{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:31:39Z","timestamp":1787027499787,"version":"build-2736575974"},"reference-count":42,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Stop Sida Association"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Antibiotics"],"abstract":"<jats:p>Background: In geriatrics, explicit criteria for potentially inappropriate prescriptions (PIPs) are useful for optimizing drug use. Objective: To produce an expert consensus on explicit definitions of antibiotic-PIPs for hospitalized older patients. Methods: We conducted a Delphi survey involving French experts on antibiotic stewardship in hospital settings. During the survey\u2019s rounds, the experts gave their opinion on each explicit definition, and could suggest new definitions. Definitions with a 1-to-9 Likert score of between 7 and 9 from at least 75% of the participants were adopted. The results were discussed during consensus meetings after each round. Results: Of the 155 invited experts, 128 (82.6%) participated in the whole survey: 59 (46%) infectious diseases specialists, 45 (35%) geriatricians, and 24 (19%) other specialists. In Round 1, 65 explicit definitions were adopted and 21 new definitions were suggested. In Round 2, 35 other explicit definitions were adopted. The results were validated during consensus meetings (with 44 participants after Round 1, and 54 after Round 2). Conclusions: The present study is the first to have provided a list of explicit definitions of potentially inappropriate antibiotic prescriptions for hospitalized older patients. It might help to disseminate key messages to prescribers and reduce inappropriate prescriptions of antibiotics.<\/jats:p>","DOI":"10.3390\/antibiotics13030283","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T13:09:36Z","timestamp":1710940176000},"page":"283","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["One Hundred Explicit Definitions of Potentially Inappropriate Prescriptions of Antibiotics in Hospitalized Older Patients: The Results of an Expert Consensus Study"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4407-2178","authenticated-orcid":false,"given":"Nicolas","family":"Baclet","sequence":"first","affiliation":[{"name":"CHU Lille, University of Lille, F-59000 Lille, France"},{"name":"Groupe Hospitalier de l\u2019Institut Catholique (GHICL), Service de Maladies Infectieuses, Universit\u00e9 Catholique de Lille, F-59160 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Forestier","sequence":"additional","affiliation":[{"name":"Service de Maladies Infectieuses, Centre Hospitalier M\u00e9tropole Savoie, F-73000 Chamb\u00e9ry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00ebtan","family":"Gavazzi","sequence":"additional","affiliation":[{"name":"Clinique Universitaire de M\u00e9decine G\u00e9riatrique, Centre Hospitalier Universitaire de Grenoble-Alpes, GREPI EA7408 Universit\u00e9 Grenoble-Alpes, F-38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0870-0979","authenticated-orcid":false,"given":"Claire","family":"Roubaud-Baudron","sequence":"additional","affiliation":[{"name":"CHU Bordeaux, P\u00f4le de G\u00e9rontologie Clinique, University of Bordeaux, INSERM 1312 BRIC, F-33000 Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Hiernard","sequence":"additional","affiliation":[{"name":"CHU Lille, University of Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozenn","family":"Hequette-Ruz","sequence":"additional","affiliation":[{"name":"Service de Maladies Infectieuses, CH Roubaix, F-59056 Roubaix, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9672-725X","authenticated-orcid":false,"given":"Serge","family":"Alfandari","sequence":"additional","affiliation":[{"name":"Service Universitaire de Maladies Infectieuses et Tropicales, H\u00f4pital Gustave Dron, F-59200 Tourcoing, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0023-7652","authenticated-orcid":false,"given":"Hugues","family":"Auma\u00eetre","sequence":"additional","affiliation":[{"name":"Service de Maladies Infectieuses et Tropicales, Centre Hospitalier de Perpignan, F-66000 Perpignan, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Botelho-Nevers","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, University Hospital of Saint-Etienne, GIMAP (EA 3064), F-42055 Cedex 02 Saint-Etienne, France"},{"name":"Faculty of Medicine of Saint-Etienne, University of Saint-Etienne, F-42023 Cedex 02 Saint-Etienne, France"},{"name":"Faculty of Medicine, University of Lyon, F-69000 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4832-0161","authenticated-orcid":false,"given":"Pauline","family":"Caraux-Paz","sequence":"additional","affiliation":[{"name":"Service de Maladies Infectieuses et Tropicales, H\u00f4pital Intercommunal de Villeneuve-Saint-Georges, F-94190 Villeneuve-Saint-Georges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Charmillon","sequence":"additional","affiliation":[{"name":"CHRU-Nancy, Infectious Diseases Department, F-54000 Nancy, France"},{"name":"Grand Est Antibiotic Stewardship Network Coordinator, AntibioEst, F-54000 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Diamantis","sequence":"additional","affiliation":[{"name":"Service de Maladies Infectieuses et Tropicales, H\u00f4pital de Melun, F-77000 Melun, France"},{"name":"Unit\u00e9 de Recherche DYNAMIC, Universit\u00e9 Paris-Est Cr\u00e9teil, F-94000 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2388-1838","authenticated-orcid":false,"given":"Thibaut","family":"Fraisse","sequence":"additional","affiliation":[{"name":"Court S\u00e9jour G\u00e9riatrique Aigu, Centre Hospitalier Al\u00e8s-C\u00e9vennes, F-30100 Al\u00e8s, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2934-7617","authenticated-orcid":false,"given":"Pierre","family":"Gazeau","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses et Tropicales, CHRU de Brest, F-29609 Brest Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2729-9420","authenticated-orcid":false,"given":"Maxime","family":"Hentzien","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Infectious Diseases and Clinical Immunology, University Hospital of Reims, F-51100 Reims, France"},{"name":"EA3797-Viellissement Fragilit\u00e9, Reims Champagne Ardennes University, F-51100 Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Lanoix","sequence":"additional","affiliation":[{"name":"AGIR UR 4294, University Picardie Jules Verne, F-80000 Amiens, France"},{"name":"Department of Infectious Diseases, Amiens University Hospital, F-80000 Amiens, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Paccalin","sequence":"additional","affiliation":[{"name":"P\u00f4le de G\u00e9riatrie, CHU Poitiers, Universit\u00e9 Poitiers, F-86000 Poitiers, France"},{"name":"Centre d\u2019Investigation Clinique CIC 1402, INSERM CHU Poitiers, Universit\u00e9 Poitiers, F-86000 Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Putot","sequence":"additional","affiliation":[{"name":"M\u00e9decine Interne et Maladies Infectieuses, H\u00f4pitaux du Pays du Mont Blanc, F-74700 Sallanches, France"},{"name":"Physiopathologie et Epid\u00e9miologie C\u00e9r\u00e9bro-Cardiovasculaires, Universit\u00e9 de Bourgogne, F-21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4713-9478","authenticated-orcid":false,"given":"Yvon","family":"Ruch","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Strasbourg University Hospital, F-67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Senneville","sequence":"additional","affiliation":[{"name":"Service Universitaire de Maladies Infectieuses et Tropicales, H\u00f4pital Gustave Dron, F-59200 Tourcoing, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Beuscart","sequence":"additional","affiliation":[{"name":"CHU Lille, University of Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,20]]},"reference":[{"key":"ref_1","unstructured":"Antimicrobial Resistance Collaborators (2022). 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