintaining and Enhancing Skin Health and Managing Skin Diseases through Microbiome-Targeted Strategies"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6494-4447","authenticated-orcid":false,"given":"Khadeejeh","family":"AL-Smadi","sequence":"first","affiliation":[{"name":"Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vania Rodrigues","family":"Leite-Silva","sequence":"additional","affiliation":[{"name":"Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia"},{"name":"Departamento de Ci\u00eancias Farmac\u00eauticas, Instituto de Ci\u00eancias Ambientais, Qu\u00edmicas e Farmac\u00eauticas, Universidade Federal de S\u00e3o Paulo, UNIFESP-Diadema, Diadema CEP 09913-030, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Newton Andreo","family":"Filho","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Farmac\u00eauticas, Instituto de Ci\u00eancias Ambientais, Qu\u00edmicas e Farmac\u00eauticas, Universidade Federal de S\u00e3o Paulo, UNIFESP-Diadema, Diadema CEP 09913-030, SP, Brazil"},{"name":"School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1353-9825","authenticated-orcid":false,"given":"Patricia Santos","family":"Lopes","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Farmac\u00eauticas, Instituto de Ci\u00eancias Ambientais, Qu\u00edmicas e Farmac\u00eauticas, Universidade Federal de S\u00e3o Paulo, UNIFESP-Diadema, Diadema CEP 09913-030, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7825-7557","authenticated-orcid":false,"given":"Yousuf","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Frazer Institute, Faculty of Medicine, The University of Queensland, Brisbane, QLD 4102, Australia"},{"name":"School of Pharmacy, The University of Queensland, Brisbane, QLD 4102, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1111\/jdv.13965","article-title":"Microbiome in healthy skin, update for dermatologists","volume":"30","author":"Araviiskaia","year":"2016","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ni, Q., Zhang, P., Li, Q., and Han, Z. (2022). Oxidative Stress and Gut Microbiome in Inflammatory Skin Diseases. Front. Cell Dev. Biol., 10.","DOI":"10.3389\/fcell.2022.849985"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Lin, Y.-K., Yang, S.-C., Hsu, C.-Y., Sung, J.-T., and Fang, J.-Y. (2021). The antibiofilm nanosystems for improved infection inhibition of microbes in skin. Molecules, 26.","DOI":"10.3390\/molecules26216392"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"L\u00facio, M., Giannino, N., Barreira, S., Catita, J., Gon\u00e7alves, H., Ribeiro, A., Fernandes, E., Carvalho, I., Pinho, H., and Cerqueira, F. (2023). Nanostructured lipid carriers enriched hydrogels for skin topical administration of quercetin and omega-3 fatty acid. Pharmaceutics, 15.","DOI":"10.3390\/pharmaceutics15082078"},{"key":"ref_5","first-page":"84","article-title":"Solid lipid nanoparticles: A promising tool for drug delivery system","volume":"3","author":"Basu","year":"2010","journal-title":"J. Pharm. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"4299","DOI":"10.1021\/acs.biomac.8b01181","article-title":"Nanofibers with incorporated autochthonous bacteria as potential probiotics for local treatment of periodontal disease","volume":"19","author":"Rijavec","year":"2018","journal-title":"Biomacromolecules"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1021\/acsabm.8b00102","article-title":"Transdermal delivery of living and biofunctional probiotics through dissolvable microneedle patches","volume":"1","author":"Chen","year":"2018","journal-title":"ACS Appl. Bio Mater."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2102580","DOI":"10.1002\/adma.202102580","article-title":"Chemically and biologically engineered bacteria-based delivery systems for emerging diagnosis and advanced therapy","volume":"33","author":"Li","year":"2021","journal-title":"Adv. Mater."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1021\/mp200394t","article-title":"Nanomedicine (s) under the microscope","volume":"8","author":"Duncan","year":"2011","journal-title":"Mol. Pharm."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Nastiti, C.M.R.R., Ponto, T., Abd, E., Grice, J.E., Benson, H.A.E., and Roberts, M.S. (2017). Topical nano and microemulsions for skin delivery. Pharmaceutics, 9.","DOI":"10.3390\/pharmaceutics9040037"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1166\/jnn.2008.274","article-title":"New aspects of nanopharmaceutical delivery systems","volume":"8","author":"Marcato","year":"2008","journal-title":"J. Nanosci. Nanotechnol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jconrel.2012.12.013","article-title":"Biocompatibility of engineered nanoparticles for drug delivery","volume":"166","author":"Naahidi","year":"2013","journal-title":"J. Control. Release"},{"key":"ref_13","first-page":"3646","article-title":"Nanoparticle systems as tools to improve drug delivery and therapeutic efficacy","volume":"101","author":"Mishra","year":"2013","journal-title":"J. Biomed. Mater. Res. Part A Off. J. Soc. Biomater. Jpn. Soc. Biomater. Aust. Soc. Biomater. Korean Soc. Biomater."