{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T21:59:08Z","timestamp":1780696748977,"version":"3.54.1"},"reference-count":74,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science, Technological Development and Innovation of the Republic of Serbia","award":["451-03-47\/2023-01\/200007"],"award-info":[{"award-number":["451-03-47\/2023-01\/200007"]}]},{"name":"Ministry of Science, Technological Development and Innovation of the Republic of Serbia","award":["451-03-47\/2023-01\/200161"],"award-info":[{"award-number":["451-03-47\/2023-01\/200161"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Plants of the genus Prangos are intensively investigated as potential new sources of bioactive isolated products. In this work, the chemical composition of volatile constituents (essential oils and headspace volatiles) and dichloromethane extracts, as well as antimicrobial and antibiofilm activities of essential oils and MFDEs (methanol fractions of dichloromethane extracts) of Prangos trifida from Serbia, were investigated. Volatiles of roots, leaves, stems and fruits, and fatty acids and phytosterols in dichloromethane extracts of roots and fruits were analyzed by GC-FID-MS, whereas coumarins in MFDEs by LC\u2013MS and some isolated coumarins by 1H-NMR. Minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations\/minimum fungicidal concentrations (MBCs\/MFCs) of essential oils and MFDEs were determined against 13 microorganisms. Antibiofilm activity was assessed against four microorganisms. Additionally, congo red and ergosterol binding assays were conducted to elucidate selected mechanisms of antibiofilm action in the case of Candida albicans. Total of 52 volatile constituents, 16 fatty acids, eight phytosterols and 10 coumarins were identified. Essential oils demonstrated significant activity, surpassing that of commercial food preservatives, against six tested molds from the Aspergillus, Penicillium and Trichoderma genera, as well as against bacteria Staphylococcus aureus and Bacillus cereus. Most of the oils strongly inhibited the formation of biofilms by S. aureus, Listeria monocytogenes and Escherichia coli. MFDEs exhibited noteworthy effects against B. cereus and the tested Aspergillus species, particularly A. niger, and significantly inhibited C. albicans biofilm formation. This inhibition was linked to a marked reduction in exopolysaccharide production, while antifungal mechanisms associated with ergosterol remained unaffected.<\/jats:p>","DOI":"10.3390\/antibiotics13010041","type":"journal-article","created":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T13:02:58Z","timestamp":1704114178000},"page":"41","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Chemical Analysis and Investigation of Antimicrobial and Antibiofilm Activities of Prangos trifida (Apiaceae)"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0796-393X","authenticated-orcid":false,"given":"Ljubo\u0161","family":"U\u0161jak","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4159-1471","authenticated-orcid":false,"given":"Dejan","family":"Stojkovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Plant Physiology, Institute for Biological Research \u201cSini\u0161a Stankovi\u0107\u201d-National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0517-3309","authenticated-orcid":false,"given":"Tamara","family":"Carevi\u0107","sequence":"additional","affiliation":[{"name":"Department of Plant Physiology, Institute for Biological Research \u201cSini\u0161a Stankovi\u0107\u201d-National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta","family":"Milutinovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7381-756X","authenticated-orcid":false,"given":"Marina","family":"Sokovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Plant Physiology, Institute for Biological Research \u201cSini\u0161a Stankovi\u0107\u201d-National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjan","family":"Niketi\u0107","sequence":"additional","affiliation":[{"name":"Natural History Museum, Njego\u0161eva 51, 11000 Belgrade, Serbia"},{"name":"Serbian Academy of Sciences and Arts, Kneza Mihaila 35\/II, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0787-3077","authenticated-orcid":false,"given":"Silvana","family":"Petrovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11221 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Stojkovi\u0107, D., Petrovi\u0107, J., Carevi\u0107, T., Sokovi\u0107, M., and Liaras, K. (2023). Synthetic and Semisynthetic Compounds as Antibacterials Targeting Virulence Traits in Resistant Strains: A Narrative Updated Review. Antibiotics, 12.","DOI":"10.3390\/antibiotics12060963"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ivanov, M., \u0106iri\u0107, A., and Stojkovi\u0107, D. (2022). Emerging Antifungal Targets and Strategies. