{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:05:55Z","timestamp":1791655555088,"version":"4.3.4"},"reference-count":45,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T00:00:00Z","timestamp":1705276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>The opportunistic human fungal pathogen Candida albicans produces and releases into the surrounding medium extracellular vesicles (EVs), which are involved in some processes as communication between fungal cells and host\u2013pathogen interactions during infection. Here, we have conducted the isolation of EVs produced by a clinical isolate of C. albicans during biofilm formation and proved their effect towards the ability of the Gram-negative bacterial pathogen Klebsiella pneumoniae to adhere to HaCaT cells and form a biofilm in vitro. The results represent the first evidence of an antagonistic action of fungal EVs against bacteria.<\/jats:p>","DOI":"10.3390\/antibiotics13010080","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T08:52:03Z","timestamp":1705308723000},"page":"80","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Extracellular Vesicles from a Biofilm of a Clinical Isolate of Candida albicans Negatively Impact on Klebsiella pneumoniae Adherence and Biofilm Formation"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5400-6854","authenticated-orcid":false,"given":"Marianna","family":"Imparato","sequence":"first","affiliation":[{"name":"Department of Biology, University of Naples \u2018Federico II\u2019, Via Cinthia, 80126 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4981-8837","authenticated-orcid":false,"given":"Angela","family":"Maione","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Naples \u2018Federico II\u2019, Via Cinthia, 80126 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Buonanno","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Naples \u2018Federico II\u2019, Via Cinthia, 80126 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Gesuele","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Naples \u2018Federico II\u2019, Via Cinthia, 80126 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemi","family":"Gallucci","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences, University of Naples \u201cFederico II\u201d, Via Cintia 4, 80126 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6834-8682","authenticated-orcid":false,"given":"Maria Michela","family":"Corsaro","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences, University of Naples \u201cFederico II\u201d, Via Cintia 4, 80126 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Paduano","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences, University of Naples \u201cFederico II\u201d, Via Cintia 4, 80126 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Casillo","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences, University of Naples \u201cFederico II\u201d, Via Cintia 4, 80126 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6805-0408","authenticated-orcid":false,"given":"Marco","family":"Guida","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Naples \u2018Federico II\u2019, Via Cinthia, 80126 Naples, Italy"},{"name":"National Biodiversity Future Center (NBFC), 90133 Palermo, Italy"},{"name":"Center for Studies on Bioinspired Agro-Environmental Technology (BAT Center), 80055 Portici, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8116-0839","authenticated-orcid":false,"given":"Emilia","family":"Galdiero","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Naples \u2018Federico II\u2019, Via Cinthia, 80126 Naples, Italy"},{"name":"Center for Studies on Bioinspired Agro-Environmental Technology (BAT Center), 80055 Portici, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"de Alteriis","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Naples \u2018Federico II\u2019, Via Cinthia, 80126 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1128\/IAI.06014-11","article-title":"Membrane vesicle release in bacteria, eukaryotes, and archaea: A conserved yet underappreciated aspect of microbial life","volume":"80","author":"Deatherage","year":"2012","journal-title":"Infect. 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