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.cocis.2005.06.004","article-title":"Nano-emulsions","volume":"10","author":"Solans","year":"2005","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.cocis.2012.07.003","article-title":"Nano-emulsions: Formation by low-energy methods","volume":"17","author":"Solans","year":"2012","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1021\/la052549n","article-title":"Thermally reversible pluronic\/heparin nanocapsules exhibiting 1000-fold volume transition","volume":"22","author":"Choi","year":"2006","journal-title":"Langmuir"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jconrel.2012.03.020","article-title":"Doxil\u00ae\u2014The first FDA-approved nano-drug: Lessons learned","volume":"160","author":"Barenholz","year":"2012","journal-title":"J. Control. Release"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Akinc, A., and Battaglia, G. (2013). Exploiting endocytosis for nanomedicines. Cold Spring Harb. Perspect. Biol., 5.","DOI":"10.1101\/cshperspect.a016980"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.1114397","article-title":"Toxic potential of materials at the nanolevel","volume":"311","author":"Nel","year":"2006","journal-title":"Science"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cmet.2016.06.004","article-title":"Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation","volume":"24","author":"Lampropoulou","year":"2016","journal-title":"Cell Metab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1080\/10715762.2017.1402303","article-title":"Levels of oxidative damage and proinflammatory cytokines are enhanced in patients with active vitiligo","volume":"51","author":"Mitra","year":"2017","journal-title":"Free Radic. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.7150\/thno.30398","article-title":"SIRT3-dependent mitochondrial dynamics remodeling contributes to oxidative stress-induced melanocyte degeneration in vitiligo","volume":"9","author":"Yi","year":"2019","journal-title":"Theranostics"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Iddir, M., Brito, A., Dingeo, G., Fernandez Del Campo, S.S., Samouda, H., La Frano, M.R., and Bohn, T. (2020). Strengthening the immune system and reducing inflammation and oxidative stress through diet and nutrition: Considerations during the COVID-19 crisis. Nutrients, 12.","DOI":"10.3390\/nu12061562"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"247","DOI":"10.5114\/pdia.2014.43497","article-title":"Current aspects of vitiligo genetics","volume":"31","author":"Czajkowski","year":"2014","journal-title":"Adv. Dermatol. Allergol.\/Post\u0119py Dermatol. I Alergol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1111\/j.1365-4632.2011.05377.x","article-title":"A review of the worldwide prevalence of vitiligo in children\/adolescents and adults","volume":"51","author":"Schallreuter","year":"2012","journal-title":"Int. J. Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1111\/j.1755-148X.2012.00997.x","article-title":"Revised classification\/nomenclature of vitiligo and related issues: The Vitiligo Global Issues Consensus Conference","volume":"25","author":"Ezzedine","year":"2012","journal-title":"Pigment Cell Melanoma Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1159\/000506103","article-title":"Vitiligo: A review","volume":"236","author":"Bergqvist","year":"2020","journal-title":"Dermatology"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Al-smadi, K., Imran, M., Leite-Silva, V.R., and Mohammed, Y. (2023). Vitiligo: A Review of Aetiology, Pathogenesis, Treatment, and Psychosocial Impact. Cosmetics, 10.","DOI":"10.3390\/cosmetics10030084"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1034\/j.1600-0749.2003.00032.x","article-title":"Epidemiology of vitiligo and associated autoimmune diseases in Caucasian probands and their families","volume":"16","author":"Alkhateeb","year":"2003","journal-title":"Pigment Cell Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1600-0749.2005.00242.x","article-title":"Early disease onset and increased risk of other autoimmune diseases in familial generalized vitiligo","volume":"18","author":"Laberge","year":"2005","journal-title":"Pigment Cell Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1365-2133.2012.11197.x","article-title":"Guidelines for the management of vitiligo: The European Dermatology Forum consensus","volume":"168","author":"Taieb","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1001\/jamadermatol.2019.0696","article-title":"Treatment outcomes of topical calcineurin inhibitor therapy for patients with vitiligo: A systematic review and meta-analysis","volume":"155","author":"Lee","year":"2019","journal-title":"JAMA Dermatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1468-3083.2009.03358.x","article-title":"Topical corticosteroids in psoriasis: Strategies for improving safety","volume":"24","author":"Horn","year":"2010","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1610-0387.2007.06280.x","article-title":"Current state of vitiligo therapy\u2013evidence-based analysis of the literature","volume":"5","author":"Forschner","year":"2007","journal-title":"JDDG J. Dtsch. Dermatol. Ges."