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23052756"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"586548","DOI":"10.3389\/fphar.2020.586548","article-title":"A Systematic Review of Plants With Antibacterial Activities: A Taxonomic and Phylogenetic Perspective","volume":"11","author":"Chassagne","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1080\/10412905.2022.2107103","article-title":"An in vitro study of the Origanum minutiflorum O. Schwarz & P. H. Davis and Coriandrum sativum L. essential oils as chronic tonsillitis therapeutics: Antibacterial, antibiofilm, antioxidant, and cytotoxic activities","volume":"34","author":"Ivanov","year":"2022","journal-title":"J. Essent. Oil Res."},{"key":"ref_5","unstructured":"(2023, December 14). Plants of the World Online. Available online: https:\/\/powo.science.kew.org."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1007\/s11101-020-09688-3","article-title":"The Prangos genus: A comprehensive review on traditional use, phytochemistry, and pharmacological activities","volume":"19","author":"Mottaghipisheh","year":"2020","journal-title":"Phytochem. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1055\/a-0873-8622","article-title":"The nonvolatile and volatile metabolites of Prangos ferulacea and their biological properties","volume":"85","author":"Bruno","year":"2019","journal-title":"Planta Med."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Badalamenti, N., Maresca, V., Di Napoli, M., Bruno, M., Basile, A., and Zanfardino, A. (2022). Chemical composition and biological activities of Prangos ferulacea essential oils. Molecules, 27.","DOI":"10.3390\/molecules27217430"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1080\/11263504.2020.1829730","article-title":"Variability in the essential oil of different wild populations of Prangos platychlaena collected from Southwestern Iran","volume":"155","author":"Azarkish","year":"2021","journal-title":"Plant Biosyst."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Zengin, G., Mahomoodally, M.F., Y\u0131ld\u0131ztugay, E., Jugreet, S., Khan, S.U., Dall\u2019Acqua, S., Mollica, A., Bouyahya, A., and Montesano, D. (2022). Chemical composition, biological activities and in silico analysis of essential oils of three endemic Prangos species from Turkey. Molecules, 27.","DOI":"10.3390\/molecules27051676"},{"key":"ref_11","first-page":"74","article-title":"Chemical Composition and Anticandidal Activity of Essential Oils Obtained from Different Parts of Prangos heyniae H. Duman & MF Watson","volume":"16","author":"Karahisar","year":"2022","journal-title":"Rec. Nat. Prod."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"114823","DOI":"10.1016\/j.jep.2021.114823","article-title":"Comparative evaluation of relaxant effects of three Prangos species on mouse corpus cavernosum: Chemical characterization and the relaxant mechanisms of action of P. pabularia and (+)-oxypeucedanin","volume":"284","author":"Sevin","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Tan, N., Yaz\u0131c\u0131-T\u00fct\u00fcni\u015f, S., Bilgin, M., Tan, E., and Miski, M. (2017). Antibacterial Activities of Pyrenylated Coumarins from the Roots of Prangos hulusii. Molecules, 22.","DOI":"10.3390\/molecules22071098"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"112572","DOI":"10.1016\/j.indcrop.2020.112572","article-title":"Chemical profile, antioxidant, antimicrobial, enzyme inhibitory, and cytotoxicity of seven Apiaceae species from Turkey: A comparative study","volume":"153","author":"Zengin","year":"2020","journal-title":"Ind. Crops Prod."