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(PROPPi\/UFF)","award":["#4387"],"award-info":[{"award-number":["#4387"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Streptococcus pneumoniae causes serious illnesses, such as pneumonia, bacteremia, and meningitis, mainly in immunocompromised individuals and those of extreme ages. Currently, pneumococcal conjugate vaccines (PCVs) are the best allies against pneumococcal diseases. In Brazil, the 10-valent and 13-valent PCVs have been available since 2010, but the threat of antimicrobial resistance persists and has been changing over time. We conducted a systematic review of the literature with works published since 2000, generating a parallel between susceptibility data on isolates recovered from colonization and invasive diseases before and after the implementation of PCVs for routine childhood use in Brazil. This systematic review was based on the Cochrane Handbook for Systematic Reviews of Interventions and Preferred Reporting Items for Systematic Literature Reviews and Meta-Analyses (PRISMA) guidelines. Despite the inclusion of PCVs at a large scale in the national territory, high frequencies of non-susceptibility to important drugs used in pneumococcal diseases are still observed, especially penicillin, as well as increasing resistance to macrolides. However, there are still drugs for which pneumococci have a comprehensive sensitivity profile.<\/jats:p>","DOI":"10.3390\/antibiotics13010066","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T10:48:06Z","timestamp":1704797286000},"page":"66","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Antimicrobial Resistance in Streptococcus pneumoniae before and after the Introduction of Pneumococcal Conjugate Vaccines in Brazil: A Systematic Review"],"prefix":"10.3390","volume":"13","author":[{"given":"Patricia Alice","family":"Knupp-Pereira","sequence":"first","affiliation":[{"name":"Instituto Biom\u00e9dico, Universidade Federal Fluminense, Niter\u00f3i 24020-150, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda Seabra","family":"Cabral","sequence":"additional","affiliation":[{"name":"Instituto Biom\u00e9dico, Universidade Federal Fluminense, Niter\u00f3i 24020-150, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00cdtalo Moraes","family":"Dolores","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 01246-903, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda Beiral","family":"da Silva","sequence":"additional","affiliation":[{"name":"Instituto Biom\u00e9dico, Universidade Federal Fluminense, Niter\u00f3i 24020-150, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helv\u00e9cio Cardoso Correa","family":"P\u00f3voa","sequence":"additional","affiliation":[{"name":"Instituto de Sa\u00fade de Nova Friburgo, Universidade Federal Fluminense, Nova Friburgo 28625-650, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3606-2540","authenticated-orcid":false,"given":"Felipe Piedade Gon\u00e7alves","family":"Neves","sequence":"additional","affiliation":[{"name":"Instituto Biom\u00e9dico, Universidade Federal Fluminense, Niter\u00f3i 24020-150, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41579-018-0001-8","article-title":"Streptococcus pneumoniae: Transmission, colonization and invasion","volume":"16","author":"Weiser","year":"2018","journal-title":"Nat. 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