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Al-Smadi, K., Ali, M., Alavi, S.E., Jin, X., Imran, M., Leite-Silva, V.R., and Mohammed, Y. (2023). Using a Topical Formulation of Vitamin D for the Treatment of Vitiligo: A Systematic Review. Cells, 12.","DOI":"10.3390\/cells12192387"},{"key":"ref_37","unstructured":"Klaassen, C.D. (2006). Goodman and Gilman\u2019s the Pharmacological Basis of Therapeutics, McGraw-Hill. [11th ed.]."},{"key":"ref_38","first-page":"1017","article-title":"Perspectives of new advances in the pathogenesis of vitiligo: From oxidative stress to autoimmunity","volume":"25","author":"Wang","year":"2019","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3899\/jrheum.180133","article-title":"The microbiome in psoriasis and psoriatic arthritis: The skin perspective","volume":"94","author":"Thio","year":"2018","journal-title":"J. Rheumatol. Suppl."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nrdp.2016.82","article-title":"Psoriasis (Primer)","volume":"2","author":"Greb","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.anai.2018.12.003","article-title":"The role of the skin microbiome in atopic dermatitis","volume":"122","author":"Nakatsuji","year":"2019","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s40257-019-00467-1","article-title":"The microbiome and atopic dermatitis: A review","volume":"20","author":"Pothmann","year":"2019","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"13","DOI":"10.53388\/life2021-0403-0315","article-title":"Research progress of microbiome and pathogenesis of vitiligo","volume":"4","author":"Chen","year":"2021","journal-title":"Life Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jaut.2019.01.008","article-title":"The microbiome and immunodeficiencies: Lessons from rare diseases","volume":"98","author":"Pellicciotta","year":"2019","journal-title":"J. Autoimmun."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.pmatsci.2011.10.001","article-title":"Current status and future prospects of nanotechnology in cosmetics","volume":"57","author":"Mihranyan","year":"2012","journal-title":"Prog. Mater. Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"150","DOI":"10.5021\/ad.2014.26.2.150","article-title":"Effect of emollients containing vegetable-derived lactobacillus in the treatment of atopic dermatitis symptoms: Split-body clinical trial","volume":"26","author":"Park","year":"2014","journal-title":"Ann. Dermatol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.jaip.2020.07.051","article-title":"The use of probiotics and bacteria-derived preparations in topical treatment of atopic dermatitis\u2014A systematic review","volume":"9","author":"Kunkiel","year":"2021","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"102437","DOI":"10.1016\/j.cis.2021.102437","article-title":"The emerging role of nanotechnology in skincare","volume":"293","author":"Salvioni","year":"2021","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Bekiaridou, A., Karlafti, E., Oikonomou, I.M., Ioannidis, A., and Papavramidis, T.S. (2021). Probiotics and their effect on surgical wound healing: A systematic review and new insights into the role of nanotechnology. Nutrients, 13.","DOI":"10.3390\/nu13124265"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s13205-012-0044-x","article-title":"The current trends and future perspectives of prebiotics research: A review","volume":"2","author":"Patel","year":"2012","journal-title":"3 Biotech"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/MCG.0b013e318269fdd5","article-title":"FAO\/WHO guidelines on probiotics: 10 years later","volume":"46","author":"Morelli","year":"2012","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_52","first-page":"1","article-title":"Probiotics: Their potential to impact human health","volume":"36","author":"Sanders","year":"2007","journal-title":"Counc. Agric. Sci. Technol. Issue Pap."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s13555-020-00476-7","article-title":"Topical probiotics in dermatological therapy and skincare: A concise review","volume":"11","year":"2021","journal-title":"Dermatol. Ther."