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Dall\u2019Acqua, S., Sut, S., Zengin, G., Peron, G., Elbasan, F., Yildiztugay, E., Bibi Sadeer, N., and Mahomoodally, M.F. (2022). Phytochemical screening, antioxidant, and enzyme inhibitory properties of three Prangos species (P. heyniae, P. meliocarpoides var. meliocarpoides, and P. uechtritzii) depicted by comprehensive LC-MS and multivariate data analysis. Antioxidants, 11.","DOI":"10.3390\/antiox11091712"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"385103","DOI":"10.1088\/1361-6528\/ac78f1","article-title":"Investigation of the antibacterial and biofilm inhibitory activities of Prangos acaulis (DC.) Bornm in nanoparticulated formulation","volume":"33","author":"Nosrati","year":"2022","journal-title":"Nanotechnology"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Sarghaleh, S.J., Behbahani, B.A., Hojjati, M., Vasiee, A., and Noshad, M. (2023). Evaluation of the constituent compounds, antioxidant, anticancer, and antimicrobial potential of Prangos ferulacea plant extract and its effect on Listeria monocytogenes virulence gene expression. Front. Microbiol., 14.","DOI":"10.3389\/fmicb.2023.1202228"},{"key":"ref_18","first-page":"1","article-title":"A monographic study of the genus Prangos (Umbelliferae)","volume":"26","author":"Herrnstadt","year":"1977","journal-title":"Boissiera"},{"key":"ref_19","unstructured":"Stevanovi\u0107, V. (1999). The Red Data Book of Flora of Serbia. Extinct and Critically Endangered Taxa, Ministry of Environment of the Republic of Serbia, Faculty of Biology, University of Belgrade, Institution for Protection of Nature of the Republic of Serbia. (In Serbian and English)."},{"key":"ref_20","unstructured":"Hand, R. (2011). Euro+Med Plantbase\u2014The Information Resource for Euro-Mediterranean Plant Diversity, Dipartimento di Scienzeambientali e Biodiversit\u00e0 ed Orto botanico, Universit\u00e0 degli Studi di Palermo. Available online: https:\/\/europlusmed.org\/cdm_dataportal\/taxon\/368c1360-c3ad-41c6-8a61-e46168b44d47#footnote-T."},{"key":"ref_21","unstructured":"Lyskov, D.F. (2015). Systematics of the Genus Prangos (Umbelliferae, Apioideae) and Related Taxa: Comparison of Morphological-Anatomic and Molecular Data. [Ph.D. Thesis, Faculty of Biology, M.V. Lomonosov Moscow State University]. (In Russian)."},{"key":"ref_22","unstructured":"Oskolski, A., Nuraliev, M., and Tilney, P. (2017). Abstract Book, Proceedings of the IX Apiales Symposium, The Gold Coast Marina Club, Guangzhou, China, 31 July\u20132 August 2017, Lomonosov Moscow State University."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1080\/10412905.2004.9698684","article-title":"Composition of the Essential Oil of Cachrys alpine Bieb","volume":"16","author":"Baser","year":"2004","journal-title":"J. Essent. Oil Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1080\/10412905.2004.9698738","article-title":"Volatile oil Constituents from Different Parts of Cachrys trifida L.","volume":"16","author":"Maqueda","year":"2004","journal-title":"J. Essent. Oil Res."},{"key":"ref_25","unstructured":"Korotkov, O.I., Shevchuk, O.M., Shatko, V.G., Timashova, L.A., and Feskov, S.A. (2018). Some biochemical characteristics of Prangos trifida (Mill.) Herrnst. & Heyn. Bull. State Nikit. Botan. Gard., 76\u201383."},{"key":"ref_26","first-page":"3772","article-title":"Chemical composition, antimicrobial and antioxidant activities of the essential oil of Italian Prangos trifida (Mill.) Herrnst. & Heyn","volume":"37","author":"Castagliuolo","year":"2022","journal-title":"Nat. Prod. Res."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Maresca, V., Badalamenti, N., Ilardi, V., Bruno, M., and Basile, A. (2023). The Antioxidant Properties and Protective Capacity of Prangos trifida and Cachrys cristata Essential Oils against Cd Stress in Lunularia cruciata and Brassica napus. Antioxidants, 12.","DOI":"10.3390\/antiox12040793"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1211\/0022357011776432","article-title":"Effects of furocoumarins from Cachrys trifida on some macrophage functions","volume":"53","author":"Abad","year":"2001","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_29","unstructured":"Adams, R.P. (2017). Identification of Essential Oil Components by Gas Chromatography\/Mass Spectrometry, Allured Publishing Corporation. [4.1 ed.]."},{"key":"ref_30","first-page":"214","article-title":"Phytochemical analysis of Ferulogo bernardii Tomk & M. Pimen","volume":"14","author":"Hadjiakhoondi","year":"2006","journal-title":"DARU J. Pharm. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.chroma.2006.02.081","article-title":"Preparative isolation of imperatorin, oxypeucedanin and isoimperatorin from traditional Chinese herb \u201cbai zhi\u201d Angelica dahurica (Fisch. ex Hoffm) Benth. et Hook using multidimensional high-speed counter-current chromatography","volume":"1115","author":"Wei","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"322","DOI":"10.4103\/0974-8490.158437","article-title":"Antiproliferative evaluation of terpenoids and terpenoid coumarins from Ferulago macrocarpa (Fenzl) Boiss. fruits","volume":"7","author":"Sajjadi","year":"2015","journal-title":"Pharmacogn. Res."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"U\u0161jak, L.J., Drobac, M.M., Niketi\u0107, M.S., and Petrovi\u0107, S.D. (2018). Chemosystematic Significance of Essential Oil Constituents and Furanocoumarins of Underground Parts and Fruits of Nine Heracleum L. Taxa from Southeastern Europe. Chem. Biodivers., 15.","DOI":"10.1002\/cbdv.201800412"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Kiyonga, A.N., Hong, G., Kim, H.S., Suh, Y.G., and Jung, K. (2021). Facile and Rapid Isolation of Oxypeucedanin Hydrate and Byakangelicin from Angelica dahurica by Using [Bmim] Tf2N Ionic Liquid. Molecules, 26.","DOI":"10.3390\/molecules26040830"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6879","DOI":"10.1021\/jf040164p","article-title":"Quantification of Total Furocoumarins in Citrus Oils by HPLC Coupled with UV, Fluorescence, and Mass Detection","volume":"52","author":"Decorzant","year":"2004","journal-title":"J. Agric. Food Chem."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Dewick, P.M. (2009). Medicinal Natural Products: A Biosynthetic Approach, John Wiley & Sons. [3rd ed.].","DOI":"10.1002\/9780470742761"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Kusano, M., Kobayashi, M., Iizuka, Y., Fukushima, A., and Saito, K. (2016). Unbiased profiling of volatile organic compounds in the headspace of Allium plants using an in-tube extraction device. BMC Res. Notes, 9.","DOI":"10.1186\/s13104-016-1942-5"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.3390\/molecules17044133","article-title":"Pressurized liquid extraction of coumarins from fruits of Heracleum leskowii with application of solvents with different polarity under increasing temperature","volume":"17","year":"2012","journal-title":"Molecules"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/12538078.2007.10516050","article-title":"Fatty acids and tocochromanol patterns of some Turkish Apiaceae (Umbelliferae) plants; a chemotaxonomic approach","volume":"154","author":"Bagci","year":"2007","journal-title":"Acta Bot. Gallica"},{"key":"ref_40","first-page":"1934578X1601101118","article-title":"Fatty Acid Methyl Ester Composition of Some Turkish Apiaceae Seed Oils: New Sources for Petroselinic Acid","volume":"11","author":"Ayaz","year":"2016","journal-title":"Nat. Prod. Commun."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Saini, R.K., Song, M.H., Yu, J.W., Shang, X., and Keum, Y.S. (2021). Phytosterol Profiling of Apiaceae Family Seeds Spices Using GC-MS. Foods, 10.","DOI":"10.3390\/foods10102378"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/BF00564086","article-title":"Prantschimgin\u2014A new coumarin from the roots of Prangos tschimganica","volume":"2","author":"Kuznetsova","year":"1966","journal-title":"Chem. Nat. Compd."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1046\/j.1365-2672.1999.00621.x","article-title":"Inhibitory effects of some spice essential oils on Aspergillus ochraceus NRRL 3174 growth and ochratoxin A production","volume":"29","author":"Basilico","year":"1999","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1128\/AEM.68.5.2326-2329.2002","article-title":"Ochratoxin production by the Aspergillus ochraceus group and Aspergillus alliaceus","volume":"68","author":"Bayman","year":"2002","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Mazaheri, T., Cervantes-Huam\u00e1n, B.R., Berm\u00fadez-Capdevila, M., Ripolles-Avila, C., and Rodr\u00edguez-Jerez, J.J. (2021). Listeria monocytogenes biofilms in the food industry: Is the current hygiene program sufficient to combat the persistence of the pathogen?. Microorganisms, 9.","DOI":"10.3390\/microorganisms9010181"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"102917","DOI":"10.1016\/j.ifset.2022.102917","article-title":"Effects of electrolysed water combined with ultrasound on inactivation kinetics and metabolite profiles of Escherichia coli biofilms on food contact surface","volume":"76","author":"Zhao","year":"2022","journal-title":"Innov. Food Sci. Emerg. Technol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Idrees, M., Sawant, S., Karodia, N., and Rahman, A. (2021). Staphylococcus aureus biofilm: Morphology, genetics, pathogenesis and treatment strategies. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18147602"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2106612","DOI":"10.1002\/smll.202106612","article-title":"Enzyme-photocatalyst tandem microrobot powered by urea for Escherichia coli biofilm eradication","volume":"18","author":"Villa","year":"2022","journal-title":"Small"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jep.2005.04.025","article-title":"Medicinal plants and antimicrobial activity","volume":"100","author":"Rios","year":"2005","journal-title":"J. Ethnopharmacol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.micpath.2017.09.057","article-title":"Synergistic effect of eugenol, carvacrol, thymol, p-cymene and \u03b3-terpinene on inhibition of drug resistance and biofilm formation of oral bacteria","volume":"112","author":"Miladi","year":"2017","journal-title":"Microb. Pathog."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1055\/a-1147-4671","article-title":"Anti-biofilm and Virulence Factor-Reducing Activities of Essential Oils and Oil Components as a Possible Option for Bacterial Infection Control","volume":"86","author":"Reichling","year":"2020","journal-title":"Planta Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/lam.13308","article-title":"Evaluation of antibiofilm efficacy of essential oil components \u03b2-caryophyllene, cinnamaldehyde and eugenol alone and in combination against biofilm formation and preformed biofilms of Listeria monocytogenes and Salmonella typhimurium","volume":"71","author":"Purkait","year":"2020","journal-title":"Lett. Appl. Microbiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/jam.12289","article-title":"Anti-biofilm forming and anti-quorum sensing activity of selected essential oils and their main components on food-related micro-organisms","volume":"115","author":"Kerekes","year":"2013","journal-title":"J. Appl. Microbiol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Khan, F., Tabassum, N., Jeong, G.J., Jung, W.K., and Kim, Y.M. (2023). Inhibition of Mixed Biofilms of Candida albicans and Staphylococcus aureus by \u03b2-Caryophyllene-Gold Nanoparticles. Antibiotics, 12.","DOI":"10.3390\/antibiotics12040726"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/10412905.2017.1372314","article-title":"Chemical diversity and antimicrobial activity of the essential oils of four Apiaceae species growing wild in Lebanon","volume":"30","author":"Khoury","year":"2018","journal-title":"J. Essent. Oil Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"75","DOI":"10.15171\/bi.2017.10","article-title":"An in vitro ethnopharmacological study on Prangos ferulacea: A wound healing agent","volume":"7","author":"Yousefi","year":"2017","journal-title":"Bioimpacts"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.sajb.2007.05.002","article-title":"Comparison of hydrodistillation and microdistillation methods for the analysis of fruit volatiles of Prangos pabularia Lindl., and evaluation of its antimicrobial activity","volume":"73","author":"Hamzaoglu","year":"2007","journal-title":"S. Afr. J. Bot."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/cbdv.201200202","article-title":"Chemical composition and antimicrobial activity of the volatile fractions from leaves and flowers of the wild Iraqi Kurdish plant Prangos peucedanifolia Fenzl","volume":"10","author":"Brusotti","year":"2013","journal-title":"Chem. Biodivers."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s10600-006-0069-7","article-title":"Composition and antimicrobial activity of Prangos platychlaena and P. uechtritzii","volume":"42","author":"Uzel","year":"2006","journal-title":"Chem. Nat. Compd."},{"key":"ref_60","first-page":"10","article-title":"Aspergillus fumigatus and Aspergillosis in 2019","volume":"33","author":"Chamilos","year":"2019","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_61","first-page":"1516","article-title":"Antimicrobial Activities of Extracts and Isolated Coumarins from the Roots of Four Ferulago Species Growing in Turkey","volume":"18","author":"Karakaya","year":"2019","journal-title":"Iran. J. Pharm. Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0378-8741(94)01215-L","article-title":"Biological activities of a Turkish medicinal plant, Prangos platychlaena","volume":"45","author":"Ulubelen","year":"1995","journal-title":"J. Ethnopharmacol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"10933","DOI":"10.1021\/acs.jafc.7b04202","article-title":"Research on Chemical Composition and Biological Properties Including Antiquorum Sensing Activity of Angelica pancicii Vandas Aerial Parts and Roots","volume":"65","author":"Mileski","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/mmy\/myu078","article-title":"Investigating the antifungal activity and mechanism(s) of geraniol against Candida albicans strains","volume":"53","author":"Leite","year":"2015","journal-title":"Med. Mycol."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Ali, S., Sudha, K.G., Thirumalaivasan, N., Ahamed, M., Pandiaraj, S., Rajeswari, V.D., Vinayagam, Y., Thiruvengadam, M., and Govindasamy, R. (2023). Green Synthesis of Magnesium Oxide Nanoparticles by Using Abrus precatorius Bark Extract and Their Photocatalytic, Antioxidant, Antibacterial, and Cytotoxicity Activities. Bioengineering, 10.","DOI":"10.3390\/bioengineering10030302"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pbiomolbio.2023.08.002","article-title":"Computational approaches for modeling and structural design of biological systems: A comprehensive review","volume":"185","author":"Gayathiri","year":"2023","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1586\/eri.09.18","article-title":"Antifungal drug resistance mechanisms","volume":"7","year":"2009","journal-title":"Expert Rev. Anti-Infect. Ther."},{"key":"ref_68","unstructured":"EDQM (2023). European Pharmacopoeia 11.0, European Directorate for the Quality of Medicine & Health Care of the Council of Europe (EDQM)."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.plaphy.2013.08.002","article-title":"A chemometrics as a powerful tool in the elucidation of the role of metals in the biosynthesis of volatile organic compounds in Hungarian thyme samples","volume":"71","year":"2013","journal-title":"Plant Physiol. Biochem."},{"key":"ref_70","first-page":"1934578X19856788","article-title":"Fatty acids, sterols, and triterpenes of the fruits of 8 Heracleum taxa","volume":"14","author":"Drobac","year":"2019","journal-title":"Nat. Prod. Commun."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Tang, J.J., Zhao, N., Gao, Y.Q., Han, R., Wang, X.Y., Tian, J.M., and Gao, J.M. (2021). Phytosterol profiles and iridoids of the edible Eucommia ulmoides Oliver seeds and their anti-inflammatory potential. Food Biosci., 43.","DOI":"10.1016\/j.fbio.2021.101295"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1039\/C7FO00887B","article-title":"Chemical, nutritive composition and a wide range of bioactive properties of honey mushroom: Armillaria mellea (Vahl: Fr.) Kummer","volume":"8","author":"Barros","year":"2017","journal-title":"Food Funct."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.sajb.2021.11.050","article-title":"Rosmarinic acid\u2013Modes of antimicrobial and antibiofilm activities of common plant polyphenol","volume":"146","author":"Ivanov","year":"2022","journal-title":"S. Afr. J. Bot."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"9961089","DOI":"10.1155\/2021\/9961089","article-title":"New Evidence for Artemisia absinthium L. Application in Gastrointestinal Ailments: Ethnopharmacology, Antimicrobial Capacity, Cytotoxicity, and Phenolic Profile","volume":"2021","author":"Ivanov","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."}],"container-title":["Antibiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2079-6382\/13\/1\/41\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:38:01Z","timestamp":1760103481000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2079-6382\/13\/1\/41"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,1]]},"references-count":74,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["antibiotics13010041"],"URL":"https:\/\/doi.org\/10.3390\/antibiotics13010041","relation":{},"ISSN":["2079-6382"],"issn-type":[{"value":"2079-6382","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,1]]}}}