{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:12:12Z","timestamp":1790194332901,"version":"4.1.0"},"reference-count":60,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Federal Institute for Risk Assessment (BfR)","award":["1322-648"],"award-info":[{"award-number":["1322-648"]}]},{"name":"German Federal Institute for Risk Assessment (BfR)","award":["1322-820"],"award-info":[{"award-number":["1322-820"]}]},{"name":"German Federal Institute for Risk Assessment (BfR)","award":["01KI2302A"],"award-info":[{"award-number":["01KI2302A"]}]},{"name":"German Federal Institute for Risk Assessment (BfR)","award":["ED481B-2021-006"],"award-info":[{"award-number":["ED481B-2021-006"]}]},{"name":"BfR","award":["1322-648"],"award-info":[{"award-number":["1322-648"]}]},{"name":"BfR","award":["1322-820"],"award-info":[{"award-number":["1322-820"]}]},{"name":"BfR","award":["01KI2302A"],"award-info":[{"award-number":["01KI2302A"]}]},{"name":"BfR","award":["ED481B-2021-006"],"award-info":[{"award-number":["ED481B-2021-006"]}]},{"name":"European Joint Programme (EJP projects: FULL_FORCE)","award":["1322-648"],"award-info":[{"award-number":["1322-648"]}]},{"name":"European Joint Programme (EJP projects: FULL_FORCE)","award":["1322-820"],"award-info":[{"award-number":["1322-820"]}]},{"name":"European Joint Programme (EJP projects: FULL_FORCE)","award":["01KI2302A"],"award-info":[{"award-number":["01KI2302A"]}]},{"name":"European Joint Programme (EJP projects: FULL_FORCE)","award":["ED481B-2021-006"],"award-info":[{"award-number":["ED481B-2021-006"]}]},{"name":"Conseller\u00eda de Cultura, Educaci\u00f3n e Ordenaci\u00f3n Universitaria","award":["1322-648"],"award-info":[{"award-number":["1322-648"]}]},{"name":"Conseller\u00eda de Cultura, Educaci\u00f3n e Ordenaci\u00f3n Universitaria","award":["1322-820"],"award-info":[{"award-number":["1322-820"]}]},{"name":"Conseller\u00eda de Cultura, Educaci\u00f3n e Ordenaci\u00f3n Universitaria","award":["01KI2302A"],"award-info":[{"award-number":["01KI2302A"]}]},{"name":"Conseller\u00eda de Cultura, Educaci\u00f3n e Ordenaci\u00f3n Universitaria","award":["ED481B-2021-006"],"award-info":[{"award-number":["ED481B-2021-006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>The interrelationship between human, animal and environmental sectors leads to the spread of antibiotic resistance due to selective pressures, evolutionary traits and genomic evolution. In particular, the frequent use of antibiotics in livestock inevitably influences the emergence of specific resistance determinants in human strains, associated with reduced treatment options in clinical therapy. In this study, ESBL-producing Klebsiella pneumoniae strains isolated from chicken meat samples were evaluated for public health implications in T\u00fcrkiye. Whole-genome sequencing was used for genetic dissection and phylogenetic comparison of their genomes. The isolates were assigned to four MLST types (ST147, ST37, ST2747 and ST219); two of them were found to represent the ST147 clone associated with severe human infections worldwide. In addition to cephalosporins, high resistance levels to quinolones\/fluoroquinolones were identified phenotypically, caused by acquired resistance genes and chromosomal point variations. One isolate was also found to carry the qacE\u22061 efflux transporter gene, which confers tolerance to quaternary ammonium compounds. The detection of virulence genes (i.e., that coding for enterobactin) associated with the pathogenicity of K. pneumoniae suggests a public health impact. Thus, comprehensive information on the occurrence and impact of K. pneumoniae from livestock is needed to derive appropriate management strategies for consumer protection. In this study, it was shown that poultry meat serves as a reservoir of clinically emerging multidrug-resistant high-risk clones.<\/jats:p>","DOI":"10.3390\/antibiotics13010014","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T03:36:17Z","timestamp":1703129777000},"page":"14","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impact and Diversity of ESBL-Producing Klebsiella pneumoniae Recovered from Raw Chicken Meat Samples in T\u00fcrkiye"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6442-2865","authenticated-orcid":false,"given":"Cemil","family":"K\u00fcrekci","sequence":"first","affiliation":[{"name":"Department of Food Hygiene and Technology, Faculty of Veterinary Medicine, Hatay Mustafa Kemal University, Hatay 31060, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"\u00dcnald\u0131","sequence":"additional","affiliation":[{"name":"Department of Microbiology Reference Laboratories, General Directorate of Public Health, Ministry of Health, Ankara 06430, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyda","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Department of Food Hygiene and Technology, Faculty of Veterinary Medicine, Sivas Cumhuriyet University, Sivas 58070, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9974-6571","authenticated-orcid":false,"given":"Isidro","family":"Garc\u00eda-Meni\u00f1o","sequence":"additional","affiliation":[{"name":"Laboratorio de Referencia de <i>Escherichia coli<\/i> (LREC), Departamento de Microbiolox\u00eda e Parasitolox\u00eda, Facultade de Veterinaria, Universidade de Santiago de Compostela (USC), 27002 Lugo, Spain"},{"name":"Department Biological Safety, German Federal Institute for Risk Assessment, 10589 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6930-4358","authenticated-orcid":false,"given":"Jens Andre","family":"Hammerl","sequence":"additional","affiliation":[{"name":"Department Biological Safety, German Federal Institute for Risk Assessment, 10589 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"key":"ref_1","unstructured":"WHO (2016). 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