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21926\/rpn.2202014","article-title":"The Potential Role of Commensal Microbes in Optimizing Nutrition Care Delivery and Nutrient Metabolism","volume":"2","author":"Swaby","year":"2022","journal-title":"Recent Prog. Nutr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.micinf.2019.06.004","article-title":"Beneficial microbiota. Probiotics and pharmaceutical products in functional nutrition and medicine","volume":"22","author":"Novik","year":"2020","journal-title":"Microbes Infect."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Gao, J., Li, Y., Wan, Y., Hu, T., Liu, L., Yang, S., Gong, Z., Zeng, Q., Wei, Y., and Yang, W. (2019). A novel postbiotic from Lactobacillus rhamnosus GG with a beneficial effect on intestinal barrier function. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.00477"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"5983","DOI":"10.1080\/10408398.2021.1895061","article-title":"The biological activities of postbiotics in gastrointestinal disorders","volume":"62","author":"Abbasi","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1146\/annurev-immunol-030409-101330","article-title":"Intestinal bacteria and the regulation of immune cell homeostasis","volume":"28","author":"Hill","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nri.2016.48","article-title":"The influence of skin microorganisms on cutaneous immunity","volume":"16","author":"Belkaid","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Boxberger, M., Cenizo, V., Cassir, N., and La Scola, B. (2021). Challenges in exploring and manipulating the human skin microbiome. Microbiome, 9.","DOI":"10.1186\/s40168-021-01062-5"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/mBio.02945-19","article-title":"Universal dermal microbiome in human skin","volume":"11","author":"Bay","year":"2020","journal-title":"MBio"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1038\/s41598-022-05244-5","article-title":"Skin microbiome profile of healthy Cameroonians and Japanese","volume":"12","author":"Ogai","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Lee, H.-J., and Kim, M. (2022). Skin barrier function and the microbiome. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232113071"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Wilson, M. (2018). The Human Microbiota in Health and Disease: An Ecological and Community-Based Approach, Garland Science.","DOI":"10.1201\/9781351068369"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"eaat6280","DOI":"10.1126\/science.aat6280","article-title":"Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury","volume":"363","author":"Harrison","year":"2019","journal-title":"Science"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Navarro-L\u00f3pez, V., N\u00fa\u00f1ez-Delegido, E., Ruzafa-Costas, B., S\u00e1nchez-Pellicer, P., Ag\u00fcera-Santos, J., and Navarro-Moratalla, L. (2021). Probiotics in the therapeutic arsenal of dermatologists. Microorganisms, 9.","DOI":"10.3390\/microorganisms9071513"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.1016\/j.ddmec.2012.12.003","article-title":"What lives on our skin: Ecology, genomics and therapeutic opportunities of the skin microbiome","volume":"10","author":"Scharschmidt","year":"2013","journal-title":"Drug Discov. Today Dis. Mech."},{"key":"ref_68","unstructured":"G\u00fcnther, J., and Seyfert, H.-M. (2018). Seminars in Immunopathology, Springer."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Nazir, Y., Hussain, S.A., Abdul Hamid, A., and Song, Y. (2018). Probiotics and their potential preventive and therapeutic role for cancer, high serum cholesterol, and allergic and HIV diseases. BioMed Res. Int., 2018.","DOI":"10.1155\/2018\/3428437"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/jid.2009.243","article-title":"Selective antimicrobial action is provided by phenol-soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skin","volume":"130","author":"Cogen","year":"2010","journal-title":"J. Investig. Dermatol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/jid.2010.276","article-title":"Urocanic acid in the skin: A mixed blessing?","volume":"131","author":"Gibbs","year":"2011","journal-title":"J. Investig. Dermatol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/ics.12594","article-title":"Revealing the secret life of skin-with the microbiome you never walk alone","volume":"42","author":"Sfriso","year":"2020","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.tim.2013.10.001","article-title":"Structure and function of the human skin microbiome","volume":"21","author":"Schommer","year":"2013","journal-title":"Trends Microbiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1111\/exd.14016","article-title":"Targeting the gut-skin axis\u2014Probiotics as new tools for skin disorder management?","volume":"28","author":"Antal","year":"2019","journal-title":"Exp. Dermatol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.addr.2020.02.001","article-title":"Advances and controversies in studying sunscreen delivery and toxicity","volume":"153","author":"Yamada","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1208\/s12248-016-9984-0","article-title":"Mechanistic evaluation of hydration effects on the human epidermal permeation of salicylate esters","volume":"19","author":"Yousef","year":"2017","journal-title":"AAPS J."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"957732","DOI":"10.3389\/fddev.2022.957732","article-title":"Recent advances and future prospective of topical and transdermal delivery systems","volume":"2","author":"Tapfumaneyi","year":"2022","journal-title":"Front. Drug Deliv."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1080\/10408398.2014.887055","article-title":"Probiotics, prebiotics, and microencapsulation: A review","volume":"57","author":"Sarao","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"eaah4680","DOI":"10.1126\/scitranslmed.aah4680","article-title":"Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis","volume":"9","author":"Nakatsuji","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Alekseyenko, A.V., Perez-Perez, G.I., De Souza, A., Strober, B., Gao, Z., Bihan, M., Li, K., Meth\u00e9, B.A., and Blaser, M.J. (2013). Community differentiation of the cutaneous microbiota in psoriasis. Microbiome, 1.","DOI":"10.1186\/2049-2618-1-31"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1038\/jid.2011.182","article-title":"Microbial symbiosis with the innate immune defense system of the skin","volume":"131","author":"Gallo","year":"2011","journal-title":"J. Investig. Dermatol."},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Chilicka, K., Dzie\u0144dziora-Urbi\u0144ska, I., Szygu\u0142a, R., Asanova, B., and Nowicka, D. (2022). Microbiome and probiotics in acne vulgaris\u2014A narrative review. Life, 12.","DOI":"10.3390\/life12030422"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Ni, Q., Ye, Z., Wang, Y., Chen, J., Zhang, W., Ma, C., Li, K., Liu, Y., Liu, L., and Han, Z. (2020). Gut microbial dysbiosis and plasma metabolic profile in individuals with vitiligo. Front. Microbiol., 11.","DOI":"10.3389\/fmicb.2020.592248"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"18761","DOI":"10.1038\/srep18761","article-title":"Microbial community profiling shows dysbiosis in the lesional skin of Vitiligo subjects","volume":"6","author":"Ganju","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.tim.2011.05.006","article-title":"Understanding the role of gut microbiome\u2013host metabolic signal disruption in health and disease","volume":"19","author":"Holmes","year":"2011","journal-title":"Trends Microbiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nrmicro2473","article-title":"Microbiota restoration: Natural and supplemented recovery of human microbial communities","volume":"9","author":"Reid","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"ps12","DOI":"10.1126\/scitranslmed.3001626","article-title":"Community health care: Therapeutic opportunities in the human microbiome","volume":"3","author":"Sonnenburg","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3945\/an.111.000604","article-title":"Structural bacterial molecules as potential candidates for an evolution of the classical concept of probiotics","volume":"2","author":"Caselli","year":"2011","journal-title":"Adv. Nutr."},{"key":"ref_89","first-page":"145","article-title":"Modern condition and prospective host microecology investigations","volume":"19","author":"Shenderov","year":"2007","journal-title":"Microb. Ecol. Health Dis."},{"key":"ref_90","first-page":"20399","article-title":"Metabiotics: Novel idea or natural development of probiotic conception","volume":"24","author":"Shenderov","year":"2013","journal-title":"Microb. Ecol. Health Dis."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/s41586-019-1291-3","article-title":"Mapping human microbiome drug metabolism by gut bacteria and their genes","volume":"570","author":"Zimmermann","year":"2019","journal-title":"Nature"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nature24661","article-title":"A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites","volume":"551","author":"Dodd","year":"2017","journal-title":"Nature"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41579-020-0433-9","article-title":"Gut microbiota in human metabolic health and disease","volume":"19","author":"Fan","year":"2021","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2013.12.015","article-title":"The role of microbiome in central nervous system disorders","volume":"38","author":"Wang","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1046\/j.0022-202x.2001.00039.x","article-title":"Microbial ecology of human skin in health and disease","volume":"6","author":"Fredricks","year":"2001","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nrmicro.2017.157","article-title":"The human skin microbiome","volume":"16","author":"Byrd","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Foulongne, V., Sauvage, V., Hebert, C., Dereure, O., Cheval, J., Gouilh, M.A., Pariente, K., Segondy, M., Burgui\u00e8re, A., and Manuguerra, J.-C. (2012). Human skin microbiota: High diversity of DNA viruses identified on the human skin by high throughput sequencing. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0038499"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3920\/BM2012.0062","article-title":"Bacterial skin commensals and their role as host guardians","volume":"5","author":"Christensen","year":"2014","journal-title":"Benef. Microbes."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/APO.0000000000000330","article-title":"Ocular surface microbiome in health and disease","volume":"9","author":"Gomes","year":"2020","journal-title":"Asia-Pac. J. Ophthalmol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"13030","DOI":"10.5070\/D3255044062","article-title":"Topical probiotics: The unknowns behind their rising popularity","volume":"25","author":"Lee","year":"2019","journal-title":"Dermatol. Online J."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Boyajian, J.L., Ghebretatios, M., Schaly, S., Islam, P., and Prakash, S. (2021). Microbiome and human aging: Probiotic and prebiotic potentials in longevity, skin health and cellular senescence. Nutrients, 13.","DOI":"10.3390\/nu13124550"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.clinthera.2015.04.002","article-title":"Gut-microbiota-brain axis and its effect on neuropsychiatric disorders with suspected immune dysregulation","volume":"37","author":"Petra","year":"2015","journal-title":"Clin. Ther."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1016\/j.jid.2021.01.036","article-title":"Analysis of matched skin and gut microbiome of patients with vitiligo reveals deep skin dysbiosis: Link with mitochondrial and immune changes","volume":"141","author":"Bzioueche","year":"2021","journal-title":"J. Investig. Dermatol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1038\/s41467-019-09963-8","article-title":"Innate lymphocyte-induced CXCR3B-mediated melanocyte apoptosis is a potential initiator of T-cell autoreactivity in vitiligo","volume":"10","author":"Tulic","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.jid.2019.08.435","article-title":"Antibiotics drive microbial imbalance and vitiligo development in mice","volume":"140","author":"Dellacecca","year":"2020","journal-title":"J. Investig. Dermatol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3920\/BM2013.0040","article-title":"Impact of prebiotics and probiotics on skin health","volume":"5","author":"Tester","year":"2014","journal-title":"Benef. Microbes."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Wallen-Russell, C., and Wallen-Russell, S. (2021). Topical Probiotics Do Not Satisfy New Criteria for Effective Use Due to Insufficient Skin Microbiome Knowledge. Cosmetics, 8.","DOI":"10.3390\/cosmetics8030090"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Renuka, S.R., Kumar, N.A., Manoharan, D., and Naidu, D.K. (2023). Probiotics: A Review on Microbiome That Helps for Better Health\u2013A Dermatologist\u2019s Perspective. J. Pharmacol. Pharmacother., 0976500X231175225.","DOI":"10.1177\/0976500X231175225"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.nut.2015.09.001","article-title":"Probiotics in dermatologic practice","volume":"32","author":"Sriram","year":"2016","journal-title":"Nutrition"},{"key":"ref_110","first-page":"30","article-title":"Cosmetics: The next microbiome frontier","volume":"95","author":"Reisch","year":"2017","journal-title":"Mitsui Chem. Catal. Sci. Award"},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Vinderola, G., Sanders, M.E., and Salminen, S. (2022). The concept of postbiotics. Foods, 11.","DOI":"10.3390\/foods11081077"},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Zommiti, M., Feuilloley, M.G.J., and Connil, N. (2020). Update of probiotics in human world: A nonstop source of benefactions till the end of time. Microorganisms, 8.","DOI":"10.3390\/microorganisms8121907"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000069031","article-title":"Bifidobacterium-fermented soy milk extract stimulates hyaluronic acid production in human skin cells and hairless mouse skin","volume":"16","author":"Miyazaki","year":"2003","journal-title":"Ski. Pharmacol. Physiol."},{"key":"ref_114","first-page":"473","article-title":"Topical application of Bifidobacterium-fermented soy milk extract containing genistein and daidzein improves rheological and physiological properties of skin","volume":"55","author":"Miyazaki","year":"2004","journal-title":"J. Cosmet. Sci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1017\/S0007114510003363","article-title":"Prebiotic effects: Metabolic and health benefits","volume":"104","author":"Roberfroid","year":"2010","journal-title":"Br. J. Nutr."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/MOG.0000000000000151","article-title":"Prebiotics, probiotics, synbiotics, and the immune system: Experimental data and clinical evidence","volume":"31","author":"Frei","year":"2015","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"eaaz8631","DOI":"10.1126\/scitranslmed.aaz8631","article-title":"Therapeutic responses to Roseomonas mucosa in atopic dermatitis may involve lipid-mediated TNF-related epithelial repair","volume":"12","author":"Myles","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"ref_118","unstructured":"Chaudhry, A., Rabiee, B., Festok, M., Gaspari, M., and Chaudhry, A. (2022). Combination of Topical Tacrolimus, Antioxidants, and Probiotics in the Treatment of Periorbital Vitiligo, Trinity Health Mid-Atlantic, Nazareth Hospital, Department of Ophthalmology. Available online: https:\/\/scholarcommons.towerhealth.org\/cgi\/viewcontent.cgi?article=1008&context=schc_researchday."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Podrini, C., Schramm, L., Marianantoni, G., Apolinarska, J., McGuckin, C., Forraz, N., Milet, C., Desroches, A.-L., Payen, P., and D\u2019Aguanno, M. (2023). Topical Administration of Lactiplantibacillus plantarum (SkinDuoTM) Serum Improves Anti-Acne Properties. Microorganisms, 11.","DOI":"10.3390\/microorganisms11020417"},{"key":"ref_120","unstructured":"Simmering, R., and Breves, R. (2010). Nutrition for Healthy Skin: Strategies for Clinical and Cosmetic Practice, Springer."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"7535","DOI":"10.2147\/IJN.S337427","article-title":"Advancements in the pharmaceutical applications of probiotics: Dosage forms and formulation technology","volume":"16","author":"Baral","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Vargason, A.M., and Anselmo, A.C. (2021). Live biotherapeutic products and probiotics for the skin. Adv. NanoBiomed Res., 1.","DOI":"10.1002\/anbr.202100118"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s11095-022-03245-7","article-title":"Application of confocal Raman microscopy for the characterization of topical semisolid formulations and their penetration into human skin ex vivo","volume":"39","author":"Jung","year":"2022","journal-title":"Pharm. Res."},{"key":"ref_124","first-page":"202","article-title":"Bacterial probiotics their importances and limitations: A review","volume":"4","author":"Ayichew","year":"2017","journal-title":"J. Nutr. Health Sci."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"4549134","DOI":"10.1155\/2022\/4549134","article-title":"The Efficacy of Lactocare\u00ae Synbiotic on the Clinical Symptoms in Patients with Psoriasis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial","volume":"2022","author":"Akbarzadeh","year":"2022","journal-title":"Dermatol. Res. Pract."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2200127","DOI":"10.1002\/mnfr.202200127","article-title":"Olive-Derived Antioxidant Dietary Fiber Modulates Gut Microbiota Composition and Attenuates Atopic Dermatitis Like Inflammation in Mice","volume":"67","author":"Lee","year":"2023","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"8957","DOI":"10.1073\/pnas.1332765100","article-title":"Functional and comparative genomic analyses of an operon involved in fructooligosaccharide utilization by Lactobacillus acidophilus","volume":"100","author":"Barrangou","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1146\/annurev-food-022814-015706","article-title":"Genetic mechanisms of prebiotic oligosaccharide metabolism in probiotic microbes","volume":"6","author":"Goh","year":"2015","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1152\/physrev.2001.81.3.1031","article-title":"Short-chain fatty acids and human colonic function: Roles of resistant starch and nonstarch polysaccharides","volume":"81","author":"Topping","year":"2001","journal-title":"Physiol. Rev."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1039\/C5FO01459J","article-title":"Prebiotics as functional food ingredients preventing diet-related diseases","volume":"7","author":"Florowska","year":"2016","journal-title":"Food Funct."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/jn\/129.1.113","article-title":"Short-chain fructo-oligosaccharide administration dose-dependently increases fecal Bifidobacteria in healthy humans","volume":"129","author":"Bouhnik","year":"1999","journal-title":"J. Nutr."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/jam.13506","article-title":"Skin resistance to UVB-induced oxidative stress and hyperpigmentation by the topical use of Lactobacillus helveticus NS8-fermented milk supernatant","volume":"123","author":"Rong","year":"2017","journal-title":"J. Appl. Microbiol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"8577116","DOI":"10.1155\/2021\/8577116","article-title":"A novel effective formulation of bioactive compounds for wound healing: Preparation, in vivo characterization, and comparison of various postbiotics cold creams in a rat model","volume":"2021","author":"Golkar","year":"2021","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"108","DOI":"10.5455\/medarh.2022.76.108-114","article-title":"The moisturizing efficacy of a proprietary dermo-cosmetic product (cls02021) versus placebo in a 4-week application period","volume":"76","author":"Catic","year":"2022","journal-title":"Med. Arch."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1177\/039463200802100115","article-title":"Increase of skin-ceramide levels in aged subjects following a short-term topical application of bacterial sphingomyelinase from Streptococcus thermophilus","volume":"21","author":"Dimarzio","year":"2008","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"104244","DOI":"10.1016\/j.jff.2020.104244","article-title":"Effect of paraprobiotic prepared from Kimchi-derived Lactobacillus plantarum K8 on skin moisturizing activity in human keratinocyte","volume":"75","author":"Kim","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"1064460","DOI":"10.3389\/fmed.2022.1064460","article-title":"A pilot study on the efficacy of topical lotion containing anti-acne postbiotic in subjects with mild-to-moderate acne","volume":"9","author":"Cui","year":"2022","journal-title":"Front. Med."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Gueniche, A., Liboutet, M., Cheilian, S., Fagot, D., Juchaux, F., and Breton, L. (2021). Vitreoscilla filiformis extract for topical skin care: A review. Front. Cell. Infect. Microbiol., 11.","DOI":"10.3389\/fcimb.2021.747663"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Majeed, M., Majeed, S., Nagabhushanam, K., Mundkur, L., Rajalakshmi, H.R., Shah, K., and Beede, K. (2020). Novel topical application of a postbiotic, LactoSporin\u00ae, in mild to moderate acne: A randomized, comparative clinical study to evaluate its efficacy, tolerability and safety. Cosmetics, 7.","DOI":"10.3390\/cosmetics7030070"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"667","DOI":"10.4103\/ijd.ijd_655_22","article-title":"Development of novel topical anti-acne cream containing postbiotics for mild-to-moderate acne: An observational study to evaluate its efficacy","volume":"67","author":"Cui","year":"2022","journal-title":"Indian J. Dermatol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/ics.12850","article-title":"Clinical evaluation of paraprobiotic-associated Bifidobacterium lactis CCT 7858 anti-dandruff shampoo efficacy: A randomized placebo-controlled clinical trial","volume":"45","author":"Rossetto","year":"2023","journal-title":"Int. J. Cosmet. Sci."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s13555-020-00369-9","article-title":"Efficacy of postbiotics in a PRP-like cosmetic product for the treatment of alopecia area Celsi: A randomized double-blinded parallel-group study","volume":"10","author":"Rinaldi","year":"2020","journal-title":"Dermatol. Ther."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1365-2133.2008.08437.x","article-title":"Skin microbiota: A source of disease or defence?","volume":"158","author":"Cogen","year":"2008","journal-title":"Br. J. Dermatol."},{"key":"ref_144","doi-asserted-by":"crossref","unstructured":"Mousa, W.K., Chehadeh, F., and Husband, S. (2022). Recent advances in understanding the structure and function of the human microbiome. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.825338"},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Gueniche, A., Perin, O., Bouslimani, A., Landemaine, L., Misra, N., Cupferman, S., Aguilar, L., Clavaud, C., Chopra, T., and Khodr, A. (2022). Advances in microbiome-derived solutions and methodologies are founding a new era in skin health and care. Pathogens, 11.","DOI":"10.3390\/pathogens11020121"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2165\/00128071-200203070-00001","article-title":"Cosmetics: What is their influence on the skin microflora?","volume":"3","author":"Holland","year":"2002","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"112859","DOI":"10.1016\/j.lwt.2021.112859","article-title":"The effect of unit operation and adjunct probiotic culture on physicochemical, biochemical, and textural properties of Dutch Edam cheese","volume":"155","author":"Amiri","year":"2022","journal-title":"Lebensm.-Wiss. Technol."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/12\/12\/1698\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:37:51Z","timestamp":1760132271000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/12\/12\/1698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,4]]},"references-count":147,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["antibiotics12121698"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics12121698","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,4]]}}}